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Can a standing CT scan reveal whether a broken bone around a knee implant is truly healing?

NCT ID NCT06525610

Diagnosis Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 17, 2026 · Last updated Sep 18, 2026 · Updated 1 time

Summary

People who break a bone around a knee replacement often need revision surgery, but doctors lack a dependable way to tell whether the bone is healing well. This study examines weight-bearing CT scans, taken while a person puts weight on the leg, as a tool to measure how bone segments move and how that movement relates to pain. Researchers plan to scan 21 adults who had revision surgery for a distal femur fracture around a knee implant, comparing the images with questionnaires about pain and knee function.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
weight-bearing CT imaging with RSA-like software
What this could lead to
If it works, weight-bearing CT could give surgeons a reliable way to see whether a broken bone around a knee implant is healing, which may help them decide when further surgery is needed.
What could go wrong
This is a small study of 21 people at a single point in their recovery, so the scans may not predict healing well or apply to other patients. CT scans also involve radiation exposure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 21 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2025

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Recently underwent revision surgery for repair of a distal femur fracture surgery for total knee arthroplasty femoral component using a fracture fixation plate. Due to the study requiring the potential participant to be scanned \<1-week post-operation, the duration of "recently" will be defined as \<1 week post-operation. * Age 50-90 years * Body mass index up to 40kg/m2 * Able to provide informed consent * Able and willing to do study assessments and follow instructions Exclusion Criteria: * Prior revision surgery on the targeted knee * Does not understand English * Undergoing and/or have undergone revision surgery for any other indication * Received intramedullary nail or distal femur replacement * Cannot independently stand on one leg in the weight-bearing CT during the inducible displacement exam

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periprosthetic fracture around prosthetic joint implant knee

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • London Health Sciences Centre Research Institute

    RECRUITING

    London, Ontario, N6A5A5, Canada

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