London Health Sciences Centre Research Institute Or Lawson Research Institute Of St. Joseph's

This trial compares two common diuretics—furosemide and mannitol—given during kidney transplant surgery to see which better prevents delayed graft function, a condition where the new kidney does not work right away and requires dialysis. The study enrolls adults receiving a decea…

This study is testing a digital app called VIRTUES that provides educational resources and treatment recommendations for heart conditions like atrial fibrillation and heart failure. Researchers will enroll 2000 patients across 11 modules to see if the app is easy to use and helps…

This trial tests a precise type of radiation called SABR on all visible tumors in people with 11 or more metastases. Participants are randomly assigned to either standard palliative radiation or SABR to every tumor. The goal is to see if this aggressive approach improves overall …

This study looks at whether the current dosing of the antibiotic gentamicin is safe and effective for newborns up to 7 days old who have early-onset sepsis. Researchers will measure drug levels in the blood and check for kidney or hearing problems. The goal is to confirm that giv…

This study tests whether giving heparin (a blood thinner) during heart catheterization through the wrist can prevent the radial artery from becoming blocked afterward. About 1,600 patients will be randomly assigned to receive no anticoagulant, a low dose, or a high dose of hepari…

This phase 2 trial is testing whether giving a short course of radiation (SBRT) and two injections of the immunotherapy drug pembrolizumab (Keytruda) before standard chemotherapy can improve outcomes for people with stage 2 or 3 breast cancer. The study aims to see if this combin…

This study compares two types of surgery for unstable ankle fractures in frail adults aged 60 and older. One group gets ankle fusion (joining the bones together), and the other gets open reduction and internal fixation (using plates and screws to hold the bones in place). A secon…

This trial tests whether using two implants (plates or nails) instead of one to fix a broken thigh bone near the knee leads to better recovery in adults aged 60+ or those with conditions like osteoporosis or diabetes. About 44 participants will be randomly assigned to receive eit…

People who break a bone around a knee replacement often need revision surgery, but doctors lack a dependable way to tell whether the bone is healing well. This study examines weight-bearing CT scans, taken while a person puts weight on the leg, as a tool to measure how bone segme…

Researchers are testing whether a personalized home-based program can help prevent dementia in older adults with mild cognitive impairment. The program combines physical activity, cognitive training, diet, sleep, and management of vascular risk factors, all tailored to each parti…

Researchers compare standard knee replacement surgery with robotic-assisted surgery that uses patient-specific alignment in people with knee osteoarthritis. Participants receive one of three surgical approaches and are followed for a year to measure implant position, inflammation…

This study is testing whether a new type of dialyzer, called Theranova, can help reduce common symptoms like pain, fatigue, and poor sleep in people with end-stage renal disease who are on dialysis. About 100 participants will use their usual dialyzer for the first 4 weeks and th…

This study tests a treatment called SMART, which uses movement and body awareness to help adults with PTSD. 80 participants will attend 8 sessions and be assessed before, after, and 3 months later. The goal is to see if this approach reduces PTSD symptoms and improves body awaren…

This study tests whether taking L-carnitine, a natural substance that helps turn fat into energy, can improve symptoms and quality of life in people with heart failure and kidney problems. About 20 adults will take the supplement for a short time while researchers monitor side ef…

This study tests whether a nerve block called PENG block can control pain after hip replacement as well as the usual method of injecting numbing medication into the surgical area. Sixty adults getting hip replacement will be randomly assigned to one of the two pain relief methods…

This study compares two ways to manage pain after video-assisted lung surgery (VATS). One group gets a single nerve block, the other gets that plus a continuous nerve block with a numbing medicine. The goal is to see if the combination improves recovery quality in the first 24 ho…

This study looks at how desmopressin, a drug that helps blood clot, affects platelet function in 100 adults undergoing heart surgery with a heart-lung machine. Researchers will use a special blood test called TEG6s to measure clotting at several time points before and after givin…

This study looks at how quickly people on dialysis gain weight from drinking fluids between sessions. It aims to understand if thirst right after dialysis leads to more fluid intake. The results could help improve care for kidney patients.

This study watches brain activity in patients who are taken off life support in the ICU. Researchers want to see when the brain stops working compared to when the heart stops. It involves 158 adults expected to die within 24 hours of stopping life support. The goal is to better u…

This study explores whether fecal microbiome transplants (FMT) can improve gut health, thinking, and mood in people with anorexia nervosa. Twenty participants with restrictive-type anorexia will receive FMT capsules. The main goal is to see if the procedure is feasible and tolera…

This study is observing 1,000 critically ill ICU patients to learn how their bodies respond to life-threatening infections and injuries. Researchers will collect blood and lung fluid samples to identify biological factors that could lead to earlier diagnosis and new treatments fo…