National Institute Of Neurological Disorders And Stroke (ninds)

This study is testing whether a drug called teriflunomide, already used for multiple sclerosis, can help people with HAM/TSP—a rare, progressive disease that causes leg weakness and has no current treatment. Researchers will give the drug to 24 adults with HAM/TSP for 9 months to…

This study is testing whether a short, high-dose course of steroids can help heal a specific type of brain lesion seen in multiple sclerosis (MS). Researchers are enrolling 30 adults with MS who have these 'ring-enhancing' lesions but no new symptoms. Participants are randomly as…

This study offers standard surgical procedures to people aged 8 and older whose seizures are not controlled by medication. The goal is to remove or treat the specific area of the brain causing the seizures to reduce or stop them. Researchers will collect data from these routine t…

This study is for people who have seizures because of a brain tumor. Researchers want to see if surgery to remove the tumor can also reduce or stop the seizures. Participants will have the surgery and then be followed for several months to track their seizure activity, quality of…

This study aims to learn more about how deep brain stimulation (DBS) surgery helps control symptoms of Parkinson's disease, essential tremor, and dystonia. Researchers will observe 200 adults with these movement disorders who are having the standard DBS surgery. During the operat…

This study offers deep brain stimulation (DBS) therapy to adults with Parkinson's disease, essential tremor, or dystonia whose symptoms are not well-controlled with medication. DBS involves surgically implanting a small device that sends electrical signals to specific brain areas…

This National Institutes of Health study provides botulinum toxin (like Botox) injections to treat movement disorders such as dystonia, tremors, and muscle spasms. It serves two main purposes: training doctors in proper injection techniques and maintaining a group of patients for…

This study is testing a new, portable, and quieter type of MRI machine to see if it can detect brain diseases as well as the large, standard machines found in hospitals. Researchers want to know if this mobile technology can make brain scans more accessible to people who face bar…

This study is testing a new imaging method to find tiny pituitary tumors that cause Cushing's disease when standard MRI scans cannot see them. Researchers will give participants a drug called DDAVP, followed by a special PET scan, to see if it makes the tumor light up. The goal i…

This study is testing a new, small MRI coil designed to help surgeons see pituitary tumors more clearly during surgery. The coil is placed near the tumor through the same surgical opening. Researchers want to see if this tool is safe to use and if it can create better images to h…

This study aims to improve how doctors use MRI brain scans to find the exact spot in the brain causing seizures in people with uncontrolled epilepsy. Researchers will compare scans from 500 epilepsy patients before and after surgery with scans from 200 healthy volunteers to creat…

This is a small, early-stage study to see if a new radioactive tracer can help special PET scans detect certain immune cells in the brains of people with multiple sclerosis (MS) or progressive multifocal leukoencephalopathy (PML). The goal is to better understand how these diseas…

This study aims to collect standard medical test data from adults with nerve or muscle disorders to build a research database. Participants will undergo routine tests like nerve conduction studies and muscle ultrasounds during 1-2 clinic visits. The collected information will be …

This study aims to better understand a wide range of inherited neurological disorders that affect nerves, muscles, and the brain. Researchers will observe up to 3,500 participants, including people with these conditions and their healthy relatives, to track symptoms, disease prog…

This study aims to better understand stroke by creating a large registry of patients and tracking the natural course of the disease. It will enroll 4,000 adults who have had or are at risk for a stroke or mini-stroke (TIA). The research involves collecting data from standard medi…

This study aims to learn more about Progressive Multifocal Leukoencephalopathy (PML), a severe brain infection. Researchers will observe 700 people who have PML over time, collecting health information, scans, and samples. The goal is to understand how the disease naturally progr…

This study aims to see if ultrasound can be a better tool for measuring the health of nerves and muscles. Researchers will scan both healthy adults and people with nerve or muscle disorders to collect normal measurements and see how they differ in disease. The goal is to gather i…

This study aims to learn more about how infections and inflammation damage the brain and nervous system over time. Researchers will observe up to 1,000 participants, including children as young as 2, who have or are suspected of having these conditions. The goal is to collect det…

This study aims to gather information about a new, painless testing device called electrical impedance myography (EIM). Researchers want to see how well it works for measuring muscle health in people with various nerve and muscle diseases, and to compare it to results from health…

This study aims to understand how changes seen on brain scans in living people with Multiple Sclerosis (MS) relate to the actual physical damage found in the brain after death. Researchers will follow about 250 participants, including people with MS and some without, for many yea…

This study aims to understand why some people with well-controlled HIV still experience memory and thinking problems. Researchers will follow 1150 participants—both people living with HIV and healthy volunteers—for up to 20 years. They will use brain scans, memory tests, and flui…

This study aims to better understand the genetic causes of inherited movement disorders by studying patients and their family members. Researchers will collect detailed health information and genetic data from up to 2,500 participants to identify disease-causing genes and learn h…

This study aims to see if a new type of MRI scan can safely and clearly show areas of the brain affected by drug-resistant epilepsy. Researchers are testing a contrast agent called mangafodipir to see if it can highlight where the brain's protective barrier is breaking down durin…

This study aims to understand how the brain processes the unpleasant feelings of pain and physical effort, particularly in people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Researchers will use MRI brain scans on about 47 participants, including both health…

This study aims to understand how spinal and bulbar muscular atrophy (SBMA or Kennedy's disease) progresses over time. Researchers will follow 70 men with and without the condition for two years, using tests like MRIs, blood work, and strength assessments. The goal is to find rel…

This study aims to understand how certain inherited neurological diseases, like ALS4, progress over time. Researchers will observe 330 participants, including people with these conditions and healthy volunteers, over several years. They will collect clinical measurements and biol…

This study aims to improve MRI scan technology by collecting detailed images from healthy volunteers. Researchers want to make MRI measurements more reliable and accurate for future medical diagnosis. Healthy adults will undergo multiple MRI scans over time to help researchers un…

This study aims to help doctors better tell the difference between two types of involuntary movements: tics related to diagnosed disorders and 'functional tics,' which have a different cause. Researchers will measure brain waves and muscle activity in 75 adults, including people …

This study aims to understand how neurofibromatosis type 2 (NF2) progresses over time. Researchers will follow 269 participants, aged 8 to 75, for up to ten years, tracking their health with annual check-ups, MRI scans, hearing tests, and blood draws. The goal is to learn what ca…

This study aims to better understand epilepsy and identify people who may be eligible for other research studies. It will screen and observe up to 1000 adults and children (age 8+) with diagnosed or suspected epilepsy. The main goal is to gather detailed clinical information to h…

This study aims to understand if inactive pieces of the COVID-19 virus remain in the body after recovery and might be linked to long COVID symptoms. Researchers will collect and analyze tissue samples from 12 adults who have recovered from COVID-19, some with and some without ong…

This study aims to understand how multiple sclerosis (MS) naturally progresses over time by regularly scanning patients' brains with MRI. It will follow 3,750 adults with MS or similar conditions, as well as healthy volunteers, to see how brain lesions change and relate to immune…

This study aims to see if researchers can detect when a person is about to make a mistake during a skilled task up to one full second before it happens. Healthy right-handed adults aged 18-35 will perform typing tasks while their brain activity is monitored using special scanners…

This study aims to develop better brain scanning technology to understand how a normal, healthy brain works. Researchers are recruiting over 1,000 healthy adults to have detailed MRI scans while performing simple tasks. The information will help create clearer pictures of the bra…

This study aims to collect medical information and samples from up to 5,000 patients aged 4 and older who are receiving standard care for neurosurgical conditions like brain tumors, epilepsy, or Parkinson's disease. Participants receive their normal medical evaluations and treatm…

This study aims to better understand inherited nerve and muscle disorders that begin in childhood, like certain muscular dystrophies. Researchers will follow 9,300 participants—including patients, their family members, and healthy volunteers—over years to track how symptoms chang…

This study aims to understand how the HTLV-1 virus affects people over time, particularly focusing on a rare nerve disorder it can cause called HAM/TSP. Researchers will follow 750 participants, including people infected with the virus (with and without symptoms) and healthy volu…

This study aims to understand why many Gulf War veterans experience chronic symptoms like fatigue, pain, and memory problems. Researchers will compare 85 veterans who have Gulf War Illness with healthy veterans from the same war. Participants will stay at the NIH for two weeks of…

This study aims to better understand related brain diseases like ALS (Lou Gehrig's disease) and frontotemporal dementia. Researchers are recruiting 360 adults who have been diagnosed with these conditions or carry a genetic risk. Participants undergo detailed testing, including b…

This study aims to understand the wide range of recovery experiences after COVID-19, often called Long COVID. Researchers will follow 1,590 adults who had COVID-19 for three years, using surveys and interviews to track their symptoms and health. The goal is to describe the differ…

This study aims to understand how social and lifestyle factors—like education, income, and where you live—affect a person's thinking skills and recovery after a stroke. Researchers will conduct a 45-minute phone interview with 450 adults who have had a stroke, asking about their …

This study aims to better understand how congenital myasthenic syndromes (CMS)—rare inherited disorders that cause muscle weakness—progress over several years. Researchers will follow about 75 participants, aged 6 months and older, for up to 5 years, performing regular physical e…

This study aims to better understand what happens in the brain during sleep. Researchers will use MRI scans and EEG recordings on healthy young adults while they sleep overnight in a lab. Throughout the night, gentle sounds will be played to see how deeply the person is sleeping …

This study aims to gather detailed information about people with movement disorders (like Parkinson's disease or tremors) and their family members. Researchers will collect medical data through exams, scans, and questions during clinic visits, but will not provide any new treatme…

This study aims to understand how the brain responds to a non-invasive stimulation technique (TMS) to potentially improve treatments for arm and hand movement problems after a stroke. Researchers are testing if timing the stimulation to match a person's natural brainwave patterns…