Lung damage after TB: a new study tests whether rehabilitation can restore breathing and quality of life

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: \*Criteria aplicable to all participants:\* * Ability and willingness to provide written informed consent (or assent with parental/legal guardian consent for minors). * Willingness and ability to comply with study procedures and scheduled visits. * Willingness and ability to participate in a pulmonary rehabilitation programme, including: supervised exercise, respiratory physiotherapy, health education and psychosocial support. * Enrolment at one of the participating study sites. \*COHORT 1: People with pulmonary tuberculosis\* * Diagnosis of pulmonary TB confirmed by bacteriological methods (genotypic or phenotypic assays). * Drug-susceptible or drug-resistant TB are both eligible. * Initiation of anti-TB treatment within ≤14 days prior to enrolment. * Identified through passive, active or intensified case finding strategies, including healthcare facilities, contact tracing, or community screening. \*COHORT 2: People with PTLD\* * History of bacteriologically confirmed pulmonary TB and completion of anti-TB treatment. * No evidence of active TB disease at the time of enrolment. * Enrolment must occur within 6 months after completion of TB treatment, or at study entry if the participant already has a previously established diagnosis of PTLD. * Presence of post-tuberculosis lung disease (PTLD), defined as abnormalities in at least two of the following domains: * \_Impaired lung function\_ * \_Persistent respiratory symptoms (e.g., cough, dyspnoea)\_ * \_Structural abnormalities on chest imaging\_ Exclusion Criteria: * Diagnosis with extrapulmonary TB without pulmonary TB. * Anti-TB treatment initiated more than 14 days before study enrolment. * Pregnant women or those with suspected pregnancy will be excluded from the study, since chest X-rays are contraindicated to avoid any potential adverse effect on foetal development. * Participants who are unable or unwilling to give their written informed consent to participate in the study or whose parents/legal guardians are unable or unwilling to provide consent for paediatric participants. * Participants aged \<5 or \>65 years old due to age-related biological response impairments that can bias the analyses.