National Institute Of Neurological Disorders And Stroke (ninds)

This early-stage study tested the safety of a new gene therapy for people with advanced Parkinson's disease. Researchers delivered a gene (AAV2-GDNF) directly into the brain to help protect and strengthen the brain cells damaged by the disease. The main goal was to see if this ex…

This small, early-stage study tested if a drug called NT-I7 could help people with a rare and serious brain infection called PML. PML happens when the immune system is weak. Researchers gave NT-I7 to 12 adults with PML to see if it safely increased their infection-fighting white …

This early-stage study tested whether a special immune cell therapy could safely treat a severe brain infection called PML. Researchers took virus-fighting immune cells from a healthy family member, grew more of them in a lab, and infused them into patients with PML to see if the…

This study aimed to better understand why women with endometriosis experience chronic pelvic pain. Researchers examined 78 women to explore how hormones, immune system chemicals, stress, and genes might be involved in creating and maintaining pain. The goal was to gather detailed…

This study aimed to better understand traumatic brain injury by observing how it develops and changes over time. Researchers followed 886 adults who recently experienced head injuries, using MRI scans, blood tests, and brain function assessments during hospital stays and follow-u…

This study aims to develop a better way to predict who might develop multiple sclerosis (MS). Researchers are testing a new risk score that combines information about a person's genes, medical history, and environmental factors. They are studying people with MS and their close fa…

This study aimed to understand how symptoms develop and change over time in people who carry a specific genetic mutation that causes ALS (Lou Gehrig's disease) and frontotemporal dementia. Researchers followed 50 adults with this mutation for up to three years, conducting brain s…

This study aimed to find biological markers that could identify people at risk for Parkinson's disease before they show any movement symptoms. Researchers followed 89 people with multiple risk factors (like family history or loss of smell) for up to 7.5 years, testing their brain…

This study screened over 3,800 people to better understand neurological conditions and identify participants for future research. It evaluated patients with nervous system disorders, their family members, and healthy volunteers. No experimental treatments were given—the goal was …

This small, early-stage study tested whether a single dose of the cancer drug pembrolizumab is safe for people with well-controlled HIV. The main goal was to check for safety, not to treat HIV. Researchers also wanted to see if the drug could help reveal if the virus was hiding i…

This study aimed to understand why some people continue to have neurological symptoms like dizziness, brain fog, or weakness long after recovering from COVID-19. Researchers at the National Institutes of Health performed detailed brain scans, memory tests, and nervous system exam…

This study aimed to find the genes that cause Chiari I malformation, a condition where part of the brain pushes into the spinal canal. Researchers studied families with multiple affected members to look for shared genetic patterns. Participants underwent MRI brain scans and gave …

This study aimed to learn more about how the brain controls movement and what goes wrong in disorders like Parkinson's disease and Tourette's syndrome. Researchers compared over 1,200 healthy volunteers with about 1,000 patients using non-invasive brain scans and tests. The goal …

This study aimed to understand the long-term effects of Ebola virus disease on the brain and nervous system in people who had the disease as children. Researchers in Liberia examined 328 participants, including survivors and their close contacts, more than five years after the in…

This study aimed to better understand how the brain controls movement and what causes tremors in conditions like Parkinson's disease and essential tremor. Researchers observed and measured brain activity in 85 participants, including people with tremor and healthy volunteers, usi…

This study aimed to understand what goes wrong in the brains of people with dystonia, a disorder that causes muscles to contract and twist involuntarily. Researchers used MRI and PET brain scans on 31 adults, some with cervical dystonia and some healthy volunteers, to measure a s…

This study aimed to understand how different layers of the brain's movement center help us learn and remember new physical skills, like typing a sequence. Researchers used advanced brain scans on 40 healthy adults while they practiced and rested during a simple typing task. The g…

This study explored how safe, non-invasive brain stimulation techniques affect movement and brain activity in healthy people. Researchers tested different stimulation settings to understand how they change motor function and brain signals. The goal was to gather information to de…

This study followed 81 stroke patients for up to 6 years to understand how damage to the brain's protective barrier relates to worsening brain changes seen on scans. Researchers used regular MRI scans with a special dye to track whether a 'leaky' blood-brain barrier predicts the …

This study aimed to understand how the brain changes in Parkinson's disease over time. Researchers used detailed brain scans (MRI) to compare 62 adults with definite Parkinson's, possible early signs, and healthy volunteers. Participants were followed for up to 9 years to see if …

This study tested whether an FDA-approved iron supplement called ferumoxytol could be used as a special dye to make inflammation in the brain show up more clearly on powerful MRI scans. Researchers enrolled 14 adults, some with multiple sclerosis and some healthy, to see if the i…