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Can a tiny dose of norepinephrine during surgery save lungs?

NCT ID NCT07627360

Disease control Sponsor: Suez Canal University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 14, 2026 · Updated 2 times

Summary

This study tests whether giving a low, steady dose of norepinephrine during laparoscopic abdominal surgery can reduce the amount of IV fluids needed and lower the risk of lung complications afterward. It includes 130 adults at high risk for lung problems. The drug is given from the start of anesthesia until the surgery ends, and the results are compared to a placebo.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
norepinephrine
What this could lead to
If it works, this could point toward a safer way to manage blood pressure during surgery, reducing fluid overload and lung complications.
What could go wrong
This is a small, early-phase trial with only 130 patients, so results may not apply to everyone. Norepinephrine can cause side effects like rapid heart rate or high blood pressure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 130 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients aged 18 years or older. * American Society of Anesthesiologists (ASA) physical status I-III. * Scheduled for elective laparoscopic major abdominal surgery under general anesthesia with an expected duration greater than 2 hours. * Patients with ARISCAT score ≥ 45 indicating high risk for postoperative pulmonary complications. Exclusion Criteria: * Known hypersensitivity to norepinephrine. * Severe left ventricular dysfunction with ejection fraction \< 35%. * Significant cardiac arrhythmia. * Uncontrolled hypertension defined as systolic blood pressure ≥ 180 mmHg or diastolic blood pressure ≥ 110 mmHg. * End-stage renal disease. * Requirement for vasopressor support before induction of anesthesia. * Emergency surgery.

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Conditions

The condition(s) this trial relates to.

water intoxication

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Fluid over-load Intraoperative hypotension Postoperative pulmonary complications (PPCS)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Suez Canal University Hospitals

    Ismailia, Ismailia Governorate, 41522, Egypt

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