London Health Sciences Centre Research Institute Or Lawson Research Institute Of St. Joseph's

This study looks at whether the current dosing of the antibiotic gentamicin is safe and effective for newborns up to 7 days old with early-onset sepsis. Researchers will measure drug levels in the blood and check for kidney or hearing problems. The goal is to confirm that giving …

This study tests a new wearable device that can gently remove extra fluid from the body between dialysis sessions. Standard dialysis removes fluid quickly, which can damage the heart and brain. The device is meant to take off leftover fluid slowly, reducing those risks. The study…

This study looks for a type of heart disease called cardiac amyloidosis in people who had carpal tunnel surgery on both hands between 2010 and 2015. Participants must be 55 or older at the time of surgery. They will get a special heart scan to check for abnormal protein buildup. …

This study tests a faster way to diagnose Alzheimer's disease using blood tests, spinal taps, and brain scans. It involves 200 people with mild memory problems or early dementia. The goal is to see if a nurse-led screening tool can help get patients diagnosed much sooner than the…

This study tests a new PET scanner designed specifically for the prostate. Researchers want to see if it can find prostate cancer more clearly than standard whole-body scans. About 25 men with known or suspected prostate cancer will get both a standard scan and the new scan, and …

This study tests whether a small, non-invasive device that gently stimulates a nerve in the ear can reduce long-term muscle and bone pain in adults with cerebral palsy. Thirty-two participants will use the device at home for 30 days, and half will receive a sham (inactive) versio…

This pilot study tests whether a small device that gently stimulates a nerve in the ear can safely reduce nerve pain in people with spinal cord injury. Thirty-two adults will use the device at home for 30 days, and researchers will measure pain levels, inflammation, and quality o…

This study looks at whether a program called Facing Your Fears can help reduce anxiety in children aged 12-18 who have both autism and intellectual disability. The program teaches coping skills through weekly sessions with a parent. The goal is to see if the program is practical …

This study tests whether Meta AI glasses, connected to the Be My Eyes network, can help people with permanent vision loss move around more easily and safely. The glasses describe scenes and objects in real time, which may reduce falls and improve independence. About 50 participan…

This study looks at whether meditation or a health education program can improve quality of life and mental health for people with irreversible age-related vision loss and their caregivers. About 150 participants (patients aged 60-85 and caregivers aged 18-85) will be assigned to…

This study tests whether a numbing injection near the cheekbone can control pain after tonsil removal in children, reducing the need for strong opioid painkillers. About 60 kids aged 3 to 9 having tonsil surgery for sleep apnea will be randomly assigned to get either the nerve bl…

This study looks at whether the bacteria in your gut can influence how well a knee replacement works. Researchers will compare the gut bacteria of 30 people with successful knee replacements to those who need a second surgery. The goal is to understand if differences in gut bacte…

This study looks at whether people with epilepsy digest food and liquids at a normal rate before surgery, even after following standard fasting rules. Researchers will use a quick, painless ultrasound scan to check the stomach contents of 30 adults with epilepsy scheduled for sur…

This study looks at why some people develop ongoing pain for months after chest surgery. Researchers will measure certain molecules in the blood before and after surgery to see if changes in these molecules are linked to long-term pain. They will also check if small modifications…

This study looks at how a drug called desmopressin helps blood clot properly in 100 adults having heart surgery with a heart-lung machine. Researchers will use a special blood test (TEG6s) to measure changes in platelet function after giving desmopressin. The goal is to better un…

This study looks at whether measuring the optic nerve sheath (the covering of the nerve at the back of the eye) using ultrasound can help predict delirium—sudden confusion or agitation—after heart surgery. Delirium is common in older adults after surgery and can lead to longer ho…