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Scientists to scan brains all night to unlock sleep secrets

NCT ID NCT02629107

Knowledge-focused Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Aug 28, 2026 · Updated 8 times

Summary

This study aims to understand how the brain behaves during sleep by using fMRI and EEG to track brain activity while playing sounds. Healthy volunteers aged 18-34 will spend nights in an MRI scanner, wearing electrodes and headphones. The goal is to see how loud a sound needs to be to wake someone up, linking brain patterns to sleep depth.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 2,378 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2016

Expected to finish

Dec 2045

An estimate. End dates often move.

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Volunteers will be recruited from the community and NIH employees.

Ages

18 to 34 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

* INCLUSION CRITERIA: 1. able to give informed consent; 2. in good general heath; 3. between the ages of 18 and 34 years; 4. able to sleep on your back for several hours (with breaks). EXCLUSION CRITERIA: 1. have a medical condition like diabetes or uncontrolled hypertension; 2. have a psychiatric or neurologic condition like depression or stroke; 3. have ever had a seizure; 4. have a sleep disorder like insomnia or sleep apnea; 5. work night shifts; 6. have metal in your body such as pacemakers, metal prostheses, or aneurysm clips that would make MRI scanning unsafe; 7. are pregnant or nursing; 8. drink too much caffeine (6 or more cups of coffee per day or 10 or more cups of caffeinated soda per day); 9. use too much alcohol (15 or more alcoholic beverages per week for men and 8 or more alcoholic beverages per week for women); 10. use too much nicotine (nicotine use within 30 minutes of waking); 11. are afraid of enclosed spaces; 12. have known hearing problems; 13. regularly use a prescription or over-the-counter drug to help you sleep or stay awake; 14. are an employee, contractor, or volunteer of the Laboratory of Functional and Molecular Imaging in the National Institute of Neurological Disorders and Stroke.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Normal physiology

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • National Institutes of Health Clinical Center

    RECRUITING

    Bethesda, Maryland, 20892, United States

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