Could donor immune cells beat a rare brain infection?
NCT ID NCT02694783
First seen Oct 31, 2025 · Last updated May 20, 2026 · Updated 21 times
Summary
This early-phase study tested whether giving special immune cells (PyVST) from a healthy relative could safely treat progressive multifocal leukoencephalopathy (PML), a serious brain infection in people with weakened immune systems. Sixty adults with PML received up to three infusions of these lab-grown virus-killing cells. The main goal was to check safety and feasibility, with secondary aims to see if brain lesions and symptoms improved.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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National Institutes of Health Clinical Center
Bethesda, Maryland, 20892, United States
Conditions
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