Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

New pill aims to protect kidneys by cutting protein loss

NCT ID NCT06522997

Disease control Sponsor: Bayer Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a new drug called BAY 3283142 in 1222 adults with chronic kidney disease and high protein in their urine. Participants took either the drug or a placebo on top of their usual treatments for 16 weeks. The goal was to see if the drug could lower urine albumin levels, a key sign of kidney damage.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
BAY 3283142
What this could lead to
If successful, this could lead to a new add-on treatment to slow kidney damage in people with chronic kidney disease.
What could go wrong
This is a mid-stage trial with 1222 participants, so results are not yet definitive. The drug may not reduce albuminuria significantly or could cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

1,222 people

The number who actually took part.

Started

Aug 2024

Finished

Nov 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participant must be ≥18 years of age * eGFR (Chronic Kidney Disease Epidemiology Collaboration formula) ≥20 and ≤75 mL/min /1.73 m\^2 at Screening Note: One re-assessment of eGFR based on central laboratory values is allowed during the Screening period" * UACR ≥200 mg/g and \<3500 mg/g as determined by the geometric mean (as calculated by the central laboratory) of 3 morning void urine specimens obtained at Screening * Treatment with the highest tolerated labeled dose of either angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blockers (ARB), unless such treatment is either not tolerated or contraindicated. Treatment dose must be stable dose for at least 4 weeks before Screening with no planned change of the therapy during the study * If the participant receives any of the following treatments it should be stable for 4 weeks prior to Screening: sodium-glucose co-transporter-2 (SGLT2) inhibitor, finerenone, diuretics, endothelin-receptor antagonists, or glucagon-like peptide (GLP) receptor agonist Exclusion Criteria: * Systolic blood pressure (SBP) \<100 mmHg at Visit 2 (baseline) * Patients with a tendency for clinically relevant orthostatic hypotension at Screening and Visit 2 (baseline) as judged by the investigator * SBP ≥160 mmHg, unless treated with ≥3 blood pressure lowering medications, at Screening or at Visit 2 (baseline) * History of secondary hypertension other than CKD * Hepatic impairment corresponding to Child-Pugh B or C or other significant liver disease (e.g., acute hepatitis, chronic active hepatitis, cirrhosis as indicated by e.g. AST or ALT \>3x ULN or total bilirubin \>2x ULN) at Screening * Polycystic kidney disease, lupus nephritis or ANCA-associated vasculitis and any other kidney disease requiring immunosuppressive therapy within 6 months prior to Screening

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Chronic kidney disease are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

chronic kidney disease chronic renal failure syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic kidney disease

Contacts and locations

Locations

  • ASST Papa Giovanni XXIII | Ospedale di Bergamo - SC Malattie Endocrine-Diabetologia

    Bergamo, 24127, Italy

  • AZ Delta / Nephrology

    Roeselare, 8800, Belgium

  • Akademiska sjukhuset (Uppsala University Hospital) - Njurkliniken

    Uppsala, Uppsala County, 751 85, Sweden

  • All India Institute of Medical Sciences (AIIMS) - New Delhi

    New Delhi, National Capital Territory of Delhi, 110029, India

  • Area Sanitaria De Ferrol | Medicina Interna

    Ferrol, A Coruña, 15405, Spain

  • Associacao Protectora dos Diabeticos de Portugal | Departamento de Ensaios Clinicos

    Lisbon, 1250-189, Portugal

  • Azienda Ospedaliera Universitaria Gaetano Martino Messina - Nefrologia e Dialisi

    Messina, 98124, Italy

  • Azienda Ospedaliero Universitaria di Modena_Policlinico - Nefrologia, Dialisi e Trapianto di Rene

    Modena, 41124, Italy

  • Azienda Ospedaliero-Universitaria Di Bologna IRCCS_Policlinico Sant'Orsola - Nefrologia, Dialisi e Trapianto

    Bologna, Emilia-Romagna, 40138, Italy

  • B. Braun Avitum Nefrologicka Ambulancia | Galanta, Slovakia

    Galanta, 924 22, Slovakia

  • B. Braun Avitum Nefrologicka ambulancia | Sala, Slovakia

    Šaľa, 92719, Slovakia

  • BIODIAL spol. s r.o.

    Púchov, 02001, Slovakia

  • Balboa Research SMO+ - Chula Vista

    Chula Vista, California, 91910, United States

  • Barts Health NHS Trust - Royal London Hospital - Nephrology

    London, Greater London, E1 1FR, United Kingdom

  • Bellvitge Hospital Universitari | Nefrologia

    L'Hospitalet de Llobregat, Barcelona, 08907, Spain

  • Brookview Hills Research Associates, LLC

    Winston-Salem, North Carolina, 27103, United States

  • CEDIC Centro de Investigación Clínica | Buenos Aires, Argentina

    CABA, Ciudad Auton. de Buenos Aires, C1018DES, Argentina

  • California Kidney Specialists - San Dimas

    San Dimas, California, 91773, United States

  • Capital Medical University (CMU) - Beijing Anzhen Hospital (BAH)

    Beijing, 100029, China

  • Cardiff and Vale University Health Board | University Hospital of Wales - Nephrology and Transplant

    Cardiff, Wales, CF14 4XW, United Kingdom

  • Center For Diabetes, Academic Specialist Center

    Stockholm, Stockholm County, 113 65, Sweden

  • Centro Clinico Academico Braga | Braga, Portugal

    Braga, 4710-243, Portugal

  • Centro Hospitalar Universitario de Lisboa Central | Hospital Curry Cabral - Nephrology Department

    Lisbon, 1069-166, Portugal

  • Centro Hospitalar do Medio Tejo | Unidade de Torres Novas - Nephrology Department

    Torres Novas, Santarém District, 2350-754, Portugal

  • Centro Privado San Vicente Diabetes

    Córdoba, 5000, Argentina

  • Centro de Educacion Medica e Investigaciones Clinicas "Norberto Quirno" (CEMIC)

    Buenos Aires, C1431FWO, Argentina

  • Centro de Especialidades Medicas (Cemedic) | Cardiology Department

    Villa Luro, Ciudad Auton. de Buenos Aires, C1440CFD, Argentina

  • Centro de Investigaciones Medicas Temperley | Buenos Aires, Argentina

    Temperley, Buenos Aires, B1834GUK, Argentina

  • Centro de Investigaciones Metabolicas | Ciudad de Autonoma de Buenos Aires, Argentina

    Ciudad Autónoma de Buenos Aire, Buenos Aires, C1056ABI, Argentina

  • Centro de Rehabilitacion Cardiovascular | San Luis, Argentina

    San Luis, San Luis Province, D5700CGR, Argentina

  • Chang Gung Memorial Hospital Kaohsiung

    Kaohsiung City, 833, Taiwan

  • Changhua Christian Hospital

    Changhua, Changhua, 50006, Taiwan

  • Changi General Hospital

    Singapore, 529889, Singapore

  • Chi-Mei Medical Center, Liouyine

    Tainan, 73657, Taiwan

  • Chubu Rosai Hospital

    Nagoya, Aichi-ken, 455-8530, Japan

  • Clinical Advancement Center, PLLC

    San Antonio, Texas, 78212, United States

  • Complexo Hospitalario Universitario A Coruna | Endocrinologia y Nutricion

    A Coruña, 15006, Spain

  • DIAB s.r.o

    Rožňava, 048 01, Slovakia

  • DIABEDA s.r.o.

    Bratislava, 83106, Slovakia

  • Eastern Nephrology Associates - New Bern

    New Bern, North Carolina, 28562, United States

  • Ehime Prefectural Central Hospital

    Matsuyama, Ehime, 790-0024, Japan

  • Elixia Central Florida

    Orlando, Florida, 32608, United States

  • Epicura / Nephrology

    Baudour, 7331, Belgium

  • Epsom and St Helier University Hospitals NHS Trust | St Helier Hospital - Clinical Trials Unit

    Carshalton, Surrey, SM5 1AA, United Kingdom

  • Far Eastern Memorial Hospital

    New Taipei City, New Taipei, 220, Taiwan

  • Florida Institue for Clinical Research

    Orlando, Florida, 32825, United States

  • Fukui Prefectural Hospital

    Fukui-shi, Fukui, 910-0846, Japan

  • Fundacion Centro de Salud e Investigaciones Medicas | Santa Rosa, Argentina

    Santa Rosa, 0, Argentina

  • General Hospital Of Thessaloniki Papageorgiou-Renal Department

    Efkarpia, Thessaloniki, 56429, Greece

  • General University Hospital Of Larissa-Nephrology Clinic

    Larissa, 41100, Greece

  • Geniko Nosokomeio Thessalonikis George Papanikolaou-Nephrology Department

    Thessaloniki, 57010, Greece

  • Hamamatsu University Hospital

    Hamamatsu, Shizuoka, 431-3192, Japan

  • Hirohata Naika Clinic

    Kitakyushu, Fukuoka, 807-0857, Japan

  • Hospital Clinico Universitario De Valencia | Nefrologia

    Valencia, 46010, Spain

  • Hospital Pedro Hispano | Clinical Research Center

    Matosinhos Municipality, Porto District, 4464-513, Portugal

  • Hospital Quironsalud Barcelona | Internal Medicine Department

    Barcelona, 8023, Spain

  • Hospital Universitario Dr Peset Aleixandre | Nefrologia

    Valencia, 46017, Spain

  • Hospital Universitario Fundacion Jimenez Diaz | Nephrology and Hypertension Department

    Madrid, 28040, Spain

  • Hospital Universitario Ramon Y Cajal | Medicina Interna

    Madrid, 28034, Spain

  • Hospital Universitario Virgen De Valme | Medicina Interna

    Seville, 41014, Spain

  • Hospital Universitario Y Politecnico La Fe | Nefrologia

    Valencia, 46026, Spain

  • Huadong Hospital, Affiliated to Fudan University

    Shanghai, 200040, China

  • Huai'an First People's Hospital, Nanjing Medical University

    Huai'an, Jiangsu, 223300, China

  • Hull University Teaching Hospitals NHS Trust | Hull Royal Infirmary - Academic Renal Research Department

    Hull, East Riding Of Yorkshire, HU3 2JZ, United Kingdom

  • Ippokratio General Hospital Of Thessaloniki- 1st Department of Nephrology

    Thessaloniki, 54642, Greece

  • Istituti Clinici Scientifici Maugeri S.p.A._Pavia - Nefrologia

    Pavia, 27100, Italy

  • Jan Yperman Ziekenhuis / Nephrology

    Ieper, 8900, Belgium

  • Japanese Red Cross Fukuoka Hospital

    Fukuoka, 815-8555, Japan

  • Japanese Red Cross Saitama Hospital

    Saitama, 330-8553, Japan

  • Jiangsu Province Hospital of Traditional Chinese Medicine (TCM)

    Nanjing, 210029, China

  • Jiyugaoka Yamada Internal Medicine Clinic

    Obihiro, Hokkaido, 080-0848, Japan

  • Juntendo University Urayasu Hospital

    Urayasu, Chiba, 279-0021, Japan

  • Kasugai Municipal Hospital

    Kasugai, Aichi-ken, 486-8510, Japan

  • Katta General Hospital

    Shiroishi, Miyagi, 989-0231, Japan

  • King's College Hospital NHS Foundation Trust | King's College Hospital - Renal Research Department

    London, Greater London, SE5 9RJ, United Kingdom

  • Knoxville Kidney Center, PLLC

    Knoxville, Tennessee, 37923, United States

  • Kokura Memorial Hospital

    Kitakyushu, Fukuoka, 802-8555, Japan

  • Komatsu Municipal Hospital

    Komatsu, Ishikawa-ken, 923-8560, Japan

  • Laiko General Hospital Of Athens_ Department of Nephrology and Renal Transplantation

    Athens, 11525, Greece

  • Lakeside Healthcare | Lakeside Surgery - Research Department

    Corby, Northamptonshire, NN17 2UR, United Kingdom

  • Life Care Clinic (LifeCare Clinic & Research Centre (LCRC))

    Bengaluru, Karnataka, 560092, India

  • Luz Saude | Hospital da Luz Lisboa - Centro de Investigacao Clinica

    Lisbon, 1500-650, Portugal

  • MEDISPEKTRUM s.r.o.

    Bratislava, 85101, Slovakia

  • Madras Diabetes Research Foundation

    Chennai, Tamil Nadu, 600086, India

  • Manassas Clinical Research Center

    Manassas, Virginia, 20110, United States

  • Manchester University NHS Foundation Trust | Manchester Royal Infirmary - Renal Care

    Manchester, Greater Manchester, M13 9WL, United Kingdom

  • Mavani Research Center

    Ahmedabad, Gujarat, 380052, India

  • Max Super Speciality Hospital, Saket (West Block), (A unit of Max Healthcare Institute Limited)

    New Delhi, National Capital Territory of Delhi, 110017, India

  • Mendez Center For Clinical Research | Woodbridge, VA

    Woodbridge, Virginia, 22192, United States

  • NTT Medical Center Tokyo

    Shinagawa-ku, Tokyo, 141-8625, Japan

  • Naka Kinen Clinic

    Naka, Ibaraki, 311-0113, Japan

  • Nara Prefecture General Medical Center

    Nara, 630-8581, Japan

  • National Heart Centre Singapore

    Singapore, 169609, Singapore

  • National Taiwan University Hospital

    Taipei, 100, Taiwan

  • National University Hospital Medical Centre

    Singapore, 119074, Singapore

  • Nemocnica Akademika L. Derera - UNB, Nefrologicka ambulancia

    Bratislava, 83101, Slovakia

  • NephroCare | FMC-dialyzacne sluzby s.r.o. - Kosice

    Košice, 04011, Slovakia

  • Nephrology Associates of Northern Illinois and Indiana - Hinsdale

    Hinsdale, Illinois, 60521, United States

  • Nephrology Consultants, LLC

    Huntsville, Alabama, 35805, United States

  • Northern Care Alliance NHS Foundation Trust | Salford Royal Hospital - Nephrology

    Salford, Greater Manchester, M6 8HD, United Kingdom

  • Nova Clinical Research - Blake Medical Center

    Bradenton, Florida, 34209, United States

  • Osaka General Medical Center

    Osaka, 558-8558, Japan

  • Peking University People's Hospital

    Beijing, 100044, China

  • Peninsula Kidney Associates - Hampton

    Hampton, Virginia, 23666, United States

  • ProbareE Stockholm

    Stockholm, Stockholm County, 113 29, Sweden

  • Renal Disease Research Institute | Landry

    Dallas, Texas, 75246, United States

  • Renji Hospital Shanghai JiaoTong University of Medicine

    Shanghai, 200001, China

  • Renstar Medical Research - Deerwood Clinic

    Ocala, Florida, 34471, United States

  • Research by Design, LLC | Chicago, IL

    Chicago, Illinois, 60643, United States

  • Rinku General Medical Center

    Izumisano, Osaka, 598-8577, Japan

  • Sahlgrenska Universitetssjukhuset - Njurkliniken

    Gothenburg, Västra Götaland County, 413 45, Sweden

  • Saiseikai Matsuyama Hospital

    Matsuyama, Ehime, 791-8026, Japan

  • Saiseikai Yokohamashi Nanbu Hospital

    Yokohama, Kanagawa, 234-0054, Japan

  • Salem VA Medical Center - Nephrology

    Salem, Virginia, 24153, United States

  • Shandong Provincial Hospital

    Jinan, Shandong, 250021, China

  • Shanxi Bethune Hospital

    Taiyuan, 030032, China

  • Shonan Kamakura General Hospital

    Kamakura, Kanagawa, 247-8533, Japan

  • Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (SAMSPH)

    Chengdu, 610072, China

  • Sichuan University - West China Hospital

    Chengdu, 610041, China

  • SingHealth Polyclinics - Pasir Ris

    Singapore, 519457, Singapore

  • Singapore General Hospital

    Singapore, 169608, Singapore

  • Southeastern Clinical Research Institute, LLC

    Augusta, Georgia, 30904, United States

  • Southern Medical University - Nanfang Hospital (Southern Hospital)

    Guangzhou, 510515, China

  • Southwest Houston Research, Ltd.

    Houston, Texas, 77099, United States

  • Steel Memorial Yawata Hospital

    Kitakyushu, Fukuoka, 805-8508, Japan

  • Taizhou Hospital of Zhejiang Province

    Taizhou, Zhejiang, 317099, China

  • Tan Tock Seng Hospital

    Singapore, 308433, Singapore

  • The First Affiliated Hospital of Guangzhou University of TCM

    Guangzhou, Guangdong, 510405, China

  • The First Affiliated Hospital of Xiamen University

    Xiamen, Fujian, 361003, China

  • The First People's Hospital - Foshan

    Foshan, 528000, China

  • The Institute of Post Graduate Medical Education & Research (IPGMER) (SSKM Hospital)

    Kolkata, West Bengal, 700020, India

  • The Second Affiliated Hospital of Nanjing Medical university

    Nanjing, Jiangsu, 210011, China

  • The Second Hospital of Jilin University

    Changchun, Jilin, 130000, China

  • The Third Xiangya Hospital of Central South University

    Changsha, Hunan, 410013, China

  • Triad Internal Medicine - Asheboro

    Asheboro, North Carolina, 27203, United States

  • UZ Brussel Nephrology

    Jette, 1090, Belgium

  • UZ Gent / Nephrology

    Ghent, 9000, Belgium

  • UZ Leuven / Nephrology

    Leuven, 3000, Belgium

  • Unidade Local De Saúde De Lisboa Ocidental E.P.E.

    Carnaxide, Lisbon District, 2790-134, Portugal

  • Unidade Local de Saude Almada-Seixal | Hospital Garcia de Orta - Research Department

    Almada, Setúbal District, 2805-267, Portugal

  • Unidade Local de Saude do Estuario do Tejo | Hospital de Vila Franca de Xira - Departamento de Formacao e Investigacao

    Vila Franca de Xira, Lisbon District, 2600-009, Portugal

  • Unidade Local de Saúde de Coimbra, E.P.E. - Hospitais da Universidade de Coimbra - Serviço de Nefrologia

    Coimbra, 3000-075, Portugal

  • Universitetssjukhuset i Linköping

    Linköping, Östergötland County, 581 85, Sweden

  • University General Hospital Of Ioannina-Nephrology Clinic

    Ioannina, 45500, Greece

  • University General Hospital of Heraklion-Nephrology Clinic

    Heraklion, 71500, Greece

  • University General Hospital of Patras | Nephrology Clinic

    Pátrai, Achaia, 26504, Greece

  • University Hospitals Birmingham NHS Foundation Trust | Queen Elizabeth Hospital Birmingham - Clinical Research Facility

    Birmingham, West Midlands, B15 2TH, United Kingdom

  • University of Yamanashi Hospital

    Chūō, Yamanashi, 409-3898, Japan

  • Univerzitná nemocnica Martin (UNM) - Transplantacno-nefrologické oddelenie

    Martin, 036 59, Slovakia

  • Utah Kidney Research Institute | Salt Lake City, UT

    South Salt Lake, Utah, 84115, United States

  • Vanderbilt University Medical Center - Nephrology Clinical Trials Center

    Nashville, Tennessee, 37232, United States

  • Yale Nephrology Clinical Research Clinic

    New Haven, Connecticut, 06510, United States

  • Yokohama City University Hospital

    Yokohama, Kanagawa, 236-0004, Japan

More trials for these conditions

Other studies related to the condition(s) this trial covers.