A second chance after overdose: does structured Follow-Up keep patients in care?
NCT ID NCT07738835
First seen Jul 31, 2026 · Last updated Jul 31, 2026
Summary
This study tests whether a structured early addiction care program, including a consultation, toxicology feedback, and regular follow-up calls over six months, helps people who come to the emergency room after a drug overdose stay engaged in addiction treatment. Adults hospitalized for acute intoxication with non-alcoholic psychoactive substances are randomly assigned to receive either this enhanced program or usual care. The main question is whether the enhanced approach improves retention in addiction care at six months, potentially reducing repeat overdoses and hospital visits.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Structured early addiction care program including addiction consultation, toxicology feedback, and scheduled follow-up contacts over 6 months
- What this could lead to
- If effective, this approach could help more people stay engaged in addiction treatment after an emergency overdose, reducing repeat episodes and hospital visits.
- What could go wrong
- The trial is relatively small and open-label, so results may not apply broadly. The intervention relies on patient participation, and some may still drop out despite the structured follow-up.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 266 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Oct 2026
An estimate. Start dates often move.
- Expected to finish
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Apr 2030
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Patients admitted and/or hospitalized in the emergency department or intensive care unit following acute poisoning must: * Be over 18 years of age * Have consumed at least one identifiable non-alcoholic narcotic, including psychoactive substances detected by standard urine drug screening (dipstick) * Have a history of using at least one non-alcoholic psychoactive substance within the last 30 days * Speak and understand French * Have at least 1 cm of hair * Be covered by a social security scheme (member or dependent) * Be the patient or a relative/close contact/trusted person who has been informed about the study and has given their informed consent (or completed the emergency inclusion procedure) * Have a mobile phone number or email address to be contacted Exclusion Criteria: * Acute suicidal crisis requiring priority psychiatric care * Acute alcohol intoxication (after confirmation by urine drug screening in the Emergency Department) * Acute episode related to exclusive opiate use, requiring opiate substitution therapy * Prolonged hospitalization in intensive care or follow-up care due to complications of alcohol intoxication beyond 8 days after the initial addiction assessment * Protected patient: under a valid legal guardianship, curatorship, or conservatorship * Patient requiring involuntary psychiatric hospitalization
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
4 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Hôpital Saint Antoine
Paris, 75012, France
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Hôpital Tenon
Paris, 75020, France
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Unité d'Addictologie Hospitalière/ELSA Hôpital Pitié Salpêtrière
Paris, 75013, France
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hôpital kremlin Bicêtre
Paris, France