London Health Sciences Centre Research Institute Or Lawson Research Institute Of St. Joseph's

This study tested a new, very precise type of radiation called SABR in 13 adults with cancer that had spread to more than 10 spots in the body. The main goal was to find the safest dose and see if it could be given without causing severe side effects. Researchers also measured qu…

This study tested whether virtual reality (VR) can reduce pain and distress in children with cancer during port-a-cath needle access. 84 children aged 5-17 who reported some fear before the procedure took part. Researchers measured their distress and pain levels during the needle…

This study examined over 31,000 older adults (age 66+) with chronic kidney disease to see if starting a higher dose of the sleep medication trazodone (75-150 mg/day) leads to more serious events like hospitalization, emergency visits, or death within 30 days compared to a lower d…

This study looked at medical records of 50,000 living kidney donors and compared them to similar people who did not donate. The goal was to see if donating a kidney increases the risk of breaking bones like the hip, wrist, or shoulder over many years. The findings will help docto…

This study looked at nearly 10,000 men to see if those who donated a kidney through keyhole surgery were more likely to need scrotal surgery years later compared to similar men who didn't donate. Researchers tracked hospital records for many years to find any link. The goal is to…

This study examined whether starting a higher dose of two common antidepressants (venlafaxine or duloxetine) increases the risk of serious events like emergency visits, hospital stays, or death within 30 days in older adults (66+) with chronic kidney disease. Researchers analyzed…

This study looked at how a drug called BYL719 affects certain proteins in head and neck cancer tumors. Fifteen patients took the drug for a short time before their planned surgery. Researchers compared tumor samples taken before and after treatment to see if the drug changed spec…

This study reviewed health records of 14,000 older adults (66+) with advanced chronic kidney disease who started taking tamsulosin, a drug for prostate problems. Researchers compared those on a higher dose (0.8 mg/day) to those on a lower dose (0.4 mg/day) to see if the higher do…

This study used health records from Ontario, Canada, to see if men who had a type of kidney surgery (laparoscopic pyeloplasty) are more likely to later need surgery for a hydrocele, a fluid-filled sac around the testicle. Researchers compared 15,000 men who had the kidney surgery…

This study tested giving one or three doses of focused radiation before breast cancer surgery, instead of the usual five to six weeks of radiation after surgery. The goal was to see if this approach can prevent cancer from coming back and spare patients from lengthy treatment. Th…

This study looked at 5,000 older adults (66+) with low kidney function who started taking nortriptyline, a common antidepressant. Researchers compared those on higher doses (over 10 mg/day) to those on a low dose (10 mg/day) to see if they had more emergency visits, hospital stay…

This study looked at whether people who donate a kidney have a higher chance of developing gout later in life. Researchers compared 50,000 living kidney donors to similar healthy people who did not donate. They used health records from three Canadian provinces to track gout diagn…

This study looked at over 12,000 older adults (65+) with low kidney function to see if starting a higher dose (10 mg/day) of the antidepressant escitalopram is riskier than a lower dose (5 mg/day). The goal was to compare rates of hospitalization, emergency visits, or death withi…

This study looked at over 12,000 older adults (age 66+) with low kidney function who started taking lorazepam, a common anxiety medication. Researchers compared those taking higher doses (more than 1 mg per day) to those on lower doses (0.5-1 mg per day) to see if the higher dose…

This study checked whether older adults (65+) with advanced chronic kidney disease who start a higher dose of the drug pramipexole have more hospital visits or deaths within 30 days compared to those on a lower dose. Researchers looked at health records of 1,100 people in Ontario…

This study analyzed health records of nearly 7,000 older adults (65+) with low kidney function who started taking the antidepressant sertraline. Researchers compared those on a 50 mg daily dose to those on 25 mg to see if the higher dose led to more hospital visits, emergency dep…

This study looked at 50,000 living kidney donors in Canada to see if they have a higher risk of heart problems or death later in life compared to similar people who didn't donate. Researchers used health records from 1992 to 2024 to track heart attacks, strokes, and deaths. The g…

This study examined the safety of starting citalopram at 20 mg/day versus 10 mg/day in adults aged 65 and older with reduced kidney function. Researchers analyzed health records from over 7,000 participants to see if the higher dose increased the risk of hospitalization, emergenc…

This study looked at health records of 40,000 men in Ontario, Canada, to see if those who had kidney cancer surgery were more likely to develop a scrotal hydrocele (fluid-filled swelling) compared to men who didn't have the surgery. Researchers compared different surgical approac…