Does a smallpox drug weaken the vaccine? new study aims to find out.
NCT ID NCT04957485
First seen Apr 23, 2026 · Last updated May 20, 2026 · Updated 5 times
Summary
This study looks at whether taking the smallpox drug TPOXX changes how well the JYNNEOS vaccine works. About 100 healthy adults aged 18 to 42 will get two doses of the JYNNEOS vaccine and either TPOXX or a placebo for 28 days. Researchers will measure side effects and immune response to see if the drug interferes with the vaccine.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Aventiv Research Inc
Columbus, Ohio, 43213-6510, United States
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Meridian Clinical Research
Omaha, Nebraska, 68134-3664, United States
Conditions
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