Iatrogenic disease

Critically ill patients on breathing machines often get hospital-acquired lung infections. This trial tests whether adjusting antibiotic doses using drug level monitoring and software works better than standard dosing. About 610 adults in intensive care units will receive either …

This study tests whether a 5-day course of inhaled amikacin can prevent ventilator-associated pneumonia in critically ill patients who already have a milder airway infection called tracheobronchitis. 250 adults on breathing machines will receive either the drug or a placebo. The …

This Phase 3 trial tests a new antibiotic called YK-1169 against a standard treatment (ceftazidime-avibactam) for adults with pneumonia caught in the hospital or from a ventilator. About 590 participants will receive either drug for 7-14 days. The main goal is to see if YK-1169 l…

This study tests a set of safety measures to lower infections from external ventricular drains (EVDs) in 248 ICU patients. The bundle includes updated care protocols, staff training, and reminder signs. The goal is to cut the current 22% infection rate by improving hygiene and ha…

This study tests a new antibiotic combination (BV100 plus other drugs) against hard-to-treat infections like pneumonia and bloodstream infections caused by carbapenem-resistant Acinetobacter baumannii. About 120 adults in the hospital will receive either the new combo or the best…

Critically ill patients on breathing machines often develop dangerous gut bacteria that can lead to hospital-acquired infections. Researchers are testing a synbiotic medical food, a mix of probiotics and prebiotics, to see if it safely reduces these harmful bacteria. The trial en…

This trial tests whether two simple, drug-free methods—Yakson touch (a gentle hands-on technique) and a dextrose-sweetened pacifier—can reduce pain in full-term newborns during blood draws. Babies in the neonatal intensive care unit will be randomly assigned to one of these comfo…

This study compares giving patients a carbohydrate-rich drink before abdominal surgery versus the standard practice of fasting. The goal is to see if the drink helps patients recover faster and leave the hospital sooner. 144 adults undergoing elective abdominal surgery will be ra…

This study tests whether adding acupuncture to standard care can lower the risk of hospital stays for a serious chemo side effect called febrile neutropenia (fever with low white blood cells). About 60 adults with sarcoma receiving doxorubicin chemotherapy will be randomly assign…

This study tests if Acoustic Resonance Therapy (ART) can relieve symptoms of Empty Nose Syndrome (ENS), a condition where past nose surgery leaves patients feeling blocked despite open airways. ART uses sound vibrations to clear mucus and reduce inflammation. About 40 adults with…

Researchers at the University of California, San Francisco are studying how well a calibrated touch device measures sensation in the larynx and throat. The study includes adults with larynx or throat disorders, including those whose condition followed radiation or other cancer tr…

This study looks at whether intensive care nurses' perceptions of leadership and quality culture are linked to antimicrobial resistance rates in their units. Researchers will survey nurses using a leadership and quality culture scale and compare those results with microbiological…

This study looks at whether giving antibiotics for just 24 hours before urological surgery works as well as the usual 48-hour course to prevent infections after the procedure. About 894 adults with a positive urine culture who are scheduled for certain types of urological endosco…

This study looks at ICU patients who carry carbapenem-resistant bacteria in their gut. Researchers want to see if patients with higher bacterial loads are more likely to contaminate their surroundings and pass the bacteria to others. By measuring bacteria levels in rectal swabs a…

This observational study will look at how often very low birth weight babies in Canadian NICUs get ventilator-associated pneumonia (VAP) and how these infections are treated. Researchers will compare different hospitals' approaches to diagnosis and care, with the goal of creating…

This observational study will follow 3000 adults having oral surgery to see how often complications like infections or nerve damage occur. Researchers will collect patient and surgery details, plus surgeon predictions, to build an AI tool that might one day help prevent these pro…

This study will see if using virtual care technologies in hospital units can reduce problems like patient falls, infections, and readmissions, while also improving patient satisfaction. About 10,000 adults admitted to six hospital units will take part, with three units using the …

This study looks at whether a faster genetic test (PCR) can help hospitals detect a dangerous bacteria called CPE more quickly than the current lab method, which takes up to 48 hours. Researchers will compare how long it takes to start or stop patient isolation using each method …

This study tests an AI-powered device called Posos that helps doctors enter prescriptions for patients on many medications in the emergency department. Researchers will measure if the AI reduces the time needed to transcribe prescriptions and lowers the number of errors compared …

This study will survey how taurolidine lock solutions are actually given to patients with a PICC line who need nutrition through a vein. Researchers will check if nurses follow the recommended steps and compare what is prescribed to what is administered. The goal is to spot any g…