Iatrogenic disease

This study tests whether a new antibiotic called polymyxin E2, given both through a vein and as a mist inhaled into the lungs, can safely cure hospital-acquired pneumonia caused by drug-resistant bacteria. About 48 adults with this serious lung infection will receive either the n…

This phase III trial is testing whether adding dexamethasone, a widely used anti-inflammatory steroid, to standard care can improve outcomes for critically ill patients with severe hospital-acquired pneumonia who show signs of a strong inflammatory response. The study randomly as…

This trial is testing an experimental antibiotic called ASK0912 against an older drug, polymyxin B, in adults with hospital-acquired or ventilator-associated pneumonia caused by multidrug-resistant bacteria. Participants will receive one of two dosing schedules of ASK0912 or the …

This study is testing the safety and how the body handles Vaborem, a combination of two antibiotics (meropenem and vaborbactam), in children from birth to under 18 years old who have serious Gram-negative bacterial infections. All 44 participants will receive the drug intravenous…

This study tests whether the antiviral drug acyclovir helps people on breathing machines who have pneumonia and also have herpes simplex virus (HSV) in their lungs. About 616 adults in intensive care will be randomly assigned to receive acyclovir or no antiviral treatment. The go…

This phase 2a trial tests an experimental antibiotic called OMN6 in 54 adults with hospital-acquired or ventilator-associated pneumonia caused by Acinetobacter baumannii. Participants receive either OMN6 or a placebo, plus standard antibiotics, for one day. The main goal is to ch…

This study tests a new IV antibiotic (aztreonam-avibactam) in hospitalized children aged 9 months to 18 years with serious gram-negative bacterial infections. About 48 participants will receive either the new drug or the best available standard treatment. The goal is to see how t…

This study compares changing IV tubing every 7 days versus every 4 days in ICU patients with central venous catheters. The goal is to see if the longer interval increases infection rates. About 2,830 adults will take part. If 7-day changes are safe, it could save nursing time and…

This phase 3 trial tests a new antibiotic combination (BV100 plus low-dose polymyxin B) against a standard treatment (colistin plus ampicillin/sulbactam) for hospital-acquired or ventilator-associated pneumonia caused by a drug-resistant bacteria called CRABC. The study will enro…

This study tests whether adding hydrogen peroxide fogging or ultraviolet light to regular cleaning can reduce infections in intensive care units. Over 5,000 adult patients in 12 Brazilian ICUs will take part. Each ICU will try all three methods (standard cleaning, cleaning plus h…

Some bacterial infections have become resistant to common antibiotics, making them very hard to treat. This study looks at a new drug combination, aztreonam-avibactam, in about 100 hospitalized adults in China with these resistant infections. Researchers will track how well patie…

This study tests a new first-line treatment for people with advanced intrahepatic cholangiocarcinoma, a type of bile duct cancer that cannot be removed by surgery. The treatment combines chemotherapy directly into the liver artery (HAIC) with two drugs: durvalumab (an immunothera…

This phase 3 trial tests a new antibiotic combination (meropenem and pralurbactam) against an existing one (ceftazidime and avibactam) for treating hospital-acquired and ventilator-associated bacterial pneumonia. About 420 adults will participate, and the main goal is to see if t…

This study compares a rapid test that identifies pneumonia-causing bacteria in about one hour to standard lab methods that take 2-4 days. Researchers want to see if the faster test helps doctors choose the right antibiotics sooner for 150 hospitalized patients with pneumonia. The…

Researchers are studying adults with Clostridioides difficile infection to learn why some people get a repeat infection. The trial follows 750 patients across multiple hospitals, collecting blood for genetic testing and stool samples to examine gut bacteria. The goal is to build …

This study evaluates a rapid diagnostic test that can detect Candida auris, a drug-resistant fungus, in about 15 minutes. Researchers will compare the test's accuracy against standard lab methods using samples from 554 patients. The goal is to help hospitals quickly identify and …

This study looks at whether measuring a substance called D-lactate in spinal fluid can help doctors diagnose meningitis (a brain infection) in patients who have a brain drain (ventriculostomy). About 185 adults with suspected meningitis will have their spinal fluid tested. The go…

Researchers at one French hospital test whether repeated on-site simulation training helps ICU staff follow standard precautions more consistently. The training uses realistic scenarios that mimic common resuscitation situations, including interruptions and high cognitive load. T…

This study tests whether inhaling a medicine called N-acetylcysteine (NAC) can prevent pneumonia in critically ill patients who need a breathing machine. About 80 adults on ventilators will receive either NAC or a placebo. Researchers will track how many develop pneumonia and how…

This study tests whether increasing kangaroo care (skin-to-skin contact) in neonatal intensive care units can reduce severe infections and antibiotic-resistant bacteria in very premature infants (born before 32 weeks). Over 3,000 babies across multiple hospitals will be involved.…

This trial tests a prevention bundle for hospital patients who carry C. difficile bacteria but have no symptoms. The bundle includes enhanced room cleaning and special precautions. Researchers hope to prevent these carriers from developing active infections and spreading the bact…

This study compares two common hand rubs—chlorhexidine and alcohol—used by medical staff before touching premature babies in the NICU. The goal is to see which one better prevents healthcare-associated infections. One hundred premature infants will be monitored with blood culture…

This study tests whether screening surgery outpatients for Staphylococcus aureus (staph) and giving them a 5-day decolonization treatment (nasal ointment, mouth rinse, and special soap) can prevent surgical site infections. About 250 adults scheduled for various surgeries will be…

This study tests whether taking a daily vitamin C pill for 10 days can prevent catheter-associated urinary tract infections in women having elective gynecologic surgery. Half of the 180 participants will receive vitamin C, and half will receive a placebo. The goal is to see if th…

This study tests whether training NICU teams on a bundle of best practices (like mouth care and proper suctioning) can reduce ventilator-associated pneumonia in newborns. About 1500 babies on breathing machines will be tracked before and after the training. The goal is to standar…

This study tests whether using a positive expiratory pressure (PEP) device before and after hip fracture surgery can prevent hospital-acquired pneumonia. About 566 patients will either receive the PEP therapy plus standard care or standard care alone. The goal is to see if this s…

This study tests whether adding calming visual, auditory, and olfactory elements to the hospital room can reduce discomfort for patients in intensive care or continuing care units. About 208 adults hospitalized for at least 48 hours will be offered this immersive sensory environm…

This study tests whether a mindfulness-based emotion regulation training program can help children aged 7-11 who are hospitalized for at least four days feel less afraid and better control their emotions. Half of the 54 participants will receive the training alongside usual care,…

This study tests a new method called the Buzdar Technique for safely removing chest tubes that have become stuck in the lung tissue. Instead of surgery, the tube is left in place for two weeks to allow healing, then slowly pulled out over several weeks. The goal is to remove the …

Ventilator-associated pneumonia is a bacterial lung infection that can strike patients in intensive care who need a breathing machine. Researchers are building a network of European ICUs to observe these patients and prepare the groundwork for future trials of prevention, diagnos…

This study observes 600 patients in Korea who receive Zavicefta for complicated abdominal or urinary tract infections or hospital-acquired pneumonia. Researchers track side effects and how well the drug works. It is required by Korean regulators to ensure the drug's safety after …

This study is testing whether artificial intelligence can predict which patients will develop hospital-acquired pneumonia after heart or vascular surgery. It will also investigate whether pneumonia after surgery is linked to a higher risk of heart and lung problems within the fol…

This study tests whether a rapid PCR test can help doctors choose the right antibiotics within 24 hours for immunocompromised ICU patients with pneumonia. Standard lab tests take days, which can lead to incorrect or overly broad antibiotics. The trial involves 31 adults with weak…

This study looks at patients who develop pneumonia while in the hospital and later need a breathing tube (mechanical ventilation). Researchers want to learn how common this is and what factors affect recovery. About 151 adults from Assiut University will take part. The goal is to…

This study is testing whether hospitals can safely stop using special contact precautions (like gowns and gloves) for a type of antibiotic-resistant bacteria called ESBLE in geriatric units. Researchers will compare infection rates before and after removing these precautions in o…

This study looks at 150 hospital patients who get a bloodstream infection from a long-term arm catheter (PICC or Midline). It checks whether having a superficial (surface) vein clot along with the infection leads to worse outcomes, like the infection coming back or spreading. The…

This study reviews medical records from 3,000 patients who had emergency surgery at a Swedish hospital between 2009 and 2019. Researchers want to understand what factors increase risks and how patients fare in the long run, including complications, repeat surgeries, and survival.…

This study uses whole genome sequencing to track how ESBL-producing bacteria (a type of drug-resistant germ) spread among hospital patients and staff. Researchers will analyze samples from 2,000 people to find out where infections come from and how they move. The goal is to bette…

This study looks at whether having a mobility technician help older patients (65+) walk up to three times a day during their hospital stay can improve their strength and recovery. Researchers will compare these patients to those receiving usual care. The goal is to see if this si…

This study follows 300 people who had hospital-acquired pneumonia to see how it affects their heart and lungs over 18 months. Researchers will take blood samples, swabs, and perform heart and lung tests to understand the link between pneumonia and later cardiovascular problems li…

This study collects blood and tissue samples from 200 adults with HIV and certain cancers (like Kaposi sarcoma, lymphoma, or anal cancer) to help researchers understand how HIV and cancer are connected. Participants donate samples, which are stored for future research. There is n…

This study helps U.S. healthcare centers figure out if patients are getting NTM lung infections from the hospital environment. Researchers will compare germs from patients' lungs with germs from water and dust in the hospital and homes. The goal is to create a standard method to …

This study will observe 1,000 critically ill patients in European ICUs to see if those with weakened immune systems are more or less likely to pick up drug-resistant bacteria. Researchers want to understand if current isolation measures are working and how to better control the s…

This study aims to figure out where bloodstream infections in children with central lines actually come from. By comparing the DNA of bacteria from the blood with bacteria from the gut, mouth, and skin, researchers hope to tell whether the infection started from the line itself o…

This study tests whether a bundle of tools—including educational videos for doctors and patients, feedback reports, and changes to computer ordering systems—can reduce unnecessary lab tests in 16 hospitals across British Columbia. The trial will include up to 700,000 adult medica…

This study follows 80 adults who had coronary bypass surgery to see how developing pneumonia in the hospital affects their heart and lung health over the next year. Researchers will compare patients who get pneumonia with those who don't, using blood tests, heart and lung functio…

This study follows 329 adults who need surgery for an infection after a hip, knee, or other joint replacement. Researchers will track which treatments—surgery and antibiotics—lead to the best outcomes. The goal is to find patterns that help cure infections more reliably and impro…

This study watches 148 adults with acute brain injury who have a drain in their head. Researchers will check fluid from the brain to see if changes in a substance called lactate can signal an infection early. The goal is to learn more, not to test a new treatment.

This study follows 540 adults admitted to the intensive care unit (ICU) to see how their immune and inflammatory responses relate to their recovery. Researchers will collect extra blood samples at several time points over one year to measure immune cells and inflammation markers.…

This study looks at whether a questionnaire called AT HARM 10 can help identify emergency room visits caused by medication problems in adults over 65. Researchers will test the tool on 100 patients at one hospital to see how many drug-related issues they can find. The goal is to …

This study brings together 120 intensive care, anesthesia, and psychiatry experts to agree on a universal definition and diagnosis for iatrogenic withdrawal syndrome in adult ICU patients. Participants will complete anonymous questionnaires to build consensus. The goal is to impr…

This study tests whether an AI-powered augmented reality system can improve hand hygiene training better than standard videos and feedback. About 1000 participants, including healthcare workers and students, will be randomly assigned to either the AI system or standard training. …

This study examines how the community of bacteria in the lungs (the microbiome) affects how well pneumonia patients respond to antibiotics. Researchers will follow 300 adults with pneumonia, taking samples from the mouth, rectum, and lungs over 90 days. The goal is to see if the …