New drug combo aims to slow kidney disease

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Men and women aged 18-75 years old 2. Body mass index (BMI) ≥18.0 and \<50.0 kg/m2 at the screening visit 3. Subjects treated with an angiotensin-converting enzyme inhibitor (ACEI) and/or angiotensin receptor blocker (ARB) for at least 3 months without any adjustments to this therapy for at least 4 weeks prior to the screening visit 4. Diagnosed with chronic kidney disease, and the estimated glomerular filtration rate (eGFR) was ≥30 and \<90 mL/min/1.73 m2 calculated using the CKD-EPI formula at the screening visit 5. Urinary albumin/creatinine ratio (UACR) was ≥300 and \<3000 mg/g for at least 2 times on different days detected by the local laboratory; at the screening visit 6. HbA1c \<9.0% at the screening visit Exclusion Criteria: 1. A known or suspected allergy to the investigational drug or its components or excipients; 2. Receive a potent inhibitor/inducer of cytochrome P450 3A4 (CYP3A4) within 7 days prior to screening; 3. Within 4 weeks before screening, the following drugs could not maintain the stable regimen: diabetes drugs, hypertension drugs, non-steroidal anti-inflammatory drugs, endothelin receptor antagonists; 4. Receive SGLT-2 or SGLT-1/2 inhibitors within 4 weeks before screening 5. Received glucagon-like peptide-1 receptor agonist (GLP-1RA) within 8 weeks before screening 6. Received systemic glucocorticoid therapy within 3 months before screening 7. Received immunosuppressive drugs or biological agents 8. Received any other study drug treatment within 3 months or 5 half-lives prior to screening 9. Severe hypertension that was not controlled at screening visit or random visit (systolic blood pressure ≥160 mmHg or diastolic blood pressure ≥100 mmHg), or systolic blood pressure \<90 mmHg 10. Have urinary tract infection or/and genital infection at the screening visit or random visit, or have a history of repeated urinary tract infection or/and genital infection 11. Diagnosed or suspected polycystic kidney disease, lupus nephritis, anti-neutrophil cytoplasmic antibody (ANCA) -associated vasculitis, acute glomerulonephritis, bilateral renal artery stenosis; 12. Acute kidney injury or dialysis treatment within 6 months before screening 13. Received kidney transplant, or plan to receive kidney transplant during the trial