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Scientists compare immune responses to viral and bacterial infections in ICU patients

NCT ID NCT05671159

Knowledge-focused Sponsor: University Hospital, Limoges Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how the immune system of patients in the intensive care unit (ICU) responds to severe infections caused by viruses or bacteria. Researchers will take extra blood samples from 38 adults to analyze immature granulocytes, a type of immune cell. The goal is to see if these cells behave differently depending on whether the infection is viral or bacterial, which could improve understanding of immune impairment in critical illness.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help doctors better understand how the immune system responds differently to viral and bacterial infections in critically ill patients.
What could go wrong
This is a small, observational study with only 38 participants, so findings may not apply to all patients. It is not testing a treatment, so no direct benefit to participants.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 38 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2023

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Bacterial infection: * Adult patient hospitalized for less than 24 hours in ICU for community documented sepsis * Vasopressor support * SOFA score \> 4 * Viral infection: * Adult patient hospitalized for less than 24 hours in ICU for confirmed viral acute infection. * High flow oxygen, non-invasive or invasive ventilation since less than 24 hours * Moderate to severe ARDS with PaO2/FiO2 \< 200mmHg and a FiO2 ≥ 0.6. Exclusion Criteria: * Bacterial infection: * Antibiotics or hospitalized in ICU in the previous 3 months * Immunocompromized patient * Ongoing acute or chronic viral infection * Viral infection: * Antibiotics or hospitalized in ICU in the previous 3 months * Immunocompromized patient * Current antibiotics * Ongoing chronic viral infection.

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Conditions

The condition(s) this trial relates to.

infectious disease with sepsis Sepsis viral infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Sepsis Viral infection

Contacts and locations

Locations

  • Limoges University Hospital

    Limoges, 87042, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.