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Timing of pain pills after C-Section could reduce need for opioids

NCT ID NCT07102641

Symptom relief Sponsor: Thomas Jefferson University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Sep 01, 2026 · Updated 3 times

Summary

This study compares two schedules for taking non-opioid pain relievers (acetaminophen and NSAIDs) after a cesarean delivery: taking them at different times (staggered) or at the same time (simultaneous). The goal is to see which approach better controls pain and reduces the need for stronger opioid drugs. The trial will enroll 825 women who have a C-section under regional anesthesia.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
acetaminophen and NSAIDs (ketorolac/ibuprofen)
What this could lead to
If it works, this could establish a simple, non-opioid dosing schedule to improve pain control after C-sections.
What could go wrong
This is a Phase 4 trial comparing two common approaches, so the difference may be small. Results may not apply to all patients or settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 825 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2025

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

16 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * \>/= 34 weeks gestation * Singleton pregnancy * Delivery via cesarean section under regional anesthesia Exclusion Criteria: * Contraindication to acetaminophen or NSAIDs * Current or history of opioid use or misuse * Intrauterine fetal demise * Major congenital anomaly * Conversion to general anesthesia intra-op or planned general anesthesia * Mid-line vertical skin incision * Receipt of intraoperative local analgesia such as Transversus Abdominis Plan (TAP) block or wound infiltration

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative paracetamol poisoning

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acetaminophen (D000082) Cesarean delivery NSAIDS Post operative pain Postpartum comfort Postpartum pain

Contacts and locations

Locations

  • Thomas Jefferson University Hospital

    Philadelphia, Pennsylvania, 19107, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.