Ebola's hidden toll on Kids' brains revealed years later
NCT ID NCT06811129
First seen Jun 25, 2026 · Last updated Sep 02, 2026 · Updated 13 times
Summary
This study looked at children who survived Ebola and compared them to close contacts who never got sick. Researchers checked for brain, nerve, and thinking problems more than 5 years after infection. The goal was to understand what lasting issues survivors face, not to test a treatment.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could help doctors understand the lasting brain and nerve problems in children after Ebola, leading to better care and support.
- What could go wrong
- This is an observational study, not a treatment trial. It only describes problems, not fixes. Results may not apply to all survivors.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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328 people
The number who actually took part.
- Started
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Feb 2025
- Finished
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Sep 2025
- Lead sponsor
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A government research agency
The lead sponsor is the US National Institutes of Health.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
This study will include participants of the PREVAIL III Natural History of Ebola Study who were of pediatric age at the time of enrollment, including EVD survivors and close contacts.
- Ages
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7 to 30 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
* INCLUSION CRITERIA: In order to be eligible to participate in this study, an individual must meet all of the following criteria: 1. Stated willingness to comply with all study procedures and availability for the duration of the study. 2. Male or female, previously enrolled in PREVAIL III Natural History of Ebola study as either an EVD survivor, or a close contact.\* 3. Aged \< 18 Years Old at the time of enrollment in PREVAIL III Natural History of Ebola study. 4. Ability of subject or Legally Authorized Representative (LAR) to understand and the willingness to sign a written informed consent document. * Close contacts are those who had a relationship with someone who survived EVD but were never diagnosed with EVD themselves. EXCLUSION CRITERIA: An individual who meets any of the following criteria will be excluded from participation in this study: 1. At the time of enrollment, lacks consent capacity due to cognitive impairment that would make them incapable of understanding the explanation of the procedures in this study. Cognitive capacity to consent will be determined at the time of enrollment. Participants with mental disorders or those participants who are cognitively impaired yet still retain consent capacity will not be excluded. 2. Is unable to comply with the procedures of the protocol. 3. Has any condition in the judgement of the study staff that would make the volunteer unable to participate in the study. 4. Is non-English speaking. Justification for the Exclusion of Non-English Speakers We plan to include speakers of simple Liberian English in this study. The tools we use for cognitive testing are not validated in any other language, other than English. It is expected that most, if not all, of the cohort we will be recruiting from will be simple Liberian English speakers.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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John F. Kennedy Medical Center
Monrovia, Liberia
More trials for these conditions
Other studies related to the condition(s) this trial covers.