Suicide Gene-Equipped t cells aim to make stem cell transplants safer

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Inclusion Criteria at Time of Procurement: 1. Lack of a suitable conventional donor (i.e. 5/6 or 6/6 related, or 5/6 or 6/6 unrelated donor), or presence of a rapidly progressive disease not permitting time to identify an unrelated donor. 2. High risk disease in one of the following: * Myelodysplastic syndrome (MDS) in one of the following categories: RCMD with an IPSS-R of intermediate, poor, or very poor, RAEB-1, or RAEB-2 * Acute myeloid leukemia (AML) after first relapse or primary refractory disease * Chronic myelogenous leukemia (CML) in Chronic Phase 2 or greater, Accelerated Phase or Blast Crisis * Acute lymphoblastic leukemia (ALL) after first relapse or primary refractory disease, or High-Grade Non Hodgkin lymphoma (NHL) Stage III or IV after first relapse or primary refractory disease * Hemophagocytic lymphohistiocytosis (HLH) * Familial hemophagocytic lymphohistiocytosis (FLH) * Viral-associated hemophagocytic syndrome (VAHS) * T or NK cell lymphoproliferative syndrome * X-linked lymphoproliferative disease (XLP) Inclusion Criteria at Time of T Cell Infusion: 1. Engrafted with an absolute neutrophil count (ANC) \> 500 cells/µL 2. Greater than or equal to 50% donor chimerism in either peripheral blood or bone marrow, or relapse of their original disease 3. Life expectancy \> 30 days 4. Lansky/Karnofsky score greater than or equal to 60 5. Absence of severe renal disease (creatinine \> 2X upper limit of normal for age) 6. Absence of severe hepatic disease (direct bilirubin \> 3X upper limit of normal or SGOT \> 3X upper limit of normal) 7. Oxygen saturation \> 94% on room air 8. Patient/Guardian able to give informed consent 9. AP1903 available in sufficient quantities to allow for treatment of the patient Exclusion Criteria: Exclusion Criteria at Time of T Cell Infusion: 1. GvHD 2. Severe intercurrent infection 3. Pregnancy\* 4. Other investigational drugs in the prior 30 days * Pregnancy test only required for at-risk individuals, defined as female patients of childbearing potential who have received a reduced-intensity conditioning regimen.