Chronic renal failure syndrome

This study tests whether people with chronic kidney disease can safely eat potassium-rich fruits and vegetables instead of following the usual low-potassium diet. Thirty participants will receive home-delivered groceries with either high- or low-potassium produce in a random orde…

This study tests whether a new drug called vicadrostat, combined with the existing drug empagliflozin, can help people with chronic kidney disease (CKD) that is getting worse. About 492 adults with CKD will be randomly assigned to start both drugs together or one after the other …

Researchers are testing whether a ketone supplement drink can reduce protein in the urine and improve kidney function in people with chronic kidney disease or polycystic kidney disease. The study includes 45 participants who receive either the ketone drink or a placebo for four w…

Researchers are testing whether finerenone, semaglutide, or the two together can lower albuminuria, a marker of kidney damage, in adults with chronic kidney disease. About 41 participants receive each treatment in turn, with urine protein measured throughout. The trial also check…

This Phase 2 trial tests whether tirzepatide, a drug already used for diabetes and weight loss, can improve kidney health in 140 people with obesity and chronic kidney disease (with or without type 2 diabetes). Researchers will use MRI scans to measure changes in kidney fat and b…

This study tests a new pill, vadadustat, taken three times a week, against the usual injected medicine for anemia in people with kidney failure who are on dialysis. About 350 adults will take part to see if the pill can safely keep their red blood cell levels in a healthy range. …

This trial tests whether a device that electrically stimulates the diaphragm during breathing, combined with inspiratory muscle training, can improve diaphragm function and clinical outcomes in people with moderate COPD. Participants aged 40 to 70 with stable COPD will receive ei…

This study tested a new dialysis filter called ELISIO-HX in 22 adults with kidney failure. Participants used the new filter three times a week for 12 weeks. The goal was to see if it safely maintained albumin levels while improving removal of certain waste products. The trial is …

This study looked at whether taking kefir peptides for three months could help people with stage 3 or 4 chronic kidney disease. Researchers measured kidney function, protein in urine, and signs of inflammation. The goal was to see if this supplement could support disease control,…

This trial tests whether an oral drug called roxadustat can treat anemia in people with diabetic nephropathy and chronic kidney disease as effectively as the standard erythropoietin injections. About 64 adults aged 18 to 75 will receive either roxadustat pills three times a week …

This study tests whether a digital dashboard can help people with chronic kidney disease in China better manage their own care. Participants and their healthcare providers receive training on using the secure online tool, which is designed to support self-management. The study wi…

This study looks at whether deep cleaning for gum disease can improve kidney health in people with uncontrolled type 2 diabetes. 46 adults with both conditions will either get gum treatment right away or after a delay. Researchers will measure kidney markers like creatinine and u…

This trial asks whether an intravenous (IV) injection of vitamin B12 works better than oral tablets to correct B12 deficiency in adults on long-term hemodialysis. Participants receive either a weekly IV dose after dialysis or oral tablets three times a day for four weeks. Researc…

This early-stage trial is testing an experimental drug called INZ-701 in adults with end-stage kidney disease who are on hemodialysis and have low levels of a natural substance called pyrophosphate, which helps prevent calcium buildup in blood vessels. The study aims to see if we…

This trial tests whether hydroxychloroquine, an anti-inflammatory drug, can reduce cardiovascular disease risk in people with chronic kidney disease (CKD). Participants with moderate-to-severe CKD will receive either hydroxychloroquine or a placebo for 18 months. Researchers will…

This trial tests whether adding specially formulated low-protein foods (FLAVIS products) to a standard low-protein diet helps people with chronic kidney disease (stages 3a-5) better control their protein intake. Participants will be randomly assigned to either a low-protein diet …

This trial tests whether sacubitril/valsartan, a newer heart failure medication, is safer and more effective for the kidneys than ramipril, an older ACE inhibitor, in people hospitalized with acute decompensated heart failure who also have chronic kidney disease. About 515 partic…

This phase 2 trial is testing whether colchicine, a drug used for gout, can safely reduce inflammation and potentially lower heart injury in people with advanced chronic kidney disease or on dialysis. Participants take colchicine daily for 16 weeks, starting at a low dose and the…

This pilot study tested whether a multicultural anti-inflammatory diet is practical and acceptable for racial/ethnic minorities with chronic kidney disease (CKD). Researchers enrolled 18 adults with stage 3 CKD in the Bronx, providing dietary counseling tailored to each person's …

This study tested a drug called TOUR006 in 143 adults with chronic kidney disease and high levels of a protein linked to inflammation (hs-CRP). The goal was to see if monthly or quarterly shots could safely lower inflammation. The study is complete, and results will show if the d…

This trial tests whether a combination of everolimus and low-dose tacrolimus is better than the standard tacrolimus plus mycophenolate mofetil at preventing serious long-term complications in children who have had a heart transplant. The study will follow 211 participants from 25…

This trial tests whether a structured nurse-led education program can improve how hemodialysis patients approach diet therapy, self-care, and chronic disease self-management. Sixty adults on maintenance hemodialysis are randomly assigned to either the eight-session program or usu…

This Phase 3 trial is testing whether a monthly injection of ziltivekimab can reduce the risk of heart attacks and strokes in 6,200 people who already have heart disease, chronic kidney disease, and signs of inflammation. Participants receive either the drug or a placebo for up t…

This trial investigates whether drinking fig leaf tea twice a day for 8 weeks, along with a low-glycemic diet, can help protect kidney function in adults with type 2 diabetes and stage 2 chronic kidney disease. Researchers will measure changes in blood sugar, cholesterol, and kid…

This study tested whether adding the drug atrasentan to standard care (including SGLT2 inhibitors) can reduce protein in the urine of people with IgA nephropathy, a kidney disease. 54 adults with biopsy-confirmed IgA nephropathy participated. The main goal was to see if atrasenta…

This study tests whether a peer coaching program delivered by phone and text can help adolescents and young adults (ages 16–22) with chronic conditions like sickle cell disease, diabetes, or cystic fibrosis improve their self-management skills. Participants are paired with a trai…

This study tests a support program for people with type 2 diabetes and chronic kidney failure who struggle to take their medications regularly. Participants receive an electronic pill bottle that tracks when they open it, plus short motivational interviews with a pharmacist. The …

This study investigates whether taking two medications—finerenone and empagliflozin—together can better slow kidney function decline in people with chronic kidney disease and type 2 diabetes compared to taking either drug alone. Participants are randomly assigned to receive the c…

This study looks at whether canagliflozin, a drug used for diabetes, can safely reduce protein in the urine (a sign of kidney damage) in people with advanced chronic kidney disease (CKD), including those on dialysis. About 35 adults with CKD stage 4 or 5 will take the drug for up…

This study tests two strategies in low-income seniors with chronic conditions like heart disease, diabetes, or kidney disease. One group gets free preventive medications (no copayment), and another receives personalized education on medication use and lifestyle. The goal is to se…

This study tests whether a 3-month community program combining nutrition education, cooking classes, and exercise can improve health outcomes for people with Cardiovascular Kidney Metabolic (CKM) syndrome—a cluster of conditions including diabetes, high blood pressure, high chole…

This study tested whether adding balcinrenone to the standard drug dapagliflozin helps people with chronic kidney disease more than dapagliflozin alone. 324 adults with kidney disease and protein in their urine took either a combination pill or dapagliflozin alone for 12 weeks. R…

This completed Phase 4 trial tested two drugs—dapagliflozin and spironolactone—alone and together in 12 adults with Alport syndrome, a genetic kidney disease. The goal was to see if these drugs could lower protein levels in urine, a key sign of kidney damage. Participants took ea…

This early-phase study tested whether stem cells taken from a patient's own urine (called KDSTEM Inj.) are safe for people with chronic kidney disease. Six participants received low or high doses of the cells through an IV. The main goal was to check for side effects, while also …

This study tested whether quickly alerting a kidney specialist team when hospitalized patients show signs of severe kidney disease could improve survival. Over 1,100 patients in France were included. The team of a nephrologist and pharmacist would help manage care during the hosp…

This study tested a new drug called BAY3283142 in 75 people with mild to moderate high blood pressure. The drug is designed to relax blood vessels and is being developed for chronic kidney disease. Participants took different doses or a placebo for up to 10 weeks to check for saf…

This completed study tested whether eating more fruits and vegetables or taking sodium bicarbonate (baking soda) tablets can slow the progression of chronic kidney disease and reduce heart risks in people with high blood pressure and kidney damage. 108 non-diabetic adults with st…

This study tested whether reducing dietary acid with fruits and vegetables or sodium bicarbonate (baking soda) can slow chronic kidney disease in people with high blood pressure. 153 participants were followed for 5 years to measure kidney function and heart risk markers. The goa…

This completed study tested whether adding AC-134, a dietary supplement, to a low-protein diet helps protect kidney function in people with chronic kidney disease. Researchers measured kidney function, protein in urine, and waste products in the blood of 100 adults aged 20-90 wit…

This study looked at whether a 24-week exercise program can improve physical fitness, muscle strength, and overall health in people who received a kidney transplant. 345 adults joined the study six months after their transplant. Researchers compared those who exercised with those…

This phase 2 trial tested whether adding the experimental drug lorundrostat to standard SGLT2 inhibitor therapy can lower blood pressure in adults with chronic kidney disease and albuminuria (protein in urine). Sixty participants received either lorundrostat or a placebo for four…

This study tested whether a smart app called Weiyin Health could improve follow-up care for 223 adults on peritoneal dialysis for kidney failure. One group used the app for reminders, AI questions, and risk alerts, while the other got standard care via WeChat and phone calls. The…

This study tested a tailored lifestyle counseling program for 120 adults with early-stage chronic kidney disease (CKD). Participants received personalized advice based on their readiness to change, focusing on diet, exercise, and kidney health knowledge. The goal was to see if th…

This completed study tested an oral supplement made from generally recognized as safe (GRAS) ingredients in 8 people with end-stage kidney disease. Two participants had not produced urine for 16 and 22 years. The goal was to see if the supplement could restore even a small amount…

This study tested whether a daily supplement called Avmacol Extra Strength, which contains sulforaphane from broccoli seeds, can slow kidney disease progression in people with stage 3 or 4 chronic kidney disease. The trial enrolled 96 adults and compared the supplement to a place…

This study compared two types of dialysis in 415 older adults (ages 65-90) with chronic kidney failure: online hemodiafiltration and conventional hemodialysis. The goal was to see which method is better tolerated and whether it reduces heart problems and other complications. Pati…

This study tested an experimental drug, ziltivekimab, in 36 adults with advanced chronic kidney disease (not on dialysis) to see if it can safely reduce inflammation and related heart risks. Participants received either a low dose, a high dose, or a placebo injection every 4 week…

This study tested a device that uses ultrasound to calm overactive nerves in the kidneys, which can drive high blood pressure. Researchers enrolled 44 people with stage 3 chronic kidney disease and uncontrolled hypertension. Half received the real procedure, half a sham, to see i…

This study tested whether a drug called Lokelma (SZC) can help people with both chronic kidney disease and heart failure safely reach higher doses of life-saving heart medications (RAAS inhibitors) without dangerous potassium spikes. 112 adults with stable kidney disease and hear…

This study looked at whether a 12-week program of exercise, a protein-controlled diet, and education could improve health in people with early-stage kidney disease (stages G1 and G2). Fifteen participants completed the program. Researchers measured changes in cholesterol, muscle …

This study looked at whether taking a prebiotic fiber (resistant starch) and doing moderate aerobic exercise for 16 weeks could reduce inflammation and improve blood vessel health, thinking, and mood in people with stage 3-4 chronic kidney disease. 68 patients were randomly assig…

This study tested whether baricitinib, a drug used for arthritis, can safely reduce high protein levels in the urine of African American adults with a specific genetic form of kidney disease (APOL1). Eight participants took the drug to see if it lowered their urine protein and pr…

This study tested a new drug called DISC-0974 in 55 adults with chronic kidney disease (not on dialysis) who also have anemia. The goal was to check the drug's safety and how the body processes it. Participants received either the drug or a placebo by injection. The results will …

This study tested a once-daily pill called orforglipron against insulin glargine in nearly 2,750 adults with type 2 diabetes, obesity or overweight, and increased cardiovascular risk. The main goal was to see if orforglipron could reduce major heart events like heart attacks or s…

This pilot study tested whether giving produce vouchers to 100 adults with chronic kidney disease and food insecurity could improve their health. Participants received $40-$60 in vouchers every two weeks for six months. Researchers measured changes in food security, diet quality,…

This study tested a special dialysis fluid called icodextrin in 439 adults with chronic kidney failure who use peritoneal dialysis at home. The goal was to see if it works better than standard glucose solutions for overnight exchanges and to check for side effects. Researchers tr…

This study tested whether taking probiotics or synbiotics (probiotics plus fiber) for 6 months could improve health in 60 adults with kidney failure on dialysis. Researchers measured changes in blood toxins, heart health, quality of life, and thinking ability. The goal was to see…

This study tested a drug called patiromer in 262 Chinese adults with chronic kidney disease and high potassium levels. Participants took patiromer for 4 weeks, then some switched to placebo for 8 weeks to see if potassium stayed controlled. The goal was to manage potassium safely…

This study tested a new drug called BAY 3283142 in 1222 adults with chronic kidney disease and high protein in their urine. Participants took either the drug or a placebo on top of their usual treatments for 16 weeks. The goal was to see if the drug could lower urine albumin leve…

This study followed 27 HIV-positive people with kidney failure who received a kidney transplant. All were on a three-drug HIV treatment including Raltegravir. The goal was to see how many had graft rejection within 6 months, using blood tests and kidney biopsies.

This study looked at whether dapagliflozin, a diabetes drug, can reduce protein in the urine (proteinuria) in people who have had a kidney transplant and have chronic kidney disease. Researchers followed 55 patients for 6 months to see if the drug lowered protein levels and prote…

This study tested whether a new training package called TEACH-PD could lower infection rates in patients starting peritoneal dialysis (PD). Over 1,400 adults from multiple countries were randomly assigned to receive either the TEACH-PD training or standard PD training. The resear…

This study tested whether a new medicine called CagriSema (a combination of two drugs) can reduce kidney damage in people with chronic kidney disease, type 2 diabetes, and overweight or obesity. About 626 participants received either CagriSema, one of the two drugs alone, or a pl…

This study tested whether an educational worksheet plus health coaching could help people with chronic kidney disease improve their blood pressure. 320 adults with moderate to severe kidney disease and uncontrolled high blood pressure took part. The goal was to see if the coachin…

This study tested whether a low dose of the blood thinner rivaroxaban (Xarelto) could reduce major heart problems like heart attacks and strokes in people with advanced chronic kidney disease or kidney failure on dialysis. About 1,753 participants were randomly assigned to receiv…

This pilot study tested whether using central blood pressure (measured near the heart) instead of the usual arm cuff leads to better outcomes in 116 people with advanced chronic kidney disease. Participants were randomly assigned to either a central BP target or a standard arm BP…

This study tested an experimental cell therapy called REACT (rilparencel) in 53 adults with type 1 or 2 diabetes and chronic kidney disease. The therapy involves injecting a person's own kidney cells into their kidneys to see if it can slow the loss of kidney function. The goal i…

This study tested whether an extended-release version of the diuretic torsemide helps heart failure patients get rid of more salt after lunch compared to the standard immediate-release version. Twenty adults with stable heart failure took both forms in a random order, and researc…

This pilot study tested a combined bone marrow and kidney transplant from a partially matched family donor in 10 people with both a blood disorder and chronic kidney disease. The goal was to treat both conditions at once and possibly reduce the need for lifelong anti-rejection dr…

This study tested the drug dapagliflozin (a diabetes medicine) against a placebo in 220 people on dialysis for kidney failure, with or without diabetes. The goal was to see if the drug could improve heart structure and be safe. Participants took the drug or placebo for a period, …

This study tested a new drug called zilebesiran in 375 adults with high blood pressure that wasn't controlled by their current medications. Participants received either zilebesiran or a placebo as an add-on to their usual pills. The goal was to see if zilebesiran could lower bloo…

This study tested whether a once-weekly injection of exenatide (a diabetes drug) can protect the heart and kidneys in 57 adults with type 2 diabetes and mild kidney problems. Participants received either exenatide or a placebo for 38 weeks. Researchers measured blood and urine ma…

This study tested whether people with type 2 diabetes and kidney damage can safely participate in a clinical trial from home. Twelve participants took the drug empagliflozin, and depending on their response, some added or switched to finerenone. The goal was to see if remote data…

This study looked at whether community health workers (CHWs) can help low-income, mostly minority adults better manage chronic diseases like diabetes, high blood pressure, and obesity. Over 10 months, 202 participants either received CHW support plus standard care or just standar…

This study tested an experimental drug called MK-2060 in 506 adults with end-stage kidney disease who need regular dialysis through a special tube (graft) in their arm. The goal was to see if the drug could prevent dangerous blood clots from blocking the graft, which would requir…

This study tested an automated insulin delivery system (a smart pump) in 15 adults with type 1 or type 2 diabetes who also had advanced kidney disease or were on dialysis. Participants used the system for 8 weeks, then switched to their usual care for another 8 weeks. The goal wa…

This study tested a digital program called DDEP, delivered through the LINE messaging app, to help people with chronic kidney disease (CKD) and their care partners make healthy lifestyle changes. Over six months, 208 participants either received the DDEP plus usual care or usual …

This small completed study looked at a blood filtering procedure called double-filtration plasmapheresis (DFPP) in 5 kidney dialysis patients with very high levels of lipoprotein(a), a fatty substance linked to heart disease and blood clots. The goal was to see if DFPP could lowe…

This study looked at whether a 12-week course of dapagliflozin can improve blood vessel function in people with chronic kidney disease. 32 participants took the drug, and researchers measured changes in artery health using ultrasound. The goal was to see if the drug could help co…

This study tested whether a thorough medication review at hospital admission and discharge could reduce mistakes and prevent patients with chronic kidney disease from being readmitted within 90 days. Researchers compared 323 patients who received this extra service to a similar g…

This study tested whether dapagliflozin, a drug typically used for diabetes, can slow kidney decline, improve anemia, and support heart health in 100 adults with chronic kidney disease who do not have diabetes. Participants took either the drug or a placebo daily for 12 months al…

This study tested a new medicine, BI 764198, in 67 adults with a kidney disease called FSGS. Participants took different doses of the medicine or a placebo daily for 12 weeks. The goal was to see if the medicine could reduce protein in the urine, a sign of better kidney health. T…

This study tested a drug called MCI-196 in 245 adults on dialysis who have high phosphate levels, a common problem in advanced kidney disease. After a 4-week washout and 12-week dose adjustment, patients were randomly assigned to continue MCI-196 or switch to a placebo for 4 week…

This study tested the long-term safety of a drug called MCI-196 (Colestilan) in 116 adults with stage 5 chronic kidney disease who are on dialysis and have high phosphorus levels. Participants took flexible doses of the drug for 52 weeks. The main goal was to see how many side ef…

This study tested a drug called MCI-196 in 336 adults on dialysis with chronic kidney disease and high phosphorus levels. After a washout period, some patients received MCI-196 and others a placebo to see if the drug could safely lower phosphorus. The goal was to manage a common …

This Phase 3 trial tested MCI-196, a drug that binds phosphorus and lowers cholesterol, in 642 adults on dialysis with chronic kidney disease. Participants received either MCI-196 or a placebo for 12 weeks. The goal was to see if the drug could safely reduce both serum phosphorus…

This large Phase 3 trial tested whether AST-120, a spherical carbon adsorbent taken as a pill, can slow the progression of chronic kidney disease. Over 1,000 adults with moderate to severe kidney disease were randomly assigned to receive AST-120 or a placebo, in addition to their…

This Phase 3 trial tested whether AST-120, a spherical carbon adsorbent taken as a powder, can slow the progression of chronic kidney disease. Over 1,000 adults with moderate to severe kidney disease received either AST-120 or a placebo alongside their usual care. The main goal w…

This study tested the long-term safety of a drug called MCI-196 in 632 adults with chronic kidney disease on dialysis who have high phosphorus levels. Participants took the drug for up to 52 weeks to see how it affected their phosphorus and cholesterol. The goal was to help contr…

This study tested a new drug called MCI-196 to lower bad cholesterol in people with advanced chronic kidney disease who are on dialysis. About 260 adults took part, comparing MCI-196 to a standard statin (simvastatin) and a placebo. The goal was to see if MCI-196 works better tha…

This study tested whether pentoxifylline, a drug used for blood flow issues, can reduce inflammation and slow kidney disease in non-diabetic patients. 42 adults with moderate chronic kidney disease took either standard therapy alone or standard therapy plus pentoxifylline for 6 m…

This early-stage trial studied how ziltivekimab works in the body of 24 Chinese adults with chronic kidney disease and signs of inflammation. Participants received either the drug or a placebo as three injections over several weeks. The study measured drug levels and safety, with…

This study tested a new drug called KBP-5074 in 162 people with moderate-to-severe chronic kidney disease whose blood pressure was still high despite treatment. Participants took either a low or high dose of the drug or a placebo daily for 84 days. The main goal was to see if the…

This study tested a drug called ziltivekimab in 264 people with advanced chronic kidney disease and high inflammation. Participants received monthly injections of either a placebo or one of three doses of ziltivekimab for six months. The goal was to see if the drug could safely l…

This study tested a program that helps low-income African Americans with diabetic kidney disease get their basic needs, like food and housing, while also providing lifestyle coaching. Fifty participants received one-on-one sessions and a device to track blood sugar and blood pres…

This study looked at 78 people with advanced kidney failure who needed a surgery to create an arteriovenous fistula (a connection between an artery and vein) for dialysis. The goal was to see if using a nerve block (axillary block) instead of local anesthesia could reduce early p…

This study tested a new device called the everlinQ endoAVF System in 24 adults with kidney failure who need dialysis. The device uses magnets and radiofrequency energy to create a connection between an artery and a vein, providing a way to access the blood for dialysis. The goal …

This study tested a device that creates a connection between an artery and a vein in the arm to make dialysis easier for people with kidney failure. Thirty-two adults with chronic kidney disease who needed dialysis took part. The main goals were to see if the connection worked we…

This completed study looked at whether remote virtual reality rehabilitation and a ketoacid supplement (Ketosteril) could help people with chronic kidney disease (stages 3b-5) who also have mild cognitive issues. The 15 participants were split into groups: one got the supplement,…

This study tested whether a daily probiotic drink could slow the buildup of calcium in blood vessels (vascular calcification) in 84 adults with advanced chronic kidney disease. Participants took either the probiotic or a placebo for 6 months, and researchers tracked changes in ki…

This completed Phase 2 trial tested two drugs, HRS-1780 and henagliflozin, in 181 adults with chronic kidney disease. Participants took the drugs or placebos for 13 weeks to see if the drugs could reduce protein in the urine, a sign of kidney damage. The study aimed to find a new…

This study tested a new device called the FLEX System that creates a connection between an artery and a vein (AV fistula) using a tube inserted through the skin, instead of surgery. The goal was to see if this method is safe and works well for people with chronic kidney disease w…

This study tested a new device called FLEX-1 that creates a special blood vessel connection (called an arteriovenous fistula) for people with advanced kidney disease who need dialysis. Sixteen adults with stage 4 or 5 chronic kidney disease took part. The goal was to see if the d…

This study looked at whether continuing a drug called sodium zirconium cyclosilicate (Lokelma) after hospital discharge helps people with chronic kidney disease maintain normal potassium levels. 186 hospitalized patients were randomly assigned to either continue the drug or recei…

This study tested a new device called FLEX-1 to create a special blood vessel connection (arteriovenous fistula) for dialysis in 17 adults with advanced chronic kidney disease. The goal was to see if the device is safe and works well for hemodialysis. The study focused on complic…

This early-stage trial tested a new drug called AZD4144 in 29 people who have both heart disease and chronic kidney disease. The main goal was to see if the drug is safe and if it lowers certain markers of inflammation in the blood. The study compared the drug against a placebo o…

This Phase 3 trial tested a new drug called AP301 in 474 Chinese adults on dialysis who had high phosphorus levels. Participants took AP301, a low dose of AP301, or the standard drug sevelamer carbonate with meals. The main goal was to see how well AP301 lowers phosphorus compare…

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This study tested a drug called daprodustat in children aged 3 months to under 18 years who have anemia due to chronic kidney disease. The goal was to see how the drug moves through the body and if it is safe. Only 4 children took part, and they received the drug for up to 52 wee…

This completed study tested a single dose of the experimental drug Gemini in 40 adults with stage 3 or 4 chronic kidney disease. The main goal was to check safety and side effects compared to a placebo. Researchers also measured how the drug moves through the body and its effect …

This Phase 3 trial tested whether finerenone, a drug already approved for kidney disease in type 2 diabetes, can also slow kidney damage in people with type 1 diabetes. 241 adults with both conditions took either finerenone or a placebo for 6 months, alongside their usual care. R…

This study tested a special collagen implant coated with sirolimus (rapamycin) placed around a new dialysis fistula during surgery. The goal was to see if it helps the fistula become usable for dialysis sooner and stay working longer. About 269 people with advanced kidney disease…

This early-stage study tested a new drug called AZD4144 in 28 adults with obesity to see if it is safe and how it affects inflammation markers in the blood. Participants took either the drug or a placebo daily for a short time. The goal was to check for side effects and measure c…

This phase 3 trial tests a sirolimus-releasing collagen implant placed around a new dialysis fistula during surgery. The goal is to help the fistula mature faster so it can be used for dialysis. The study involves 136 people aged 65+ with kidney failure who are new to hemodialysi…

This phase 2 trial tested the safety and effectiveness of metformin extended release (XR) in 12 adults with type 2 diabetes and mild to moderate chronic kidney disease (stages 1 to 3). Participants took metformin XR tablets for 6 to 12 weeks, and researchers monitored their blood…

This study tested whether sevelamer carbonate, a drug that binds phosphate in the gut, can lower levels of a hormone called FGF-23 in people with chronic kidney disease (CKD) who are not yet on dialysis. The trial included 98 adults with moderate to severe CKD and high FGF-23 lev…

This study tested whether clopidogrel, a blood thinner, could prevent early failure of arteriovenous fistulas in 877 people with kidney failure starting hemodialysis. While clopidogrel reduced the risk of fistula clotting, it did not improve the chance that the fistula would be u…

This early study tested a single shot of an experimental drug called MK-2060 in 14 people with stage 4 chronic kidney disease. The main goal was to see if it was safe and how the body handles it. Only the first part of the study was completed; the later parts were not started for…

This study tested whether a mobile game could help children aged 11-14 with chronic kidney failure better manage their condition. 68 children were split into two groups: one used the game, the other received standard education. Researchers measured changes in BMI, blood pressure,…

This completed trial tested a new drug called QRX-3 (Eseronate) in 45 people with chronic kidney disease stages 3-5. The goal was to see if the drug could slow the decline in kidney function and reduce protein in the urine. The study compared changes in kidney function over time.

This study tested whether the usual vitamin D doses given to children with chronic kidney disease, kidney transplants, or nephrotic syndrome are enough to raise their vitamin D levels to a healthy range. Forty-three children received vitamin D vials based on their weight and star…

This study looked at whether people with kidney failure who still have some kidney function can do well with only two dialysis sessions per week instead of the usual three. Fifty-eight patients each tried both schedules for four weeks. Researchers measured quality of life, sympto…

This study evaluates a portable digital test called KF4+ that measures urea and potassium from a tiny drop of capillary blood, like a finger prick. The trial involves 55 adults with end-stage kidney disease who are on dialysis. The goal is to see if the KF4+ results match standar…

This study uses machine learning to tell apart diabetic kidney disease from other kidney diseases in people with type 2 diabetes. Researchers analyzed data from over 2,200 patients across 14 medical centers to build a model that uses routine clinical and lab information. The goal…

This study tested a short questionnaire called SCORED to see if it can accurately identify adults in Asia who are at risk for chronic kidney disease (CKD). Over 1,400 people took part across multiple hospitals. Researchers measured how well the questionnaire predicted kidney prob…

This study tested whether a small, chest-worn ECG device can detect high potassium levels (hyperkalemia) in people with chronic kidney disease undergoing dialysis. Thirty-two patients wore the device during dialysis sessions, and the ECG readings were compared with blood test res…

This study tested whether advanced ultrasound techniques can predict if an arteriovenous fistula (AVF) will work for dialysis in people with end-stage kidney disease. Researchers measured artery stiffness and blood flow in 76 patients before and after AVF surgery. The goal was to…

This study looked at tiny particles called extracellular vesicles found in urine to see if they can help tell the difference between healthy kidneys and chronic kidney disease. Researchers measured these particles in 143 people, including healthy volunteers and patients with kidn…

This trial asks whether giving dialysis patients four doses of a double-strength hepatitis B vaccine offers better protection than the standard three doses. People with kidney failure on dialysis often respond weakly to vaccines, leaving many unprotected. The study will compare a…

This trial tests whether screening for chronic kidney disease (CKD) in trusted community settings, like churches, can identify people with early kidney damage who don't yet have symptoms. Participants are adults aged 18-70 without known kidney disease who attend community health …

This study tested whether pentoxifylline, a drug that improves blood flow, can prevent kidney damage caused by contrast dye used in medical imaging. The trial included 70 adults with chronic kidney disease who were in the intensive care unit and needed contrast dye. Researchers m…

This study tested whether regular retraining on infection prevention can lower peritonitis rates in new peritoneal dialysis patients. Over 700 adults from eight European countries were randomly assigned to either standard care or extra testing and retraining on dialysis technique…

This study tested two non-drug methods—reflexology (foot massage) and sleep hygiene education—to improve sleep and comfort in 60 adults on hemodialysis. Both approaches helped, but reflexology was more effective. The results suggest a simple, drug-free option for better rest in d…

Researchers are testing whether a guided mindfulness program can help adults with end-stage kidney disease who receive hemodialysis. The program involves listening to audio recordings for 30 minutes, three times a week for five weeks, during regular dialysis sessions. The study m…

This study tests whether a guided internet-based education and support program can help people with severe kidney failure who are waiting for a kidney transplant. The program includes 9 weekly modules covering kidney disease, treatment, self-care, and coping strategies. Researche…

This study tests whether a special teaching method called Pecha Kucha can help people on hemodialysis better follow their fluid and diet restrictions. The method uses a fast, visual slideshow to make information easier to remember. 70 patients will be split into two groups: one g…

This study tested whether a 10-minute vibration massage or static stretching exercise could reduce the severity and duration of muscle cramps that often occur during hemodialysis. Thirty adults with chronic kidney disease on dialysis were randomly assigned to receive vibration ma…

This trial tests whether virtual reality exercise games or electrical muscle stimulation can reduce shoulder pain and improve movement in people with chronic kidney disease who are on dialysis. Participants will receive one of the two therapies several times a week for eight week…

This study compares two types of exercise programs for married women receiving long-term hemodialysis for kidney failure. One group exercises during dialysis sessions, while another follows a home-based routine. The goal is to see if either approach improves quality of life, self…

This study tested a program that sends text reminders and uses social support and game-like features to encourage people with chronic kidney disease, diabetes, and high blood pressure to check their blood pressure regularly. 70 adults from a University of Pennsylvania clinic part…

This study tested a device that uses ultrasound to help guide needles into the blood vessels of people with end-stage kidney disease who need dialysis. Ten adults with an arteriovenous fistula or graft took part. The main goal was to see if the device could help place needles suc…

This study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…

This study tested a drug called nemolizumab to see if it can reduce severe itching in adults with chronic kidney disease who are on dialysis. 258 participants received either nemolizumab or a placebo as injections every 4 weeks for 12 weeks. The main goal was to see how many peop…

This study tested whether adding empagliflozin (a diabetes drug) to standard diuretics helps hospitalized heart failure patients with moderate to advanced kidney disease urinate more fluid. 25 participants were given the combination, and researchers measured urine output. The goa…

This study tested whether nurse-led mindfulness sessions could help people on hemodialysis feel better and follow their treatment more closely. Eighty patients were split into two groups: one received six weekly mindfulness sessions, the other got usual care. After the program, t…

This study looked at whether doing specific exercises during dialysis sessions can improve how well people with chronic kidney disease function in daily life. Fifty-six adults on maintenance hemodialysis were split into groups doing lumbar stabilization exercises, breathing muscl…

This study looked at whether a training booklet based on Roy's Adaptation Model could help kidney patients who are starting immunosuppressive therapy. The booklet covers topics like what the drugs do, side effects, and how to adapt to the disease. Researchers measured patients' m…

This study tested a traditional Chinese medicine patch made from herbs like ginger and Artemisia on 21 dialysis patients who had pain from their fistula. The patch was placed on specific acupoints during dialysis sessions for 4 weeks. Researchers measured pain, depression, and qu…

This study tested whether a guided mindfulness meditation program, practiced during dialysis sessions, could reduce anxiety and improve spiritual well-being in people with chronic kidney disease. Fifty-eight adults on hemodialysis were randomly assigned to either the meditation g…

This study looked at whether a 12-week home exercise program could help people aged 45 and older with advanced chronic kidney disease (stages 4-5) who are not on dialysis. The program included strength and aerobic exercises done 3-4 times a week. Researchers measured changes in m…

This study looked at whether resistance exercises or relaxation therapy better improve physical function and quality of life in people with mild-to-moderate chronic kidney disease. Fifty adults aged 30 to 65 took part, with one group doing both relaxation and resistance exercises…

This study tested two simple, drug-free ways to reduce pain when inserting needles for dialysis. 75 patients were split into three groups: one listened to calming music, one looked at their healthy arm in a mirror, and one received standard care. Pain scores were compared right a…

This small pilot study tested a cognitive behavioral program to help reduce fatigue in people with chronic kidney disease. Five adults with moderate-to-severe kidney disease took part in remote sessions. The goal was to see if the program was acceptable and to gather data for a l…

This small pilot study looked at whether treating constipation with a common laxative (lactulose) is practical for people with chronic kidney disease. Fourteen participants took lactulose daily for up to 6 weeks. The main goal was to see if people would stick with the treatment a…

This study tested whether listening to live music, hearing a ney flute, or interacting with a robotic parrot could help people on dialysis feel less anxious and less tired. 64 adults on regular hemodialysis took part. Researchers measured their anxiety and fatigue levels before, …

This study tested if doing hand grip exercises for six weeks helps the arm blood vessel connection (fistula) used for dialysis grow stronger and work better. 34 adults with kidney failure on dialysis were randomly assigned to either do the exercises or receive standard care. The …

This study tested whether 8 weeks of respiratory muscle training using a special breathing device could improve lung function and muscle strength in 30 children aged 8-18 who had a kidney transplant at least 6 months earlier. The training involved both inspiratory and expiratory …

This early-stage study is testing a single dose of the drug MK-2828 in 24 people with different levels of kidney function, including those with severe kidney failure or on dialysis. The goal is to measure how the drug moves through the body over time and compare it to healthy vol…

This study uses computer simulations to compare two treatment strategies for people with chronic kidney disease and type 2 diabetes. Researchers will model whether adding empagliflozin to finerenone reduces heart failure, hospitalizations, and cardiovascular death more than finer…

Researchers measure blood levels of zinc, copper, selenium, lead, mercury and other trace elements in older adults with advanced chronic kidney disease who receive hemodialysis. The study compares levels before and after a dialysis session in patients new to treatment and in thos…

This trial tests whether a shared decision making approach, where doctors and patients weigh options together, helps people with advanced chronic kidney disease choose their treatment. Participants are patients whose kidneys are failing and who may need dialysis or a transplant w…

This study looks back at treatment records from 119 people with kidney failure who underwent haemodialysis using Genius SleddFlux filters, Ultraflux AV 600 S filters, and Genius 90 concentrates. The goal is to assess how well these devices performed in acute and chronic dialysis …

This study tests a program that combines an AI chatbot and genetic counseling to help African American living kidney donor candidates understand APOL1 genetic testing. The goal is to reduce uncertainty and improve informed consent about donation. Researchers will enroll about 280…

This study looks at whether children with chronic kidney disease (CKD) have weaker muscles, poorer lung function, and lower exercise capacity compared to healthy children. Researchers will measure bone density, muscle mass, arterial stiffness, breathing strength, and physical act…

This study looks at thousands of Chinese adults aged 60 and older to understand how kidney function changes with age. Researchers are examining a range of blood and urine markers to see which ones best predict kidney failure, heart problems, and death. They are also testing diffe…

This study investigates the link between gut bacteria and diabetic kidney disease, a common complication of type 2 diabetes. Researchers will analyze blood, urine, and stool samples from 556 adults with the condition to look for bacterial and metabolic markers. The goal is to und…

This study developed and tested HistoMX, an automated platform that analyzes gene activity in kidney transplant biopsy samples. Researchers used over 2,400 archived biopsies from adult kidney transplant recipients to see if the platform could accurately identify different types o…

This study looks at 1,700 people with heart disease to see how different treatments—surgery, stents, or medication—affect kidney function over 5 years. Researchers will track changes in kidney health and check for new or worsening kidney disease. The goal is to help doctors choos…

This study aims to create and validate a questionnaire that measures how people with chronic kidney failure experience each hemodialysis session. Researchers want to capture physical, emotional, and relational factors that affect the quality of the session. The tool could help he…

This study looks at how often chronic kidney disease (CKD) is diagnosed in adults with high blood pressure who have early signs of kidney trouble but no prior CKD diagnosis. Researchers will review medical records and follow patients over time to see how many are formally diagnos…

This study investigates how moderate and severe kidney impairment affects the way the body processes a single dose of the drug BI 764198. Researchers compare people with kidney disease to healthy volunteers with normal kidney function. The goal is to understand how kidney functio…

This study looks at whether eating a single dose of dark chocolate (70% cocoa) changes blood flow to the kidneys and blood pressure, compared to white chocolate. Researchers will use ultrasound to measure kidney blood flow two hours after eating. The study includes 32 people: hea…

This completed study looked at the safety of the diabetes drug JARDIANCE (empagliflozin) in 299 Korean adults with chronic kidney disease. Researchers tracked side effects and measured changes in a key kidney health marker (urine albumin-creatinine ratio) after 12 and 24 weeks of…

This study looked at 287 patients with acute kidney injury caused by tubular necrosis. Researchers measured two substances in urine (PIIINP and NGAL) to see if they could predict whether kidney function would return or if chronic kidney disease would develop. The goal is to find …

This completed observational study looked at 4500 patients admitted to internal medicine wards with heart failure, COPD, or chronic kidney disease. Researchers aimed to identify which other chronic conditions tend to cluster with these diseases, and how those clusters affect pati…

This study follows people over 75 with advanced chronic kidney disease to better understand their health and treatment paths. Researchers want to create a tool that predicts which patients are at high risk of dying soon after starting dialysis. The goal is to help patients, famil…

This study looked at how cannabidiol (CBD) interacts with tacrolimus, a drug used to prevent organ rejection in transplant patients. Researchers wanted to understand how to adjust doses for better health outcomes. The study involved 57 healthy adults and those with chronic kidney…

This study looked at two tools to help people with chronic kidney disease (CKD) stay healthier. One tool gave doctors a registry to track patients, and the other offered phone coaching from a health coach. The goal was to see if these approaches could lower blood pressure and imp…

This study looked at how well a new dialysis solution works compared to the usual one in people with kidney failure who are on peritoneal dialysis. Seven stable patients each tried both solutions during a single 4-hour session. The goal was to measure fluid removal and changes in…

This study looked at how two types of exercise affect bone health in people with chronic kidney disease. Sixty patients did either treadmill walking or resistance training for 6 months. Researchers measured bone turnover markers and bone density before and after the program to se…

This study followed more than 3,000 adults with moderate to advanced chronic kidney disease (CKD) for up to 5 years. Researchers collected health data and blood/urine samples to identify factors that lead to kidney failure, heart problems, and other complications. The goal was to…

This completed observational study analyzed electronic health records of nearly 13,000 adults with chronic kidney disease in Spain to see how the drug dapagliflozin is used in everyday practice. Researchers looked at patient characteristics, lab results, and healthcare costs over…

This study followed 268 adults with end-stage kidney disease on dialysis. Each participant wore a Holter heart monitor for 7 days to track irregular heartbeats. Researchers then looked for links between those heart patterns and serious outcomes like sudden cardiac death, heart at…

This study looked at 88 adults with chronic kidney disease to see how their oral health changes at different stages. Researchers checked teeth, gums, saliva, and breath to find links with nutrition and inflammation. The goal is to understand if dental problems can worsen kidney d…

This study tested whether a program of videos and text messages (called KidneyTIME) helps people with kidney failure learn more about getting a kidney from a living donor. 422 adults who were already being evaluated for a kidney transplant took part. The study compared those who …

This study looked at whether starting dialysis at a specific time, based on a new mathematical formula, could help people with end-stage kidney disease live longer. 388 patients were randomly assigned to start dialysis either at an 'optimal' or 'late' time. Researchers tracked de…

This completed study collected blood and urine samples from 240 people with ciliopathies—rare genetic disorders that often lead to kidney failure. Researchers analyzed these samples to find biological markers that could predict how the disease will progress. The goal is to develo…

This completed study asked 140 people—including patients with chronic kidney disease, their families, healthcare professionals, and researchers—to identify the most important outcomes for self-managing the condition before dialysis is needed. Through multiple survey rounds, parti…

This study tested a communication tool called 'Best Case/Worst Case' for older adults with advanced kidney disease. Doctors were trained to discuss best, worst, and most likely outcomes for treatment options. The goal was to see if this approach helps patients receive more pallia…

This completed Phase 2 study investigated how the drugs dapagliflozin and balcinrenone, alone or together, affect the body's handling of water and salts in people over 50 with stage 3 chronic kidney disease. Over 28 days, 103 participants took daily pills to measure changes in ur…

This study worked with community groups to screen Hispanic/Latinx adults for kidney disease and diabetes, then referred them to a primary care doctor. It also gave local clinics guidelines to help doctors screen and treat Hispanic and Black patients with diabetes. The goal was to…

This study looked at 395 adults on long-term dialysis to find out how often their blood pressure drops dangerously during treatment and what makes it more likely. Researchers collected information on patients' health history, medications, and dialysis settings. The goal is to hel…

This completed study analyzed electronic health records from over 6,500 patients in China who started taking finerenone for chronic kidney disease and type 2 diabetes. Researchers tracked kidney function, potassium levels, and side effects like high potassium. The goal was to see…

This study looked at how a high-fat, high-calorie meal changes the amount of two drugs (zibotentan and dapagliflozin) in the blood of healthy people. Twenty-six adults took a single dose of the combined pill once after eating and once on an empty stomach. The goal was to see if f…

This study looked at data from 348 people with type 2 diabetes in Germany who use the myTherapy app. Researchers wanted to see how many had high levels of a protein called albumin in their urine, which is a sign of kidney damage. They also tracked how these levels changed over a …

This study looked at specific molecules in the blood of 180 people with chronic kidney disease (CKD) and 60 healthy volunteers. The goal was to see if these molecules could help diagnose CKD early or predict when a common treatment for anemia stops working. The researchers measur…

This study tested a single dose of the drug AZD4144 in 41 adults with severe kidney disease, end-stage kidney disease, and healthy volunteers. Researchers measured how the drug moves through the body and checked for side effects. The goal was to understand how kidney problems aff…

This study tested whether 3D ultrasound can accurately measure kidney and tumor volumes compared to standard CT or MRI scans. 53 adults with chronic kidney disease or kidney tumors participated. Researchers compared 3D ultrasound measurements to those from contrast-enhanced CT or…

This study tested whether home automation and remote monitoring can help elderly people (65+) with multiple chronic conditions live safely at home. Over 500 participants had their homes equipped with sensors that tracked health signs and sent alerts to doctors. The main goal was …

This study looks at how a single 5 mg dose of the blood thinner apixaban is processed in people with end-stage kidney disease who are on peritoneal dialysis, compared to people with normal kidney function. Researchers measured drug levels in the blood over time. The goal is to un…

This study looked at whether giving African American adults with high blood pressure early access to genetic testing for a kidney disease risk gene (APOL1) could improve their care. Over 6,700 participants were randomly assigned to get their genetic results right away or later. T…

This study tested a program called DIAL-SDM that trains kidney doctors and coaches older patients (65+) with advanced kidney disease to have better conversations about dialysis. The goal was to see if the program was practical and acceptable. 102 patients, their caregivers, and 2…

This study tested a machine learning algorithm to predict if a patient being cared for at home would deteriorate. Researchers used data from over 500 patients to train the algorithm and compared its alerts to traditional vital sign alarms. The goal is to catch problems earlier an…

This completed study at Huashan Hospital looked at data from 778 adults on long-term hemodialysis. Researchers used artificial intelligence to build models that could give early warnings about inadequate dialysis and help diagnose complications like heart disease. The goal is to …

This study looked at data from 372 patients to see if a computer program could predict who would need to be readmitted to the hospital within 30 days. Researchers used information like age and health history to train the computer model. The goal was to find patterns that could he…

This study tested whether having dialysis patients regularly fill out questionnaires about their symptoms and well-being helps them communicate better with their doctors and nurses. Over 3,900 adults on dialysis in Alberta and Ontario took part. The goal was to see if sharing the…

This early-stage study tested a new oral medicine, NNC0705-0001, in 116 healthy adults to see if it is safe and how the body handles it. The drug is being developed to treat chronic inflammation, which can lead to heart and metabolic diseases. Participants received either the dru…

This study looked at whether eating at different times during hemodialysis affects blood pressure stability and how well the treatment removes waste from the body. Researchers divided 40 adults with chronic kidney disease into groups that ate at set times or followed their usual …

This study examined over 31,000 older adults (65+) with chronic kidney disease to see if starting a higher dose of the sleep medication trazodone (75-150 mg/day) leads to more serious events like hospital visits or death within 30 days compared to a lower dose (25-75 mg/day). The…

This completed study examined blood vessel function in 101 elderly patients (65 and older) with chronic kidney disease who were not on dialysis. Researchers used ultrasound and other non-invasive tests to measure blood vessel health and looked for links to certain blood markers. …

This completed study looked at 50 non-diabetic people with chronic kidney disease to see if the drug dapagliflozin changes the types of bacteria in their gut. Researchers measured gut bacteria diversity and related waste products in the blood before and after 12 weeks of treatmen…

This study surveyed 608 heart and kidney doctors to understand their awareness and use of a blood test called hsCRP, which measures inflammation. The goal was to learn what doctors think about inflammation's role in treating patients with heart disease, kidney disease, or heart f…

This study tested whether a personalized, home-based exercise program done via video calls could improve muscle function in people with moderate-to-severe chronic kidney disease (CKD) who are not on dialysis. Thirty-two sedentary adults aged 30-75 with CKD took part. They did com…

This study looked at how semaglutide, a diabetes medicine, affects the kidneys in people with type 2 diabetes and chronic kidney disease. 106 participants received either semaglutide or a placebo injection once a week for about a year. Researchers used MRI scans, blood and urine …

This study tested a Turkish version of the Respiratory Distress Observation Scale (RDOS) in 100 adult palliative care patients who cannot describe their breathing trouble. The scale uses eight physical signs like heart rate and restlessness to rate distress. The goal was to see i…

This study tested a small, handheld device called the Nova Max Pro StatSensor that measures creatinine levels in the blood, a key marker of kidney function. The goal was to see if kidney transplant patients could use it reliably at home, compared to standard lab tests. One hundre…

This study tested a prediction tool that uses routine lab results to estimate a patient's risk of kidney injury after heart surgery. Researchers looked at data from 2,500 adults who had heart surgery to see how well the tool worked. The goal is to help doctors catch kidney proble…

This study looked at how salt in the diet affects blood pressure in 130 adults with chronic kidney disease. Researchers measured a protein called uromodulin in urine to see if it predicts salt sensitivity. The goal was to understand why some patients' blood pressure rises more wi…

This completed study looked at whether special outreach programs—using transplant social workers and coordinators—can help Black and non-Black patients with chronic kidney disease get kidney transplants earlier and more fairly. Over 1,100 adults took part. The goal was to see if …

This study looked at whether training community health workers to focus on kidney disease care, and teaching doctors about trauma-informed care, could improve quality of life for Black and Hispanic patients with advanced chronic kidney disease. The study involved 153 patients fro…

This study tested a computer program that acts like a virtual doctor to teach people with advanced chronic kidney disease about kidney transplants. 148 patients took part. The goal was to see if talking with this virtual agent could increase their interest in considering a transp…

This study looked at how common prediabetes is in people with end-stage kidney disease who are on dialysis. Researchers screened 262 adult dialysis patients who had never been diagnosed with diabetes or prediabetes. The goal was to find out how many had prediabetes, which can inc…

This study examined whether a marker of inflammation called interleukin-6 (IL-6) is linked to thyroid hormone problems in people with chronic kidney disease on dialysis. Researchers analyzed blood samples from 65 stable dialysis patients. The goal was to see if higher IL-6 levels…

This completed Phase 1 trial looked at how colestilan, a drug for high phosphate levels in kidney disease, affects the body's processing of candesartan, a blood pressure medication. Eighteen healthy men took candesartan alone or with colestilan at different times. The goal was to…

This study used advanced MRI scans to look at the hearts of 276 people with chronic kidney disease, including those on dialysis. The goal was to identify different types of heart damage and link them to patient outcomes. No new treatment was tested; instead, researchers aimed to …

This study measured how often teenagers develop chronic kidney disease after having heart surgery as young children. Researchers collected blood and urine samples from 120 teens aged 10 to 15 during their regular heart check-ups. The goal was to find out how common kidney damage …

This study looked at whether a simple urine test could predict scarring in kidney transplants, instead of using a needle biopsy. Researchers measured certain genetic markers in urine cells from 300 kidney transplant recipients over the first year after transplant. The goal was to…

This early-stage study tested a single dose of the experimental drug KBP-5074 in 11 people with severe chronic kidney disease, including some on dialysis. The main goal was to check safety and how the drug moves through the body. No treatment benefits were measured; the study onl…

This study tested whether giving an education booklet to people with stage 3 or 4 chronic kidney disease helps them follow their treatment plan, take care of themselves, and feel better overall. 119 patients participated, and researchers measured changes using standard questionna…

This study looked at how a class of diabetes drugs called SGLT2 inhibitors changes kidney function in people with chronic kidney disease (CKD). Researchers compared 60 patients with and without diabetes to see if the drug affects their estimated glomerular filtration rate (eGFR) …

This completed study in 49 veterans with early chronic kidney disease (CKD) tested whether diuretics (water pills) can reduce fluid overload and improve heart health. Researchers measured changes in heart stress markers and symptoms like fatigue after 4 weeks of treatment. The go…

This study tested an electronic alert system that reminds doctors to screen, monitor, and refer patients with chronic kidney disease (CKD). It involved 66 primary care centers in Stockholm, covering about 780,000 people. The goal was to see if the system improves detection and ma…

This study looked at whether certain gene variants (APOL1) are linked to advanced chronic kidney disease (stage 4) in Afro-Caribbean adults living in Guadeloupe. Researchers analyzed blood samples from 88 participants to find how common these gene variants are. The goal was to be…

This study followed nearly 6,000 people with kidney disease from around the world. Researchers collected routine test results like kidney function and protein in urine to better understand how the disease progresses. The goal was to gather information, not to test a new treatment…

This study surveyed 1,500 Chinese heart and kidney specialists to understand their awareness and perceptions of systemic inflammation in patients with both atherosclerotic cardiovascular disease and chronic kidney disease. The goal was to learn how doctors currently identify and …

This completed study from University Hospital Freiburg looked back at 490 patients with liver cirrhosis and signs of chronic kidney disease who were treated for hepatorenal syndrome. Researchers compared how well patients with and without pre-existing kidney disease responded to …

This completed study observed 178 patients with advanced cancer, chronic kidney failure, or chronic lung diseases to assess their palliative care needs and survival factors. Researchers used two scoring tools to evaluate when and how to best introduce palliative care alongside re…

This completed pilot study tested whether the HemoCept device can accurately measure fluid removal during dialysis in 26 adults with end-stage kidney disease. Researchers compared device readings before and after dialysis to changes in dry weight. The goal is to see if this non-i…

This study reviewed medical records of 345 adults to see if primary care doctors referred patients with chronic kidney disease to a kidney specialist at the right time and with the right treatment. The goal was to understand how well current referral practices work, not to test a…

This study looked at how the drug zibotentan is absorbed and cleared by the body in 30 healthy adults, including both non-Asian and Japanese participants. It was a phase 1 trial, meaning it was an early step to gather safety and drug-level information. The study did not aim to tr…

This study looked at 225 adults with a rare, inherited form of kidney disease to find the genetic causes. Participants had chronic kidney failure and often had a family history of gout. Researchers tested for known gene mutations and searched for new ones in families without a cl…

This study tested whether having a clinical pharmacist work alongside doctors in a hospital ward could reduce medication errors in patients with kidney disease. Researchers followed 160 adults with reduced kidney function, comparing usual care, doctor education, and active pharma…

This pilot study tested a smartphone-based tool called SMART-HABITS in 47 adults with chronic kidney disease and high blood pressure. The tool provided reminders, feedback, and educational resources through text messages or an app, and linked to wearable devices like Fitbits and …

This study looked at 319 patients who needed dialysis for severe acute kidney injury. Researchers collected their medical information to identify risk factors for developing chronic kidney disease. The goal was to create a scoring system that helps doctors decide which patients w…

This completed trial tested whether an on-screen electronic alert in the doctor's computer system could increase testing for chronic kidney disease (CKD) in people with type 2 diabetes. About 400 patients who hadn't had a key kidney test in the past year took part. The alert remi…

This study looked at how doctors in seven Central Eastern European countries prescribe dapagliflozin for chronic kidney disease in routine care. Researchers reviewed medical records of about 1,090 adults to understand who gets the drug and what happens over the next year. The goa…

This completed Phase 1 study looked at how the drug MK-5684 behaves in the body of men with severe kidney disease or end-stage renal disease compared to healthy men. Twenty-four participants received a single dose, and researchers measured drug levels in the blood over time. The …

This pilot study tested a device called HemoCept in 12 adults with end-stage kidney disease on dialysis. The goal was to see if the device could accurately track changes in hydration during fluid removal. Researchers compared device readings to changes in dry weight before, durin…

This study looked at how the drug BMS-986278 behaves in people with normal kidneys, severe kidney disease, or kidney failure on dialysis. 27 adults took a single dose to measure drug levels and check for side effects. The goal was to gather safety information, not to treat the di…

This completed study tracked over 1,000 chronic kidney disease patients taking Forxiga in everyday medical practice. The main goal was to see how often side effects occur and what factors might increase risks. The study did not test whether the drug works, but rather gathered saf…

This study looked at 167 adults with chronic kidney disease on either hemodialysis or peritoneal dialysis to compare their blood levels of calcium, phosphorus, and other minerals linked to bone health. The goal was to see if one dialysis method is associated with fewer mineral an…

This completed study screened over 8,400 Brazilian adults with known risk factors for chronic kidney disease (CKD) using a portable creatinine test. Participants were randomly selected from five regions. Those with abnormal results were referred for lab confirmation and follow-up…

This study tested whether sending digital letters to patients with chronic kidney disease and their family doctors could increase the use of recommended medications. Over 28,000 adults in Denmark took part. The goal was to see if simple reminders through the official government e…

This study analyzed electronic medical records of nearly 920,000 Canadian adults to see how the COVID-19 pandemic affected primary care for chronic conditions like diabetes, heart failure, and depression. Researchers compared care before and during the pandemic, looking at visits…

This study looked at how sex hormones, especially estradiol, affect blood vessel function in women with chronic kidney disease (CKD). Researchers compared pre- and post-menopausal women with CKD to healthy women of the same age. They measured blood vessel dilation and stiffness, …

This completed study looked at fat tissue in 23 men with advanced chronic kidney disease (stage V) who were not on dialysis. Researchers compared their fat cells to those of healthy men to understand why kidney disease causes problems like weight loss and insulin resistance. Fat …

This completed phase 1 study looked at how the drug stiripentol behaves in people with mild, moderate, or severe chronic kidney disease compared to those with normal kidney function. Thirty-nine participants took stiripentol by mouth for 15 days. The goal was to see if kidney imp…