New pill shows promise for Tough-to-Treat blood pressure in kidney patients

NCT ID NCT06150924

Completed Disease control Sponsor: Mineralys Therapeutics Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 24, 2026

Summary

This phase 2 trial tested whether adding the experimental drug lorundrostat to standard SGLT2 inhibitor therapy can lower blood pressure in adults with chronic kidney disease and albuminuria (protein in urine). Sixty participants received either lorundrostat or a placebo for four weeks, then switched. The study is complete, and results will show if the drug safely improves blood pressure control.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Academic Medical Research Institute (AMRI) - Los Angeles

Los Angeles, California, 90022, United States
American Clinical Trials Llc

Acworth, Georgia, 30101, United States
Amicis Research Center

Northridge, California, 91324, United States
Amicis Research Center - Granada Hills

Granada Hills, California, 91344, United States
Amicis Research Center - Vacaville

Vacaville, California, 95687-3560, United States
Arizona Kidney Disease & Hypertension Centers (AKDHC) - Thomas Office

Phoenix, Arizona, 85016, United States
Arizona Kidney Disease & Hypertension Centers (AKDHC) - Thunderbird Office

Glendale, Arizona, 85306, United States
Balboa Nephrology Medical Group, Inc. (BNMG) - California Institute of Renal Research (CIRR) - Chula Vista

Chula Vista, California, 91910, United States
Balboa Nephrology Medical Group, Inc. (BNMG) - El Centro

El Centro, California, 92243, United States
Balboa Nephrology Medical Group, Inc. (Bnmg) - La Mesa

La Mesa, California, 91942-3059, United States
Chrysalis Clinical Research (CCR)

St. George, Utah, 84790, United States
ClinCept, LLC

Columbus, Georgia, 32896, United States
Colorado Kidney Care (Denver Nephrology) - Denver Office

Denver, Colorado, 80218-1216, United States
Columbia Nephrology

Columbia, South Carolina, 29203, United States
Dallas Nephrology Associates (Dna) - Renal Disease Research Institute (Rdri)

Dallas, Texas, 75235, United States
E T Nephrology Associates - Lufkin

Lufkin, Texas, 75904, United States
Elixia Central Florida, LLC

Orlando, Florida, 32806, United States
Elixia MKC, LLC

Pontiac, Michigan, 48341, United States
Elixia Pines, LLC

Hollywood, Florida, 33024, United States
Gamma Medical Research, Inc

Mission, Texas, 78572, United States
Genesis Clinical Research - Tampa

Tampa, Florida, 33614, United States
Georgia Nephrology, Llc

Lawrenceville, Georgia, 30046-8761, United States
Indago Research and Health Center

Hialeah, Florida, 33012, United States
Infigo Clinical Research, Llc

Sanford, Florida, 32771, United States
Kansas City Kidney Consultants (Arms, Dodge, Robinson, Wilber & Crouch, Inc.) - Kansas City

Kansas City, Missouri, 64111, United States
Lcms Health University Medical Center New Orleans

New Orleans, Louisiana, 70112-3018, United States
Liberty Research Center

Dallas, Texas, 75237, United States
Mendez Center for Clinical Research, LLC

Woodbridge, Virginia, 22191, United States
Nephrology Associates

Fresh Meadows, New York, 11365, United States
Nephrology Associates of Kentuckiana, PSC (NAK)

Louisville, Kentucky, 40205, United States
Nephrology Associates, PC

Fresh Meadows, New York, 11365, United States
Nephrology Associates, Pllc - Winston-Salem

Winston-Salem, North Carolina, 27103, United States
Nephrology Consultants - Oklahoma City

Oklahoma City, Oklahoma, 73116-1516, United States
Nephrology of the Golden Isles - Brunswick

Brunswick, Georgia, 31520, United States
Northwest Louisiana Nephrology, Llc - Shreveport

Shreveport, Louisiana, 71101, United States
Palm Beach Diabetes and Endocrine Specialists, PA (PBDES) - West Palm Beach Office

West Palm Beach, Florida, 33401, United States
Prx Research

Mesquite, Texas, 75149, United States
Qway Research

Coconut Grove, Florida, 33133, United States
R&H Clinical Research

Katy, Texas, 27205, United States
Seacoast Kidney & Hypertension Specialists - Portsmouth Office

Portsmouth, New Hampshire, 03801, United States
Southeast Renal Research Institute

Chattanooga, Tennessee, 37408, United States
Suny Downstate Medical Center - Parkside Dialysis Center

Brooklyn, New York, 11226-1508, United States
Triad Internal Medicine

Asheboro, North Carolina, 27205, United States
Tufts University School of Medicine (Tusm) - Tufts Medical Center (Tmc) (Tufts-New England Medical Center)

Boston, Massachusetts, 02111, United States

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Lorundrostat (an aldosterone synthase inhibitor) taken as a pill once daily

What this could lead to

If successful, this could point toward a new add-on treatment to better control blood pressure and protect kidney function in people with chronic kidney disease.

What could go wrong

This is a small, early-phase trial with only 60 participants and short treatment periods. Results may not apply to everyone, and the drug may cause side effects or fail to show clear benefit.

Conditions

The condition(s) this trial relates to.

Albuminuria chronic kidney disease chronic renal failure syndrome diabetic kidney disease hypertensive disorder proteinuria

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC KIDNEY DISEASE