Disease of primarily extrinsic mechanism

Researchers are testing whether a combination of two long-acting HIV antibodies and a low dose of the cancer immunotherapy nivolumab can help people with HIV control the virus without antiretroviral therapy. The trial enrolls 90 adults whose HIV is already well suppressed on stan…

Researchers in Gabon are testing whether a tea made from dried Artemisia annua leaves can clear malaria parasites in adults who carry the infection without feeling sick. The trial enrolls 20 semi-immune adults aged 18 to 45 who have low levels of Plasmodium falciparum in their bl…

This study tests whether bone marrow from deceased donors can be used to treat people with blood cancers like leukemia and lymphoma. Participants receive a transplant of cryopreserved marrow from a deceased donor or standard cells from a living donor. The goal is to see if the de…

Researchers are testing whether adding a PD-1 antibody and pegylated interferon to standard antiviral pills can help people with chronic hepatitis B lose the hepatitis B surface antigen. The trial enrolls adults whose virus is already suppressed by nucleos(t)ide analogues and who…

This Phase 1 trial tests a new type of cell therapy for people with relapsed or refractory CD30-positive lymphomas, including Hodgkin lymphoma and certain non-Hodgkin lymphomas. The treatment uses a patient's own immune cells that are genetically engineered to recognize and attac…

This study investigates whether combining two immune checkpoint inhibitors—one targeting GARP:TGF-β1 and another targeting PD-1—can better reactivate and eliminate dormant HIV-infected cells. Using blood samples from people with HIV-1 on suppressive antiretroviral therapy, resear…

This study tests whether a higher dose of the drug rifampicin can safely shorten tuberculosis treatment for children aged 3 months to 10 years. About 230 children with drug-susceptible TB will receive either the standard or a higher rifampicin dose, with treatment duration adjust…

This early-stage trial will test a new HIV vaccine in 22 infants who were exposed to HIV during birth but are not infected. The vaccine is designed to train the immune system to recognize and fight HIV. The main goal is to see if the vaccine is safe and whether it triggers an imm…

This study tests a new type of COVID-19 booster vaccine given as a nasal spray. The vaccine uses a weakened live virus to train the immune system, potentially offering stronger protection in the nose and throat where the virus enters. Researchers are enrolling 80 healthy adults a…

This Phase 1 trial tests experimental mRNA vaccines designed to protect against many types of influenza A by targeting a stable part of the virus. Healthy adults aged 18 to 59 receive one or two doses of the vaccine candidates, alone or in combination. The study checks for side e…

This study tests a new COVID-19 vaccine (LUNAR-COV19) in 56 adults who received a blood stem cell transplant within the past year. These patients often have weaker immune responses to standard vaccines. The new vaccine uses a self-amplifying mRNA that may produce a stronger and l…

Researchers are testing an RSV vaccine in healthy adults aged 60 and older to see how safe it is and how well it triggers an immune response. The trial enrolls about 600 people in China and the United States. In China, participants receive either the vaccine or a placebo; in the …

Researchers are testing an experimental tuberculosis vaccine called VIR-1778 in healthy adults who do not have HIV. The vaccine uses a weakened form of human cytomegalovirus to deliver seven TB proteins to the immune system. The trial aims to see if VIR-1778 is safe and whether i…

Researchers are testing an experimental mRNA COVID-19 vaccine called mRNA-1283 in children from 6 months to under 12 years old. The trial compares two different dose levels to find the best dose for each age group. About 300 children in good general health will receive the vaccin…

Researchers are testing an experimental vaccine against respiratory syncytial virus (RSV) in adults aged 18 and older. The trial aims to see if the vaccine is safe and whether it triggers an immune response. Participants receive one of several vaccine formulations or a placebo, a…

This trial tests whether the 9-valent HPV vaccine (V503) can trigger a strong immune response against nine HPV types in Chinese females aged 10 to 45 who previously received the bivalent (2-type) HPV vaccine. Participants will receive either the 9-valent vaccine or a placebo, and…

This phase 1 trial tests a higher dose of the experimental HIV vaccine VIR-1388 in about 12 adults aged 18 to 55 who already carry cytomegalovirus (CMV). The vaccine uses a weakened CMV virus to deliver HIV proteins, aiming to trigger a strong immune response. Participants receiv…

This trial tests whether the 9-valent HPV vaccine is safe and triggers a protective immune response in adults with HIV. People with HIV face higher risks of HPV infection and related cancers, but vaccine research in this group is limited. The study enrolls 60 HIV-infected adults …

This Phase 3 trial tests updated versions of the BNT162b2 COVID-19 vaccine in adults and children aged 5 and older. Participants include those aged 5 to 64 with medical conditions that raise their risk of severe COVID-19, as well as everyone aged 65 and older. The study compares …

This trial tests an inactivated EV71 vaccine in healthy children aged 6 to 71 months. The vaccine targets enterovirus 71, a major cause of severe hand, foot, and mouth disease in the Asia-Pacific region. Each child receives two doses, 30 days apart. Researchers measure whether th…

This trial tests a new pneumococcal vaccine, called PG4, in adults aged 18 to 49. Researchers compare three batches of PG4 to each other and to the current vaccine, Prevnar 20, to see if they produce similar immune responses and are equally safe. Participants receive one injectio…

This trial tests a new malaria vaccine, PfSPZ-LARC2, made from live but genetically weakened malaria parasites that stop developing in the liver and never reach the bloodstream. The goal is to see if a single dose can safely and effectively protect healthy adults in Burkina Faso …

This study tests whether a two-dose regimen of the Butantan-DV dengue vaccine, given nine months apart, produces a stronger immune response than a single dose in children and adolescents aged 2 to 17 who have never had dengue. The trial also checks that the vaccine made at a new …

This first-in-human study tests a new microneedle patch (Miracus) that dissolves in the skin to deliver a tetanus vaccine without a needle. Thirty healthy adults will receive either an empty patch or one loaded with vaccine. Researchers will check safety, tolerability, and whethe…

This study tests a new vaccine called TdaP2gen in 320 pregnant women in Thailand to see if it safely protects their babies from tetanus, diphtheria, and whooping cough. The vaccine is given during pregnancy, and researchers measure antibody levels in mothers and infants up to 18 …

This early-stage trial tests an oral capsule containing a genetically modified probiotic yeast designed to neutralize toxins produced by C. diff bacteria. The study first evaluates safety in healthy adults, then in people at risk for recurrent C. diff infection. Participants take…

Researchers are studying depemokimab, an injected biologic drug, in adults aged 18 to 75 who have allergic bronchopulmonary aspergillosis (ABPA) along with severe eosinophilic asthma. The study tracks how many asthma attacks need systemic steroids and whether participants' qualit…

This phase II trial tests whether combining bevacizumab, a drug that limits blood vessel growth, with PRGN-2012, a vaccine-based therapy, can help adults with recurrent respiratory papillomatosis (RRP) avoid needing more surgeries. RRP causes wart-like growths in the airway that …

This study tests a new drug called SX-682 (a tablet) combined with the chemotherapy docetaxel in people whose head/neck, salivary gland, or prostate cancer has spread or returned after treatment. The goal is to find the right dose and see if the combination shrinks tumors. About …

Researchers are testing a new immunotherapy called Lm-LLO-TT in adults with advanced pancreatic ductal adenocarcinoma that has already been treated with chemotherapy. Lm-LLO-TT uses a weakened form of Listeria bacteria engineered to carry a tetanus toxoid antigen, aiming to spark…

Researchers test whether Bacillus probiotics, given alongside standard four-drug antibiotics for H. pylori infection, reduce gut side effects and improve treatment tolerance. The trial enrolls 336 adults with H. pylori who receive either a single-strain probiotic, a multi-strain …

Researchers are testing whether adding CT-guided thermal ablation of liver or lung metastases to standard systemic therapy improves tumor response in people with nasopharyngeal carcinoma. The trial enrolls 138 adults whose primary tumor was cured but who later developed up to fiv…

Researchers are testing a new way to deliver antibiotics to the brain in people with moderate to severe bacterial meningitis who are not improving on standard intravenous treatment. The approach combines standard IV antibiotics with a continuous infusion of three antibiotics (van…

Researchers are testing whether infusions of bone marrow-derived mesenchymal stem cells, called MesenCell, are safe for adults with moderate or severe chronic graft-versus-host disease that has not responded to steroids and other standard treatments. The trial enrolls up to 20 pe…

This phase 2 trial is testing whether a lower dose of the immunotherapy drug nivolumab, given less often, can still control cancer in people with various advanced or metastatic cancers. The goal is to see if a cheaper, more accessible regimen works as well as the standard high-co…

Researchers compare two oral antifungal medicines, itraconazole and posaconazole, in people with chronic pulmonary aspergillosis, a fungal infection that damages the lungs over time. The trial enrolls 220 adults who have not yet received antifungal treatment and assigns them to o…

This phase II trial tests whether the experimental drug BL-B01D1, given with or without a PD-1 antibody, can improve tumor shrinkage in people with high-risk locally advanced nasopharyngeal carcinoma, a type of throat cancer. Participants also receive standard chemotherapy drugs …

This study tests if a single high dose of an antifungal drug works better than the standard daily dose for treating moderate to severe histoplasmosis, a serious lung infection. It also compares a newer oral drug to the standard one, and checks if 6 months of treatment is as good …

This study tests whether a pharmacist-led electronic consultation can improve lung health for people with HIV who smoke or use certain medications that raise pneumonia risk. Pharmacists will review records and suggest changes like smoking cessation aids, vaccines, or stopping unn…

Researchers at a Malaysian hospital reviewed ten years of records for 160 adults who received intrapleural fibrinolytic therapy, a mix of alteplase and DNase delivered through a chest tube, for complicated pleural infection. The study compares how well the treatment cleared fluid…

This phase III trial is testing whether adding an experimental drug called BL-B01D1 to standard maintenance therapy with a PD-1 antibody can help people with recurrent or metastatic nasopharyngeal carcinoma live longer without their cancer progressing. Participants first receive …

Researchers are testing whether a probiotic yeast, Saccharomyces boulardii, works as well as the antibiotic rifaximin for adults with small intestinal bacterial overgrowth (SIBO) who have bloating and diarrhea. The trial enrolls 222 people aged 18 to 70 with a positive breath tes…

Critically ill patients on breathing machines often get hospital-acquired lung infections. This trial tests whether adjusting antibiotic doses using drug level monitoring and software works better than standard dosing. About 610 adults in intensive care units will receive either …

This phase 3 trial is testing whether the oral drug belumosudil works better than the best available therapy for people aged 12 and older with chronic graft-versus-host disease (cGVHD) that has not improved or has returned after 2 to 5 prior treatments. Participants are randomly …

Researchers are testing whether combining trastuzumab with retlirafusp alfa helps people with HER2-positive gastric or gastroesophageal junction cancer that has worsened after standard first-line treatment. The trial enrolls about 35 adults whose tumors test HER2 2+ or 3+. Partic…

When a kidney stone blocks urine flow and causes a severe infection, doctors must quickly relieve the blockage and control the infection. They can place a stent through the urinary tract, insert a drainage tube through the skin, or start antibiotics alone. This study observes 1,6…

This early-stage trial is testing a new drug called ACT500 in 24 people who have both fatty liver disease and chronic hepatitis B. The main goal is to check the drug's safety and how the body processes it at different doses. Participants will take ACT500 or a placebo daily, and r…

Researchers are testing an experimental antibody called EA5 in adults with generalized myasthenia gravis whose blood contains antibodies against the acetylcholine receptor and who have not tried complement inhibitor drugs. EA5 targets complement protein C5, part of the immune cas…

Researchers are testing an experimental drug called BL-M08D1 in adults with nasopharyngeal carcinoma that has come back or spread, as well as other solid tumors. Participants receive the drug by intravenous infusion every three weeks. The trial aims to find a safe dose for furthe…

Researchers are testing an experimental drug called VSA012 against eculizumab in adults with paroxysmal nocturnal hemoglobinuria (PNH) who have not received complement inhibitor therapy. The trial enrolls about 70 participants and compares how well each treatment controls hemolys…

This phase 1 trial tests a new cell therapy called KITE-753 for adults with B-cell acute lymphoblastic leukemia (B-ALL) that has come back or not responded to standard treatments. KITE-753 is made from a patient's own immune cells, which are modified to recognize and attack leuke…

Researchers are testing whether a two-drug injectable regimen can control HIV in adults who have not yet started treatment. The trial pairs an experimental drug called VH4011499 with cabotegravir, an existing injectable HIV medicine, and compares different dose combinations again…

This study tests whether a blood test that detects HPV DNA can help doctors choose the right treatment for people with HPV-positive oropharyngeal cancer. About 116 participants with stage I to III cancer will receive either the immunotherapy drug pembrolizumab (Keytruda) or stand…

This trial tests whether adding diloxanide furoate to the standard antibiotic metronidazole improves recovery from amoebic liver abscess, a serious infection of the liver caused by a parasite. About 220 adults with a new diagnosis will receive either the added drug or a placebo, …

This trial tests a combination of sirolimus, ruxolitinib, and mycophenolate mofetil to prevent acute graft-versus-host disease (aGVHD) in patients receiving a half-matched stem cell transplant. The study focuses on patients with blood cancers or severe aplastic anemia who cannot …

Researchers compare two common antibiotics, moxifloxacin and clindamycin, for adults with dental infections that have spread to the face or jaw. All participants first receive minor surgical drainage in a clinic. Then they are randomly assigned to take either moxifloxacin once da…

This study tests a drug called mezagitamab in people who have had a kidney transplant and are experiencing a type of rejection called antibody-mediated rejection (AMR). AMR happens when the body's immune system attacks the donor kidney, which can lead to kidney failure. The study…

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

This trial tests whether B-OK bottles, which use beads to visually explain how HIV affects health and how treatment lowers viral load, can help people with HIV stick to their medication. Researchers will roll out the bottles across HIV case management agencies in Philadelphia and…

This phase 2 trial tests an inhaled drug called YKYY018 in adults with respiratory syncytial virus (RSV) infection. The goal is to see if the drug can shorten the time until lower respiratory symptoms, like cough and wheezing, improve. Participants receive either YKYY018 or a pla…

This pilot study tests whether a cream containing ruxolitinib, a drug that blocks certain immune signals, is safe and helpful for people who develop acute skin graft-versus-host disease (GVHD) after a stem cell transplant. Participants aged 2 to 35 with a malignancy and skin GVHD…

This study tests whether metformin, a standard diabetes medicine, can slow the worsening of idiopathic pulmonary fibrosis (IPF), a serious lung disease. About 400 high-risk patients will receive either metformin or a placebo. The goal is to see if metformin can delay death, hospi…

This Phase 2 trial tests an oral antifungal drug called oteseconazole in adults with dimorphic fungal infections, including coccidioidomycosis, blastomycosis, and histoplasmosis. Participants must already be on antifungal therapy but need a different option because standard first…

This trial tests whether a smartphone app called PL4Y can help young adults aged 18 to 29 who have HIV stay engaged in their care. For the first 6 months, participants receive standard care. Then they get the app, which sends daily medication reminders, appointment alerts, secure…

This trial tests whether inhaling bacteriophages, which are viruses that specifically kill Pseudomonas aeruginosa bacteria, can help clear a serious lung infection in patients on breathing machines. The study includes adults with ventilator-associated pneumonia caused by this bac…

This trial tests whether an automated alert, triggered when a patient's sepsis risk score rises, can speed up critical care and improve outcomes. When the alert fires, the bedside nurse can activate a critical care team, and if no response occurs, the team is paged automatically.…

This pilot study tests whether an herbal supplement called Biocidin REMOVE can clear small intestinal bacterial overgrowth (SIBO) in adults with irritable bowel syndrome (IBS). SIBO involves an overgrowth of bacteria in the small intestine, which can worsen IBS symptoms. About 40…

This trial tests whether a gentle electrical earpiece, worn twice daily for two weeks, can reduce brain swelling caused by radiation necrosis. The device stimulates a nerve in the ear to calm inflammation. Forty people with brain tumors who need a laser procedure will be randomly…

This Phase 1 trial tests a personalized approach to treating acute viral respiratory infections using a platform called Dynamic Pathology-Based Therapy (DPBT). Researchers use a predefined algorithm to match each adult participant's specific inflammatory state with a botanical fo…

This study tests whether injecting stem cells into the eye can help people with severe dry eye caused by graft-versus-host disease (GVHD), a complication of bone marrow transplants. The trial will include 30 adults who have not improved with standard treatments. Participants will…

This trial is testing whether a 10-week course of fluconazole works as well as the standard 24-week course for people with HIV who have a cryptococcal infection in their blood (antigenemia) but no symptoms. It also compares starting HIV medications right away versus waiting 14 da…

This trial tests whether adding an experimental drug called TQA3605 to standard antiviral therapy helps more adults with chronic hepatitis B reach undetectable virus levels. About 930 participants who have been on antiviral treatment for at least a year will receive either TQA360…

This study tests whether combining two drugs—ASTX727 (a pill) and retifanlimab (given through a vein)—can shrink tumors and control advanced Merkel cell cancer in people whose disease has worsened after standard immunotherapy. About 31 adults with stage III or IV Merkel cell canc…

This early-phase trial tests whether adding vitamin C to standard steroid treatment helps people with gastrointestinal graft-versus-host disease (GVHD), a serious complication after a donor stem cell transplant. About 35 participants aged 5 and older will receive vitamin C plus s…

This study looks at whether giving women living with HIV the option to collect their own HPV test samples at home or in their community, with help from health workers, increases how many get screened for cervical cancer. About 17,700 women will take part across multiple clinics. …

This study tests whether a 10-day course of oral amoxicillin works as well as a single injected dose of penicillin to treat congenital syphilis in newborns up to 30 days old. About 374 infants across 12 U.S. sites will be randomly assigned to one of the two treatments. The goal i…

This study looks at two methods of giving beta-lactam antibiotics to patients with sepsis or septic shock in the ICU: a slow 4-hour infusion versus a quick 30-minute infusion. Researchers will track survival at 90 days and whether the infection clears within 14 days. The goal is …

This study tests whether a low-dose anti-inflammatory drug called colchicine can help people who have had a brain hemorrhage (a type of stroke) recover better and avoid future heart attacks or strokes. About 1,125 adults with signs of artery disease will take either colchicine or…

Researchers are testing an experimental oral drug called SYH2085 in adults with uncomplicated influenza. The study compares SYH2085 against a placebo to see if it can shorten the time to resolution of flu symptoms like fever, cough, and body aches. Participants must have tested p…

This trial tests a new monitoring device, the Linshom CPRM, which fits into an oxygen mask or nasal cannula and alerts nurses when a patient's breathing starts to fail. Researchers will compare standard monitoring plus the Linshom alarm against standard monitoring alone in about …

This trial investigates whether a shorter course of the antifungal drug caspofungin is as effective as the standard 14-day treatment for uncomplicated candidemia, a bloodstream infection caused by Candida yeast. Adults with this infection will be randomly assigned to receive eith…

This study follows over 2,000 elderly patients hospitalized with community-acquired pneumonia to see whether adding traditional Chinese medicine (TCM) to standard care improves recovery. Researchers will compare patients who receive TCM with those who do not, tracking hospital st…

Researchers in Peru are testing whether starting antiretroviral therapy on the same day as diagnosis can reduce the stigma that people with HIV face. The study involves developing a same-day treatment protocol with input from HIV experts, then piloting it with patients and their …

This trial tests whether a single inhaled dose of peramivir can help adults with uncomplicated influenza feel better faster. About 600 adults aged 18 to 64 with lab-confirmed flu and symptoms starting within 48 hours will receive either the drug or a placebo. Researchers will mea…

This trial tests whether a single oral dose of ondansetron, a drug that curbs vomiting, can help children with cholera keep down oral rehydration solution (ORS). About 120 children aged 6 months to 17 years with suspected or confirmed cholera and active vomiting will receive eith…

This phase II trial tests a new treatment approach for people with locally advanced nasopharyngeal carcinoma, a type of head and neck cancer. The regimen avoids platinum-based chemotherapy, using a combination of gemcitabine, camrelizumab, endostar, and low-dose radiotherapy befo…

This trial tests whether a dietary fiber called resistant potato starch can reduce the amount of drug-resistant bacteria living in the gut. The study enrolls Veterans who carry these bacteria without symptoms, and half will take the starch daily while the other half takes a place…

This phase III trial asks whether giving dexamethasone early to adults with severe influenza pneumonia and low blood oxygen can improve outcomes. Participants in intensive or intermediate care receive either the steroid or a placebo for up to 10 days, alongside standard flu treat…

This trial tests whether children and teens with uncomplicated bloodstream infections can safely switch from intravenous (IV) antibiotics to oral antibiotics earlier than usual. Half the participants will switch to oral antibiotics as soon as they are stable, within 4 days of sta…

This trial compares different HIV drug combinations in children and teens aged 4 weeks to under 15 years, including those starting treatment for the first time and those whose current drugs are failing. Researchers want to see which combinations best keep the virus at very low le…

This study looks at how long-acting injectable HIV drugs (cabotegravir and rilpivirine) work in the body during pregnancy and after childbirth. About 40 pregnant women with HIV will receive the shots every 4 weeks. The goal is to measure drug levels and see if they stay effective…

This trial tests whether genistein, a natural compound found in soy, can reduce inflammation and improve blood vessel health in people living with HIV. Even with effective HIV treatment, the body stays inflamed, raising the risk of heart disease and other problems. The study give…

This trial tests whether two oral antibiotic combinations—doxycycline with levofloxacin or moxifloxacin—can treat brucellosis as effectively as the standard doxycycline-rifampicin regimen. Brucellosis is a bacterial infection from animals that can cause fever and joint pain, and …

This clinical trial aims to find the safest and most effective hepatitis C treatment for people with chronic kidney disease (CKD). Researchers will compare two drug combinations based on how well the kidneys are working: one for patients with moderate kidney function and another …

This trial tests whether adding a lab-made antibody (ePGT121v1-LS) to standard HIV medication can help infants under one year old achieve better viral suppression. About 87 infants in South Africa will receive either the antibody or a placebo injection every 12 weeks for 48 weeks…

This trial tests whether adding two lab-made antibodies (ePGT121v1-LS and VRC07-523-LS) to standard antiretroviral therapy can help infants living with HIV achieve viral suppression. Infants up to one year old in Mozambique and Cameroon receive four injections of the antibodies o…

This phase 2 trial is testing whether new combinations of anti-tuberculosis drugs, including the experimental drug TBAJ-587, can effectively treat newly diagnosed, drug-sensitive pulmonary tuberculosis. The study involves 135 adults and compares several experimental regimens agai…

This trial tests whether a 7-day course of doxycycline can effectively cure asymptomatic anal lymphogranuloma venereum (LGV), a sexually transmitted infection caused by Chlamydia trachomatis. Currently, treatment lasts 21 days, but recent studies suggest a shorter course may work…

This study follows about 1,020 people who receive the oneKNEE total knee prosthesis during knee replacement surgery. Researchers track safety and how well the implant works by measuring changes in knee pain and function using the Oxford Knee Score two years after surgery. The goa…

This trial is testing whether adding an immunotherapy drug called penpulimab to a standard chemotherapy regimen can help people with primary central nervous system lymphoma, a rare type of brain cancer. Participants, who have not yet received treatment, are randomly assigned to r…

This trial tests a six-session peer-led program called Gwan Enjoy Life for sexual minority men living with HIV in Jamaica. The program aims to reduce depression, anxiety, and loneliness while helping participants stay engaged in HIV care and take their medications. Sixty men will…

This trial tests whether giving praziquantel three times a year, instead of the standard once a year, can improve liver fibrosis (scarring) caused by schistosomiasis in people aged 15-40 in Uganda. Participants with liver fibrosis will be randomly assigned to one of two treatment…

This trial explores whether a single dose of psilocybin, combined with motivational support therapy, can help people with HIV who have moderate-to-severe methamphetamine use disorder reduce or stop their meth use. Participants will be randomly assigned to receive either a higher …

New nurses often struggle in fast-paced trauma units, and many leave within two years. This study tests whether a two-day Basic Trauma Training (BTT) program, added to standard orientation, helps newly graduated nurses in Saudi trauma hospitals feel more satisfied, engaged, and l…

This trial is testing whether a special type of radiation called radscopal radiotherapy—which combines low-dose radiation to the main tumor and precise high-dose radiation to distant metastases—can enhance the effects of two immunotherapy drugs (sintilimab and ipilimumab) in peop…

This phase III trial is testing whether regular antibody infusions (immunoglobulin replacement therapy) can prevent infections better than standard antibiotic prophylaxis in people who have received CAR-T cell therapy for B-cell acute lymphoblastic leukemia or B-cell lymphoma. CA…

This study tests a program called Light Inside, designed to reduce stigma for women living with HIV who use drugs. The program involves five small-group sessions that teach coping skills and communication strategies to help participants stay engaged in HIV care and adhere to thei…

This early-phase trial is testing a combination of two drugs, loncastuximab tesirine and rituximab, as a first treatment for a rare blood cancer called post-transplant lymphoproliferative disorder (PTLD) that can occur after an organ transplant. The study will first find the safe…

This study tests whether a structured early addiction care program, including a consultation, toxicology feedback, and regular follow-up calls over six months, helps people who come to the emergency room after a drug overdose stay engaged in addiction treatment. Adults hospitaliz…

This study tests a program that provides overdose education and naloxone (a drug that reverses opioid overdoses) to homeless veterans at risk. The program is being rolled out at VA sites that serve veterans in supportive housing. Researchers will measure how well sites adopt the …

Many people who recover from tuberculosis are left with long-term lung damage, known as post-tuberculosis lung disease (PTLD), which can cause breathing problems and reduce quality of life. This study follows 760 participants—including people with active TB, those with establishe…

This study follows over 500 hospitalized adults with drug-resistant bacterial pneumonia to see whether those who receive systemic traditional Chinese medicine (such as herbal decoctions or injections) have fewer lower respiratory tract infections in the six months after leaving t…

This trial investigates whether antibiotics like amoxicillin or amoxicillin-clavulanate ease symptoms of ear infections (acute otitis media) in children aged 6 months to 3 years better than a placebo. Over 1,100 children are randomly assigned to one of three groups, and families …

This phase 2 trial tests whether an experimental drug called HSK50042 can improve lung function in adults with idiopathic pulmonary fibrosis (IPF), a chronic condition that causes lung scarring and breathing difficulties. Participants take HSK50042 or a placebo once daily for 26 …

This trial tests whether inebilizumab, an antibody that wipes out certain immune cells called B cells, can improve physical function in adults with ME/CFS that started after an infection. Participants receive three infusions over six months, and the study measures changes in mobi…

This study is testing whether a new antibiotic combination, cefepime/enmetazobactam, works as well as the best current treatments for complicated urinary tract infections that have spread to the bloodstream. These infections are caused by bacteria resistant to many common antibio…

This trial tests whether a package of support from a community health worker can help adults hospitalized with advanced HIV in Lusaka, Zambia, stay in care and survive longer. Participants are randomly assigned to receive the ARC intervention or standard care and are followed for…

This study tests a new treatment for chronic active antibody-mediated rejection (caABMR) in kidney transplant recipients. Patients receive a single injection of a CD38 monoclonal antibody to deplete harmful immune cells, followed by long-term azathioprine pills to maintain contro…

This pilot trial tests whether a special cartridge placed in a blood-filtering machine can improve outcomes for people with septic shock, a severe and often deadly infection response. The cartridge is designed to remove inflammatory molecules from the blood, which may reduce orga…

People living with HIV have twice the risk of heart attacks and stroke compared to the general population. This trial tests whether integrating clinical pharmacists into HIV care can improve blood pressure control and reduce cardiovascular disease risk. The study enrolls 450 adul…

This trial investigates whether a blood-filtering device called CytoSorb can reduce damage to blood vessels in people with septic shock, a life-threatening condition. The device removes inflammatory molecules from the blood. Researchers will measure changes in a marker of vessel …

This phase 2 trial tests an experimental antifungal drug called olorofim in people with a severe, body-wide form of Valley Fever (disseminated coccidioidomycosis) that has not responded to standard treatments. The study also evaluates new questionnaires about symptoms and quality…

This trial tests whether a device that uses alternating magnetic fields to heat metal knee implants can help treat infections without removing the implant. Adults with a knee implant infection receive surgery, antibiotics, and either active or sham magnetic treatment. The study m…

This study tests whether a vaginal ovule device, used alongside standard antibiotics or antifungals, improves vaginal health in women with bacterial vaginosis or yeast infections. Eighty women aged 18 to 60 receive either the active device or a placebo ovule over three treatment …

This study tests whether adding Qiling Yiqi tablets, a Chinese herbal medicine, to standard HIV therapy can improve immune function in people whose CD4 counts remain low despite successful viral suppression. The trial involves 240 adults with HIV who have been on antiretroviral t…

This study tests whether adding Fuyang Jiedu Granules, a traditional Chinese herbal mixture, to standard antiretroviral therapy can improve immune function in people with HIV who have persistently low CD4 counts despite viral suppression. The trial includes 240 adults aged 18–60 …

This study compares a long-acting antibiotic called dalbavancin to standard therapy for treating infective endocarditis, a serious infection of the heart valves caused by certain bacteria. Dalbavancin is given as one or two intravenous infusions, while standard therapy requires d…

This trial investigates whether adding bacteriophages—viruses that specifically target and kill bacteria—to standard surgery and antibiotics can improve outcomes for people with infected hip or knee replacements. The study enrolls adults with an infection caused by Staphylococcus…

This study tests whether giving a low, steady dose of norepinephrine during laparoscopic abdominal surgery can reduce the amount of IV fluids needed and lower the risk of lung complications afterward. It includes 130 adults at high risk for lung problems. The drug is given from t…

This phase 2 study tests whether the drug bepirovirsen can achieve a functional cure for chronic hepatitis B in 30 adults with low virus levels. Participants receive weekly injections for 24 weeks and undergo liver biopsies to measure changes in the virus and immune response. The…

This study looks at whether the RSV vaccine given in late pregnancy can help protect babies born to mothers with HIV. RSV is a leading cause of infant hospitalization, and babies exposed to HIV are at higher risk. Researchers will measure antibody levels in mothers and infants to…

This study tests a new approach for treating high-grade cervical precancer (HSIL) using a cream called HAL that is activated by a special light, instead of standard surgery. About 230 women will be randomly assigned to receive either the light therapy or surgery. The main goal is…

This study looks at whether switching to a daily pill containing bictegravir, emtricitabine, and tenofovir alafenamide (BIC/FTC/TAF) can help people with HIV who previously did not respond to a long-acting injectable treatment (CAB/RPV LAI). The study includes 30 adults and will …

This study tests whether special blood purification devices can help people with septic shock, a life-threatening condition where infection causes organ failure. The trial includes adults aged 18 to 80 with severe septic shock. Depending on their level of endotoxins, patients rec…

This Phase II trial tests whether a combination of therapeutic plasma exchange (filtering the blood), rituximab (a drug that targets certain immune cells), and intravenous immunoglobulin (IVIg) can slow lung decline in people with progressive idiopathic pulmonary fibrosis (IPF). …

This study tests whether offering rapid HIV testing during a dental visit leads more people to get tested than simply referring them to a lab. About 6,700 adult dental patients at four community health centers will be offered either a quick oral swab test on-site or a referral fo…

This study tests whether oxymetazoline, a common nasal decongestant, can replace sodium hypochlorite as a bleeding control agent during pulp treatment in children's baby teeth. About 50 Egyptian children aged 4-8 with decayed molars will receive either treatment. The goal is to s…

This phase 3 trial tests whether a 6-month combination of five drugs (bedaquiline, delamanid, delpazolid, levofloxacin, and pyrazinamide) works as well as standard treatment for rifampicin-resistant tuberculosis in adults and adolescents aged 15 and older in South Africa. The stu…

This study tests whether ulinastatin, a drug that reduces inflammation, can help patients with severe abdominal infections. The infection often causes the immune system to overreact, leading to organ failure and high risk of death. Researchers will give patients either a low or h…

This trial tests whether giving patients a special type of donor immune cell, called CD45RA-depleted DLI, can prevent serious viral infections after a stem cell transplant. The study includes 30 high-risk patients who have received a transplant for blood cancer. Researchers will …

This study tests whether fecal microbiota transplantation (FMT) can help ICU patients with sepsis. Sepsis is a life-threatening infection that can cause organ failure. The trial will give 60 adults either standard care or standard care plus FMT through a tube into the gut for thr…

This phase 3 trial tests whether combining two drugs—albendazole and ivermectin—works better than the standard single drug for treating whipworm infection in schoolchildren aged 6 to 15 in Honduras. Participants receive a single dose of either placebo, albendazole alone, albendaz…

This study looks at whether shorter, rifapentine-based treatments for tuberculosis and latent TB are safe and effective in real-world settings in Kazakhstan. It will follow 350 adults, including those with HIV, comparing a 4-month regimen to the standard 6-month one for active TB…

This study tests whether a 5-day course of inhaled amikacin can prevent ventilator-associated pneumonia in critically ill patients who already have a milder airway infection called tracheobronchitis. 250 adults on breathing machines will receive either the drug or a placebo. The …

This phase 3 trial compares a single intravenous dose of temocillin to the standard ceftriaxone shot for treating gonorrhea. The goal is to see if temocillin works just as well while having less impact on the gut's healthy bacteria, which can help prevent the rise of drug-resista…

This pilot study tests a program called Kisoboka Amaka for men living with HIV who drink heavily and have pregnant partners. The program combines counseling, financial training, and mobile savings to help men drink less and take their HIV medication consistently. Researchers will…

This study tests whether two FDA-approved drugs, maraviroc and atorvastatin, can help people with Long COVID. 252 adults aged 18-65 with persistent symptoms will take either the drug combination or a placebo for 16 weeks. The main goal is to see if it reduces fatigue and improves…

This study tests whether the drug elranatamab can help keep plasmablastic lymphoma, a rare and aggressive blood cancer, from returning after initial chemotherapy. About 17 adults with or without HIV who have already responded to first treatment will receive elranatamab injections…

This study tests whether a 3-day course of amoxicillin works as well as a 5-day course for children aged 3 months to 5 years with uncomplicated pneumonia. The goal is to see if shorter treatment can reduce side effects, lower costs, and fight antibiotic resistance. About 250 chil…

This study looks at whether giving antibiotics directly into the bone during surgery can prevent infections in people with osseointegration implants (a type of prosthetic that attaches directly to the bone). About 100 adults who already have or are getting these implants will rec…

This phase 2 trial tests a combination of two oral drugs, ruxolitinib and belumosudil, for chronic graft-versus-host disease (cGvHD) that hasn't improved with steroids. cGvHD is a serious condition where donor immune cells attack the patient's body after a stem cell transplant. T…

This study tests a program that combines group counseling, financial literacy training, and savings accounts to help Ugandan teens with HIV manage depression and stick to their medication. About 588 adolescents aged 15-19 will take part. The goal is to see if this approach can re…

This study will compare two different HIV medication combinations in 60 people who also have active tuberculosis. Participants will receive either a newer drug (Ainuovirine) or a standard one (Efavirenz), along with their TB meds. The goal is to see which regimen better suppresse…

This study will test if taking oral azithromycin pills for three days each month works as well as getting a monthly penicillin shot to prevent rheumatic heart disease from getting worse. The trial plans to enroll 474 Nigerian secondary school students aged 10-18 with mild or mode…

This study tests a set of safety measures to lower infections from external ventricular drains (EVDs) in 248 ICU patients. The bundle includes updated care protocols, staff training, and reminder signs. The goal is to cut the current 22% infection rate by improving hygiene and ha…

This early-phase study tests a new injectable drug called AHB-171 in 144 adults with chronic hepatitis B. The main goals are to check the drug's safety and how the body processes it. Some participants will also take standard oral antivirals. The study is not yet recruiting.

This study looks at whether a long-acting injectable HIV prevention drug (cabotegravir) can be delivered fairly and effectively in NHS sexual health clinics. Researchers will follow 200 people taking the drug for 12 months, along with 20 healthcare professionals, to see how well …

This study tests whether infusing fluid into the uterus during labor (amnioinfusion) can reduce brain injury in newborns whose mothers have a uterine infection called chorioamnionitis. The infection can cause inflammation and fever that may stress the baby's brain before birth. R…

This early-stage trial tests a new treatment for children, adolescents, and young adults with a certain type of Hodgkin lymphoma that has come back after initial therapy. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack cancer…

This early-stage trial tests a drug called romiplostim in 280 sepsis patients with very low platelet counts (under 50). The drug is given as a weekly shot to try to raise platelet levels. Researchers will compare it to a standard treatment and check how well it works after 7 days…

This phase 2 trial tests whether a combination of three drugs—valacyclovir, celecoxib, and Paxlovid—can reduce Long COVID symptoms in adults. About 150 participants aged 18-65 with diagnosed Long COVID will receive either the drug combo or a placebo. The main goal is to see if th…

This pilot study will test whether flushing the chest tube with saline alone can treat complicated pleural infections (fluid buildup around the lungs). If saline doesn't work, patients will receive stronger clot-busting drugs (fibrinolytics) or surgery. The study will track how l…

This study tests a posture protection program for 60 hospital cleaners to see if it reduces muscle and bone pain. The program includes training on safe lifting, body mechanics, and posture awareness, plus reminders via posters and messages. Researchers will measure pain levels an…

This study tests whether taking a short course of the drug sirolimus (Rapamycin) can improve how well older adults on hemodialysis respond to flu and RSV vaccines. Sixty participants will receive the vaccines plus sirolimus at different times. The goal is to see if this approach …

This study looks at whether people with HIV who are already well-controlled on daily pills can switch to a long-acting injection given every two months. The goal is to see how many stay on the injection without stopping or needing to change treatment over 48 weeks. The study will…

This study compares a new dressing called POLTX_Fiber to a standard one for chronic wounds like leg ulcers and pressure sores. Sixty adults with moderate-to-heavy wound drainage will be followed for 30 days. Researchers will track healing, infection, pain, and patient satisfactio…

This study tests whether a one-visit, point-of-care test and treat approach helps more people with HIV, hepatitis B, or hepatitis C complete hepatitis C treatment within 24 weeks compared to standard care. About 1,280 participants will be randomly assigned to either the simplifie…

This study tests whether a sedative called dexmedetomidine can improve survival in people with refractory septic shock, a life-threatening condition where blood pressure stays dangerously low despite standard treatments. The drug aims to calm an overactive stress response that ma…

Researchers are testing whether sex work managers, called queen mothers, can hand out and collect HIV self-tests and self-collected STI test kits at places where female sex workers meet and work in Lusaka. The study compares this peer-supported approach with the current standard …

Radiation pneumonitis is a lung inflammation that can appear weeks after radiotherapy for lung cancer, and patients may not link their symptoms to the earlier treatment. Researchers developed a smartphone app called PneumoCheck for patients to use at home, hoping it helps detect …

Researchers are running a large observational registry to see how a blood test called metagenomic sequencing is used in routine care for people with or at risk of serious infections, including those with weakened immune systems. The study enrolls participants at multiple hospital…

Sepsis is hard to spot early because its first symptoms look like many other conditions. Researchers at emergency departments in Taiwan are studying whether two blood markers, presepsin and immature granulocytes, can help doctors tell sepsis apart from other causes of inflammatio…

Helicobacter pylori is a common stomach infection, and doctors often treat it with clarithromycin. Resistance to this antibiotic is growing, so researchers want to know if a DNA test called qPCR can spot resistant infections using stomach biopsy tissue that is already collected a…

Researchers swab the noses of children scheduled for elective surgery under general anesthesia to check for respiratory viruses. They want to learn how many children carry viruses without showing symptoms and whether those children have more breathing problems during or after sur…

Researchers are building a web-based simulation platform to model how long blood cultures take from collection to result reporting in sepsis cases. The study involves microbiological laboratories that perform blood culture analysis. The goal is to understand how lab infrastructur…

This trial is testing a new rapid urine test called Jiddu that aims to quickly identify urinary tract infections (UTIs) and determine which antibiotics will work best. The study involves 100 adults with neurogenic bladder who use catheters and suspect they have a UTI. Participant…

Researchers at Turku University Hospital are testing a PET imaging tracer called Al[18F]F-NOTA-folate to see how well it detects two heart conditions: cardiac sarcoidosis, an inflammatory disease of the heart muscle, and infective endocarditis, an infection of the heart valves. T…

This study tests whether two simple blood markers, the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), can signal inflammation caused by Helicobacter pylori infection in the stomach. Researchers will compare these ratios in adults with dyspepsia who h…

This early-stage study tests whether wearable biosensors (like a wristband or earphones) can detect malaria infection before symptoms appear. 32 healthy adults will be exposed to the malaria parasite or a placebo in a controlled setting. Researchers will compare biosensor reading…

This trial tests two ultrasound techniques to see which one detects fluid overload earlier in adults with septic shock who need fluid resuscitation. One method uses lung ultrasound, the other measures blood flow velocity in the heart's main outflow tract. Researchers will compare…

This study tests whether a blood protein called neprilysin can predict if ICU patients with an infection will develop sepsis within 48 hours. Researchers will measure neprilysin and other biomarkers in blood samples from 488 adults at two hospitals. They will also check microcirc…

This study tests whether special MRI scans can predict how well HPV-positive throat cancer responds to standard chemotherapy and radiation. Researchers will scan 30 adults before treatment and track their outcomes. The goal is to see if MRI patterns can identify low-risk patients…

This study tests whether a molecular assay (MBLA) can tell apart two causes of swollen lymph nodes in people being treated for extrapulmonary tuberculosis: a paradoxical immune reaction (IRIS) or actual treatment failure. Researchers will compare MBLA results from routine lymph n…

Researchers are testing whether a urine-based self-test can accurately detect tenofovir, a drug used in PrEP for HIV prevention. The study enrolls HIV-negative women in North Carolina who use stimulants and are either on PrEP or eligible for it. Participants will complete the sel…

This study tests whether a quick, bedside ultrasound of the internal jugular vein in the neck can help tell how severe bronchiolitis is in infants aged 1 to 23 months. Researchers will measure how much the vein's diameter changes with breathing and compare that to standard clinic…

This pilot study is testing whether a rapid, point-of-care blood test can help identify early signs of infection and sepsis in preterm infants. Researchers will measure inflammatory markers like IL-6, PCT, CRP, and MxA in blood samples from about 40 to 80 premature babies, compar…

This study looks at whether two simple calculations, called Cancer Ratio and Cancer Ratio Plus, can help doctors tell the difference between fluid around the lungs caused by cancer and fluid caused by tuberculosis. These calculations use results from routine blood and fluid tests…

This study is testing whether new biomarkers in urine can more accurately diagnose urinary tract infections (UTIs) in two groups where current tests often fail: young children not yet toilet-trained and adults aged 65 and older. In these groups, standard urine tests can be mislea…

This study tests a community-based screening strategy for tuberculosis (TB) in migrant communities in New York City. A mobile van offers digital chest X-rays with AI interpretation, along with TB symptom checks, blood tests for latent TB, and HIV testing. The goal is to see wheth…

This study tests whether an automated algorithm called SmartWedge can accurately measure pulmonary artery occlusion pressure (PAOP) in intensive care patients with septic shock. PAOP is a key measurement for guiding treatment, but manual readings can vary. The trial compares the …

This study tests whether an AI-powered digital stethoscope can help health workers more accurately diagnose pneumonia in children aged 2 months to 5 years. 350 children with cough or breathing difficulty will be randomly assigned to standard care or care plus the AI stethoscope. …

This trial tests three ways to manage urinary symptoms in women aged 65 and older who have frequent urinary tract infections. Some participants receive antibiotics right away, while others get treatment only after a urine test or a lab culture. The goal is to find out which appro…

This study investigates whether a real-time breath analysis device can quickly and non-invasively diagnose lower respiratory tract infections. Researchers will collect breath samples from 450 patients with suspected infections or chronic airway colonization and analyze volatile o…

This trial investigates whether a rapid test for antibiotic resistance genes (integrons) can help doctors choose narrower-spectrum antibiotics for hospitalized adults with urinary tract infections (UTIs). Participants must have had a recent infection with a resistant bacterium. T…

This study will test a new, fast method to measure levels of beta-lactam antibiotics in the blood of intensive care patients. Researchers will compare the new method with standard lab tests using daily blood samples from 200 patients. The goal is to develop a point-of-care tool t…

This study aims to validate a new blood test that uses artificial intelligence to detect disseminated intravascular coagulation (DIC) early in patients with septic shock. DIC is a severe clotting disorder that often leads to death, but current diagnostic methods are complex and r…

This study will test whether a new, continuous method of measuring heart function (using pressure waves) matches the current standard method (thermodilution) in 43 ICU patients with septic shock. Both methods use the same catheter already placed for treatment. The goal is to see …

This study will test whether analyzing stool and urine samples using a technique called metagenomics can find infections in people with weakened immune systems (due to HIV, chemotherapy, or immunosuppressive drugs). Currently, doctors often need to take invasive samples like bloo…

The PRIORITY study is testing a new approach to diagnose cervical cancer earlier by combining self-sampling at home with digital colposcopy and telemedicine. Researchers will enroll 700 women aged 30 to 65 to see if this method is more accurate and faster than current care. The g…

Researchers at the University of Washington are studying whether an online community of practice helps pharmacists learn to prescribe PrEP, a daily pill that prevents HIV. The study enrolls about 500 pharmacists and pharmacy staff across the United States whose pharmacies do not …

Researchers are testing whether a single dose of the antiviral drug baloxavir marboxil can stop influenza from spreading among people who live with someone who has the flu. The trial enrolls households in China where one person has confirmed influenza and up to five other members…

Clesrovimab is an FDA-approved antibody shot for infants under 8 months entering their first RSV season when their mothers did not get an RSV vaccine in pregnancy. Researchers at Emory University are measuring antibody levels in the blood and noses of 24 healthy infants who recei…

This study tests whether the drug rituximab can safely clear Epstein-Barr virus (EBV) from the blood of people who have received a solid organ transplant. High levels of EBV can lead to a serious cancer called post-transplant lymphoproliferative disorder (PTLD). The trial will en…

Researchers are testing whether a quadrivalent HPV vaccine can be given at the same time as a tetanus-diphtheria booster in healthy children and adolescents aged 9 to 15 in Indonesia. The trial compares children who receive both vaccines together with those who receive the HPV va…

This study tests whether a program led by community health workers can improve lung health for 800 people in Bhaktapur, Nepal, who are at risk for chronic respiratory diseases. The program includes tobacco cessation counseling, mask use during high pollution, handwashing, and flu…

Researchers at Emory University are running a rapid randomized controlled trial to see if small changes to digital messages and website design can help more people start and stay on HIV prevention medication (PrEP) through telehealth. The study includes adults in the United State…

This study will test if using two heat probes instead of one can better prevent cervical cancer in 300 women with HIV in Zimbabwe. The standard single-probe treatment often fails in these women. The goal is to see if the two-probe method is safe, acceptable, and more effective at…

This trial tests whether a short educational session during a routine primary care visit can help young people aged 13 to 26 understand overdose risks, recognize an overdose, and respond with naloxone. Providers in the intervention group deliver the education and offer naloxone a…

Researchers are testing a new injectable drug called VH5356136 to see if it is safe and how the body processes it. The trial enrolls about 160 healthy adults without HIV, ages 18 to 55. Participants receive a single dose of the drug or a placebo, and researchers monitor side effe…

This study will test whether a single antibiotic injection given during cataract surgery can prevent endophthalmitis, a rare but severe eye infection. About 60,000 people with cataracts will receive either the antibiotic or a placebo. The goal is to see if the antibiotic reduces …

This study tests whether sending fentanyl test strips by mail and providing online education can reduce opioid overdoses. Researchers will enroll 100 adults who use opioids or stimulants and live in states where test strips are legal. The goal is to find the most effective and lo…

Researchers at Karolinska Institutet are testing a digital self-help tool called Preventox for patients discharged from intensive care after an intoxication or overdose. The tool lets patients set goals, track substance use, identify high-risk situations, and make a crisis plan. …

Researchers are testing an experimental injectable drug called VH4367310 in healthy adults aged 18 to 55. The drug is a long-acting form of cabotegravir, a medicine already used to prevent HIV. This phase 1 trial gives a single increasing dose to measure how the body processes th…

Researchers are testing whether removing a specific type of immune cell, called CD45RA-positive naive T cells, from donor stem cells can prevent graft-versus-host disease in older adults undergoing stem cell transplants for acute leukemia or myelodysplastic syndrome. The trial en…

People with multiple sclerosis or neuromyelitis optica spectrum disorder who take anti-CD20 drugs have a higher risk of shingles. The shingles vaccine is recommended for them, but the drug may weaken its effect. This trial compares two dosing schedules: one gives the second shot …

HPV vaccines can prevent thousands of cancer cases each year, but many children do not get them. Researchers at the University of Florida test whether a tablet app called Protect Me 4 helps parents and doctors talk about the vaccine and decide to give it. The trial enrolls parent…

This study tests whether giving malaria medicine to school-age children can lower malaria cases in the entire community. School children often carry the malaria parasite without symptoms and spread it to others. The trial will involve about 4,800 children in The Gambia and measur…

This study looks at whether taking the antibiotic TMP-SMX for a full year after a kidney transplant can prevent urinary tract infections (UTIs) better than stopping after 6 months. Fifty children and young adults who recently had a kidney transplant will either keep taking TMP-SM…

This study looks at how to keep HIV self-test kits available for adolescent girls and young women in sub-Saharan Africa. Researchers will test two subsidy levels (high and low) for shopkeepers, with decreasing support over time. The goal is to find a sustainable way for private d…

Critically ill patients on breathing machines often develop dangerous gut bacteria that can lead to hospital-acquired infections. Researchers are testing a synbiotic medical food, a mix of probiotics and prebiotics, to see if it safely reduces these harmful bacteria. The trial en…

This study tests a program to help parents in rural Kentucky feel more confident about the HPV vaccine for their teens. About 58 vaccine-hesitant mothers or female guardians will use a web app with short videos and then talk to their child's doctor, who will use special prompts. …

Assistant nurses often develop back, neck, and shoulder pain from frequent patient handling. This trial tests whether workplace ergonomic training can reduce that pain, and whether adding biofeedback for six weeks provides extra benefit. Sixty female assistant nurses with musculo…

Researchers are testing whether a protein called Pancreatic Stone Protein (PSP) can identify emergency room patients with infection who are at risk of developing sepsis. Adults with suspected infection receive either a single dose of the antibiotic meropenem or a placebo. The tri…

This phase II trial tests whether adding axatilimab to standard care can prevent graft-versus-host disease (GVHD), a serious complication where donor immune cells attack the recipient's body after a stem cell transplant. Adults with blood cancers receiving a myeloablative allogen…

This trial tests whether training nursing home staff to provide better oral hygiene can reduce pneumonia in residents aged 60 and older. Participants will use special toothpastes and mouthwashes, including stannous fluoride and chlorhexidine options. The study measures how many r…

This study tests whether using two probes during a heat-based treatment (thermal ablation) works better than the usual one-probe method to prevent cervical cancer in women living with HIV. About 200 women aged 25-49 with HIV and cervical precancer will be enrolled. The goal is to…

This study will test whether using two heat probes instead of one to treat cervical precancer works better for women living with HIV. Researchers in Rwanda will enroll 300 women to see if the two-probe approach is safe, acceptable, and more effective at clearing HPV. The goal is …

This study aims to see if watching video logs and receiving personalized messages can make Black women more willing to use PrEP, a daily pill that prevents HIV. It also looks at whether healthcare providers become more willing to prescribe PrEP. About 78 participants in Texas wil…

This study tests whether using two heat probes instead of one can better prevent cervical cancer in women living with HIV, who face a much higher risk. Researchers will enroll 300 women in Kenya to see if the two-probe method is safe, acceptable, and more effective at clearing HP…

This study looks at how to make HIV prevention pills (PrEP) easier for young people to get and keep using. Researchers will follow 1000 current or eligible PrEP users in Alabama and Botswana for 2 years. They will also create and test a decision-support toolkit to help patients a…

This trial tests whether a peer-led program that lets women choose and switch HIV prevention methods can increase consistent use compared to standard care. The program includes peer mentor support, HIV testing, access to PEP, and STI care. It enrolls HIV-negative women at elevate…

This trial tests whether mailed letters, patient portal messages, or texts can encourage flu vaccination among adults with multiple risk factors for severe influenza. Researchers will identify high-risk patients using a simple rule-based scoring system, then send reminders and tr…

This trial tests whether giving schoolchildren in Kenya an antimalarial drug every month, instead of every three months, better protects their brain function and school performance. Researchers will enroll 1,500 children aged 6 to 10 from six primary schools. Half will receive mo…

This study tests a 6-session telehealth program called EMPOWER for African American women in the South. The program helps women make informed choices about HIV prevention, including PrEP. Researchers will enroll 80 women to see if the program is feasible and acceptable.

Researchers are testing a 10-session bilingual therapy program called PrEPared Minds/Mentes PrEParadas. The program uses cognitive behavioral therapy to reduce anxiety and depression in men who have sex with men. The goal is to see if improving mental health helps these men learn…

This trial tests whether a self-administered vaginal swab, analyzed with advanced molecular technology, can detect and treat bacterial imbalances early in pregnancy. Pregnant women at high risk of preterm birth will either receive this screening plus targeted antibiotics or stand…

This trial tests whether a single combined mRNA vaccine, mCombriax (mRNA-1083), can protect adults aged 65 and older against both influenza and COVID-19 as effectively as getting two separate shots on the same day. Researchers will compare how many participants in each group deve…

This trial tests whether a structured education program can improve how adults perceive infectious diseases, recognize risks, and adopt protective behaviors. Around 200 adults from a family health center will either receive the program or continue with routine care. The program c…

This trial tests whether a daily supplement called Immune X can help prevent common colds in healthy adults who often get upper respiratory infections. Over 16 weeks during winter, participants take either Immune X or a placebo and track any cold symptoms. The study compares how …

This study investigates whether the drug letermovir can prevent cytomegalovirus (CMV) infection in adults who have received a kidney or liver transplant and have been previously exposed to CMV. Participants take one letermovir tablet daily for 84 days after transplant. The goal i…

This trial tests a handheld light device (RD-X19) to see if using it for 5 minutes every other day can prevent upper respiratory infections like COVID-19 and flu. It involves 130 military personnel and their families at a single base. Half will get the real device, half a sham de…

This trial tests a program designed to help assisted living staff adopt healthier habits, reduce job stress, and encourage residents to be more physically active. Researchers will measure physical activity, sleep, blood pressure, and other health markers in both staff and residen…

This study tests whether a nurse-led program can help incarcerated individuals start and stay on HIV pre-exposure prophylaxis (PrEP) after they return to the community. Participants receive behavioral sessions during incarceration to boost motivation, and some get extra navigatio…

This trial investigates whether annual re-screening for tuberculosis infection using a blood test (IGRA) can prevent active TB in people with autoimmune rheumatic diseases who are taking biologic or immunosuppressive medications. Participants who initially test negative for TB ar…

This trial asks whether taking 50 mL of extra virgin olive oil every day can reduce the chance of heart attacks, strokes, and related deaths in people living with HIV. About 1,300 adults aged 50–75 with well-controlled HIV and at least one heart risk factor will be randomly assig…

This study compares monitoring by nurses versus physicians for people taking HIV pre-exposure prophylaxis (PrEP). It looks at how well patients follow their PrEP schedule, their satisfaction with care, and the cost of each approach. The goal is to see if nurse-led care can be a s…

This pilot trial tests a mobile app called Bandi, designed to support HIV prevention among young men who have sex with men in South Korea. Participants are randomly assigned to either the full app, which includes interactive health content, peer forums, a sexual health log, and a…

This study tests an investigational vaccine that combines protection against measles, mumps, rubella, and chickenpox (varicella) in a single shot. It will be given as a second dose to healthy children aged 4 to 6 years who have already received a first dose of a similar vaccine. …

This pilot study tests whether training popular opinion leaders in rural South Africa can increase uptake of HIV prevention tools. Researchers will select and train young adults to share sexual health information and distribute HIV self-tests to their peers. The study will assess…

This trial tests whether offering a needle-free flu vaccine (FLUMIST) for self-administration at home, picked up from a pharmacy, increases flu vaccination rates compared to usual care. Households with children aged 2 to 17 in Burlington, Ontario, are randomly assigned to either …

This trial tests whether offering a seasonal flu vaccine to heart patients while they are still in the hospital, along with active counseling, increases vaccination rates compared to counseling alone. The study enrolls adults hospitalized for acute coronary syndrome or heart fail…

This study explores whether offering HIV prevention medication (PrEP) through pharmacies can help more young women aged 18-24 in Tanzania access and consistently use it. Researchers compare four different pharmacy-based service models to standard care, and later test cost-sharing…

This study tests whether a device called the Guardian spatial emanator, which releases mosquito-repelling ingredients into the air, can be effectively added to an existing program that distributes antibiotics to children in Niger. The goal is to see if this integrated approach ca…

This study explores whether community health workers can use a new skin test, with or without AI help, to test close contacts of TB patients at home instead of at a clinic. The goal is to make it easier for people, especially children and families in Tajikistan and Tanzania, to g…

This study tests a mobile health app called mSYNC designed to help prevent HIV in people who use drugs and visit the emergency department. The app provides counseling and support for risk behaviors, mental health, and access to care. Researchers want to see if the app is acceptab…

This study tests a 5-month text-messaging program called #TranscendentHealth, created specifically for transgender boys and gender-diverse youth assigned female at birth, ages 14 to 18. The program aims to improve condom use, birth control use, and HIV/STI testing by addressing t…

This study tests whether a special combination of supplements (sodium nucleinate, magnesium, vitamin B6, and high-dose vitamin D) can prevent respiratory infections like colds and flu better than standard multivitamins. Two hundred healthy male military recruits in Kazakhstan wil…

This study adapts a program called CARES to help 2,100 adolescent girls and young women (ages 16-24) in South Africa and Zimbabwe consistently use HIV prevention methods like pills, rings, or injections. The program includes counseling, text reminders, and peer support. Researche…

This study tests a mobile app called LOTUS designed to help people who use drugs engage with HIV prevention services like testing and PrEP. The app provides tips, reminders, peer support, and a way to ask healthcare professionals questions. The trial will enroll 40 participants t…

This study will test whether a 12-week program of supervised aerobic and strength exercises can prevent heart problems in 60 adults undergoing chemotherapy for cancer. Participants will be split into an exercise group and a usual-care group. Researchers will measure heart functio…

This study tests whether a lower dose of the antibiotic TMP-SMX works as well as the standard dose to prevent a serious lung infection called PJP in people who have just had a kidney transplant. About 1,084 adult first-time kidney transplant recipients will take either a low or s…

This pilot study will test a program called INSPIRE, designed to reduce stigma and increase HIV testing among Chinese immigrant women who work in massage parlors in Queens, NYC. The program involves four one-on-one conversations with a peer advocate over six weeks, plus weekly te…

This study tests Project LYNX, a program that helps young adults (ages 18-29) who have recently been involved with the criminal legal system find and connect to substance use treatment and HIV-prevention services. The program pairs each participant with a trained peer navigator a…

This study aims to help 400 male commercial minibus drivers in Nigeria use HIV self-testing and long-acting injectable medications for both HIV treatment and prevention. Drivers will be trained as peer educators to promote these tools among their community. The goal is to make it…

This study tests whether a taurolidine lock solution, placed inside central catheters, can prevent bloodstream infections in newborns. About 576 infants with central lines will receive either the taurolidine lock or a saline lock every 48 hours. The goal is to see if this approac…

This study tests whether a single dose of nirsevimab, an antibody that targets RSV, can prevent respiratory infections in Aboriginal and Torres Strait Islander children aged 6 months. Around 1,000 children will be randomly assigned to receive either the antibody or standard care.…

This early-stage trial tests whether a single dose of pembrolizumab (Keytruda), a drug used for cancer, can safely reduce long-term neurological symptoms like brain fog and dizziness in people with long COVID. Fifteen adults who had COVID-19 at least six months ago and still have…

Researchers are testing an experimental drug called GMDTC in adults with solid tumors who have mild kidney problems caused by cisplatin chemotherapy. The trial aims to find out if GMDTC is safe, what side effects it causes, and how the body processes it. Participants receive cisp…

Researchers test traditional Chinese medicine body acupuncture in nurses, midwives, and doctors at an acute care hospital who report moderate or higher stress. Participants receive eight sessions over four weeks, with treatment chosen by TCM pulse and symptom patterns. The study …

This study compares two doses of the antibiotic ceftriaxone for adults hospitalized with pneumonia (but not in the ICU). The goal is to see if a 1-gram daily dose works just as well as a 2-gram daily dose while causing fewer side effects. About 430 participants will be followed t…

This study looks at whether using different root canal tools (TruNatomy vs ProTaper Gold) and different sealers (AH Plus vs TotalFill BC) can reduce pain after a root canal. About 144 adults with a tooth infection will take part. They will rate their pain at several times over a …

Researchers are testing whether giving naloxone soon after resuscitation starts can help people whose hearts stop outside the hospital after an opioid overdose. The trial enrolls adults in out-of-hospital cardiac arrest who are at risk of opioid involvement and who have received …

This study looks at whether a long-acting G-CSF called telpegfilgrastim causes less bone pain than other long-acting G-CSFs in breast cancer patients receiving chemotherapy. About 132 patients will be divided into two groups based on which G-CSF their doctor prescribes. Researche…

This study tests whether a special vitamin B3 tablet, called CICR-NAM, can help people with post-COVID syndrome. The tablet releases nicotinamide in the lower intestine to support energy metabolism. Researchers will give one 500 mg tablet daily for up to 4 months to 100 adults wi…

This Phase 2 trial tests an oral drug called AND017 for cancer-related anemia caused by chemotherapy. About 36 adults with non-myeloid cancers and low hemoglobin will take AND017 three times a week for 6 weeks. The goal is to see if it safely raises hemoglobin levels and reduces …

This study tests whether a smartphone app that plays personalized music can help people with HIV manage chronic pain. Sixty participants will either use the music app daily for 3 months or receive educational materials about pain. The main goal is to see if the app is practical a…

This trial tests whether two simple, drug-free methods—Yakson touch (a gentle hands-on technique) and a dextrose-sweetened pacifier—can reduce pain in full-term newborns during blood draws. Babies in the neonatal intensive care unit will be randomly assigned to one of these comfo…

This trial investigates whether a single injection of dexamethasone, a steroid, given before a root canal can lower pain during the procedure. It includes adults with severe tooth pain from symptomatic irreversible pulpitis. Participants receive either dexamethasone or a placebo,…

This study tests a program called ICU-SUCCEED, designed to help survivors of acute respiratory failure and their family caregivers cope and manage recovery together. The program includes one in-person session and four follow-up sessions by phone or video, focusing on communicatio…

This study investigates whether taking taurine—a natural amino acid found in the body and sold as a supplement—can help adolescents aged 10 to 17 who have Long COVID. Researchers will measure taurine levels in the blood and track changes in symptoms like fatigue, brain fog, and m…

This study tests whether a gentle, non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) can improve quality of life, reduce fatigue, and clear brain fog in people with long COVID. Twenty adults with persistent fatigue or cognitive problem…

This study tests whether a low dose of aripiprazole, a drug used for psychiatric conditions, can reduce fatigue and improve thinking in adults with Long COVID or other post-infection syndromes. About 138 participants will receive either the drug or a placebo for 8 weeks, then swi…

This study tests whether a 3% hypertonic saline (saltwater) rinse, used at the end of a root canal procedure, can reduce pain and inflammation better than the standard 0.9% saline rinse. Forty adults with painful tooth inflammation will receive one of the two rinses, and their pa…

This trial compares two approaches for managing long COVID fatigue: the Lightning Process, a mind-body program that teaches ways to change thought patterns and body responses, versus activity pacing, which helps balance rest and daily tasks. One hundred adults aged 18 to 65 with …

This pilot study tests two homeopathic approaches for people with long COVID: a specific remedy for the condition, and individually tailored treatments from a homeopath. Around 120 adults who had COVID-19 at least 12 weeks ago and have a medical diagnosis of long COVID will be ra…

This study tests a mobile mindfulness program called Lift for people who survived a serious illness in the ICU and now struggle with depression, anxiety, or stress. About 450 adults will use either the Lift app or a health education app for 6 months. The goal is to see if the min…

Cellulitis is a painful bacterial skin infection. This study tests whether adding naproxen (an anti-inflammatory drug) to standard antibiotics helps reduce redness and pain faster than antibiotics alone. About 884 adults with cellulitis will take either naproxen or a placebo for …

This study tests whether using very cold water (around 2-3°C) to rinse the inside of a tooth during a root canal can lower pain afterward. The trial includes adults aged 20-40 with painful, infected lower molars. Participants are randomly assigned to receive either cold rinses th…

This study tests a new herbal blend designed to shorten the duration and reduce the severity of common cold symptoms. Researchers will enroll 300 healthy adults in Australia who get frequent colds. Participants will take the herbal product or a placebo whenever they feel a cold c…

This study tests whether adding deep breathing exercises to a massage routine can quickly reduce neck pain and stiffness in operating room nurses after surgery. Thirty-eight nurses will receive either massage alone or massage plus breathing exercises in a single session. Research…

This small pilot study tests whether adding mild electrical stimulation to simple breathing exercises can improve breathing, reduce fatigue, and boost quality of life in people with Long COVID. Ten adults aged 18-65 with a Long COVID diagnosis will be split into two groups: one d…

This study looks at how well and how safely SIROPSEDAL syrup works for acute cough caused by colds or upper respiratory infections. About 124 children and adults will take the syrup as prescribed by their doctor and report their cough severity over one week. The main goal is to s…

This study compares two strengths of sodium hypochlorite (a disinfectant used during root canals) to see which causes less pain afterward. 116 adults needing a root canal will be randomly assigned to receive either a 2.5% or 5.25% solution. Pain levels will be measured at 6, 12, …

This study looks at how well RHINOSEDAL works for people aged 8 and older with a stuffy nose caused by colds, allergies, or sinus issues. About 126 participants will use the treatment as prescribed and report their symptoms over 6 days. The goal is to see if it provides meaningfu…

This study looks at whether changing body position and doing special breathing exercises can help prevent lung issues like pneumonia after heart surgery. About 124 adults having planned heart surgery will be split into four groups: one getting usual care, one doing only breathing…

This study tests a lidocaine spray (APC101) for people with postherpetic neuralgia, a painful nerve condition after shingles. The spray delivers pain relief without touching the sensitive skin. About 333 adults will use the spray or a placebo to see if it reduces pain over 24 hou…

This study tests a special gel applied to the skin to see if it can quickly reduce pain from shingles. Thirty adults with shingles-related pain will receive a single application of the gel. Researchers will measure pain levels before and after application, focusing on relief with…

Researchers at the University of California, San Francisco are studying how well a calibrated touch device measures sensation in the larynx and throat. The study includes adults with larynx or throat disorders, including those whose condition followed radiation or other cancer tr…

Researchers at Suleyman Demirel University are surveying lawyers registered with the Isparta Bar Association to understand how physical activity, stress, burnout, and job satisfaction relate to musculoskeletal pain. About 102 lawyers with at least five years of experience answer …

This study looks at how HIV and substance use disorder (SUD) affect the sense of smell and decision-making. Researchers will test 120 adults aged 18–65, including people with HIV, SUD, both, or neither. Participants will complete smell tests and computer tasks over two visits, an…

This study tests better ways to screen and treat cervical cancer in women living with HIV in Kenya, who face a much higher risk. Researchers will use HPV self-testing, care navigators, and a mobile app to help more women get diagnosed and treated. The goal is to find strategies t…

This study will use advanced MRI scans to look at kidney transplants in 140 patients. The goal is to see if MRI can measure how well the kidney is working and tell the difference between stable function and problems like rejection. Researchers hope this could lead to a non-invasi…

Filoviruses such as Ebola and Marburg cause severe hemorrhagic fevers with high death rates, and doctors know little about rare types like Bundibugyo virus. This observational study follows patients in France with confirmed filovirus disease to record how the illness unfolds. Res…

This study will follow 85 adults receiving stem cell transplants to track a serious but often missed complication called TA-TMA. Researchers want to find out how common it is and how it affects survival. Participants will provide blood samples and have standard follow-up care.

This study tests whether a video app that explains 'Undetectable = Untransmittable' (U=U) can help people with HIV stay on treatment and keep the virus under control. About 880 people from clinics in South Africa will use the app during counseling. The goal is to see if better un…

This study aims to find the best way to dose the antibiotic ceftazidime for patients in intensive care with serious infections. Many ICU patients don't get enough of the drug because their bodies process it differently. The researchers will test a personalized dosing plan to keep…

Researchers are studying whether repeated bedside ultrasound scans of the diaphragm can predict breathing failure in adults with septic shock. The study follows 120 patients in intensive care for up to 72 hours, measuring how far the diaphragm moves and how thick it is. The team …

Researchers are studying where the bacteria that infect skin sores come from in people with scabies or atopic dermatitis. They will compare bacteria grown from infected skin lesions with bacteria from nasal swabs to see if the same species appear in both places. A group of health…

Doctors often see creatinine rise in patients taking vancomycin plus piperacillin-tazobactam, a common antibiotic pair. It is unclear whether that rise means real kidney injury or a harmless lab change. This study follows 304 adults on either that pair or vancomycin plus meropene…

Researchers at Assiut University Children Hospital observe newborns diagnosed with sepsis to record any neurological signs that appear. The study follows 100 newborns aged 0 to 28 days, both full-term and preterm, who are admitted to the neonatal intensive care unit. Investigator…

Researchers are following about 1,200 children in Zhejiang Province, China, from birth through age 7 to understand how the immune system develops and why some children get more respiratory infections or asthma. The study includes healthy children, children with a history of serio…

Researchers at Emory University are running a study to see whether influenza A or B spreads from adults who caught the flu in the community to healthy adults under controlled hospital conditions. Instead of using a lab-made flu strain, the study uses naturally infected donors as …

Researchers at Assiut University are studying whether ionized calcium levels, measured from a routine blood sample when a patient enters the ICU, can signal how severe sepsis or septic shock is. The study follows 160 adults admitted to intensive care within 24 hours of presentati…

Some people with inflammatory bowel disease who take anti-TNF drugs develop painful rashes in skin folds and around the mouth, a condition called SPIDER. Researchers at a French hospital are studying whether levels of Staphylococcus aureus bacteria in these rashes change over six…

Sepsis is a life-threatening reaction to infection that can leave the immune system weakened long after the initial crisis. Researchers in Dijon are studying whether mesenchymal stromal stem cells can correct immune and metabolic problems in blood cells taken from adults with sev…

Researchers are studying how the HIV combination pill Descovy, which contains tenofovir alafenamide and emtricitabine, moves through the bodies of people with HIV who also have advanced chronic kidney disease. About 50 adults with stage 3b or stage 4 kidney disease will take part…

Researchers are tracking 1,000 hospitalized patients aged 65 and older who test positive for a respiratory virus, including human metapneumovirus (hMPV), influenza, RSV, and others. The study compares how each virus relates to death, organ complications, loss of independence, and…

Researchers in Panama survey adults age 50 and older about pneumococcal disease and the PCV21 vaccine, which protects against pneumonia and other serious infections. One group covers ages 50 to 64; another covers adults 65 and older plus a caregiver who helps them. Each person an…

This study aims to develop and pilot a program for people with HIV in South Africa who also face depression, trauma, and food insecurity. Researchers will first explore how these problems interact, then create a treatment called CBT-SA that combines therapy, nutrition support, an…

This study develops and pilot tests a written 'practice companion' designed to help clinicians and other trusted adults provide developmentally appropriate substance use care to youth ages 14 to 24. The companion offers practical guidance on cannabis, opioids, and other substance…

Researchers at Vanderbilt University Medical Center want to understand how immune cells use glucose, the body's main sugar, during critical illness. They give 25 adult ICU patients an intravenous infusion of a non-radioactive carbon-13 glucose tracer over a few hours. Then they c…

Researchers are measuring how often five animal-borne infections appear among inmates at the French Guiana Correctional Facility. The study follows newly arrived adults for up to 12 months, testing for Q fever, leptospirosis, Chagas disease, histoplasmosis, and toxoplasmosis. The…

This study will look at balance, core strength, leg strength, walking ability, and fatigue in 32 children aged 6-18 with demyelinating diseases (conditions affecting the protective coating of nerves). Each child will undergo a single session of non-invasive tests like balance exe…

This study checks how long protection from a tetanus vaccine lasts. Researchers take blood samples from 240 people who received the vaccine or a control in an earlier trial, 2.5 years after their shots. They measure antibody levels to see if they still meet protective thresholds.…

This study follows adults hospitalized with a lower respiratory tract infection, such as pneumonia or bronchitis, to measure how their quality of life changes over one year. Researchers use a standard questionnaire to track physical, mental, and social well-being at several point…

This registry study collects real-world data from about 300 adults treated with urinary bladder matrix (UBM) products for various wounds, including pressure ulcers, surgical incisions, and infections like Fournier's gangrene. Researchers track patient characteristics, treatment p…

This study tests whether a multi-day training program can reduce stigma that doctors in Vietnam show toward people with HIV and men who have sex with men. Researchers will send trained actors ("standardized patients") to clinics to pose as real patients and measure how doctors tr…

This study examines children aged 1 to 18 with tinea capitis, a common fungal infection of the scalp. Researchers will use clinical exams, dermoscopy, and laboratory tests to describe the infection's patterns and identify the specific fungi causing it. The goal is to improve unde…

This observational study follows 235 people hospitalised with dengue in Vietnam to map how the illness unfolds, especially the leaking of blood vessels that can lead to severe disease. Researchers will collect routine clinical data, blood samples, and ultrasound scans during the …

This study examines whether a probiotic's cell-free supernatant, a liquid containing its secreted products, can alter the behavior of methicillin-resistant Staphylococcus aureus (MRSA) isolated from surgical site infections. Researchers will collect 100 MRSA samples from patients…

This study looks at adults with ringworm infections that resist standard antifungal treatment. Researchers will scrape the edge of the skin lesions and examine the samples under a microscope and in the lab to identify the fungus and test which antifungals might work. The goal is …

This study looks at how to make cervical cancer screening easier for women with HIV, who are at higher risk for this cancer. Researchers will talk to patients and doctors to find out what gets in the way of screening and follow-up care. They will also explore using HPV self-testi…

This trial tests whether people living with HIV can collect their own anal swabs for anal cancer screening, compared with swabs taken by a clinician. About 700 participants in Australia will provide both types of swabs, which will be checked for high-risk HPV and precancerous cel…

This study explores whether providing home self-sampling kits for six sexually transmitted infections (STIs) can help sex workers get tested more easily. Participants receive a kit to collect samples at home and return them by mail, along with a questionnaire about their backgrou…

This study looks at whether changes in regulatory T cells (a type of immune cell) after facial reconstruction surgery can predict how quickly patients heal and how long they stay in the hospital. Researchers will collect blood samples from about 60 adults before, during, and afte…

This study looks at blood samples from children with HIV who started treatment very early in life, comparing them to children without HIV. Even with early treatment, these children often have lower cognitive test scores. The goal is to see if certain metabolic patterns in the blo…

This study tests a tablet game called Mystic Wizard, designed to help children aged 7-14 who have received a solid organ transplant learn about their daily medications. In the game, players act as a young wizard who must give 'potions' to keep a magical flame (representing their …

This study looks at how well an inhaled antifungal drug (liposomal amphotericin B) reaches the lungs in people with chronic pulmonary aspergillosis, a long-term lung infection. About 18 adults will inhale two different doses on separate days and then have special scans to see whe…

This study will give a single dose of oral methamphetamine to 20 people with HIV who are on effective antiretroviral therapy and have undetectable virus levels. The goal is to see if the drug can temporarily wake up dormant HIV hiding in cells, which could help researchers find n…

This study is a large international registry that will look back at the medical records of about 1,000 adults who were treated with the AngioVac system, a device that uses suction to remove blood clots, infected tissue, or other unwanted material from the heart and major blood ve…

This study looks at whether a structured surveillance program using regular ultrasound and a blood test (alpha-fetoprotein) can detect liver cancer at an earlier, more treatable stage in people at high risk. About 300 adults with liver cirrhosis, chronic hepatitis B, or advanced …

This study follows people who had COVID-19 to see how long-term symptoms, known as long COVID, change over five years. Researchers will interview participants and assess their physical, mental, and cognitive health to understand the lasting impact of the infection. The goal is to…

This study investigates whether the thickness of fat over the shin bone, measured on a standard knee X-ray, is a better predictor of infection after total knee replacement than Body Mass Index (BMI). Researchers will review data from 400 adults who had knee replacement surgery, c…

This observational study aims to uncover the biological mechanisms behind long COVID by comparing adults with long COVID, those who fully recovered from COVID-19, and healthy controls. Researchers will analyze blood and, when available, intestinal tissue to examine gene activity,…

This study looks at whether certain proteins in the blood, which signal brain injury, can predict memory and thinking problems in people who survive sepsis or septic shock. Researchers will measure these biomarkers in 210 adults admitted to intensive care and check their cognitiv…

This study aims to better understand tuberculosis (TB) across its entire spectrum—from early, symptom-free infection to active disease and after treatment. Researchers will recruit TB patients and their close contacts to analyze immune responses and identify biomarkers that could…

This pilot study tests whether a new index, based on changes in hemoglobin levels after a standard fluid infusion, can measure capillary leak in people with septic shock. Researchers will compare this index to known markers of blood vessel damage in 100 ICU patients. If it works,…

This observational study follows adults in France who are newly diagnosed with chronic hepatitis B (with or without hepatitis D). Researchers will measure liver scarring, treatment eligibility, and viral characteristics to understand how severe the disease is at diagnosis. The go…

This study investigates how the immune system inside the nose responds to the FluMist nasal flu vaccine in healthy adults aged 18 to 65. Participants receive a single dose of the vaccine, and researchers collect nasal swabs and gentle saline washes before vaccination and again tw…

This study uses web-based interviews to explore how adults in Japan with pulmonary fibrosis decide whether to continue or stop antifibrotic therapy after experiencing side effects. Researchers aim to understand the personal and psychological factors behind these decisions. The fi…

This study is testing whether an integrated precision medicine platform can improve how doctors diagnose and manage chronic inflammatory lung diseases like COPD and idiopathic pulmonary fibrosis. Researchers will collect blood and saliva samples for biomarker analysis, monitor in…

This study surveys 400 licensed physiotherapists in Turkey to identify which factors — such as workload, organisational support, psychological resilience, self-efficacy, and Type A behaviour — best predict burnout. Participants complete an anonymous online questionnaire measuring…

Septic shock is a life-threatening condition with high mortality. This study investigates whether patients with septic shock have a deficiency of angiotensin II, a hormone that helps regulate blood pressure. Researchers will measure hormone levels in blood and urine samples from …

This study explores the personal stories of people diagnosed with cancer of unknown primary (CUP) and their carers. Through interviews and focus groups, researchers aim to understand the emotional and practical challenges of living with this uncertain diagnosis. The findings will…

This study follows adults with multiple myeloma or B-cell lymphoma who receive CAR-T cell therapy, a powerful immune treatment. Researchers track infections that occur in the first year after treatment, looking at how common they are, what causes them, and which factors raise the…

This observational study looks at whether children aged 3 months to 16 years are more likely to complete their full course of antibiotics when prescribed at a primary care clinic versus a hospital emergency department. Researchers surveyed parents by phone after treatment ended t…

This study follows 500 adults with open limb injuries from drone attacks to understand why some develop severe wound infections. Researchers will collect detailed medical data to link the extent of tissue damage with infection outcomes. The goal is to improve early identification…

This study looks at how well the right side of the heart works with the lungs in people who have high blood pressure in their lung arteries caused by schistosomiasis, a parasitic infection common in parts of Africa and South America. Researchers will use echocardiography to measu…

This study explores a new way to diagnose Lyme disease by measuring immune cell responses to the bacteria. Researchers use a technique called flow cytometry to analyze T-cells from patients with a late-stage form of Lyme disease. The goal is to see if this method can tell active …

This study looks at whether the standard dose of the antibiotic ceftazidime-avibactam reaches high enough levels in the blood of people with blood cancers or those who have had a stem cell transplant. These patients are at high risk for severe infections from drug-resistant bacte…

This pilot study tests whether using pleuropulmonary ultrasound in the emergency department can help doctors prescribe antibiotics sooner for suspected pneumonia. Fifteen adults with respiratory symptoms will receive an ultrasound in addition to standard care. The main goal is to…

This study looks at how the drug vasopressin affects the heart and blood flow in people with septic shock, a life-threatening condition from severe infection. Researchers want to see if different patients respond differently based on their specific heart and blood vessel status. …

This study follows 300 adults in intensive care with septic shock to track how their immune systems change over time. Researchers will analyze blood samples taken alongside routine care to measure different types of immune cells. The goal is to understand why some patients develo…

This study investigates whether a particularly dangerous strain of Klebsiella pneumoniae bacteria (hvKP) raises the risk of lung injury in adults with sepsis, compared to a more common strain. Researchers will analyze blood samples for tiny bacterial particles and markers of a sp…

This study brings together data from multiple previous trials to investigate a rare group of people with HIV who can keep the virus under control even after stopping antiretroviral therapy. Researchers will analyze stored blood samples and clinical records to look for biological …

This study looks at how a person's migration history and social situation affect how well HIV treatment works. Researchers will compare the health outcomes of 150 migrants living with HIV in France, based on their social and administrative status. The goal is to understand whethe…

This study examines the genetic makeup of carbapenem-resistant E. coli bacteria collected from patients in southern France. Researchers will sequence the bacteria's full genomes to identify different strains, resistance genes, and virulence factors. The goal is to understand how …

This study works with African and South Asian immigrants to design a tuberculosis (TB) screening program that fits their needs. Researchers will hold workshops with immigrants, community leaders, and doctors to identify barriers and create a screening pathway. Then, they will tes…

This study observes how the bodies of people with septic shock respond to fluid loading, a common treatment. Researchers track markers of blood flow and fluid buildup to see which patients improve and which get worse. The goal is to find better ways to give fluids without causing…

This study looks at ICU patients who carry carbapenem-resistant bacteria in their gut. Researchers want to see if patients with higher bacterial loads are more likely to contaminate their surroundings and pass the bacteria to others. By measuring bacteria levels in rectal swabs a…

This study looks at 200 people with pneumonia to find out how many actually have an infection caused by Chlamydia pneumoniae, a type of bacteria. Researchers will use PCR tests to check for the germ and compare results with standard care. The goal is to see if this infection is o…

This study tests whether people with fibrotic interstitial lung disease can use home monitoring devices—like a spirometer, pulse oximeter, and scale—to help detect serious lung events such as flare-ups or hospitalizations. About 200 participants will use these devices connected t…

This study looks at sleep health in people with HIV who are on different antiretroviral therapies. Some participants switch from a dolutegravir-based regimen to a doravirine-based one, while others stay on dolutegravir. Sleep is measured using questionnaires, wrist-worn activity …

This study collects blood, tissue, and other biological samples from adults who have been exposed to, are at risk of, or are diagnosed with an emerging infectious disease. The goal is to create a ready-to-use resource for researchers to better understand how these infections work…

This study tests whether adding special air quality sensors and software to hospital ventilation systems can lower the number of respiratory infections among healthcare workers. About 850 Mayo Clinic staff will report symptoms and provide self-swabs when sick. The goal is to see …

This pilot study looks at how migration experiences and social bonds influence HIV prevention decisions among first-generation African immigrants aged 18-50 in New York and Massachusetts. Researchers will work with the community to develop a relationship-tailored behavioral inter…

This study will analyze respiratory samples from 1,000 patients in France to understand why some Aspergillus fungi become resistant to common antifungal drugs. Researchers will test samples for resistance and collect information about patients' environments, jobs, and medication …

This study will observe 120 solid organ transplant recipients who have invasive fungal infections. Researchers will track how well the drug liposomal amphotericin B works and its side effects, compared to historical patients who received other antifungal treatments. The goal is t…

This study follows 100 adults diagnosed with skull base osteomyelitis, a rare and serious bone infection near the ear and skull base. Researchers will track how often the infection returns or leads to death within 12 months. The goal is to gather real-world data to help standardi…

This study investigates whether a simple coronary CT scan can detect early signs of heart disease in people with HIV. Researchers will measure calcium buildup in the heart arteries of 384 Mexican adults with HIV who have undetectable viral loads. The goal is to better understand …

This study looks at thinking skills, memory, and quality of life in people who are 3 to 5 years past successful treatment for Hodgkin lymphoma or certain types of B-cell lymphoma. Participants take a series of tests and questionnaires once during a regular follow-up visit. The go…

This study looks at how HIV-1 hides in immune cells in the gut of people on effective antiretroviral therapy. Researchers will collect blood and colon tissue from 30 HIV-positive volunteers and healthy controls during routine colonoscopies. The goal is to understand why these gut…

This study looks at how the sedative dexmedetomidine affects the smallest blood vessels in people with septic shock, a life-threatening condition caused by severe infection. Researchers will measure blood flow in the tongue's tiny vessels and other key blood pressure indicators b…

This pilot study will test a drug called anisodamine in 20 adults with septic shock who are on a ventilator. The goal is to see if the drug can improve blood flow in small blood vessels and help with a phenomenon called 'vascular waterfall.' This is a very early study to gather i…

This study tests whether a safe dose of ivermectin, a common deworming drug, can make human feces deadly to flies that spread trachoma. Trachoma is a leading cause of blindness, and these flies carry the bacteria from person to person. Twelve healthy adults will take ivermectin, …

This study looks at how muscle tiredness changes the way female volleyball players move their legs when landing on one foot. Researchers will use smartphone videos to measure hip, knee, and ankle motion in 35 athletes. The goal is to understand injury risks better, not to test a …

This study looks at whether testing the liquid used to preserve donor livers and kidneys can predict infections in recipients. Researchers will check if bacteria or fungi in that fluid match infections that develop after transplant. The goal is to see if this simple test could he…

This study will look at medical records of 350 children with sickle cell disease in France who had serious bacterial infections between 2020 and 2025. The goal is to find out which bacteria are causing these infections today, especially with new vaccines available. The results co…

This study looks at how HIV might change the way the body handles fats in the liver, leading to fatty liver disease. Researchers will collect one blood sample from 120 adults: people with HIV and fatty liver, people without HIV but with fatty liver, and healthy controls. By analy…

This study follows 150 adults aged 60 and older who have a respiratory infection (flu, RSV, or COVID-19) or who test negative. Researchers will measure specific immune markers in the blood over 60 days to see how they change from early infection to recovery. The goal is to better…

This study tests a new website designed to help 11-12 year olds and their parents learn about the HPV vaccine. The goal is to see if the tool is easy to use and helpful in real school settings, especially in areas where fewer people get vaccinated. About 100 students and their fa…

This study will follow 400 people recently diagnosed with polymyalgia rheumatica, a condition causing shoulder and hip pain. Researchers will track symptoms, treatments, and outcomes over 5 years to better understand the disease and improve diagnosis. Participants will provide bl…

This study will use artificial intelligence to analyze data from over 31,000 tuberculosis patients. The goal is to create a system that helps doctors decide which patients can be cured with a short treatment course and which need longer therapy. The AI will be tested to see if it…

This study looks at how the immune system of people with leptospirosis responds to the infection and to antibiotics. Researchers will collect blood samples from 70 adults in New Caledonia before and after antibiotic treatment to measure immune cell activity. They will also test a…

This study looks at how people diagnosed with tuberculosis (TB) in rural and coastal areas of Southwest England experience stigma. Researchers will interview 20 patients to understand how stigma affects their lives and access to care. The goal is to develop better ways to support…

This study looks at whether a simple well-being questionnaire can predict which employees will take long-term sick leave (30 days or more). Researchers will survey 2,000 workers in French companies over six months and compare their answers to actual sick leave records. The goal i…

This study will test whether combining data from wearable sensors—measuring temperature, humidity, and sweat lactate—can predict the onset of sepsis in ICU patients. Researchers will monitor 360 adults at risk of sepsis for up to 48 hours. The goal is to use this data to train ar…

This study looks at how well the body remembers mpox after an infection. Researchers will measure antibodies and special immune cells in 60 people who had mpox. The goal is to understand how long protection might last and how strong it is.

This study looks at whether measuring the fluorescence of certain white blood cells (neutrophils) can help doctors quickly identify sepsis patients at risk of severe complications like organ failure or septic shock. Researchers will analyze blood samples from 492 adults in the em…

This study follows 250 patients receiving stem cell transplants to better understand engraftment syndrome, an early inflammatory complication. Researchers will track how different types of this syndrome relate to the risk of graft-versus-host disease and overall recovery. The goa…