Disease of primarily extrinsic mechanism

This trial tests a one-time gene therapy for WHIM syndrome, a rare inherited immune disorder that causes severe infections. Doctors collect a person's own blood stem cells, use base editing to correct the faulty CXCR4 gene, and return the edited cells to the body. The goal is to …

This early-phase trial tests whether a bone marrow transplant from a partially matched relative can safely cure chronic granulomatous disease (CGD), a condition that causes severe infections and inflammation. Four people aged 4 to 65 with CGD and no perfect donor will receive che…

Infants with severe combined immunodeficiency (SCID) lack working immune cells and face life-threatening infections. A matched sibling donor transplant is the standard cure, but most babies do not have one. This trial tests a refined transplant using a parent or other partially m…

Researchers are observing patients diagnosed with smallpox who receive the antiviral drug tecovirimat (TPOXX). The study tracks how many patients survive at day 44 and monitors safety. Because smallpox is rare, the study relies on cases that occur naturally or in outbreaks, and i…

Researchers are testing whether adding abatacept to standard immune-suppressing drugs can prevent severe graft-versus-host disease after a double umbilical cord blood transplant. The trial enrolls people with blood cancers such as leukemia, lymphoma, and myelodysplastic syndromes…

This study tests whether combining the drug pembrolizumab with a precise form of radiation can cure people with early-stage Hodgkin lymphoma that has returned or not responded to initial treatment. About 22 participants will receive this combination, with the goal of avoiding the…

This early-stage trial is testing a new vaccine called HydroVax-001B WNV to see if it is safe and triggers an immune response against West Nile virus, a mosquito-borne disease. About 30 healthy adults aged 18 to 49 will receive either the vaccine or a placebo. The study will comp…

This large phase 3 trial is testing a typhoid conjugate vaccine (Vi-TCV) in 30,000 healthy children aged 9 months to 12 years in Malawi. Half get the typhoid vaccine, half get a meningitis vaccine for comparison. The goal is to see if the typhoid vaccine prevents blood-confirmed …

This study looks at how well a pneumonia vaccine (PCV20) works in people who have recovered from B-cell lymphoma and were treated with anti-CD20 therapy. Researchers want to see if a single dose or a boosted dose is safer and more effective at preventing pneumococcal infections. …

This phase 2 trial tests V540A, an experimental vaccine designed to protect against 9 HPV types already covered by Gardasil 9, plus additional unique types. About 525 healthy women aged 16-26 will receive either V540A or Gardasil 9 to compare safety and immune response. The goal …

This early-stage trial will test the SUM-101 malaria vaccine in 24 healthy adults in Tanzania who have been exposed to malaria before. Participants will receive three doses of the vaccine or a rabies control shot, then be deliberately infected with a controlled dose of malaria pa…

This phase 1 trial is testing whether an experimental HIV vaccine can safely stimulate the immune system to produce antibodies against HIV in people who are already living with the virus and taking antiretroviral therapy. The study involves 30 adults from the Swiss HIV Cohort Stu…

Researchers are testing a booster shot called PTX-COVID19-B in adults who have already been vaccinated against COVID-19. The trial compares the immune response from PTX-COVID19-B to that from Comirnaty, a widely used mRNA vaccine. Participants receive one 40 microgram dose and gi…

This study tests an experimental vaccine against Marburg virus, a rare but severe disease. About 200 healthy adults will receive either the vaccine or a placebo to check for side effects and measure immune responses. The goal is to see if the vaccine is safe and prompts the body …

This study tests a new vaccine called GBP511, designed to protect against several sarbecoviruses (a group that includes SARS-CoV-2). About 368 healthy adults will receive one or two doses at different strengths, with or without an adjuvant to boost immune response. The goal is to…

This study tests a new vaccine called MTBVAC to see if it can prevent tuberculosis (TB) disease in teens and adults aged 14 to 45 who live in areas where TB is common. About 5,500 volunteers will receive either the vaccine or a placebo, and researchers will track who develops TB …

Researchers are studying blood from HIV-positive adults to identify parts of the virus that trigger protective T cells, which fight HIV, while avoiding parts that help the virus infect CD4+ T cells. By comparing these viral components across human and animal AIDS viruses, they ho…

This study in Tanzania tests whether one dose of the HPV vaccine works as well as the standard two or three doses in girls aged 9-14. Cervical cancer is a major killer in East Africa, and reducing the number of shots could cut costs and make vaccination more accessible. The trial…

This study follows women who previously received the GBS-NN/NN2 vaccine during pregnancy to see how long their immune protection lasts. It also tests whether a booster dose given in a new pregnancy is safe and boosts immunity, aiming to protect newborns from group B strep infecti…

This trial tests a new vaccine called LBVD, which combines protection against six diseases: diphtheria, tetanus, whooping cough, hepatitis B, polio, and Hib. The study enrolls healthy infants around 6 to 8 weeks old who receive three doses at 6, 10, and 14 weeks of age. Researche…

This trial tests an investigational yellow fever vaccine called vYF against the standard YF-VAX vaccine in healthy adults aged 18 to 60. The goal is to see if vYF produces a similar immune response, measured by antibody levels 28 days after a single dose. Researchers will also co…

This phase 2 trial is testing a new pneumococcal vaccine (PG4) in about 605 healthy infants to see if it is safe and triggers a strong immune response. Infants will receive four doses starting at 2 months old, and the new vaccine will be compared to existing vaccines like Prevnar…

This study tests an experimental vaccine called AZD6489 in adults aged 60 and older. The vaccine is designed to protect against respiratory syncytial virus (RSV), a common virus that can cause serious lung infections in older people. Participants receive a single injection of eit…

This study was designed to check how long the Ebola vaccine (ERVEBO) protects people who might be exposed at work, like lab workers or healthcare staff. It also planned to see if a booster shot could extend that protection. However, the trial was withdrawn before enrolling any pa…

This study looks at whether a second, inactivated hepatitis A vaccine can safely boost protection in healthy Thai children and teens who did not develop enough antibodies after a single dose of a live-attenuated hepatitis A vaccine. About 36 participants who took part in an earli…

This study tests a single dose of an updated Novavax COVID-19 vaccine designed to target the JN.1 variant. About 6,500 healthy adults aged 50 to under 65 who are not at high risk for severe COVID will receive either the vaccine or a placebo. Researchers will track how well the va…

This phase II trial tests a new tuberculosis vaccine called MTBVAC (BBV169) in 164 healthy adolescents and adults. Some participants get the new vaccine, others get the standard BCG vaccine. The study checks how safe the vaccine is and how well it triggers an immune response, aim…

This Phase 3 study is testing the MVA-BN mpox vaccine in 344 infants and children aged 4 to 24 months in the Democratic Republic of the Congo, a region heavily affected by mpox. Researchers are comparing a standard dose to a half-dose to see if the lower dose is still effective a…

This early-stage trial tests a new vaccine called AVX70371, designed to treat chronic hepatitis B by training the immune system to fight the virus. It involves 16 healthy adults aged 18 to 40 to check for safety and immune responses. The study is not yet testing if it works again…

This study looked at whether adding the drug cidofovir to usual care helps people who develop painful bladder bleeding from the BK virus after a stem cell transplant. About 27 participants received either cidofovir or standard supportive care. The goal was to see if symptoms impr…

This study tests a new drug called ION717 for people with early-stage prion disease, a rare and fatal brain condition. The drug is given via a spinal injection and aims to reduce harmful prion proteins. The trial will check safety, side effects, and how the drug moves through the…

This early-phase trial is testing whether adding the targeted drug polatuzumab vedotin (with or without another drug called glofitamab) to standard chemotherapy is safe for people with untreated, aggressive B-cell lymphoma. About 56 participants will receive the combination to se…

This study tests whether high doses of vitamin C given through an IV can help people recover better after a liver transplant. About 90 adults having their first liver transplant will receive either vitamin C or a placebo for two days. The goal is to see if vitamin C reduces organ…

This study tests whether giving two IV antibiotics early, instead of one, can clear Staphylococcus aureus bloodstream infections faster and improve outcomes. About 300 hospitalized adults will be randomly assigned to receive either a single antibiotic or a combination of two. Onc…

This study tests the drug ruxolitinib in 36 Chinese adults and teens (12+) who have severe graft-versus-host disease after a stem cell transplant and did not improve with steroids. Participants take ruxolitinib pills daily for up to 56 days. The main goal is to see how many patie…

This phase III trial compares an experimental drug called YL201 with standard chemotherapy in people whose nasopharyngeal carcinoma has returned or spread and no longer responds to PD-(L)1 inhibitors and at least two prior chemotherapy regimens. About 400 participants will receiv…

Researchers are collecting data on how well donor livers preserved with the LIVERguard device function after transplantation. The study includes liver transplant recipients whose donor organs were stored in the device, as well as a comparison group of patients who received livers…

This study tests a drug called bedaquiline in children and teens (0 months to under 18 years) with multidrug-resistant tuberculosis (MDR-TB), a lung infection that does not respond to standard antibiotics. About 60 participants will receive bedaquiline along with other TB medicat…

This study tests whether a cancer-killing virus (T-VEC) combined with radiation can shrink soft tissue sarcomas before surgery. About 40 adults with newly diagnosed, removable sarcomas will receive the virus injected into the tumor plus radiation. The main goals are to see how ma…

This study is for people with liver cancer who need surgery but don't have enough healthy liver left. Doctors use a special radiation treatment (Y90) to help the liver grow larger. Once the liver is big enough, patients can have surgery to remove the cancer. The study compares st…

This early-phase study tests a combination of two drugs, acalabrutinib and durvalumab, in people with primary central nervous system (CNS) lymphoma—a rare and aggressive brain cancer. The study includes up to 25 patients whose cancer has returned after prior treatment or who cann…

This study tests a new oral drug called alvelestat (MPH966) in adults who have lung damage (bronchiolitis obliterans syndrome) after a stem cell transplant. The drug aims to block an enzyme that may cause lung injury. The trial has two parts: first to find the safest and most eff…

This study tests two immune-boosting drugs, ipilimumab and nivolumab, in people with classic Hodgkin lymphoma that has returned or not responded to prior therapy. The goal is to see if giving these drugs alone or together can shrink tumors. The trial involves 13 adults with measu…

This phase II trial tests whether bevacizumab, a drug that blocks blood vessel growth, can lengthen the time between surgeries for adults with recurrent respiratory papillomatosis (RRP), a rare condition causing wart-like growths in the airways. Participants receive 11 doses of t…

Researchers test a treatment plan for adults with Hodgkin lymphoma that has come back or stopped responding to initial therapy. Participants receive nivolumab, an immunotherapy, plus three chemotherapy drugs. PET scans help doctors decide how much treatment each person needs. The…

This trial tests whether a dietary supplement called protocatechuic acid (PCA) can improve health markers in people undergoing revision surgery for a knee prosthetic joint infection. Participants take PCA before and after surgery, and researchers measure changes in immune and met…

This study tests a personalized approach for people with early-stage Hodgkin lymphoma. Doctors use PET scans to decide if standard chemotherapy alone is enough or if adding immunotherapy drugs can improve results. The goal is to boost survival while limiting unnecessary treatment…

This early-phase study tests whether 30 minutes of moderate exercise (like walking or cycling) right before standard immunotherapy can improve treatment for certain skin cancers (melanoma, squamous cell carcinoma, Merkel cell carcinoma). About 22 adults will exercise before each …

This early-stage trial tests a therapeutic vaccine called ISA104 in 24 people with chronic hepatitis B who are already on antiviral drugs. The goal is to see if the vaccine is safe and can boost the immune system to better fight the virus. Participants will receive either ISA104 …

This phase 2 trial tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy can help children and young adults (ages 3-25) with newly diagnosed classical Hodgkin lymphoma who did not respond well to initial chemo. About 340 participants will receive pemb…

This study tests a new way to treat children and young adults with high-risk blood cancers like leukemia and lymphoma. Doctors take blood cells from a family donor, remove certain T cells that can cause a harmful immune reaction, and then transplant the modified cells. The goal i…

This phase 2 trial tests whether Gardasil-9, a vaccine normally used to prevent HPV infection, can treat warts that have not responded to standard treatments. Researchers inject the vaccine directly into the wart, rather than into a muscle, and compare its effect against a placeb…

Researchers test whether adding black seed oil to a vonoprazan-based triple therapy clears Helicobacter pylori infection better than the standard triple therapy alone. The trial enrolls 90 adults with confirmed H. pylori who have not been treated before. Participants receive eith…

This early-phase trial is testing a new type of immunotherapy called tri-specific CAR T-cells that target three proteins (CD19, CD20, CD22) on cancer cells. It is for adults with B-cell lymphomas that have come back or not responded to standard treatments. The study will enroll 1…

This phase 2 trial tests whether giving the HPV vaccine (Gardasil 9) to adults before a kidney transplant helps their immune system fight HPV after transplant, when they must take drugs that weaken immunity. About 51 participants will receive the vaccine before surgery, and resea…

This phase II trial tests whether combining two drugs, atezolizumab and bevacizumab, can shrink rare solid tumors like appendix cancer, anal cancer, and mesothelioma. About 133 participants with various rare cancers will receive the drugs intravenously. The goal is to see if the …

This study tests whether adding the targeted therapy cabozantinib to a standard immunotherapy combination (nivolumab and ipilimumab) can better control advanced nasopharyngeal cancer that has returned or spread. About 50 adults whose cancer worsened after platinum chemotherapy an…

This early-stage trial tests a DNA vaccine called INO-8000, given with an immune booster, to see if it can help people with chronic hepatitis C fight the virus. The study involves 33 participants and focuses on safety and finding the best dose. The vaccine is delivered through in…

This study looks at 600 ICU patients with hospital-acquired sepsis to see if giving antibiotics continuously or adding a second antibiotic improves survival. Patients will be randomly assigned to receive a beta-lactam antibiotic either continuously or intermittently, and some wil…

This phase 2 trial tests whether adjusting treatment based on a very early PET scan can improve outcomes and reduce side effects for people with advanced Hodgkin lymphoma. Participants receive brentuximab vedotin plus chemotherapy, with the regimen modified according to how well …

This study tests whether adding the immunotherapy drug atezolizumab to standard chemotherapy (BEGEV) helps people with Hodgkin's lymphoma that has returned or not responded to first treatment. About 122 adults aged 18-60 will receive the combination before a stem cell transplant.…

This study tests a stem cell transplant to control peripheral T-cell lymphoma in people whose cancer has not responded to standard treatments. Participants receive a donor's stem cells after chemotherapy or antibody therapy to prepare their body. The goal is to see if this approa…

This Phase 2 study tests an experimental drug called ALG-000184 against a standard hepatitis B medication (tenofovir) in 200 adults with chronic hepatitis B. Participants take one pill daily for 48 weeks. The main goal is to see if the new drug can lower hepatitis B virus levels …

This study follows 75 adults who have had a stem cell or solid organ transplant and are being treated with maribavir for cytomegalovirus (CMV) infection. Researchers will track how well the drug clears the virus, how long treatment lasts, and any side effects. The goal is to see …

This Phase 2 trial tests whether adding TQ-A3334 tablets to standard nucleoside analog drugs can better control chronic hepatitis B. About 116 adults with the infection will receive either the combination or a placebo plus standard drugs. The main goal is to see if the combinatio…

This study tests the safety of an antibiotic called Vabomere in children aged 3 months to 12 years who have complicated urinary tract infections, including kidney infections. The children receive the medicine through an IV while in the hospital. Researchers monitor for side effec…

This study in Botswana tests whether giving three powerful antibodies by infusion can help children who started HIV treatment early keep the virus suppressed without taking daily antiretroviral pills. About 41 children aged 2 to 12 will receive the antibodies while stopping their…

This study tests whether a blood test for Epstein-Barr virus (EBV) DNA can help doctors choose the best chemotherapy after standard radiation for nasopharyngeal cancer. About 685 patients will first receive standard chemoradiation. Then, based on whether EBV DNA is still detectab…

This study tests whether a community mentoring program called Generation Xchange (GenX) can help older African-American adults fight off respiratory viruses. 160 participants over age 50 will be randomly assigned to the program or a control group. Researchers will measure immune …

This study tests whether a simple program—including an education session for oral surgeons, patient instruction sheets, and blister packs of acetaminophen and ibuprofen—can reduce opioid prescriptions to adolescents and young adults after tooth extraction. About 38,000 patients a…

This early study is testing whether bone marrow from deceased donors can be safely used for transplants in people with blood cancers like leukemia and lymphoma. Twelve patients will receive the transplant along with chemotherapy or radiation. The main goal is to see if the new ma…

This study tests whether delivering healthy food boxes, remote health monitoring, and one-on-one coaching can help low-income Black adults with type 2 diabetes better control their blood sugar. The trial enrolls 304 participants in the Deep South and tracks changes in HbA1c level…

This study offers kidney transplant patients with antibody-mediated rejection (AMR) the chance to receive felzartamab for up to 4 more years. AMR occurs when the immune system attacks the new kidney. The main goal is to check long-term safety and monitor kidney health through bio…

This study tests whether infusions of cord blood stem cells can help people with moderate to critical COVID-19 pneumonia. The trial includes 65 adults with COVID-19-related acute respiratory distress syndrome (ARDS). Researchers will compare stem cell treatment plus standard care…

This Phase 3 trial tests whether hydroxychloroquine, given alone or with azithromycin, can improve outcomes for adults hospitalized with moderate to severe COVID-19 lung disease. Participants receive hydroxychloroquine for 10 days, and some also get azithromycin for 5 days. Resea…

This early study tests a new gene therapy called INT2104 in 10 adults with B-cell cancers that have come back or not responded to treatment. The therapy is given as a single IV infusion and works by instructing the body to create its own cancer-fighting T cells and natural killer…

This study compares a high-dose flu vaccine to the standard dose in 270 lung transplant recipients who are 1 to 35 months post-transplant. The goal is to see if the high-dose vaccine triggers a stronger immune response and provides better protection against influenza. Participant…

This phase 2 trial tests a combination of six drugs (TEDDI-R) in 48 adults with aggressive B-cell lymphoma that has spread to the central nervous system. The goal is to see if this mix can control the cancer better than current treatments. Participants receive the drugs in 21-day…

This trial tests whether adding an experimental cell therapy called Amimaitosai to standard steroids can treat severe gut inflammation that sometimes occurs after a stem cell transplant. The study enrolls people with blood cancers who develop this condition, called gastrointestin…

This study tests whether a smoking cessation medication (varenicline) combined with tools to help people stick with treatment can improve quit rates for smokers living with HIV. About 340 participants will be followed for 6 months to see if they stop smoking, confirmed by breath …

This early-stage trial tests a combination of four drugs—lenalidomide, nivolumab, rituximab, and methotrexate—in people with primary CNS lymphoma, a rare cancer of the brain or spinal cord. The goal is to find the safest dose and see if adding lenalidomide and nivolumab to standa…

This study tests whether giving a newborn a nasal microbiome transplant from their parent can increase the diversity of bacteria in the baby's nose. The goal is to see if this can help prevent infections like those caused by Staphylococcus aureus. The study involves 175 premature…

This phase II trial tests whether adding the drug axatilimab to standard care can prevent graft-versus-host disease (GVHD) in 72 blood cancer patients receiving a stem cell transplant. GVHD occurs when donor cells attack the patient's body, causing serious symptoms. Axatilimab is…

This study looks at the long-term safety of an inhaled medication called treprostinil for people with fibrotic lung diseases like idiopathic pulmonary fibrosis. About 1,850 adults who completed a prior related study will take the drug and be monitored for side effects. The goal i…

This study tests whether removing a specific type of immune cell (naive T cells) from donor stem cells can prevent chronic graft-versus-host disease (GVHD) in children and young adults with blood cancers. GVHD occurs when donor cells attack the patient's body after a stem cell tr…

This trial tests whether taking a daily low dose of colchicine, an anti-inflammatory drug, can reduce the risk of heart attacks, strokes, and other heart problems in Chinese patients who have had a stent placed for coronary heart disease. Researchers will compare two different do…

This trial studies women whose water breaks before labor starts, a condition called premature rupture of membranes, at 37 to 42 weeks of pregnancy. Half the participants will have labor induced within 24 hours using a vaginal gel, while the other half will wait up to 24 hours for…

This study tests whether personalized ventilator settings can reduce lung injury in adults with severe respiratory failure who are on ECMO (a heart-lung machine). Researchers will use esophageal manometry or electrical impedance tomography to tailor the ventilator's positive pres…

This trial tests whether applying local heat to the cervix can clear high-risk HPV and treat early cervical precancerous lesions (CIN I and II). Women aged 18-65 with persistent high-risk HPV will receive heat therapy at 44°C for 30 minutes on several days. The study measures whe…

This study tests a new treatment plan for adults with B-cell acute lymphoblastic leukemia (B-ALL) who cannot or choose not to have a donor stem cell transplant. The approach uses a 'sandwich' strategy: first, patients receive two types of CAR T-cells (targeting CD22 and CD19), th…

This early-stage trial tests FF-10850, a liposome-wrapped version of the chemotherapy drug topotecan, in 96 adults with advanced solid tumors like ovarian, cervical, and Merkel cell carcinoma. The main goals are to find the safest dose and understand side effects. Researchers hop…

This study tests whether a special T-cell vaccine, combined with an immune-boosting drug (vesatolimod) and two powerful antibodies, can help people with HIV control the virus without needing daily antiretroviral therapy. The trial involves 36 adults who started HIV treatment soon…

This study tests whether fecal microbiota transplantation (FMT) — transferring healthy donor stool into the gut — can lower the risk of death in ventilated ICU patients with multidrug-resistant lung infections. The idea is that restoring gut bacteria may help fight lung infection…

This early-phase trial tests a personalized cell therapy for adults aged 60 and older with B-cell acute lymphoblastic leukemia (ALL) who are in first remission. Researchers take a patient's own immune cells, modify them in the lab to recognize and attack leukemia cells, and infus…

This phase III trial compares adding the immunotherapy drug cemiplimab before surgery (with or without radiation) to standard surgery alone for people with stage III/IV squamous cell skin cancer that can be removed. The goal is to see if the combination improves event-free surviv…

This early study tests whether giving gene therapy after standard chemotherapy is safe for people with AIDS-related non-Hodgkin lymphoma. The gene therapy adds anti-HIV genes to the patient's own blood stem cells, aiming to help the body fight HIV. Only 3 participants were enroll…

This trial tests an experimental drug called CS5001, designed to seek out and destroy cancer cells that carry a specific marker (ROR1). It is being studied in people with advanced solid tumors or lymphomas that have progressed after standard treatments. The study will first find …

This study tests whether providing medically tailored meals along with intensive lifestyle coaching can help adults with HIV and type 2 diabetes or prediabetes better manage their weight and blood sugar. About 200 participants will be randomly assigned to receive either the meals…

This trial tests whether mepolizumab, an antibody that blocks a key immune signal, can produce lasting improvements in people with severe nasal polyps. Participants receive twelve monthly injections and are followed for six months after stopping to see if benefits persist. Resear…

This early-stage trial tests a new drug called IBRX-042 in 12 people with HPV-related cancers that have come back or worsened. The main goal is to find the safest dose and understand side effects. Participants get three injections, one every three weeks, and are closely monitored…

This study tests whether a telemedicine program that combines brief counseling with cognitive-behavioral therapy can help people with HIV reduce unhealthy alcohol use and improve their overall health. About 308 participants in Alabama will receive either the combined program or b…

This study tests a drug called MRG003 in adults whose nasopharyngeal cancer has come back or spread and hasn't responded to standard treatments. The goal is to see if the drug can shrink tumors and how safe it is. About 238 participants will receive the drug, and researchers will…

This study tests a combination of three drugs—bintrafusp alfa, PDS01ADC, and entinostat—in adults with advanced HPV-related cancers (like cervical, anal, or throat cancer) or certain colon cancers that haven't responded to standard treatment. The goal is to find a safe dose and s…

This trial compares two treatments for people with severe sepsis who also have adrenal insufficiency, a condition where the adrenal glands do not make enough cortisol. Researchers test whether giving fludrocortisone along with hydrocortisone works better than hydrocortisone alone…

This trial tests whether a drug called cyclophosphamide (PTCY) can prevent graft-versus-host disease (GVHD) better than the current standard, ATG, in patients receiving stem cell transplants from unrelated donors. GVHD is a serious complication where donor immune cells attack the…

This trial tests a new model where patients with infections receive intravenous antibiotics at home instead of staying in the hospital. Nurses from a municipal response team visit the patient, while hospital doctors oversee the treatment remotely using telemedicine and welfare te…

This trial tests whether a structured improvement strategy, called SAIA, can help syringe service programs in the U.S. deliver more HIV testing and referrals to prevention and treatment services. The study will compare programs using SAIA with those continuing their usual practic…

This study compares two approaches for replacing an infected aortic valve: using a cryopreserved aortic homograft (a preserved human donor valve) versus conventional mechanical or tissue prosthetic valves. The goal is to see which method leads to fewer complications, such as deat…

This trial tests whether adding interferon-gamma to standard antifungal medication can help people with chronic pulmonary aspergillosis, a progressive lung infection caused by the Aspergillus fungus. The study will include 50 adults starting antifungal treatment, who will be rand…

This trial tests whether removing the urinary catheter within 24 hours after a kidney transplant is as safe as keeping it longer. The goal is to see if early removal reduces urinary tract infections without increasing the risk of urine leaks or narrowing of the ureter. About 120 …

This phase II trial is investigating whether higher doses of two tuberculosis (TB) drugs, rifampicin and pyrazinamide, can safely shorten treatment for people with mild to moderate pulmonary TB. The study compares drug levels and safety of this high-dose regimen against the stand…

This trial tests a smart pillbox that sends text alerts when a person misses their HIV medication. The alerts go to the user, a support person, and a case manager to help them get back on track. The study involves African American men who have sex with men and have trouble sticki…

This study tests whether two lab-made antibodies, given as a single infusion, can help control HIV in adults who are starting standard antiretroviral therapy (ART). The trial will see if these antibodies reduce the hidden virus in blood cells and delay the virus from rebounding i…

This study tests whether giving the drug anakinra early can prevent severe cytokine release syndrome (CRS) in children and young adults with B-cell acute lymphoblastic leukemia (B-ALL) who are receiving CAR-T cell therapy. Participants receive anakinra at the first sign of fever,…

This phase 3 trial is testing whether adding the immunotherapy drug toripalimab to standard chemotherapy and radiation can improve outcomes for people with locally advanced nasopharyngeal carcinoma, a type of head-and-neck cancer. Participants will receive either toripalimab or a…

This trial compares removing a urinary catheter on day 3 versus day 6 after a living donor kidney transplant. The goal is to see if earlier removal reduces urinary tract infections within 30 days without causing more complications like urine leaks. The study involves 172 adult ki…

This trial compares two dental procedures—direct pulp capping and partial pulpotomy—for treating permanent teeth with deep cavities that expose the pulp. Adults with deep caries and reversible pulpitis will be randomly assigned to one of the two procedures. The study will follow …

This early-phase trial is testing a type of immunotherapy called CD19CAR T-cells in people aged 16 and older with relapsed or refractory primary CNS lymphoma, a rare cancer of the brain or spinal cord. The treatment involves collecting a patient's own immune cells, engineering th…

This study tests whether the level of a specific inflammatory marker (MMP9) in the dental pulp can predict the success of a full pulpotomy, a procedure that removes the inflamed pulp from the crown of a tooth and seals it with a special material. Adults with deep cavities causing…

This phase 3 trial is testing whether adding tocilizumab to standard care can slow the decline in kidney function for people who have chronic antibody-mediated rejection after a kidney transplant. Half of the 50 participants will receive tocilizumab plus standard care, while the …

This study tests whether person-centered counseling and community outreach can help people with HIV who have fallen out of care get back on track. Researchers will work with 3,000 patients in Zambia who are late for appointments or missing viral load tests. The goal is to see if …

This study tests a simplified, accelerated HIV care model called ACCELERATE. It combines rapid telehealth appointments, a pre-approved HIV medication, and a free 30-day starter supply to help people with HIV who have fallen out of care get back on track. The goal is to see if thi…

This trial investigates whether adding high-dose inhaled nitric oxide to standard antibiotics can help people with pneumonia recover faster. The study includes 200 adults with hospital-acquired or community-acquired pneumonia. Participants receive either nitric oxide or a sham tr…

This trial tests whether implanting a thin disc of donor cornea tissue — called a stromal lenticule — can improve corneal transparency and vision in people with herpetic stromal keratitis, a herpes infection that scars the cornea. The lenticule contains stem cells and other livin…

This trial tests whether combining an oral immunomodulator with a vaginal ovule can help the body clear persistent high-risk human papillomavirus (HPV) infection, a key cause of cervical cancer. About 76 women with low-grade cervical changes will receive either the dual immunothe…

This trial compares a fixed 28-day antibiotic course against standard care (where the duration is decided by the doctor) in adults hospitalized with complicated intra-abdominal infections. About 1,100 participants will be randomly assigned to one of the two approaches and followe…

This trial investigates whether a shorter course of antibiotics, tailored to each patient's response, can treat left-sided endocarditis as safely as the standard 4-6 week regimen. Adults with endocarditis caused by specific bacteria (Streptococci, Enterococcus faecalis, or Staphy…

This trial investigates whether a shorter course of antibiotics, tailored to each patient's response, can safely treat bacterial endocarditis. Standard treatment lasts 4-6 weeks, but this study tests a personalized approach based on factors like fever and blood tests. The goal is…

This study tests whether a brief screening and a telehealth counseling session in the emergency department can help people reduce their use of drugs or alcohol. About 650 adults who are at low or moderate risk for substance use problems will take part. The goal is to see if this …

This study tests whether giving patients hyperbaric oxygen (breathing pure oxygen in a pressurized chamber) after an umbilical cord blood stem cell transplant helps the donated stem cells grow faster. The trial enrolls people with blood cancers like leukemia or lymphoma who lack …

This study tests whether starting antiretroviral therapy right away during the first weeks of HIV infection can protect key immune cells from being destroyed. Adults with very early HIV (infected within the last 90 days) receive a combination of dolutegravir and emtricitabine/ten…

This trial is for people with advanced cancers who have already responded well to 6 months of standard immunotherapy. It compares continuing the same drugs at the usual frequency versus giving them every 3 months. The goal is to see if the reduced schedule can prevent cancer prog…

This study tests a program called Ssinga Nze that combines training for clinic staff with one-on-one support for people living with or at risk of HIV. The goal is to reduce HIV-related stigma and help sex workers in Uganda stick with their HIV prevention or treatment. Researchers…

This study tests a transitional care model for older adults (65+) hospitalized with heart failure, COPD, or pneumonia. The model provides extra education, social services, and coordination among doctors after discharge. Researchers compare this to usual care to see if it reduces …

This study tests whether giving two experimental drugs in sequence can achieve a functional cure for chronic hepatitis B. Participants are adults with chronic HBV who are already on standard antiviral therapy. They will receive either one of two doses of daplusiran/tomligisiran f…

This study tests a digital package called CARE-TB to help people with tuberculosis take their medication as prescribed. The package includes video observation of pill-taking, digital reminders, telecounselling, and educational materials. Researchers will compare this approach to …

This study tests whether dasatinib, a drug currently used for leukemia, can safely control HIV in people who were infected within the past 3 to 12 months and have not yet taken standard HIV medications. Participants receive either dasatinib or a placebo for 16 weeks. The goal is …

This study tests a new approach for people receiving a stem cell transplant from a partially matched family donor. The donor's immune cells (T cells) are modified in the lab to include a 'suicide gene' that can be activated by a drug if the cells attack the patient's body, causin…

This trial tests whether specially modified T cells from a partially matched donor can help patients recover their immune system faster after a stem cell transplant. The T cells are engineered with a 'suicide gene' that allows doctors to destroy them if they cause graft-versus-ho…

This study tests whether specially grown immune cells can fight three common viruses—adenovirus, CMV, and EBV—in people whose immune systems are weak due to a stem cell or organ transplant, or an inherited immune disorder. The cells are made from a donor's blood and trained to re…

This study tests whether personalized text messages can motivate people living with HIV in Vietnam to quit smoking. Participants receive motivational texts over six months and are encouraged to use a free government quitline that provides nicotine patches. The goal is to see if t…

This study tests a counseling program for people living with HIV who also face mental health challenges or substance use. The program uses one-on-one sessions to help with medication adherence, stress, and other life issues. Researchers will see if participants complete the progr…

This study tests a virus called AdAPT-001 that is injected directly into tumors to kill cancer cells. It is for adults with advanced solid tumors that have not responded to standard treatments. The trial will check if the virus is safe and whether it works better when combined wi…

This study looks at two antiviral drugs, TAF and TDF, in pregnant women with chronic hepatitis B. It aims to see which one better controls the virus and keeps the mother's liver healthy without harming the baby. About 816 women in early or middle pregnancy will take one of the dr…

This study tests dalbavancin, a long-acting antibiotic given as a few shots over two months, for infections that occur after hip or knee replacement surgery. The standard treatment requires 12 weeks of daily antibiotics, which can be hard to tolerate and complete. The trial inclu…

This study compares banked donor breast milk to preterm formula for late preterm infants (born at 34–36 weeks) who need extra nutrition while their mothers' milk supply increases. Researchers will track the babies' weight gain and analyze their gut bacteria to see which supplemen…

This study was designed to see if corticosteroids (prednisone or hydrocortisone) could help COVID-19 patients who need extra oxygen. It planned to enroll adults with confirmed COVID-19 and pneumonia, using CT scans to identify those likely to benefit. However, the trial was withd…

This early-stage trial tests a biologic treatment for 20 people with moderate COVID-19 who also have controlled cancer. The treatment aims to help the immune system recognize and kill the virus. Researchers will check if the virus clears and if the immune response improves.

This study is for adult women living with HIV who have experienced intimate partner violence. It tests a program that combines trauma-informed counseling with a safety planning app to improve mental health, HIV management, and safety. The goal is to see if this approach can reduc…

This phase 2 trial is testing whether combining pembrolizumab (an immunotherapy) with olaparib (a PARP inhibitor) can shrink tumors in people with nasopharyngeal cancer that has become resistant to platinum-based chemotherapy. The study plans to enroll 30 adults whose cancer has …

This study looks at whether the antibiotic omadacycline can help people with a hard-to-treat lung infection caused by Mycobacterium abscessus. Researchers will review medical records of 200 patients to see how many get better or are cured. The goal is to find out which patients b…

This study tests whether the antiviral drug tecovirimat can help people with monkeypox heal faster. About 480 adults and teens (14+) with active lesions will receive either tecovirimat or a placebo, alongside standard care. The main goal is to see how quickly skin and mouth sores…

This study tests whether the antiviral drug entecavir can prevent hepatitis B from reactivating in people with a type of blood cancer (CD20-positive B-cell lymphoma) who have had hepatitis B in the past but cleared it. The 84 participants will take entecavir before starting their…

This study tests a drug called 177Lu-DOTATATE, which delivers radiation directly to cancer cells, in people with metastatic nasopharyngeal cancer that has not responded to at least two prior treatments. Only patients whose tumors show up on a special scan are eligible. The main g…

This early-phase trial tests a biological product mix designed to train the immune system to recognize and clear multiple strains of HPV. The study involves 20 participants with cervical HPV infection who do not have symptoms or signs of cancer. The treatment is given through the…

This pilot study tests a personalized radiation plan for people with HPV-related throat cancer that is considered high-risk. Using advanced scans (MRI and PET), doctors adjust the radiation dose to target the most aggressive parts of the tumor. The goal is to see if this approach…

This study was designed to test whether an inhaled drug called ZYESAMI could help people with severe COVID-19 avoid getting worse and needing a ventilator. It was a Phase 3 trial, meaning it was in the final stage of testing. However, the study was withdrawn before any participan…

This study was designed to test whether the drug itolizumab could help hospitalized COVID-19 patients recover faster. The trial was planned for 18 years and older with confirmed COVID-19 pneumonia and low oxygen levels. However, the study was withdrawn before enrolling any partic…

This study tests a new home-use LED light device to treat nail fungus (onychomycosis). Researchers want to find the best light dose and how often to use it. Fifty adults with nail fungus will use the device at home and be monitored for improvement.

This study tests whether offering small prizes (phone credit) can encourage young people aged 15-30 with HIV to take their medication every day. 560 participants in Uganda are split into groups with different reward rules. The goal is to see if these low-cost incentives improve a…

This study tests whether pomalidomide, a drug currently used for multiple myeloma, can help control HIV when people temporarily stop their standard antiretroviral therapy (ART). Thirty-two adults with well-controlled HIV will receive either pomalidomide or a placebo alongside low…

This study compares a single-stage surgery using implants coated with an antibiotic-loaded hydrogel to the standard two-stage surgery for treating chronic hip prosthesis infections. The single-stage approach aims to remove the infected implant and place a new one in the same oper…

This study tests whether a drug called Angiotensin II can raise blood pressure more effectively than standard medications in people with liver cirrhosis who have septic shock. Researchers will measure how well the heart and blood vessels work together over 24 hours. The trial inv…

This study is testing whether using a disinfectant called TauroPace during heart device surgery can prevent infections. About 2300 patients having procedures like pacemaker placement or replacement are being followed for up to 12 months. The goal is to see if this approach reduce…

This study tests whether adding the targeted drug rituximab to standard chemotherapy can improve outcomes for children and teens with aggressive B-cell lymphoma or leukemia. About 650 participants from Europe will receive different treatment schedules to find the best balance of …

This pilot study tests a new rinse device (SwishKit) plus standard oral care against standard care alone in 21 intubated ICU patients. The goal is to see if the device reduces harmful bacteria in the mouth and throat, which could lower the risk of lung infections. The study is sm…

This phase 2 trial tests a combination of two drugs, tislelizumab and pemetrexed, in 28 adults with a rare type of brain lymphoma (primary DLBCL of the CNS) that has relapsed or not responded to standard treatment. The goal is to see if the combination can shrink tumors and impro…

This study tests two antiviral medications, TAF and TDF, in 200 pregnant women with chronic hepatitis B. The goal is to see which drug better prevents passing the virus to the baby and causes fewer birth defects or side effects. Participants take the drug daily during pregnancy a…

This study aimed to see if a special blood filter (Seraph 100) could reduce BK virus levels in kidney transplant patients with high viral loads. It planned to enroll adults with a BK virus level of 10,000 IU/mL or higher who already had dialysis access. However, the trial was wit…

This trial tests a video-based counseling program for adolescents living with HIV in Malawi. About 1,800 teens and their treatment supporters will either receive the video intervention or standard care. The goal is to see if the videos help teens take their medication regularly a…

This study tests a program called PASEO that helps teenagers with HIV in Lima, Peru, successfully move from pediatric to adult HIV care. The program includes a helper who checks in monthly, peer support groups, education sessions, and mental health support. About 160 teens will t…

This phase 2 trial tests whether a single, low dose of radiation to the chest can reduce lung inflammation in hospitalized COVID-19 pneumonia patients. Researchers compare two radiation doses (35 cGy and 100 cGy) to standard care. The goal is to see if this treatment lowers the n…

This early-phase study tests whether taking prebiotic fiber and probiotics can improve fatty liver disease in people with HIV. Researchers believe changes in gut bacteria may contribute to liver problems. The trial involves 63 participants and measures liver fat and gut health ma…

Researchers compare two ways to collect vaginal samples for high-risk HPV testing: swabs stored dry and swabs stored in liquid. The study enrolls 1,306 women aged 30 and older who have abnormal cervical screening results. The goal is to see if dry swabs detect HPV as accurately a…

Researchers are studying whether people can accurately use a rapid COVID-19 antibody test at home. Participants in New York City who have recovered from or suspect they had COVID-19 take the finger-prick test themselves and photograph the result for a doctor to check. The study a…

Researchers are studying whether two tests, one on sputum and one on urine, can accurately detect tuberculosis in people suspected of having the infection. The trial enrolls 150 patients at tertiary care hospitals who can provide both sputum and urine samples. The goal is to see …

This project tests an integrated approach to lung health in Zambia. Community and primary care clinics screen people with cough, breathlessness or other respiratory symptoms for TB, post-TB lung disease, COPD, silicosis and pneumonia. All participants get a symptom check and a di…

Researchers are comparing the SavvyCheck Vaginal Yeast Test, a rapid swab test women use themselves, against standard vaginal yeast culture done in a lab. The study enrolls women with symptoms such as vaginal itching, discharge, soreness, or burning. The goal is to measure how ac…

Researchers are testing whether artificial intelligence can combine ultrasound images with routine health data to track changes in a person's physiology over time. The study enrolls adults with heart, lung, kidney, or blood vessel conditions, as well as healthy volunteers. The go…

This study tests whether a blood test measuring donor-derived cell-free DNA can reliably detect kidney transplant rejection. Researchers will compare the test results with kidney biopsy findings in 5,000 transplant recipients across multiple countries. The goal is to see if this …

This study tests a new device called the esophageal string test (EST) to diagnose H. pylori, a stomach bacteria that can cause ulcers and cancer. Participants swallow a capsule with a string inside that collects stomach fluids. Researchers compare the results to standard tests. T…

Researchers are testing whether a blood test that looks at DNA methylation patterns can find nasopharyngeal carcinoma earlier and more accurately than the standard Epstein-Barr virus (EBV) tests. The study will compare the new multi-omics model with EBV DNA quantification and two…

This trial tests whether a rapid genetic test, called multiplex PCR, can identify the cause of pneumonia in critically ill patients faster than standard lab cultures. The study enrolls adults in the ICU with suspected hospital-acquired or ventilator-associated pneumonia. Research…

This study looks at whether taking blood for culture in one go is as good as taking it from two separate spots to find bloodstream infections. Adults with suspected infections will have blood drawn twice: first, a larger sample from one vein, then a smaller sample from another ve…

This trial tests whether an artificial intelligence system can help less-experienced doctors—like final-year medical students and early-career general practitioners—interpret chest X-rays more accurately. Participants will read the same set of X-rays twice: once with AI assistanc…

This study planned to compare a newer blood test (presepsine) with a standard one (lactate) for diagnosing severe sepsis and septic shock in emergency department patients. The goal was to see if presepsine could detect these life-threatening infections more accurately. However, t…

This study tests a device called OtoSight that helps doctors see inside a child's ear more clearly. The goal is to see if using it leads to fewer unnecessary antibiotic prescriptions, better outcomes, and lower costs. About 700 children aged 6 months to 17 years with ear pain are…

This study planned to compare a rapid antigen detection test against the standard PCR test for diagnosing COVID-19 in people who were close contacts of infected patients but had no symptoms. The goal was to see if the quick, inexpensive antigen test could reliably identify contag…

This large phase 3 trial is testing whether a new oral pill called MK-8527, taken just once a month, can prevent HIV infection as well as the standard daily PrEP pill. About 4,390 people at risk of HIV will be randomly assigned to receive either the monthly pill or daily Truvada …

Researchers are testing three mouthwashes, licorice, clove, and chlorhexidine, in Egyptian children aged 7 to 12 who have a high risk of cavities. The trial measures levels of Streptococcus mutans, a bacterium linked to tooth decay, in saliva before and after children use their a…

This phase 3 trial is testing whether a single dose of CD388, a long-acting antiviral injection, can prevent the flu in 10,000 adults and teens at higher risk of complications. Participants receive either CD388 or a placebo and are monitored for flu-like illness over 24 weeks. Th…

Researchers are tracking HPV-16 and HPV-18 neutralizing antibodies in females who received a bivalent HPV vaccine in an earlier study. Participants were 9 to 26 years old when first vaccinated and received either two or three doses. No vaccine is given in this extension. Blood sa…

Researchers are testing whether repeat couples HIV testing and counseling helps male couples at high risk of HIV. The study enrolls couples who already took part in an earlier testing program. Couples are assigned by chance to either retest together or to individual HIV testing. …

This study tests a new program where trained village health workers use tablet-based tools to provide HIV prevention services, including PrEP and emergency PEP, to people at high risk in rural Lesotho. About 380 participants will be enrolled to see if this approach increases mont…

Researchers are testing whether a 4-week daily course of isoniazid and rifapentine can prevent active tuberculosis as well as the standard 12-week weekly course in people with HIV who have latent TB infection. The trial enrolls about 2,500 adults in a high TB burden country. Both…

This Phase 1 trial in Mali will test the safety of the PfSPZ malaria vaccine in 400 healthy pregnant women aged 18-34. Participants will receive three injections of either the vaccine or a placebo. The study will monitor both mothers and their infants for up to a year after birth…

This study tests whether peer-led support—either one-on-one, in a group, or both—can help transgender men who have sex with men start and continue taking PrEP, a daily pill that prevents HIV. Participants are randomly assigned to receive standard HIV prevention information, a tai…

This study tests whether adding a communication skills video and a substance use module to standard couples HIV testing can help male couples reduce drug use and risky sex. About 484 male couples are randomly assigned to receive standard testing alone or with one or both extra mo…

This trial tests whether proactive follow-up by community health workers can increase HPV vaccination coverage among adolescent girls in Mali and Côte d'Ivoire. Researchers compare girls who receive home visits and digital reminders to those getting standard outreach. The goal is…

This study tests whether the nine-valent HPV vaccine can prevent long-lasting oral HPV infections in men who have HIV. About 700 men will receive either the vaccine or a placebo. The goal is to see if the vaccine reduces new persistent infections with HPV types linked to throat c…

This study looks at how to best help HIV clinics in Vietnam offer a short alcohol counseling program to patients who drink heavily. The goal is to reduce risky drinking and lower the chance of spreading HIV. Over 3,200 people living with HIV and clinic staff are taking part to se…

This early-stage trial tests whether the drug ruxolitinib can prevent chronic graft-versus-host disease (cGVHD) in 42 adults who had a stem cell transplant for blood cancer. Doctors use a blood test to find patients at high risk for cGVHD and then give them ruxolitinib to block t…

This study tests an experimental drug called LMN-201 to see if it can prevent C. difficile infection from coming back after standard antibiotic treatment. About 375 adults with a recent C. diff infection will receive either LMN-201 or a placebo. The main goal is to see if more pe…

This study tests whether offering lottery-based rewards for saving money can help Kenyan men reduce behaviors that raise their risk for HIV and other STIs. About 1,500 men aged 18-39 who drink alcohol and have paid for sex in the past will be split into two groups. One group gets…

Tuberculosis infection can progress to active, contagious TB disease, but preventive treatment often lasts three to nine months and many people do not finish it. This Phase 3 trial in Hanoi, Vietnam, compares a new one-month regimen of daily isoniazid and rifapentine with the sta…

This study tests the safety of palivizumab, a drug given as monthly injections, in infants under 24 months who are at high risk for severe RSV disease. About 138 children born prematurely or with certain lung or heart conditions will receive up to 5 doses. Researchers will monito…

This phase 3 trial will give a single dose of the dTpa vaccine (Boostrix) to 95 healthy Japanese pregnant women between 27 and 37 weeks of pregnancy. The goal is to see if the vaccine triggers strong immunity in the mothers and passes protective antibodies to their babies at birt…

This trial tests different vaccination schedules for Japanese encephalitis in healthy children starting at 8 months old. Researchers compare how well each schedule triggers and maintains protective antibodies through age 6, including the effect of booster doses. The study also mo…

This trial tests whether a game-based mobile app can increase HPV vaccination among young cancer survivors. Participants use the app to learn about HPV risks and get reminders to complete the vaccine series. The study includes survivors aged 18-26 and caregivers of younger surviv…

This trial tests whether routinely screening heart attack patients for H. pylori, a common stomach bacteria, can prevent upper gastrointestinal bleeding. The bacteria can cause ulcers that bleed, especially when patients take blood thinners after a heart attack. Researchers will …

This phase 3 study tests a 9-valent HPV vaccine (V503) in 6,000 Chinese women aged 20-45 to see if it prevents persistent infection and cervical disease from five additional HPV types compared to the current 4-valent vaccine. Participants receive either the new vaccine or Gardasi…

This study follows women who previously received either one or two doses of the Gardasil9 HPV vaccine to see how long protection against HPV infection lasts. Researchers will check for persistent infections with HPV types linked to cancer. The goal is to understand if fewer doses…

This early-stage study tests a vaginal ring designed to slowly release two HIV prevention drugs (tenofovir disoproxil fumarate and emtricitabine) over 28 days. About 15 healthy women will wear the ring for a month and a placebo ring for another month to compare safety, drug level…

This study tests a 24-week program called CoMPASS that uses rewards (contingency management) and extra support to help people who inject drugs take PrEP consistently for HIV prevention. About 526 participants with opioid use disorder will be enrolled. Those who don't stick with P…

This trial tests a strategy called SAIA-N, which uses coaching and data review to help syringe service programs in California distribute more naloxone, a medication that reverses opioid overdoses. About 31 programs will either use this strategy for a year or continue their usual …

This trial tests whether giving the smallpox vaccine to people who have been exposed to mpox can prevent them from getting sick or reduce the severity of the disease. It involves about 3,000 household members of people with confirmed mpox, who receive either the vaccine or a cont…

This trial is testing whether taking daily vitamin D3 and fish oil supplements can reduce the risk of lung problems like COPD flare-ups, asthma attacks, and pneumonia in older adults. It involves over 25,000 men and women aged 50 and older who do not have a history of cancer or h…

This trial tests whether a single dose of an experimental antibody, L9LS, can prevent malaria in children who have just been hospitalized with severe malaria or severe anemia. These children face a high risk of getting sick again for months after leaving the hospital. The study c…

This trial tests whether a program that combines educational materials with electronic health record reminders can increase HPV vaccination rates among children and young adults aged 11–26 in four Appalachian states. The goal is to improve vaccine uptake and ultimately prevent ce…

This study is testing a web-based platform called Jom-TestPlus for men who have sex with men in Malaysia. The platform offers HIV self-testing, real-time online counseling, and help connecting to prevention or treatment services. Researchers want to see if this approach increases…

This Phase 3 trial in Uganda tests whether giving young children monthly malaria prevention medicine (dihydroartemisinin-piperaquine) from 8 weeks to 1 or 2 years of age helps them develop stronger immunity against malaria later. 924 children are enrolled and followed until age 4…

This study is testing a mobile-friendly app called DASH that provides information and guidance about PrEP (a daily pill that prevents HIV) to people who have used an HIV self-test kit. The app helps users explore their values and make informed decisions about starting PrEP, with …

This study is testing whether the MVA-BN mpox vaccine is safe and triggers a strong immune response in 600 adults living with HIV in Kinshasa, DRC. Participants receive two vaccine doses 28 days apart and are grouped by their CD4 count. The goal is to see if the vaccine works wel…

This study tests a program to help HIV-positive adults get the HPV vaccine, which can prevent HPV-related cancers. The program gives clinics and staff tools to encourage vaccination. Researchers will track how many people start and finish the vaccine series over two years.

This study aimed to see if sending health workers to find malaria cases in high-risk villages and among forest workers could lower malaria rates better than usual care. It planned to track infections over 18 months in southern Laos. However, the study was withdrawn before any par…

This study tests whether a short educational session plus weekly text reminders can increase HPV vaccination rates among children of Mexican-American parents. About 672 parents will be randomly assigned to receive either education alone or education plus text reminders. The goal …

This study is testing whether an online course can help people with multiple sclerosis, long COVID, fibromyalgia, or cancer-related fatigue adopt healthier diets and self-care habits. Researchers will measure changes in quality of life, fatigue, and mental health. The goal is to …

This study adapts Project YES+, a behavioral program, to improve mental health and reduce HIV-related stigma for adolescent and young men who have sex with men living with HIV in Vietnam. Eighty participants aged 16-24 will receive individual and group sessions with peer mentors.…

This study tests a group counseling program called Healing HEARTS to help people with conditions like obesity, skin disease, cancer, HIV, diabetes, or chronic pain deal with internalized stigma. Participants will either join the counseling program or a peer support group. The goa…

This trial compares two final rinses used during two-visit root canal treatment for adults with symptomatic irreversible pulpitis, a painful tooth infection. Participants receive either a dexamethasone solution or normal saline as the last rinse inside the root canal. Researchers…

Researchers are testing whether a virtual walking program can reduce chronic pain and psychological distress in people with severe mobility impairment, mostly from spinal cord injuries or polio. Participants wear a head-mounted display and use a controller to guide an avatar thro…

Researchers are testing a new medical device called Bocaliner in people who have painful mouth sores caused by chemotherapy or radiation. The device is held in the mouth after using medicated mouthwashes, gels, or rinses, with the goal of keeping those treatments in contact with …

This Phase 3 trial tests whether catechins (compounds found in green tea) given as a pill or spray can prevent or treat skin damage caused by radiation therapy. About 162 cancer patients will receive either catechins or a placebo, alongside standard care. The goal is to see if th…

This early-stage study tests whether LCFA-01, a natural gel containing oleic acid, is safe and comfortable when placed in the vagina. Thirty healthy women aged 18-40 will use the gel and be monitored for side effects, discomfort, and how much of the product enters the bloodstream…

Researchers are testing whether semaglutide, a drug used for diabetes and weight loss, is safe and tolerable in adults with cocaine use disorder. The trial includes 40 people who use cocaine often, some of whom also have HIV. Participants receive weekly injections of semaglutide …

This study tests a 4-month coaching program for pregnant or recently postpartum doctors-in-training. Half the participants get one-on-one and group coaching sessions; the other half do not. Researchers will measure burnout, well-being, and confidence through surveys at the start,…

This study tests a proprietary amino acid drink given twice daily for up to 4 days to older adults (60+) hospitalized with infections who have delirium. 20 participants get the drink, 20 get standard care, and 20 non-delirious controls are observed. The goal is to see if the drin…

Researchers are adapting a mobile health program that pairs the PositiveLinks app with video counseling from a community health worker. The study enrolls 60 people in Florida who have HIV and mild to moderate anxiety or depression. Participants receive either the enhanced counsel…

This study tests a program called FOREST that teaches positive emotion skills to staff working in gun violence prevention. The goal is to reduce burnout, anxiety, and depression, and improve well-being and job retention. One hundred employees from UCAN in Chicago will take part o…

This study tests whether a tailored physical activity program can help lymphoma and breast cancer patients preserve their exercise ability, heart function, memory, and quality of life while undergoing cancer treatment. About 110 adults aged 18-85 with Hodgkin or non-Hodgkin lymph…

Researchers are testing whether a non-invasive device that stimulates the vagus nerve through the ear can help people with Long COVID recover after exertion. The trial enrolls 120 people with persistent symptoms such as fatigue, brain fog, and shortness of breath. Participants us…

Researchers are testing whether baricitinib, a drug that calms parts of the immune system, can improve memory and thinking problems in adults who have had COVID-19. The trial enrolls people with Long COVID who show cognitive impairment or heart and lung symptoms lasting months af…

This study tests whether using a portable oxygen concentrator (a lightweight, battery-powered device) during walking or exercise helps people with interstitial lung disease (ILD) or COPD feel less breathless and be more active in their daily lives. Twenty-four participants will t…

This study tests whether a computer model can predict vomiting in children with cancer who are in the hospital. The model uses each child's medical information to estimate their risk of vomiting in the next 96 hours. Doctors and pharmacists will use this information to give extra…

This study tests whether a 16-week high-intensity interval training (HIIT) program on a stationary bike can improve thinking, memory, and heart health in women undergoing chemotherapy for breast cancer. Thirty participants will be randomly assigned to either HIIT or a stretching …

This study is testing whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can improve symptoms like fatigue and brain fog in people with post-COVID syndrome. About 40 adults with long COVID will receive the treatment. The main goal is to see if a la…

This study compares two schedules for taking non-opioid pain relievers (acetaminophen and NSAIDs) after a cesarean delivery: taking them at different times (staggered) or at the same time (simultaneous). The goal is to see which approach better controls pain and reduces the need …

This study looks at whether a 10-week workplace yoga program can help healthcare workers feel less burned out and stressed. Participants—doctors, nurses, physiotherapists, and support staff—will complete psychological assessments before and after the program. The goal is to see i…

This trial tests whether two dental cements, MTA and CIMMO DTA®, differ in reducing pain after a pulpotomy—a procedure that removes the inflamed pulp inside a tooth—in children aged 6 to 16 with molar-incisor hypomineralization (MIH), deep decay, and irreversible pulpitis. Partic…

This trial tests whether using sodium hypochlorite as a gel or solution, with or without tiny nanoparticles, affects pain after a pulpotomy—a procedure that removes the inflamed pulp inside a tooth. Adults aged 15 to 40 with severe pulpitis in a lower molar will be randomly assig…

This trial tests whether applying cryotherapy (cold therapy) along with different concentrations of sodium hypochlorite irrigation during vital pulp therapy can reduce post-operative pain in permanent mandibular molars. Adults aged 15-40 with symptomatic irreversible pulpitis wil…

This trial tests a counseling program called Mpata Yathu ('Our Space') for adolescent girls and young women in Zambia who have experienced gender-based violence and may be living with or at risk for HIV. The program uses problem-solving therapy delivered by trained lay counselors…

This study tests whether a structured cognitive training program, called Goal Management Training, can improve attention and executive function in adults who have persistent cognitive difficulties after a COVID-19 infection. Participants aged 18 to 65 with confirmed COVID-19 and …

This study tests a 10-week group program called Compensatory Cognitive Training for COVID-19 (CCT-C) to help veterans with long COVID improve memory, attention, and everyday functioning. Participants are veterans who report cognitive problems after a COVID-19 infection. The progr…

This study tests whether structured hypnotherapy sessions can improve quality of life for women with breast cancer undergoing chemotherapy. Participants in the intervention group receive 10 hypnotherapy sessions alongside standard care, while the control group receives standard c…

This trial tests whether training general practitioners to better manage persistent symptoms after COVID-19 can improve patients' quality of life. Adults with at least two long COVID symptoms (like fatigue, breathlessness, or brain fog) lasting over two months will be enrolled. T…

This study compares two types of talk therapy—Acceptance and Commitment Therapy (ACT) and Cognitive Behavioral Therapy (CBT)—for HIV/AIDS patients experiencing psychological distress. 72 adults on antiretroviral therapy will receive 8 weekly sessions of either therapy or standard…

This study tests whether an 8-week mindfulness booster course (30-minute weekly sessions) can reduce stress in 186 UK healthcare staff who have already completed a mindfulness course. Participants are randomly assigned to the booster or usual care, and they fill out stress questi…

This study tests ORCHID, an online skills-building program designed to improve mental health and reduce the risk of dropping out of care for aging women with HIV who also have HPV. The program includes 8 online sessions and optional meetings with a navigator. The study aims to se…

This pilot study tests a compounded DMSO-based ear drops and cream for adults with bothersome tinnitus linked to long-COVID or post-COVID-19 vaccine injury. Twenty participants who have not improved with at least two prior treatments will use the ear drops every 4 days and apply …

This study tests a personalized health pathway for 400 people with persistent COVID-19 symptoms lasting more than 12 weeks. Participants receive nurse follow-up and can choose workshops on disease management, anxiety, and fatigue. The goal is to see if this approach improves qual…

This study tests a mobile app called RN-SLEEP that teaches night-shift nurses cognitive-behavioral strategies to improve sleep and reduce fatigue. 76 nurses will use either the RN-SLEEP app or a control app for several weeks. Researchers will measure sleep duration, quality, and …

This study tests whether wearing pressurized gloves and foot caps during chemotherapy can prevent nerve damage (peripheral neuropathy) caused by the drug paclitaxel. It involves 182 people with nasopharyngeal cancer who have not yet started treatment. Each patient serves as their…

This pilot study tests whether an electronic health record tool can help doctors identify patients at higher risk for HIV and prescribe PrEP, a daily pill that prevents HIV. Researchers will roll out the tool in 2-3 community health centers and compare PrEP prescription rates to …

This study tracks 80 adults with different smell disorders (like total loss, partial loss, or distorted smell) plus healthy volunteers over one year. Researchers use brain scans, smell tests, and questionnaires to see how the brain changes and how smell loss impacts mood and dail…

This study looks at how the body processes doxycycline, an antibiotic, when taken in different ways—either as a single dose or repeated doses (daily or every three days). Healthy adults without any sexually transmitted infections will be randomly assigned to one of these schedule…

This study follows 500 adults who had COVID-19 to see what health problems they face months later. Researchers will track symptoms like tiredness, breathing trouble, and lung damage. The goal is to learn how common these long-term issues are and who is most likely to have them.

This study involves 383 people who have chronic graft-versus-host disease (GVHD) after a stem cell transplant. Researchers are developing and testing new ways to measure whether a treatment is working, including a symptom-based activity index and a score that predicts long-term s…

Infective endocarditis is an infection of the heart's inner lining or valves. About half of patients need surgery during their hospital stay, while others receive antibiotics alone. Researchers are following 1,046 adults with confirmed endocarditis for up to 24 months to compare …

This study tests a mobile chatbot called AskDoki, which provides age-appropriate sexual health information via WhatsApp, along with trained youth peer leaders (Digital Champions) who help teens access and use the program. About 610 adolescents aged 15-19 living in urban informal …

This study is measuring certain substances in the blood, stool, saliva, and airway fluid of 200 adults with sepsis. The goal is to see if these biomarkers, combined with standard medical data, can predict which patients are more likely to die or develop long-term critical illness…

This study collects and analyzes blood, DNA, and tissue samples from 315 adults with pulmonary fibrosis, their relatives, and healthy volunteers. The goal is to learn more about the disease's causes, not to test a new treatment. Researchers hope the findings will guide future the…

This study enrolls up to 10,000 cancer patients at the National Cancer Institute who are not on an active treatment research protocol. Participants receive standard medical care, including lab tests and scans, while researchers collect their health information to build a data rep…

This study follows 583 adults who recovered from COVID-19 or were close contacts. Researchers will track their health, mental well-being, and immune responses over 3 years to understand long-term effects and whether prior infection prevents reinfection. Participants undergo regul…

Researchers at Peking University First Hospital are studying how the immune system responds to SARS-CoV-2 infection in people who have blood cancers compared with people who have no underlying diseases. The observational study enrolls 60 participants and collects clinical details…

This study looks at HIV-infected adults who have been on antiretroviral therapy for a long time and have very low virus levels. Researchers want to see if the virus stays stable or changes over time. Participants visit the clinic every six months for blood tests and a special whi…

This study follows 200 people who have had the flu to see how their immune system changes over two years. Participants give blood and nasal samples every three months. The goal is to learn how long antibodies last and how they change, which could help create more effective flu va…

This long-term study looks at people and families with a higher chance of developing blood or lymph node cancers like leukemia or lymphoma. Researchers collect medical histories, genetic samples, and sometimes perform exams to find inherited genes or environmental triggers. The g…

This study examines how social and genetic factors influence long-term health in 2000 adolescent and young adult survivors of Hodgkin or non-Hodgkin lymphoma. Researchers will collect blood samples and health information to identify risks for disease recurrence, other illnesses, …

This study looks at whether taking the smallpox drug TPOXX changes how well the JYNNEOS vaccine works. About 100 healthy adults aged 18 to 42 will get two doses of the vaccine and either TPOXX or a placebo for 28 days. Researchers will check for side effects and measure immune re…

Researchers are testing a coaching program to help primary care clinics in rural West Virginia screen and treat opioid use disorder, HIV, and hepatitis C. The program includes group priority-setting, rapid-cycle improvement coaching, and provider training. Twenty clinics will tak…

This study talks to people living with HIV from diverse backgrounds to learn what helps or hinders them from getting oral health care and cancer prevention. Researchers will hold focus groups and use questionnaires to understand barriers and gather ideas for improvement. The goal…

This study compares how well two FDA-approved COVID-19 vaccines—Novavax (a protein-based vaccine) and Pfizer (an mRNA vaccine)—trigger the immune system. Researchers will measure antibody levels against several virus variants in 54 healthy adults aged 18-79 who have risk factors …

The KIDCOV study investigates whether mild or asymptomatic COVID-19 that does not require hospitalization increases the risk of kidney injury. Researchers enroll 2,000 adults who tested positive or negative for COVID-19, balanced by race and ethnicity across California, Michigan,…

Researchers at two Beijing hospitals are following more than 800 patients who develop sepsis after surgery. The team collects clinical data and biological samples to map immune patterns linked to acute kidney injury. Using multi-omics and single-cell sequencing, they aim to build…

Researchers are reviewing medical records from a large hospital network in Buenos Aires to understand what happens to adults with severely weakened immune systems after they catch RSV, influenza, or SARS-CoV-2. The study covers 350 patients and looks at how sick they were at diag…

This study uses interviews and focus groups to understand how transcutaneous tibial nerve stimulation (TTNS) impacts quality of life and daily activities in 75 people with neurogenic bladder from spinal cord injuries. Researchers aim to identify key themes about bladder function …

Researchers at Columbia University are studying how SARS-CoV-2, the virus that causes COVID-19, spreads among people living in the same home. They enroll households with at least one person who tests positive or was exposed to the virus, including children and health care workers…

This study tests whether a World Health Organization program called Self-Help Plus (SH+) can help reduce stress in social service workers. About 50 workers from four institutions in Istanbul will be randomly assigned to either receive SH+ plus usual support, or usual support alon…

Researchers in Buenos Aires reviewed safety reports filed after people received the Qdenga dengue vaccine at private clinics over a two-year period. The review covers anyone aged 4 and older, with a special look at adults over 60 and at allergic-type reactions. The goal is to see…

This study, run by Fudan University and local health authorities, uses computer models to predict the best way to use dengue vaccines in Yunnan, China. Researchers will collect blood samples from 220 residents to measure antibody levels and simulate different vaccination scenario…

This study aims to understand how the immune system responds to a second infection with a mild bird flu virus (H10N7). Healthy adults who were infected with H10N7 in a previous study will be infected again and monitored closely in the hospital for 9 days. The goal is to learn mor…

This completed study tested different messages to see which ones make adults more willing to get the HPV vaccine, which prevents certain cancers. Over 5,300 adults aged 18-45 were randomly assigned to read one of five theory-based messages or a control message. The goal was to fi…

Researchers at the University of Florida are studying sepsis survivors in the surgical intensive care unit to understand why some develop chronic critical illness, a condition marked by persistent inflammation, immune suppression, and muscle wasting. The trial follows 668 adults,…

Researchers are testing whether an online HIV stigma training can reduce stigmatizing attitudes and behaviors in nursing students. Third- and fourth-year nursing students will either take this training or a standard HIV epidemiology course. Before and after, the students will com…

This study looks at whether fungi moving from the gut into the blood can cause inflammation and worsen lung function in people with HIV. Researchers will measure a fungal marker called BDG in blood and urine, and track lung health over three years. The goal is to better understan…

This study follows 121 adults who have been cured of chronic hepatitis C to understand why some still develop liver complications like scarring or cancer. Participants are monitored for up to 10 years with regular tests, scans, and occasional liver biopsies. The goal is to learn …

Researchers are assembling a large group of adults with idiopathic pulmonary fibrosis (IPF), a progressive lung disease, to support future patient-centered studies. The team will combine electronic health records with patient-reported outcomes from clinics at several academic med…

Researchers in Uzbekistan are studying common respiratory and heart conditions in children from birth to age 15. They will analyze medical records and examine blood samples to understand immune and antioxidant function in affected children. The goal is to develop and test improve…

This study looks at whether measuring IL-6 and lactate in cord blood can detect early signs of infection or inflammation in full-term newborns. Researchers will compare 160 women whose fetal heart rate patterns suggest possible inflammation with those whose patterns are normal. I…

This study follows over 2,700 heart transplant recipients to see how well HeartCare testing services work in routine care. Researchers will track whether patients develop certain antibodies that may signal rejection. The goal is to understand if regular monitoring helps catch pro…

Duke University is creating a secure, centralized repository to store data and medical specimens from COVID-19 patients and suspected cases. The repository will support multiple COVID-19 research studies by housing core data and consent forms, and samples may be collected specifi…

This study looks at people with HIV who are 75 or older and take at least five medications regularly. Researchers want to understand how this 'polypharmacy' affects healthy aging and quality of life. They will interview participants and review their medical records to count medic…

This study tracks how paramedics use the ZOLL 731 ventilator when helping people with serious conditions like cardiac arrest, sepsis, or heart failure before they reach the hospital. Researchers will record which ventilator modes and settings are used, and how often alarms go off…

Researchers in Zambia are tracking 374 adults with pulmonary tuberculosis to compare treatment outcomes between those with and without HIV. The study follows participants through the end of TB treatment to see who achieves a successful outcome. The goal is to inform TB treatment …

This study measures how common infections caused by multidrug-resistant organisms are among adults hospitalized in general medical and surgical wards in Argentina, and whether these infections are linked to death in the hospital. On a single day in August 2026, doctors at partici…

This study looks at how the bacteria and fungi living in and on our bodies change when someone stays in the hospital. Researchers will take swabs and samples from 250 patients aged 2 and older during their hospital stay and follow-up visits. The goal is to learn which germs sprea…

This study looks at lung tissue from 80 people with pulmonary fibrosis to find unique genetic markers linked to scarring. By analyzing gene activity, researchers hope to better understand the disease and pave the way for new diagnostic tools and treatments. Participants must be 1…

Researchers in the UK are following 1,000 people with cystic fibrosis (CF), including children and adults, to see how many develop antibodies to the virus that causes COVID-19 over two years. They will take blood samples every six months to measure antibody levels after natural i…

This study will use wearable devices like heart rate monitors and sleep trackers to see how financial stress and news affect your body. Researchers will follow 2,500 adults remotely, collecting data on heart rate, sleep, and stress levels. The goal is to create AI tools that can …

This nationwide study follows thousands of pregnant women from early pregnancy through the first year of their baby's life to understand how COVID-19 infection affects both mother and child. Researchers will track infections, including those without symptoms, and compare pregnanc…

This study tests whether a radioactive tracer called 68Ga-FAPi-46 can light up areas of scarring (fibrosis) in the lungs of people with interstitial lung disease. Participants receive the tracer and undergo a PET/CT scan to see where it collects. The goal is to understand how the…

This study looks at how often CD4 cell counts are measured when adults in Zambia begin or restart antiretroviral therapy (ART) after a long break. The goal is to see how many people have advanced HIV disease and whether low testing rates prevent proper care. Researchers will asse…

This study follows 200 hospitalized patients with suspected or confirmed leptospirosis, a bacterial infection spread by animals. Researchers will collect blood and urine samples and track patients for a year to gather data on the disease's symptoms, severity, and immune response.…

This study tests a new AI-powered toolkit designed to help public health officials at local CDC offices respond more quickly to emerging infectious diseases such as COVID-19, mpox, influenza, and dengue. The toolkit combines data analysis, risk assessment, decision support, and e…

This study examines a program in two Boston-area jails designed to make HIV testing and treatment easier for people with opioid use disorder. Researchers will follow about 59 participants who are leaving jail within a month to see if they use HIV services, get tested, or take PrE…

This study compares a standard early-warning system called NEWS2 with a machine-learning model to see which can detect sepsis earlier in hospital patients. Researchers will monitor 100 adults admitted with suspected infection, recording when each system first raises an alert and …

This study aims to understand why some women get recurrent vaginal yeast infections (vulvovaginal candidiasis) and others don't. Researchers will compare the vaginal microbiome, immune markers, and metabolic profiles of women with and without the infection. By identifying key dif…

This study investigates whether Zika and Tonate viruses can replicate in human placental tissue grown in the lab. Researchers will infect placental samples from early and full-term pregnancies and measure viral levels to compare how each virus behaves. The goal is to better under…

This study compares over 1,500 people living with HIV to a similar group from the general population to see if conditions like heart disease, COPD, and liver disease are more common or develop faster in those with HIV. Using detailed scans and tests, researchers will measure the …

This study looks at how the immune system of kidney transplant patients responds to the shingles vaccine and to natural shingles infection. Researchers will track antibody and T-cell levels over time in patients who have had a transplant or are on the waiting list. The goal is to…

This study looks at how the immune system's T cells respond to two common herpesviruses—cytomegalovirus (CMV) and varicella-zoster virus (VZV)—in people who have had a liver transplant. Because transplant recipients take drugs that suppress their immune system to prevent organ re…

This study examines whether extreme temperatures, humidity, and wind speed are linked to the occurrence and severity of occupational injuries in Israel. Researchers will analyze data from over 350,000 workplace injuries that occurred between 2020 and 2024, matching each injury to…

This study looks at how the natural bacteria in the body (the microbiome) interact with immunosuppressant drugs taken by kidney transplant recipients. Researchers will collect samples from the gut, mouth, nose, and urine to see if the microbiome influences how the body processes …

This study looks at whether the bacteria in your gut and blood can help predict if a kidney transplant will be rejected. Researchers will follow 70 people who are getting a kidney transplant and taking a drug called Nulojix (belatacept) as part of their usual care. They will coll…

This study follows 75 adults aged 65 and older over three to four flu seasons to learn why the flu vaccine becomes less effective as people age. Participants will receive a different FDA-approved flu vaccine each year, and researchers will collect blood, nasal swab, and stool sam…

This trial tests whether the PulsePoint app — already used to alert trained bystanders to nearby cardiac arrests — can also be used to teach people how to recognize and reverse an opioid overdose using naloxone. Researchers will send either standard or customized push messages to…

This study looks at whether measuring lactate in stool can help doctors predict how well critically ill patients with low blood flow will respond to treatment. About 40 adults in the ICU will provide a stool sample within 24 hours of admission. Researchers will check if high stoo…

This study looks at specific immune cells called myeloid cells in people who were hospitalized with COVID-19 pneumonia. Researchers want to understand how these cells respond to the virus and whether certain cell types can predict how sick a person gets. The goal is to find new w…

This study in 140 rural secondary schools in Madagascar tests which parts of a hygiene program — new latrines and handwashing stations, peer-led sensitization, or free sanitary pad vouchers — most improve adolescent girls' learning, stress, and physical health. Researchers will m…

This observational study follows people who have been exposed to Andes virus, a hantavirus that can cause severe respiratory illness. Researchers collect blood samples and monitor symptoms at key points from exposure through infection and recovery. The goal is to understand how t…

This study uses a new, child-friendly brain imaging technique called OPM-MEG to understand how immune-related brain diseases (like autoimmune encephalitis and multiple sclerosis) and other brain conditions affect children aged 2 to 25. Standard scans often miss problems with memo…

This long-term study follows 7,500 adults with HIV who are taking antiretroviral therapy. Researchers track their health over time to understand complications, side effects, and how the infection evolves. The goal is to improve monitoring and care for people living with HIV.

This study investigates whether a blood test can detect the bacteria that cause tuberculosis (TB) in people with active TB and their asymptomatic household contacts. Researchers in Uganda will use several methods, including a DNA-based test, to look for TB bacteria in blood sampl…

This observational study looks back at 22,000 adults in Sweden diagnosed with infective endocarditis, a serious heart valve infection, since 1997. By linking national health records, researchers aim to understand which patients benefit most from valve surgery and what factors aff…

This study investigates whether hospital caregivers working in COVID-19 patient areas are more likely to get infected than those in non-COVID areas. Researchers will take blood samples from participants on day 0, day 15, and day 30 to check for antibodies that signal past infecti…

This study looks for biological markers in blood and lung samples from people with idiopathic pulmonary fibrosis (IPF) and other interstitial lung diseases. The goal is to find markers that can predict how the disease will progress and to group patients into subtypes. Researchers…

This study tests whether training primary care providers on how to talk to patients about vaccines can increase flu and COVID-19 vaccination rates. Over 24,500 patients and their doctors at multiple clinics will take part. Doctors in some clinics will receive special communicatio…

This study explores whether a genetic test (CYP2C19) can help doctors choose the right dose of the antifungal drug voriconazole more quickly. Patients starting voriconazole for an infection will give a blood sample for genotyping. The goal is to see if this personalized dosing re…

This study looks back at medical records of 500 adults with aggressive B-cell lymphoma that has a MYC gene change. Researchers want to see if a stronger chemotherapy plan called CARMEN leads to better survival and remission rates compared to other treatments. Since it's a review …

This study looks at how the immune system of patients in the intensive care unit (ICU) responds to severe infections caused by viruses or bacteria. Researchers will take extra blood samples from 38 adults to analyze immature granulocytes, a type of immune cell. The goal is to see…

This pilot study tracks 24 adults who were hospitalized for COVID-19. Researchers use diaphragm ultrasound to see how well the main breathing muscle works 3 and 6 months after leaving the hospital. The goal is to describe long-term breathing changes, not to test a treatment.

This study tracks 56 follicular lymphoma patients to see how long their COVID-19 and other vaccine immunity lasts while they receive chemotherapy and maintenance therapy. Researchers will collect blood samples at several time points to measure immune responses. The goal is to und…

This study looks at how chronic hepatitis B virus (HBV) infection affects natural killer (NK) cells, which are key immune cells that fight infections. Researchers will collect blood samples from 80 people with HBV and compare them to healthy donors. The goal is to understand why …

This study looks at why people who have had an organ transplant are more likely to get cancer. Researchers will combine existing health records from over 85,000 transplant patients in England to track cancer cases and deaths. The goal is to better understand risks and improve car…

This study tests a short guide called the 'Jumpstart Guide' to help doctors have better conversations with dementia patients and their families about healthcare goals. Over 1,800 patients and their caregivers are taking part. Researchers will compare whether those whose doctors u…

This study follows about 360 people with chronic hepatitis B who had a good response to the experimental drug bepirovirsen in earlier trials. No new drug is given; researchers simply monitor whether the response lasts over time. Participants may or may not continue standard antiv…

This study investigates whether T2 biomarkers, measured in sputum, can predict which people with occupational asthma will go into remission after stopping exposure to workplace triggers. Only about 30% of patients currently recover, and there is no way to predict who will. Resear…

This study aimed to see if the antibiotic doxycycline could protect people from severe COVID-19. Researchers planned to analyze health records of patients who took doxycycline for acne during the pandemic. However, the study was withdrawn before enrolling any participants, so no …

This study follows 200 adults on ECMO (a heart-lung machine) for severe breathing problems. Researchers track how many get hospital-acquired infections and measure antibiotic levels in their blood and lungs. The goal is to learn more about infections and drug dosing in these crit…

This study looks at HIV patients over 40 (or those on HIV therapy for over 10 years) who switched to either a three-drug or a two-drug antiretroviral regimen. Researchers will measure markers of inflammation in the blood and track how many patients develop other health conditions…

This study uses a special bronchoscopy technique called narrow band imaging to look at blood vessel patterns in the airways of people with COVID-19. Researchers will compare images from three groups: patients with COVID-19, patients with other lung infections, and patients with l…

This study looks at 200 people with ongoing stomach discomfort (functional dyspepsia) to find out how often they have small intestinal bacterial overgrowth (SIBO). Researchers will compare two methods—growing bacteria in a lab and DNA testing—to identify which germs are present. …

This study looks at how COVID-19 impacts people with hepatocellular carcinoma, a type of liver cancer. Researchers will track infection rates and see how the virus affects liver function, cancer treatment, and overall health. About 23 participants from a French national liver can…

This study follows 98 elderly residents in French nursing homes to see how long their COVID-19 antibodies last. Researchers will also measure immune markers linked to aging to understand why some older people have weaker immune responses. The goal is to learn how to better protec…

This study follows 35 people with Merkel cell carcinoma, a rare and aggressive skin cancer, to see if two blood markers (T-antigen antibodies and miR-375) can detect when the cancer comes back. Currently, follow-up relies on physical exams and scans, which may miss early recurren…

This pilot study aimed to see if giving a logbook to patients hospitalized for a stem cell transplant could help reduce feelings of isolation and psychological stress. The study was withdrawn before enrolling any participants, so no results are available. It was planned at the Un…

This study tracked 81 critically ill COVID-19 patients admitted to a French intensive care unit. Researchers compared factors like age, medical history, and treatments to understand who becomes severely ill. The goal is to improve care for future patients.

This study aims to create a tool that predicts which patients with inflammatory rheumatic diseases (like rheumatoid arthritis, vasculitis, or polymyalgia rheumatica) will develop serious side effects from long-term steroid use. Researchers will collect routine medical data—such a…

This study planned to test telemonitoring for older adults (75+) in nursing homes with confirmed or probable COVID-19. The goal was to see if remote monitoring could improve healthcare management and reduce deaths within 30 days. However, the study was withdrawn before enrolling …

This study is testing whether a computer can automatically measure how much lung tissue is damaged in patients with severe breathing problems from COVID-19 or after surgery. Researchers will compare the computer's lung measurements to standard severity scores in 500 patients. The…

This study tests a program where veteran peer workers provide education, healthcare navigation, and social support to 150 veterans with opioid use disorder who are not connected to VA healthcare. The goal is to reduce risky behaviors related to overdose and HIV/HCV infection. Res…

This study adapts an existing stigma-reduction program specifically for pregnant and postpartum women living with HIV in Ghana. Researchers will interview 30 women and 20 providers to understand their experiences, then work with stakeholders to tailor the program. Finally, 90 pre…

This study follows 4,000 people who have had a lung transplant to see how their lungs and overall health change over many years. Researchers will collect data from clinic visits, lung function tests, and surveys about daily activities and quality of life. The goal is to better un…

This study looks at patients in intensive care who have an infection in a joint replacement (like a hip or knee). Researchers want to understand their care path, recovery, and survival over two years. The study will collect data from medical records and phone calls with patients …

This study aimed to see if personalized computer-based brain exercises could improve thinking skills in adults with HIV who have mild memory or attention problems. Researchers planned to enroll 120 people aged 40 and older, giving half of them training focused on their weakest me…

This study follows 298 older adults with HIV in Zambia to compare brain health between those who have had HIV for a long time (7+ years) and those with a shorter infection (1-2 years). Researchers will track memory, thinking, mental health, frailty, and nerve health over 6 years.…

This study screens adults interested in fecal microbiota transplant (FMT) for Clostridium difficile infection. Researchers will collect medical information and run basic health tests to create a database of potential participants. The goal is to make it faster and easier to enrol…

This study is tracking over 2,200 tuberculosis patients to see how the amount of TB drugs in their blood relates to how well the treatment works and whether they have side effects. By measuring drug levels, researchers hope to find ways to adjust doses for each person, especially…

This study follows 90 people who survived severe COVID-19 pneumonia and needed intensive care. Researchers will check their physical health, mental health, and quality of life at 3 months, 6 months, 1 year, and 5 years after leaving the ICU. The goal is to better understand the l…

This study tracks side effects and severe dengue cases in 2,000 people who already got the QDENGA dengue vaccine in Malaysia. No new vaccine is given—researchers simply collect health data from participants. The goal is to understand real-world safety and whether vaccinated peopl…

This study was designed to track how many healthcare workers at Lille University Hospital caught COVID-19 over 10 weeks. Researchers planned to test 100 workers every two weeks using nasal swabs and blood tests, along with questionnaires about their work and home exposures. The g…

This study aimed to collect medical information from people who developed unusual blood clots within four weeks of receiving a COVID-19 vaccine. The goal was to better understand any possible link between the vaccine and these rare events. However, the study was withdrawn before …

This study was designed to track how COVID-19 infection might worsen the condition of people with inherited metabolic diseases (IMD). Researchers planned to collect information from French patients with IMD who had or had COVID-19 to see how often their metabolic disease got wors…

This study follows 28 kidney transplant recipients who are switching from one anti-rejection drug (anticalcineurin) to another (belatacept). Researchers want to see how this change affects the immune system's ability to fight the common CMV virus. Participants will have blood tes…

This study was designed to compare how often patients with severe COVID-19 developed lung infections while on a ventilator during the first and second waves of the pandemic. It was an observational study that would have looked back at patient records across European ICUs. However…

This study is a medical registry that follows over 21,000 adults hospitalized in 2021 at a Russian hospital. Researchers will analyze their health records, including chronic conditions, COVID-19 history, and outcomes like heart attacks or strokes, over five years. The goal is to …

This study looks at how well the HPV vaccine works in women living with HIV and whether self-collected HPV tests can improve cervical cancer screening. About 650 women will use a self-swab kit at home or in the clinic. Those with positive results will get follow-up exams. The goa…

This study looks at 500 elderly patients (65 and older) with severe pneumonia to understand why some recover and others don't. Researchers will review medical records from hospitals across Europe, focusing on death rates and complications. No new drugs or treatments are being tes…

This pilot study is testing whether two natural dietary supplements—taxifolin (found in apples and onions) and ergothioneine (found in mushrooms)—can improve immune function in healthy adults aged 50 to 65. Researchers will measure how well immune cells engulf and destroy threats…

This study looks at how things in the environment and at work might affect people with interstitial lung diseases (a group of lung conditions). Researchers will ask 1,000 adults with a new diagnosis about their exposures to things like pollution, chemicals, and dust. The goal is …

This study follows 250 Italian adults with genetic forms of pulmonary fibrosis to see how their lung function changes over time. Researchers will track breathing tests and compare patients who receive immune-modulating drugs with those who do not. The goal is to understand how in…

This study looks at how tuberculosis (TB) medications travel through a mother's body, into her breastmilk, and to her nursing baby. Researchers will take blood and milk samples from 20 mothers and small blood samples from their infants at several time points after a dose. The goa…

This study tests whether a Norwegian clinic (NSAC) helps people with common mental health issues or muscle pain return to work sooner. 2500 adults are split into three groups: one gets treatment quickly, one waits 10-14 weeks, and one gets a basic check-up. Researchers will track…

This study is creating a large registry of 600 adults who use catheters to empty their bladder due to nerve damage or other causes. Participants will report on their satisfaction, quality of life, and any infections or complications. The goal is to gather real-world data to bette…

This study looks at whether a booster dose of the acellular pertussis vaccine (Tdap-IPV) can reduce the amount of whooping cough bacteria in the nose after intentional exposure. Healthy adults who were vaccinated as children will receive either the Tdap-IPV booster or a control v…

This study looks at 120 Canadian women to understand why some get repeated yeast infections while others don't. Researchers will compare the vaginal yeast and bacteria of women with their first infection, those with recurrent infections, and those with yeast but no symptoms. Part…

This study planned to see if faster testing and treatment for hepatitis C could be given to inmates right when they enter prison. The goal was to start medication sooner to reduce the spread of the virus. However, the study was withdrawn and no one took part.

This study tracks how the malaria drug artemether-lumefantrine passes from a breastfeeding mother into her breastmilk and then into her nursing infant. Researchers will take blood and milk samples from 30 mother-infant pairs in Uganda over two weeks. The goal is to understand dru…

This study looks at whether a package of tools and support can help staff and tenants in 20 supportive housing buildings in New York adopt proven overdose prevention practices. Researchers will survey tenants and staff, observe what happens, and check health records to see if the…

This study looks at whether coaching existing workplace health and safety committees can improve employee health, safety, and well-being. About 3,300 healthcare workers in New England will take part. Researchers will compare coached teams to uncoached ones to see if team engageme…

This study tests better ways to detect early artery narrowing in new hearts after transplant, a condition called cardiac allograft vasculopathy (CAV). About 80 adult heart transplant patients will be followed within their first three months to compare advanced imaging and blood t…

This study looks at how the bacteria in a pregnant woman's gut (her microbiome) and her nutrition affect her baby's growth and health. Researchers are following 800 young pregnant women (28 and under) in Toronto throughout pregnancy and for a year after birth. They collect stool,…

This study is collecting saliva, stool, blood, bile, and tumor samples from 200 people undergoing surgery for pancreatic or related cancers. Researchers want to see if the types of bacteria in these samples can help predict who will have complications after surgery and how the ca…

This study was designed to test a new system that uses tiny silica particles on HIV medication (Biktarvy) and a smartphone app to help people track whether they have taken their pills. The goal was to see if the system is easy to use and accurate over 90 days. However, the study …

This study uses special MRI scans with inhaled gases to see how lungs work in people with asthma, COPD, or COVID-19. Researchers will follow up to 160 participants over several years to track changes in lung function. The goal is to better understand why some patients struggle wi…

This study aims to create a test that predicts how hospitalized COVID-19 patients will fare in the short and long term (up to one year). Researchers will enroll 600 adults from hospitals and Veterans' facilities, using medical records and lab data to forecast risks like frailty, …

This study aims to improve how we predict and prevent dengue outbreaks by looking at how people move around the city. Researchers in Cuba will collect information from 810 residents about their daily travel, along with mosquito and weather data. The goal is to build better comput…

This study follows about 190,000 Korean radiation workers to see if low-dose radiation exposure over time increases the risk of cancer and other diseases. Researchers will link national health records to track health outcomes. The goal is to better understand the long-term effect…

This study tests a machine-learning tool that gives doctors a pop-up alert when they prescribe opioids to a patient at high risk of overdose. The alert explains why the patient is at risk and suggests safer options, like prescribing naloxone or referring to pain therapy. Research…