London Health Sciences Centre Research Institute Or Lawson Research Institute Of St. Joseph's

This trial compares two ways of delivering radiation to the pelvis in men with unfavorable intermediate- or high-risk prostate cancer. One group receives the standard 25 sessions of radiation, while the other receives just 5 sessions with a higher dose per session. The goal is to…

This pilot study tests whether adding a special type of dialysis (peritoneal dialysis) between regular hemodialysis sessions can remove extra sodium and fluid from the body. Ten adults on hemodialysis will receive this extra treatment twice a week for three weeks. Researchers wil…

This study looks at whether adding more magnesium to the fluid used during dialysis can help people with kidney failure live longer and have fewer heart-related hospital stays. Many dialysis patients have low magnesium, which can lead to muscle cramps and heart issues. The trial …

This trial is testing whether giving a small dose of targeted radiation to a part of the breast tumor before standard chemotherapy can help the immune system fight the cancer more effectively. The study includes 40 people with high-risk or locally advanced breast cancer. After ra…

This study compares two standard treatments—radiation therapy and surgery—for people with HPV-related throat cancer. The goal is to see which approach provides better survival and quality of life. About 61 adults with early-stage cancer are taking part to help guide future treatm…

This study looks at whether giving precise, high-dose radiation to a small number of growing cancer spots can help people with metastatic non-small cell lung cancer stay stable longer. About 90 adults whose cancer has started to grow in just a few places while on standard treatme…

This trial tests whether giving a higher radiation dose to the most active parts of a lung tumor can better control the cancer. About 78 people with locally advanced non-small cell lung cancer will receive either standard chemoradiation or chemoradiation with an extra radiation b…

This phase 1 trial tests a precise, high-dose radiation technique called SBRT for patients with non-small cell lung cancer whose tumors are located in the ultra-central part of the chest, near the windpipe and major blood vessels. The study enrolls 30 participants to find the hig…

This phase II trial tests a precise type of radiation called SABR in 39 people with early-stage non-small cell lung cancer who also have interstitial lung disease (lung scarring). The goal is to see if this treatment can control the cancer while keeping side effects manageable. P…

This early-stage trial tests whether taking capsules containing processed stool from healthy donors can prevent severe immune-related side effects in people with advanced kidney cancer receiving a combination of two immunotherapy drugs (ipilimumab and nivolumab). The study involv…

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare blood disorder that can cause dangerous blood clots. Researchers want to know how often PNH appears in people under 50 who have had a stroke, mini-stroke, or brain vein clot with no clear cause. The study will screen 200 partici…

Hospital stays often leave patients weaker and more frail because they spend so much time in bed. Researchers are testing whether having trained volunteers walk with patients twice a day can prevent this decline. The trial enrolls 800 adults admitted to internal medicine wards wh…

This study aimed to see if hydroxychloroquine could prevent COVID-19 in older adults living in long-term care homes. It planned to give either the drug or a placebo to high-risk residents after they were exposed to the virus. However, the trial was withdrawn before enrolling anyo…

Researchers are comparing two ways to perform total knee replacement in patients with obesity and knee arthritis. One method uses custom-made guides based on each patient's knee scans, while the other uses standard surgical tools. The trial measures how well the knee aligns, how …

Researchers are testing whether isometric handgrip training, squeezing an inflatable ball in a steady hold, can lower resting blood pressure in people doing cardiac rehabilitation from home. Adults with coronary artery disease who are cleared for exercise-based rehab join the stu…

This study tests a therapy called Deep Brain Reorienting (DBR) for people with PTSD. DBR helps patients focus on physical tension linked to traumatic memories. 234 adults will be randomly assigned to either DBR or a waitlist, and researchers will measure changes in PTSD symptoms.

This study tests a group therapy called Awareness, Courage, and Love (ACL) for older adults with psychiatric disorders who feel lonely. The therapy focuses on mindfulness, sharing feelings, and building connections. Researchers want to see if the program is practical and helpful …

This pilot study tests whether a group therapy called Awareness, Courage, and Love Groups can help reduce loneliness in older adults admitted to a psychiatric hospital. Fifty participants will attend either this therapy or a standard mutual-help group. Researchers will measure so…

Researchers are examining health records to see whether older adults with advanced chronic kidney disease who start domperidone at 30 mg per day or more face a higher 30-day risk of hospitalization, emergency visits, or death compared with those taking lower doses. The study draw…

This study looked at health records of 15,000 males in Ontario, Canada, to see if those who had laparoscopic pyeloplasty (a surgery to fix a blocked kidney) were more likely to later need surgery for a hydrocele (a fluid-filled sac in the scrotum). Researchers compared these pati…

This completed study looked at nearly 7,000 older adults (65+) with low kidney function who started taking the antidepressant sertraline. Researchers compared the safety of a 50 mg daily dose versus a 25 mg daily dose, tracking hospital visits, emergency department visits, or dea…

This study reviewed health records of 40,000 men in Ontario, Canada, to see if those who had kidney cancer surgery (nephrectomy) were more likely to develop a hydrocele—a fluid-filled sac in the scrotum. Researchers compared men who had laparoscopic or open surgery to similar men…

This study looked at whether people who donate a kidney have a higher chance of developing gout later in life compared to similar healthy people who did not donate. Researchers reviewed health records from 50,000 donors and matched non-donors in Canada over many years. The goal i…

This completed study looked at 1,100 older adults (65+) with advanced chronic kidney disease who started taking pramipexole, a drug for restless legs or Parkinson's. Researchers compared a very low starting dose (0.125 mg/day) to slightly higher doses (0.25 or 0.375 mg/day) to se…

This study looked at over 7,000 older adults (65+) with reduced kidney function who started taking the antidepressant citalopram. Researchers compared a 20 mg/day dose to a 10 mg/day dose to see if the higher dose increased the risk of serious events like hospitalization, emergen…

This study compared 50,000 living kidney donors to similar healthy non-donors to see if donating a kidney raises the long-term risk of heart attack, stroke, or death. Researchers looked at health records from 1992 to 2024 in three Canadian provinces. The goal is to help doctors a…

This study examines whether people who donate a kidney have a higher long-term risk of breaking bones like the hip, wrist, or pelvis. Researchers will compare 50,000 living kidney donors from Canada to a matched group of healthy non-donors using health records from 1992 to 2024. …

This completed study looked at over 12,000 older adults (66+) with low kidney function who started taking lorazepam. Researchers compared higher doses (1-4 mg/day) to lower doses (0.5-1 mg/day) to see if there was a greater risk of hospitalization, emergency visits, or death with…

This completed study looked at 5000 older adults (66+) with low kidney function who started taking the antidepressant nortriptyline. Researchers compared those taking more than 10 mg per day to those taking exactly 10 mg per day to see if higher doses increased the chance of an e…

This study looked at 50,000 living kidney donors in Canada to see if they are more likely to develop kidney stones years after donating, compared to similar people who never donated. Researchers used health records from 1992 to 2024 to track surgeries or hospital visits for kidne…

This study looked at over 12,000 older adults (age 66+) with low kidney function who started taking the antidepressant escitalopram. Researchers compared the safety of a 10 mg daily dose versus a 5 mg daily dose. The goal was to see if the higher dose led to more hospital visits,…

This study looked at 14,000 older adults (66+) with advanced chronic kidney disease who started taking tamsulosin. Researchers compared those on a higher dose (0.8 mg/day) to those on a lower dose (0.4 mg/day) to see if the higher dose led to more hospital visits or deaths within…

This study examined whether starting a higher dose of two common antidepressants (venlafaxine and duloxetine) increases the risk of emergency visits, hospital stays, or death within 30 days in older adults with chronic kidney disease. Researchers analyzed health records from over…

This study looks at whether measuring salt levels in the kidneys using a special MRI can help doctors predict which heart failure patients will not respond well to water pills (diuretics). About 50 adults with heart failure and kidney disease will be scanned to compare salt conte…

This study looks at how kidney dialysis affects brain blood flow in 37 adults with chronic kidney failure. Researchers use a special breathing device called RespirAct to measure the brain's response to carbon dioxide before and after dialysis sessions. The goal is to find ways to…

This study looks at whether high-intensity cycling during hemodialysis can protect the heart from damage that dialysis sometimes causes. Fifteen adults on dialysis will exercise at different intensities during their sessions. Researchers will use echocardiograms to measure heart …

This study was designed to compare a newer pacing method (left bundle branch area pacing) with the standard method (right ventricular pacing) in patients who developed heart block after TAVR valve replacement. The goal was to see which method better preserves heart function and r…

This study aimed to compare a less invasive procedure called vacuum-assisted excision (VAPE) to standard surgery for removing non-cancerous but high-risk breast lesions. The goal was to see if VAPE worked as well, was safer, and left better cosmetic results. However, the study wa…

This study looks at 100 breast cancer patients taking CDK4/6 inhibitor drugs. Researchers want to find genetic and blood markers that can predict who will have bad side effects or not get enough benefit from the medication. The goal is to help doctors choose safer and more effect…