London Health Sciences Centre Research Institute Or Lawson Research Institute Of St. Joseph's

This study tests a new approach for people with many cancer spots (metastases). Half get standard care, the other half get precise, high-dose radiation (SABR) to every tumor. The goal is to see if this aggressive treatment improves survival and quality of life. About 138 adults w…

This study tests a digital app called VIRTUES that helps people with heart conditions manage their health from home. The app provides personalized recommendations for medications, diet, exercise, and more. Researchers will enroll 2,000 patients to see if the app is easy to use an…

This study tests whether giving heparin (a blood thinner) during heart catheterization through the wrist can prevent the wrist artery from closing up afterward. About 1,600 adults having this procedure will be randomly assigned to receive no blood thinner, a low dose, or a high d…

This study tests a new approach for people with stage 2 or 3 breast cancer. Before standard chemotherapy, participants receive targeted radiation and an immunotherapy drug (pembrolizumab) injected into the tumor. The goal is to see if this combination can improve the chance of el…

This study tests a treatment called SMART, which uses movement and body awareness to help adults with PTSD. 80 participants will attend 8 sessions and complete assessments before, after, and 3 months later. The goal is to see if this approach reduces PTSD symptoms and improves bo…

This study compares two pain relief methods for people having lung surgery with small incisions (VATS). One group gets a single shot of numbing medicine near the ribs, while the other gets that shot plus a continuous drip of numbing medicine through a small tube placed under the …

This study tests if a nerve block called PENG can control pain after hip replacement as well as the standard method of injecting pain medicine into the surgery site. About 60 adults having hip replacement will be randomly assigned to one of the two pain relief methods. Researcher…

This study looks at two different surgeries for treating broken ankles in frail older adults (age 60+). One method uses a rod inside the bone, and the other uses plates and screws. The goal is to see which approach helps patients feel better and recover more easily. About 172 peo…

This study tests whether taking L-Carnitine by mouth can improve symptoms, heart function, and quality of life in people with heart failure who also have kidney problems. About 20 adults will take the supplement and be monitored for side effects and benefits. The goal is to see i…

This study looks at why people on hemodialysis gain fluid between treatments, which can be harmful. It focuses on how quickly they drink after a session and what factors, like thirst or salt intake, play a role. Researchers will track 20 adults on thrice-weekly dialysis to map th…

This study looks at whether using two metal implants instead of one to fix a broken thigh bone near the knee helps older or medically fragile adults recover better. About 44 participants will be randomly assigned to receive either one or two implants. The main goal is to see if a…

This study is watching 1,000 ICU patients to find early signs in their bodies that could help doctors diagnose life-threatening conditions like sepsis and ARDS sooner. The goal is to learn which patients might benefit from specific treatments and to discover new therapies. No exp…

This study watches brain activity in adults who are taken off life support in the ICU. Researchers want to learn exactly when the brain stops working compared to when the heart stops. About 158 patients will take part. The goal is to better understand the process of dying, not to…

This study is testing whether fecal microbiome transplants (FMT) can help people with anorexia nervosa by changing their gut bacteria. The researchers want to see if this treatment is safe and tolerable for 20 adults with anorexia. They will also look at how FMT affects thinking,…