Smallpox
MONDO:0004651A condition that is caused by infection with Variola, and that is characterized by small, raised bumps.
Also known as: Variola virus caused disease or disorder, Variola virus disease or disorder, Variola virus infectious disease, ordinary smallpox, Variola, smallpox virus infection, variola virus VAR infection, variola virus infection
18 clinical trials for this condition and its sub-types, 15 tagged with Smallpox itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Smallpox
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Variola major infectious disease 0 trials
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Variola minor infection 0 trials
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New mRNA vaccine against mpox enters key trial in africa
Vaccine Recruiting nowThis study tests an experimental mRNA vaccine called BNT166a to see if it is safe and can protect against mpox (monkeypox). About 310 healthy adults in Africa will receive either the vaccine or a placebo. The trial is double-blind, meaning neither participants nor doctors know wh…
Phase 2 • Sponsor: BioNTech SE • Aim: Vaccine
Last updated Aug 13, 2026 00:00 UTC
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Supercharged donor cells take on viruses after transplant
Disease control Recruiting nowThis study tests whether specially grown donor immune cells (viral-specific T-cells) can safely treat viral infections that often occur after a stem cell transplant. These infections can be serious and sometimes don't respond to standard antiviral drugs. The approach aims to boos…
Phase 1/2 • Sponsor: Children's Hospital Medical Center, Cincinnati • Aim: Disease control
Last updated Sep 06, 2026 00:00 UTC
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Can donor cells stop viruses after transplant?
Disease control Recruiting nowThis study tests whether giving patients donor-derived immune cells (VSTs) on a regular schedule can prevent dangerous viral infections after a stem cell transplant. 180 participants will be randomly assigned to receive VSTs either on a fixed schedule or only when a virus is dete…
Phase 2 • Sponsor: Children's Hospital Medical Center, Cincinnati • Aim: Disease control
Last updated Sep 06, 2026 00:00 UTC
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Experimental drug targets smallpox and monkeypox after exposure
Disease control Expanded accessThis trial tests the drug tecovirimat in people who have been exposed to or infected with orthopox viruses, including smallpox, monkeypox, and cowpox. Participants receive oral tecovirimat to see if it can control the infection and prevent serious complications. The study include…
Sponsor: U.S. Army Medical Research and Development Command • Aim: Disease control
Last updated Jul 08, 2026 00:00 UTC
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New poxvirus drug candidate tested in healthy people
Knowledge-focused Recruiting nowThis early-stage study tests the safety and how the body processes a new drug called BSY001 in 76 healthy adults aged 18 to 50. Participants receive either the drug or a placebo, and researchers monitor side effects and drug levels in the blood. The goal is to gather safety infor…
Phase 1 • Sponsor: China National Biotec Group Company Limited • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC