ICU superbug study aims to protect vulnerable patients
NCT ID NCT06652126
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study will observe 1,000 critically ill patients in European ICUs to see if those with weakened immune systems are more or less likely to pick up drug-resistant bacteria. Researchers want to understand if current isolation measures are working and how to better control the spread of these dangerous germs. The goal is to improve antibiotic use and infection prevention for all ICU patients.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 1,000 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2025
- Expected to finish
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Dec 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients hospitalized in intensive care units (ICU).
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Patients aged 18 and over. 2. Admitted to intensive care and whose length of stay is greater than 48 hours (inclusion is at the 48th hour after admission). 3. Immunocompetent OR immunocompromised patients according to one of the following criteria: 1. Solid cancer under treatment or in remission for less than 5 years (including cancers diagnosed during hospitalization in intensive care); 2. Hematological malignancies under treatment or in remission for less than 5 years (including hematological malignancies diagnosed during hospitalization in intensive care); 3. Neutropenia \< 0.7 G/L for ≥ 7 days; 4. Solid organ transplants; 5. Patients with systemic or transplant pathologies requiring treatment with corticosteroids (prednisone equivalent \> 10 mg/day) or other high-dose immunosuppressants for \> 28 days; 6. Human Immunodeficiency Virus (HIV) infection with CD4+ \<200 μL; 7. Genetic immune deficiency. 4. Patients undergoing invasive mechanical ventilation and/or vasopressive amines. 5. Persons who have given their non-opposition. For patients unable to give their non-opposition, this will be obtained from the trusted support person. The patient will be informed as soon as possible and asked to agree to participate in any further research. 6. Patients affiliated to a social security system. Exclusion Criteria: 1. Minor patients (\< 18 years), 2. Length of stay in intensive care less than 48 hours, 3. Moribund patients. 4. Absence of BMR screening (rectal swab routinely, combined with nasal swab in some centers) within 48 hours of admission. 5. Refusal to participate in the study. 6. Vulnerable and/or susceptible patients according to one of the following criteria: 1. Patients under legal protection (guardianship, curatorship, etc.); 2. Patients in prison; 3. Pregnant or breast-feeding women. 7. Patients without social security coverage. 8. Simultaneous participation in another interventional study that could interfere with the evaluation of primary and secondary endpoints (particularly in the case of participation in an interventional study that could modulate the risk of CAR or BMR-ARI).
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Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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chu de Lille
RECRUITINGLille, France
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