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Blood test aims to unmask hidden TB infections before they turn deadly

NCT ID NCT06751706

Knowledge-focused Sponsor: Queen Mary University of London Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 02, 2026 · Last updated Jul 02, 2026

Summary

This study investigates whether a blood test can detect the bacteria that cause tuberculosis (TB) in people with active TB and their asymptomatic household contacts. Researchers in Uganda will use several methods, including a DNA-based test, to look for TB bacteria in blood samples. The goal is to develop a better way to identify individuals with latent TB who are at highest risk of developing active disease, so they can receive preventive treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a better blood test to identify who is at highest risk of developing active TB, allowing targeted preventive therapy.
What could go wrong
This is a small, early-stage study (60 participants) focused on detection methods, not treatment. The test may not prove accurate enough for widespread use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2024

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

* 20 index cases of pulmonary TB (Group A) * 20 recent household contacts of Group A index cases * 20 historical TB contacts who previously participated in a TB household contact study

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

TB patients (Group A): Inclusion Criteria: * Able and willing to give written informed consent to participate * Age ≥18 years * New diagnosis of smear-positive or Xpert-confirmed pulmonary TB * At least one asymptomatic adult household contact likely to fulfil TB contact eligibility criteria below Exclusion criteria: * More than 7 days of anti-TB treatment taken * Confirmed or suspected pregnancy (female participants) * Existing medical condition which in the opinion of the investigator may adversely affect the participant's safety or ability to participate in the study. Recent TB contacts (Group B): Inclusion Criteria: * Able and willing to give written informed consent to participate * Age ≥18 years * Household contact with an index case of smear-positive pulmonary TB in Group A above. Exclusion Criteria: * Clinical or radiological features of active TB * Current or previous anti-TB treatment * Confirmed or suspected pregnancy (female participants) * Existing medical condition which in the opinion of the investigator may adversely affect the participant's safety or ability to participate in the study. Historical TB contacts (Group C): Inclusion Criteria: * Able and willing to give written informed consent to participate * Age ≥18 years * Participant in previous TB household contact study Exclusion Criteria: * Clinical or radiological features of active TB * Current or previous anti-TB treatment * Confirmed or suspected pregnancy (female participants) * Existing medical condition which in the opinion of the investigator may adversely affect the participant's safety or ability to participate in the study.

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Conditions

The condition(s) this trial relates to.

latent tuberculosis infection pulmonary tuberculosis tuberculosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Latent tuberculosis Tuberculosis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Infectious diseases institute, Makarere University

    Kampala, P.O. Box 22418, Uganda

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