University Of Rochester

This study aims to find out if heart failure patients at low risk for dangerous heart rhythms need an implantable defibrillator (ICD) or if they can do just as well with medication alone. It will enroll 3,290 adults with heart failure who are already on stable, optimal medication…

This study aims to find out which of two common bone graft materials works better for preserving jawbone after a front tooth is extracted. Fifty adults needing a dental implant will be randomly assigned to receive either a freeze-dried human bone graft or a collagen-enriched cow …

This study is testing whether a digital, self-guided therapy program using an avatar can help people manage substance use and reduce conflict in relationships. It will compare this online program to standard one-on-one talk therapy. The research involves 40 men who are entering o…

This study is testing whether a combination of a single chemotherapy drug and an immunotherapy drug (pembrolizumab) is safe and effective for people with advanced non-small cell lung cancer who are too frail for standard, more intensive treatments. It aims to help patients who sp…

This study is testing whether adding radiation therapy to the chest can prevent painful or difficult symptoms from developing in patients with advanced lung cancer that has spread. The radiation targets large tumors or tumors near sensitive areas in the chest. All participants wi…

This study tests whether adding a heart rhythm procedure during heart pump (LVAD) surgery reduces dangerous irregular heartbeats afterward. It involves 100 patients with advanced heart failure and a history of serious rhythm problems. Half will receive the extra rhythm surgery du…

This study is observing how well umbilical cord blood stem cells from unrelated donors work for patients with serious blood cancers and disorders. Researchers will track how quickly patients' blood counts recover, how often the transplant fails, and the rates of disease relapse a…

This study aims to figure out which parts of therapy work best to help children and teenagers recover from post-traumatic stress disorder (PTSD). Researchers will test different combinations of therapy techniques with 200 young participants who have experienced trauma. The goal i…

This study is testing whether directly treating feelings of loneliness can help people who are struggling with opioid addiction. It will enroll 300 adults who have both an opioid use disorder and report feeling lonely or disconnected. Participants will be randomly assigned to one…

This study is testing whether a combination of two drugs, neratinib and capecitabine, can help control breast cancer that has spread to the brain. It is for patients whose cancer is officially classified as HER2-negative but shows signs of abnormal HER2 activity on a special test…

This study is testing a new support program for people who have been admitted to a crisis center for a suicidal crisis. The program includes group sessions during the stay and follow-up phone coaching for a month after leaving. Researchers want to see if this extra support helps …

This study is testing if a simple blood test can help doctors better manage early-stage lymphoma. It aims to see if tracking tiny bits of tumor DNA in the blood can predict treatment success and help decide which patients need radiation. The goal is to personalize therapy to cont…

This study is testing if adding a kidney nerve treatment to the standard heart ablation procedure helps people with a persistent form of atrial fibrillation (AFib) stay in normal rhythm longer. It will compare the combined procedure to the standard ablation alone in 50 participan…

This study aims to find out which of two commonly used heart failure medications works better for patients who also have an implanted defibrillator. It will follow 2,000 participants for up to 3 years to see which drug leads to fewer defibrillator shocks, fewer hospital visits, a…

This study is testing whether taking a high weekly dose of vitamin D can help protect bone strength in older men with prostate cancer who are receiving hormone therapy. Hormone therapy can weaken bones, increasing the risk of fractures and falls. Researchers will compare the bone…

This study is testing whether disulfiram, a medication used to treat alcohol use disorder, can improve vision in people with retinal degeneration diseases like macular degeneration and retinitis pigmentosa. The trial will enroll 15 adults who have both a retinal condition and alc…

This study is testing if a newer, more precise pacemaker technique (His-CRT) works better than the standard method (BIV-CRT) for people with heart failure and a specific electrical problem in their heart. About 120 participants will be randomly assigned to receive one of the two …

This study is testing whether applying a topical iodine solution to children's teeth can help prevent new cavities from forming. It involves about 200 children, aged 2 to 5 years, who have severe tooth decay and are getting dental surgery. The children will receive either the iod…

This early-stage study is testing if lisinopril, a common blood pressure medication, can prevent urinary side effects in men receiving radiation treatment for prostate cancer. Researchers will give the drug to about 30 men during and after their radiation therapy to find the best…

This study is testing if sending text messages can help more people get screened for lung cancer. Researchers will enroll 40 adults who are at risk for lung cancer but haven't had their yearly screening. They will compare people who get text message reminders to those who receive…

This study aims to prevent HPV-related cancers by increasing vaccination rates in children aged 9-17. It will test if allowing nurses to give the HPV vaccine without needing a separate doctor's order for each patient works better than just training doctors to recommend it. The tr…

This study is testing if a sleep medication called daridorexant can prevent delirium—a state of sudden confusion and disorientation—in older adults after heart surgery. About 80 participants aged 60+ will take either the study drug or a placebo for three nights after their surger…

This study is testing whether an 8-week course of a seaweed-based supplement called fucoidan can help reduce fatigue and inflammation in people who have finished cancer treatment. It will involve 40 cancer survivors who report significant fatigue. The main goal is to see if this …

This study is testing a special support program for older adults who have finished cancer treatment. The program includes health education, exercise plans, and consultations to help improve daily physical abilities, mental well-being, and memory. Researchers want to see if this a…

This study is testing whether a smartphone app called 'My Health Coach' helps adults with fetal alcohol spectrum disorders (FASD) improve their quality of life and daily management. Researchers will enroll 200 adults with FASD and randomly assign half to use the app right away, w…

This study is testing a communication coaching program called COACH-Cog. It's designed to help older adults who have both dementia and cancer, along with their family caregivers, talk more effectively with their doctors about treatment choices. The goal is to make sure the patien…

This study is testing whether a mobile phone-based exercise program can help older adults with blood cancers maintain their physical strength and reduce fatigue during chemotherapy. Researchers will compare the exercise app against standard education materials in 170 participants…

This study is testing whether a non-invasive electrical stimulation therapy, similar to acupuncture, can help relieve dry mouth in people who had radiation treatment for head and neck cancer. Researchers want to see if this therapy improves quality of life for patients who suffer…

This study is testing whether a compound found in green tea, called EGCG, can help older adults who have survived cancer feel less frail and reduce body inflammation. About 118 participants aged 65+ who have finished cancer treatment will take either EGCG or a placebo pill daily …

This study is testing if a TENS unit, which uses mild electrical pulses on the skin, can reduce pain during a common outpatient procedure for stress urinary incontinence. 100 women will be randomly assigned to receive either a real TENS device or a placebo device during their pro…

This study is testing whether a 12-week home exercise program can help people with pulmonary arterial hypertension. Researchers want to see if the program reduces how hard the heart has to work during walking and improves patients' quality of life. The program involves daily mess…

This study is testing whether a telehealth program helps older patients with serious blood cancers have better conversations with their doctors about future care wishes. It aims to see if these structured video calls reduce patient anxiety and distress, and help more people compl…

This study is testing a social support coaching program called SONATA to see if it helps older adults cope with cancer treatment. The program involves about six sessions over four months, where patients and their chosen support people learn to work together. Researchers want to s…

This study is testing whether daily text message reminders help men do their pelvic floor exercises after prostate surgery. Researchers want to see if these reminders help men regain bladder control faster and reduce incontinence symptoms. The study will compare two groups: one t…

This study is testing whether a 'Dyadic Life Review' program, where older patients with advanced cancer and their caregivers share and discuss life stories together, is practical to run and if it helps. It will compare this program to usual care, which involves a social work refe…

This study is testing a decision-making support tool designed to help older adults with acute myeloid leukemia (AML) and their caregivers. It aims to reduce emotional distress and improve the quality of shared decisions about cancer treatment. The trial will compare the new tool …

This study aims to understand how the brain changes when people with partial vision loss from a stroke do special vision training exercises. Researchers will use MRI brain scans to look at brain structure and activity before and after the training in 100 participants. The goal is…

This study is testing a digital tool designed to help patients with serious blood cancers make difficult decisions about bone marrow transplants. The tool uses real video stories from past patients and exercises to help clarify personal values. Researchers want to see if this app…

This study aims to better understand why symptoms of myotonic dystrophy type 1 (DM1) vary so much between people. Researchers will work remotely with 1,000 adults who have DM1 to measure symptoms like strength and memory and analyze their genetics from a blood sample. The goal is…

This study aims to understand why people feel short of breath. Researchers will test 50 adults who have been referred for a standard exercise breathing test. They will compare results from a new, simple breathing measurement to see if it can help explain the cause of breathing di…

This study aims to understand how Batten disease progresses over time by tracking 500 children and adults with the condition. Researchers will use regular check-ups and questionnaires to measure changes in movement, thinking, behavior, and daily function. The goal is to create be…

This study aims to understand how our brain combines what we see with our sense of balance to figure out how we are moving. Researchers will test 300 people, including healthy individuals and those with balance disorders, using special motion simulators. The goal is to learn how …

This study aims to understand if having a higher body weight increases the risk of gum inflammation, tooth discoloration, and harmful mouth bacteria in teenagers getting braces. Researchers will observe 52 adolescents over 6 months, comparing those with higher and normal weight. …

This study is testing whether an early telehealth visit can help patients newly diagnosed with a fast-growing brain tumor discuss and document their end-of-life care wishes. The goal is to see if this structured conversation, done soon after diagnosis, improves the patient's expe…

This study creates a national registry to connect people with myotonic dystrophy or facioscapulohumeral muscular dystrophy (FSHD) with researchers. It aims to better understand these rare muscle diseases by tracking symptoms over time and helping match interested participants to …

This study aims to better understand cancer cachexia, the severe weight and muscle loss that often occurs with advanced cancers. Researchers will observe 800 patients with advanced colorectal, lung, or pancreatic cancer to identify different patterns or 'subtypes' of this conditi…

This study aims to gather detailed information about meningitis in northern Uganda to identify gaps in care and improve prevention. Researchers will collect data from 1,100 hospitalized patients with meningitis symptoms and screen 10,000 HIV-positive patients for a specific funga…

This study aims to understand how vision loss caused by a stroke affects a person's ability to drive and navigate. Researchers will use a virtual reality driving simulator to compare the steering behavior of 40 people with stroke-related vision loss to people with normal vision. …

This study aims to see if wearable devices can reliably measure walking problems and involuntary movements in people with Huntington's disease during their daily lives at home. Researchers will enroll 100 participants, including people with Huntington's and healthy volunteers, wh…

This study aims to find new brain-based markers for psychosis by measuring visual processing in people with schizophrenia, bipolar disorder, and healthy controls. Researchers will use EEG (electroencephalography) to record brain waves while participants view images. The goal is t…

This study is developing more sensitive blood tests to find tiny amounts of hidden cancer cells that remain after treatment for acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Researchers want to see if these tests can identify patients who are at higher risk of t…

This study aims to understand how breast milk changes throughout the day and how it relates to a baby's sleep and gut health. Researchers are comparing 240 mother-baby pairs: half who feed mostly directly from the breast and half who feed mostly pumped milk. The goal is to gather…