Brain scans reveal why effort feels worse for some

NCT ID NCT06472622

Recruiting now Knowledge-focused Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 22, 2026 · Updated 34 times

Summary

This study uses brain scans to see how people with chronic fatigue syndrome (ME/CFS) experience unpleasant sensations like pain and physical effort. Researchers will compare brain activity between 47 adults with ME/CFS and healthy volunteers while they feel mild heat or squeeze a bar. The goal is to understand which brain regions are linked to these feelings, not to test a treatment.

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Contacts and locations

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Study contacts

Contact

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Contact

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Locations

National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

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FATIGUE SYNDROME, CHRONIC