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HIV study seeks clues to brain aging in Long-Term survivors

NCT ID NCT05678660

Knowledge-focused Sponsor: University of Rochester Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study follows 298 older adults with HIV in Zambia to compare brain health between those who have had HIV for a long time (7+ years) and those with a shorter infection (1-2 years). Researchers will track memory, thinking, mental health, frailty, and nerve health over 6 years. The goal is to understand if longer HIV infection leads to faster brain aging.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could reveal how the length of HIV infection affects brain aging and frailty, pointing toward ways to support healthy aging in people with HIV.
What could go wrong
This is an observational study, not a treatment trial. It cannot prove cause and effect, and results may not apply to all populations or regions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

298 people

The number who actually took part.

Started

Jul 2022

Expected to finish

Apr 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Potential participants will be identified through the antiretroviral clinics associated with Chikankata Hospital and Monze Mission Hospital in Zambia's Southern Province. Individuals will first be identified in the long group and will then be matched to a PLWH in the short group matching based upon gender, age and community of residents

Ages

45 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * For the short group, stable on ART for 1 year, but no more than 2 years. * For long group, on ART for 7 or more years Exclusion Criteria: * Acute medical illness. * Decisional impairment precluding informed consent as noted by clinicians providing care to the patient or by the research staff team members. * Communication impairments-unable to hear or unable to speak. * Being unable to communicate in English or in the dominant language at the study site (Tonga).

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction Frailty HIV infectious disease premature aging syndrome Psychological Well-Being

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aging, premature

Contacts and locations

Locations

  • Chikankata Hospital

    Mazabuka, Southern Province, Zambia

  • Chilenje Level 1 Hospital

    Lusaka, Zambia

  • Monze Mission Hospital

    Monze, Southern Province, Zambia

More trials for these conditions

Other studies related to the condition(s) this trial covers.