National Institute Of Neurological Disorders And Stroke (ninds)

This study tested a gene therapy for giant axonal neuropathy (GAN), a rare genetic disease that damages nerves and makes walking, eating, and breathing difficult. Fourteen people aged 3 and older received a single injection of the therapy into the fluid around their spinal cord. …

This early-phase study tested a drug called NT-I7 in 12 adults with progressive multifocal leukoencephalopathy (PML), a rare and serious brain infection caused by a virus. The goal was to see if NT-I7 could increase the number of infection-fighting white blood cells (lymphocytes)…

This study tested a gene therapy that delivers a protective protein (GDNF) directly to the brain to help strengthen cells damaged by Parkinson's disease. 25 adults with advanced Parkinson's received the treatment through a special infusion during surgery. The main goal was to che…

This early-phase study tested whether giving special immune cells (PyVST) from a healthy relative could safely treat progressive multifocal leukoencephalopathy (PML), a serious brain infection in people with weakened immune systems. Sixty adults with PML received up to three infu…

This study followed 50 adults with a specific gene mutation (C9ORF72) that can cause either ALS or frontotemporal dementia. Researchers tracked changes in strength, thinking, memory, and behavior over three years using brain scans, spinal fluid tests, and other exams. The goal wa…

This study looked at whether a score that combines genetic and environmental factors can help predict who might develop multiple sclerosis (MS). Researchers studied 181 people, including those with MS and their close relatives. Participants provided medical history, blood, and sa…

This study aimed to learn more about why people have tremors by observing brain activity and movement in 85 adults with conditions like Parkinson's disease, essential tremor, or dystonia, as well as healthy volunteers. Participants completed tasks while researchers used tools lik…

This study looked at whether ferumoxytol, an iron-based contrast agent, can help spot inflammation in the brains of people with multiple sclerosis (MS) using a powerful 7 Tesla MRI. Fourteen participants (some with MS, some healthy) received ferumoxytol and had multiple MRI scans…

This study looked at how specific layers in the brain's motor area help us learn and remember new movement skills, like typing a sequence. Forty healthy, right-handed adults practiced key sequences and had brain scans to see which layers were active. The goal was to understand th…

This study followed 81 adults who had stroke-like symptoms to see how damage to the blood-brain barrier relates to white matter changes in the brain. Participants had MRI scans and thinking tests over 6 years. The goal was to learn more about these changes, not to test a treatmen…

This study tested various noninvasive brain and nerve stimulation techniques, like magnetic or electrical stimulation, to see how they affect movement in healthy volunteers. Over 1,000 adults aged 18 and older took part in up to 20 sessions each. The goal was to find the best sti…

This study looked at how a brain chemical called acetylcholine works in people with dystonia, a condition that causes muscles to contract on their own. Researchers used PET and MRI scans to compare brain activity in 31 adults with dystonia and healthy volunteers. The goal was to …

This study used brain scans to understand how Parkinson's disease changes the brain over time. Researchers compared people with definite or possible Parkinson's to healthy volunteers. Participants had up to 6 visits over 9 years for MRI scans and symptom checks. The goal was to f…

This study examined 328 children who either survived Ebola or were close contacts, to understand long-term brain and nerve problems. Researchers tested memory, thinking, and physical abilities, and checked for symptoms like headaches or tremors more than 5 years after infection. …

This study screened over 3,800 people with neurological conditions and healthy volunteers to collect information for future research. No treatments were given. The goal was to understand these conditions better and find suitable participants for other studies.

This study looked at the genetic causes of Chiari I malformation, a condition where part of the brain extends into the spinal canal. Researchers studied 152 people, including patients and their family members, using MRI scans and blood samples to find gene locations linked to the…

This study looked for early biological signs (biomarkers) of Parkinson disease in 89 people who had certain risk factors, like a family history or loss of smell. Participants underwent a series of tests, including brain scans, blood draws, and spinal taps, and were followed for s…

This study looked at how the brain controls movement in adults with conditions like Parkinson's disease, Tourette's syndrome, and dystonia, compared to healthy volunteers. It used brain scans and other tests to gather information, but did not provide any treatment. The goal was t…

This study followed 180 adults with syringomyelia (a fluid-filled cyst in the spinal cord) or related conditions for up to 5 years. Researchers tracked symptoms, muscle strength, and MRI scans to learn how the disease progresses and how surgery affects outcomes. The goal was to g…

This early study tested whether a single dose of the cancer drug pembrolizumab is safe for people with well-controlled HIV. Researchers wanted to see if the drug could help reveal HIV that may be hiding in the brain. Thirteen adults with HIV took part, and the main goal was to ch…

This study looked at 13 adults who had COVID-19 and still had symptoms like memory or smell problems after recovery. Researchers used brain scans, memory tests, and other exams to find possible long-term changes in the nervous system. The goal was to better understand how COVID-1…

This study looked at people who had a recent head injury to learn more about how traumatic brain injury (TBI) affects the brain over time. Researchers used MRI scans and thinking tests to track changes for up to three months after the injury. The goal was to find better ways to d…

This study looked at 78 women to understand why standard treatments for endometriosis often fail to relieve chronic pelvic pain. Researchers examined the roles of hormones, immune chemicals, stress, and genetics, and how nerves and muscles contribute to pain. The goal was to gath…