Hepatitis b mutations linked to higher virus levels
NCT ID NCT03625258
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at how certain genetic changes (mutations) in the hepatitis B virus (HBV) affect the amount of virus in the blood of people with chronic infection. Researchers analyzed blood samples from 92 patients not on antiviral treatment. They found that specific mutations in the pre-core and core promoter regions of the virus are linked to higher viral loads, which may influence liver damage. The goal is to better understand which viral strains are more aggressive.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this research could help identify which HBV mutations lead to higher viral loads, potentially guiding future treatment decisions.
- What could go wrong
- This is an observational study, not a treatment trial. It aims to understand the virus better, but may not directly lead to new therapies.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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200 people
The number who actually took part.
- Started
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Jan 2009
- Finished
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Feb 2017
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
the study will be carried out from the blood samples following consultations Hepatogastroenterology in the clinical follow-up of patients chronically infected with HBV. Blood samples are stored in the Virology laboratory as part of legislation on the conservation of samples during Virology analyzes.
- Ages
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18 years and older
- Sex
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Anyone
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients included will be chronic carriers (HBsAg + for more than 6 months) of HBV, with detectable serum viral load greater than or equal to 100 IU / mL, included in the queue followed by Drs. Dominique Capron and Eric N'Guyen-Khac. These patients will not be on anti-HBV treatment. Exclusion Criteria: * Patients under 18 years old * Patients with their hepatitis B * Patients with HBV viral load undetectable or less than 100 IU / mL. * Immunosuppressive treatments such as corticosteroids or other * The co-infection with the hepatitis C and / or HIV virus * Patients with cancer
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CHU Amiens-Picardie
Amiens, 80054, France
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