London Health Sciences Centre Research Institute Or Lawson Research Institute Of St. Joseph's

This study was designed to compare a less invasive method called vacuum-assisted excision (VAPE) with standard surgery for removing non-cancerous but high-risk breast lesions. The goal was to see if VAPE works as well, is safer, leaves better scars, and makes patients happier. Ho…

This study tests a precise, high-dose radiation treatment (SABR) for people with early-stage non-small cell lung cancer who also have interstitial lung disease (ILD), a condition that causes lung scarring. About 39 participants will be grouped by ILD severity to see how well the …

This study tests whether giving extra radiation to the most active parts of a lung tumor can reduce the chance of cancer returning in the chest. About 78 adults with advanced non-small cell lung cancer will receive either standard chemoradiotherapy or chemoradiotherapy with a tar…

This early-stage trial tests a precise, high-dose radiation therapy for people with non-small cell lung cancer located near the center of the chest. The goal is to find the highest dose that can control the tumor while keeping the risk of serious side effects below 30%. About 30 …

This early-phase study tests whether giving kidney cancer patients a fecal microbiota transplant (FMT) before and during immunotherapy can prevent severe side effects like colitis. About 20 adults with advanced kidney cancer will receive FMT alongside the drugs ipilimumab and niv…

This study aimed to compare a newer, more natural pacing method (left bundle branch area pacing) with the standard method (right ventricular pacing) in people who developed heart block after TAVR valve replacement. It planned to enroll 60 patients across six centers and follow th…

This study tests whether adding a second type of dialysis (peritoneal dialysis) between regular hemodialysis sessions can safely remove extra sodium and fluid from the body. Ten adults with end-stage kidney disease who struggle with fluid buildup will receive this extra treatment…

This study tests whether giving a small, focused dose of radiation to the tumor before standard chemotherapy can improve treatment for people with high-risk or locally advanced breast cancer. The radiation is meant to 'prime' the immune system to fight the cancer better. About 40…

This study looks at whether adding more magnesium to the fluid used in dialysis can help people with kidney failure live longer and have fewer heart problems. Many dialysis patients have low magnesium, which can lead to muscle cramps and heart issues. The trial will compare two d…

This study compares two standard treatments for HPV-related throat cancer: radiation therapy or surgery to remove the tumor. The goal is to see which approach leads to better survival and quality of life, especially swallowing function. The study involves 61 adults with early-sta…

This study looks at whether giving focused, high-dose radiation (SABR) to a small number of growing cancer spots can help people with advanced lung cancer stay stable longer. About 90 adults with non-small cell lung cancer that has spread and is growing in just a few places will …

This study aimed to see if hydroxychloroquine could safely prevent COVID-19 in older adults living in long-term care homes. It planned to give the drug to people who were at high risk due to age and health conditions. However, the trial was withdrawn before any participants were …

This study tests a group therapy program called Awareness, Courage, and Love (ACL) for older adults with mental health conditions who feel lonely. The goal is to see if the program is practical and acceptable for this group. Researchers will measure loneliness and satisfaction be…

This pilot study tests a group therapy program called Awareness, Courage, and Love Groups for older adults admitted to a psychiatric hospital who feel lonely. The goal is to see if the program is practical and acceptable, and whether it helps reduce loneliness and improve social …

This study tests a therapy called Deep Brain Reorienting (DBR) for people with PTSD. 234 adults will be randomly assigned to receive DBR or join a waitlist. Researchers will measure changes in PTSD symptoms using a standard scale to see if DBR helps.

This study looks at whether high-intensity exercise during hemodialysis can protect the heart from the stress of treatment. 15 adults on dialysis for at least 3 months will be monitored. Researchers will measure heart function and blood vessel health to see if exercise intensity …

This study looks at how dialysis treatment affects blood flow in the brains of people with chronic kidney failure. Researchers will measure brain blood flow before and after dialysis sessions using a special breathing device and ultrasound. The goal is to find ways to adjust dial…

This study looks at 100 women with breast cancer who are taking a type of drug called a CDK4/6 inhibitor. The goal is to find genetic and blood markers that can predict which patients might have severe side effects or not get enough benefit from the drug. By understanding these m…

This study looks at why people on dialysis for kidney failure often have dangerous heart rhythm problems. Researchers are using a small implantable device to track heartbeats over time, along with heart scans, to see how dialysis treatments may injure the heart. The goal is to be…

This study looks at whether a special MRI that measures salt (sodium) in the kidneys can help doctors predict if heart failure patients will become resistant to water pills (diuretics). About 50 adults with heart failure and kidney disease will have their kidney salt levels scann…