Can Lab-Grown placenta tissue reveal how zika and tonate viruses strike?
NCT ID NCT05589012
First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time
Summary
This study investigates whether Zika and Tonate viruses can replicate in human placental tissue grown in the lab. Researchers will infect placental samples from early and full-term pregnancies and measure viral levels to compare how each virus behaves. The goal is to better understand the potential risk these viruses pose during pregnancy and to validate a lab model for studying them.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Zika virus and Tonate virus used to infect placental tissue samples in the lab
- What this could lead to
- If this works, it could clarify how Zika and Tonate viruses infect the placenta, potentially guiding future prevention strategies for pregnant women.
- What could go wrong
- This is a lab-based study using tissue samples, not a clinical treatment trial. Results may not fully reflect what happens in the body, and the viruses used are lab-adapted strains.
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Study facts
What this study's own registry entry says, in plain language.
- Expected to start
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Nov 2023
An estimate. Start dates often move.
- Expected to finish
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Apr 2024
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Pregnant women
- Ages
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18 years and older
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patient over 18 years old * Singleton pregnancy of normal course, at term, birth by caesarean section OR * Trophoblast from Voluntary Termination of Pregnancy (IVG), after endo-uterine aspiration Exclusion Criteria: * Need for pathological, genetic or bacteriological examination of the placenta * Multiple pregnancy * HBV+ (Hepatitis B positive), HCV+ (Hepatitis C positive) , known CMV seroconversion during pregnancy (CytoMégaloVirus) * Immunosuppression (drugs, corticosteroids, etc.) * Diabetes * Pre eclampsia * Intrauterine growth retardation (IUGR), * Vascular or placental pathology. * Refusal to participate * Patient under guardianship / curatorship / security measure * Patient under AME (state medical aid)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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