National Institute Of Neurological Disorders And Stroke (ninds)

This study looks at whether removing a brain tumor and the nearby area causing seizures can reduce or stop those seizures. About 100 people aged 8 and older with brain tumors and related seizures will have surgery and be followed for up to a year. The goal is to see if surgery im…

This study tests a new drug called LMP744 in 40 adults whose glioblastoma (a type of brain cancer) has come back after standard treatment. The drug is given through a vein for 5 days each month for up to a year. The goal is to see if it can shrink tumors or slow their growth.

This study tests brain surgery for children and adults with epilepsy that medication cannot control. Participants will have surgery to remove or treat the part of the brain causing seizures. The goal is to stop or greatly reduce seizures, though some patients may still need ongoi…

This study tests an antiviral drug called brincidofovir in people with progressive multifocal leukoencephalopathy (PML), a rare and often fatal brain infection caused by the JC virus. The drug is given through a vein twice a week for up to 12 weeks. The main goal is to check safe…

This study tests deep brain stimulation (DBS) surgery for people with Parkinson's disease, essential tremor, or dystonia whose symptoms are not well controlled by medication. A small device, like a pacemaker, is placed in the chest and sends electrical signals to specific brain a…

This study provides deep brain stimulation (DBS) therapy to 300 adults with Parkinson's disease, dystonia, or essential tremor. DBS uses a device implanted in the chest to send electrical pulses to brain areas controlling movement, aiming to reduce symptoms like shaking and stiff…

This study tests whether teriflunomide, a drug already used for multiple sclerosis, can help people with HAM/TSP, a rare progressive disease that causes leg weakness and other serious problems. About 24 adults with HAM/TSP will take the drug daily for 9 months. Researchers will c…

This study uses botulinum toxin (Botox) injections to treat movement disorders like dystonia, tremors, and spasms. It aims to improve symptoms and train doctors in injection techniques. Up to 2000 people aged 2 and older with these conditions can join. Treatment is ongoing and do…

This study tests whether a PET scan, boosted by a drug called desmopressin, can find tiny pituitary tumors in people with Cushing's disease that standard MRI scans miss. About 22 patients aged 8 and older will receive the PET scan before surgery to remove the tumor. Doctors will …

This study looks at whether a short course of high-dose steroids can help heal a specific type of brain lesion in people with multiple sclerosis (MS). These ring-enhancing lesions may not heal as well on their own. About 30 adults with MS and such a lesion will either receive ste…

This study aims to improve MRI technology for imaging the brain. Researchers will test new scanning methods on 1,100 healthy adults aged 18 and older. Participants will have yearly MRI scans and may perform simple tasks like listening to sounds or tapping fingers. The goal is to …

This study follows 75 people with congenital myasthenic syndromes (CMS) for up to 5 years to learn how the disease changes over time. Participants will have tests like heart and lung exams, muscle ultrasounds, and MRI scans. The goal is to better understand CMS and improve future…

This study looks at how things like education, race, and income might affect a person's memory and thinking after a stroke. Researchers will talk with 450 adults who had a stroke and review their brain scans. The goal is to understand why some people recover better than others.

This study aims to learn more about movement disorders like Parkinson's disease and tremors by observing and collecting data from affected individuals and their family members. Participants will undergo tests such as physical exams, blood work, and imaging scans during one or two…

This study looks at people with brain and nerve conditions who get standard medical care. It collects information and samples from their regular doctor visits to help future research. No new treatments are tested. Anyone 4 years or older with a neurosurgical condition can join.

This study aims to understand how the brain works during sleep by using brain scans (fMRI) and brain wave recordings (EEG). Healthy volunteers aged 18 to 34 will sleep in an MRI scanner while sounds are played to measure how deeply they sleep. The goal is to learn more about slee…

This study tests a small MRI coil placed inside the nose during pituitary tumor surgery to get clearer images of the tumor and nearby areas. About 70 adults with pituitary tumors will take part. The goal is to see if the coil is safe and helps surgeons find small tumors that stan…

This study aims to find better ways to tell the difference between two types of tics: those caused by known disorders and those with other causes. Researchers will use sensors on the scalp and muscles to measure brain and muscle activity in 75 adults with and without tics. Partic…

This study aims to learn more about stroke and TIA by observing up to 4,000 adults who have had or are at risk for these conditions. Researchers will collect data from standard medical tests and some extra research procedures, such as blood draws and brain scans, to track changes…

This study aims to understand how the brain responds to magnetic stimulation when it is timed with natural brain oscillations. Researchers will test healthy adults and people who had a stroke at least 6 months ago. The goal is to find ways to make brain stimulation more effective…

This study aims to understand Gulf War Illness (GWI), a condition affecting up to 210,000 veterans with symptoms like fatigue, pain, and memory problems. Researchers will compare 85 Gulf War veterans—some with GWI and some without—through a 2-week hospital stay involving blood te…

This study is testing a new, painless technique called electrical impedance myography (EIM) to see how well it measures muscle health in people with and without neuromuscular diseases. Researchers will compare EIM results with standard tests like ultrasound and nerve studies. The…

This study looks at why some people with HIV who have very low virus levels still develop thinking and memory issues. Researchers will follow 1,150 participants, including healthy volunteers, for up to 10 years with brain scans, memory tests, and blood/spinal fluid samples. The g…

This study looks at whether brain activity can predict when someone will make a mistake during a typing task, up to 1 second before it happens. Researchers will use brain scans (MRI and MEG) to measure brain signals in 40 healthy, right-handed adults aged 18-35. The goal is to un…

This study follows 1,590 adults who had COVID-19 to track their symptoms and recovery over three years. Participants complete phone interviews and online surveys every three months. The goal is to understand the range of recovery experiences and identify why some people have last…

This study aims to learn more about progressive multifocal leukoencephalopathy (PML), a rare and serious brain infection caused by the JC virus. Researchers will follow up to 700 people with suspected or confirmed PML over time, collecting samples and scans to track how the disea…

This study aims to learn more about rare inherited neurological disorders by observing up to 3,500 people with these conditions and their relatives. Researchers will collect medical history, perform exams, and take blood or skin samples to study genetics and disease progression. …

This study uses brain scans to see how people with chronic fatigue syndrome (ME/CFS) experience unpleasant sensations like pain and physical effort. Researchers will compare brain activity between 47 adults with ME/CFS and healthy volunteers while they feel mild heat or squeeze a…

This study aims to better understand epilepsy and find new ways to help people whose seizures don't improve with medication. Researchers will screen up to 1,000 adults and children aged 8 and older using tests like brain scans and EEGs. The goal is to identify participants who ma…

This study aims to improve how doctors observe nerves and muscles using ultrasound, a safe imaging technique. Researchers will collect normal measurements from healthy adults and compare them to people with neuromuscular disorders. Participants will have up to 5 clinic visits for…

This study follows 269 people aged 8 to 75 with neurofibromatosis type 2 (NF2) for up to 10 years. Researchers will track tumor growth, hearing, speech, and other health changes using yearly scans and tests. The goal is to better understand how NF2 progresses, not to test a new t…

This study aims to learn more about neurodegenerative disorders such as ALS, frontotemporal dementia, and progressive supranuclear palsy. Researchers will screen up to 360 adults with these conditions using tests like memory exams, movement assessments, MRI scans, and genetic tes…

This study aims to understand how infections and inflammation harm the brain and nerves by observing people with these conditions. Participants, aged 2 and older, will provide blood, urine, saliva, and may have MRI scans and spinal taps. No new treatments are tested; the goal is …

This study gathers medical information from 200 adults with nerve or muscle problems who are not already in other NIH studies. Researchers will perform standard tests like nerve studies, ultrasounds, and sweat measurements to create a database for future research. The goal is to …

This study looks at men with spinal and bulbar muscular atrophy (SBMA), also called Kennedy's disease, to find ways to measure how the disease progresses over time. Researchers will use muscle tests, imaging scans, and lab tests to track changes. The goal is to identify reliable …

This study uses MRI scans to follow how multiple sclerosis (MS) changes over time in up to 3750 people, including those with MS and healthy volunteers. Researchers will compare brain images with immune system markers to better understand the disease. The goal is to learn more abo…

This study is testing whether a special MRI dye called mangafodipir is safe and can better show areas of the brain affected by epilepsy in people whose seizures are not controlled by medication. About 40 adults aged 18-60 with drug-resistant epilepsy will receive the dye and have…

This study looks at how well different brain scan methods can find the exact spot in the brain where seizures start in people with epilepsy that doesn't get better with medicine. Researchers will compare scan results before and after surgery to see which methods work best. They w…

This study tests whether a radioactive tracer can help PET scans detect certain immune cells in the brain and spinal cord of people with multiple sclerosis (MS) or progressive multifocal leukoencephalopathy (PML). About 15 adults will receive the tracer and undergo scans to see w…

This study aims to understand the genetic causes of movement disorders by studying patients and their family members. Researchers will analyze symptoms and genes to find links between them. Up to 2,500 people with movement disorders and their relatives can join. The goal is to im…

This study aims to understand how multiple sclerosis (MS) damages the brain and spinal cord over a person's lifetime. Researchers will follow 250 adults with MS or similar conditions, using yearly MRI scans, eye tests, and other exams. Participants agree to donate their brain and…

This study compares a new portable ultra-low field (ULF) MRI to standard MRI for detecting brain diseases like stroke, cancer, and epilepsy. About 200 people (ages 3 and older) with or without neurological symptoms will get both scans to see if the portable version works just as …

This study aims to improve MRI technology by scanning healthy volunteers. Researchers want to collect data to make MRI measurements more accurate and reliable. Participants must be 18 or older and in good health. They will have one or more MRI scans of the brain, liver, or other …

This study aims to understand how the binding of RNA with DNA (called R-loops) is linked to amyotrophic lateral sclerosis type 4 (ALS4) and other inherited neurological disorders. Researchers will observe up to 330 people aged 5 and older, including those with ALS4, related condi…

This study follows people with HTLV-I-associated myelopathy (HAM/TSP), a rare spinal cord disorder, to learn how the disease changes over time. Up to 750 participants, including infected individuals, family members, and healthy volunteers, will provide blood and spinal fluid samp…

This study aims to find out if people with long COVID still have inactive pieces of the SARS-CoV-2 virus hiding in their bodies. Researchers will collect tissue samples from 12 adults who have recovered from COVID-19, some with long-term nerve symptoms and some without. The goal …