Sleep aid trazodone may pose hidden dangers for seniors with kidney trouble

This study examined over 31,000 older adults (age 66+) with chronic kidney disease to see if starting a higher dose of the sleep medication trazodone (75-150 mg/day) leads to more serious events like hospitalization, emergency visits, or death within 30 days compared to a lower dose (25-75 mg/day). The goal was to understand the safety of trazodone in this vulnerable group. The study did not test a new treatment but rather analyzed existing health records to gather knowledge for safer prescribing.