National Institute Of Neurological Disorders And Stroke (ninds)

This early-stage trial tests whether a single dose of pembrolizumab (Keytruda), a drug used for cancer, can safely reduce long-term neurological symptoms like brain fog and dizziness in people with long COVID. Fifteen adults who had COVID-19 at least six months ago and still have…

This pilot study tests whether transcranial magnetic stimulation (TMS), a noninvasive technique that uses magnetic pulses to influence brain activity, can reduce chronic neuropathic pain. Researchers target a brain network involved in assigning value to experiences, based on each…

This early-stage trial tests a drug called resiniferatoxin (RTX) for people with severe bone pain from cancer that hasn't been helped by standard treatments. About 30 adults will receive a single injection into the spine to see if it safely reduces pain. The study will track pain…

Researchers are testing whether a contrast dye called gadobutrol, injected into the fluid around the brain and spinal cord, can safely improve MRI images of how that fluid flows. Healthy volunteers aged 18 and older will receive the dye and undergo several brain scans over a week…

This study follows 70 people with PRKN- or PINK1-linked Parkinson's disease, as well as those with typical Parkinson's and healthy volunteers, over 5 years. Researchers will track movement, thinking, and mood symptoms, and collect blood, urine, and optional spinal fluid or muscle…

This study aims to build a registry of healthy adults aged 18 and older who have been prescreened for future research at the National Institute of Neurological Disorders and Stroke (NINDS). Volunteers undergo a single visit lasting about 5 hours, which includes a physical exam, n…