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Can a kidney salt scan predict who Won't respond to water pills?

NCT ID NCT04170855

Knowledge-focused Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether measuring salt levels in the kidneys using a special MRI can help doctors predict which heart failure patients will not respond well to water pills (diuretics). About 50 adults with heart failure and kidney disease will be scanned to compare salt content between those who respond to diuretics and those who don't. The goal is to help doctors prescribe the right dose from the start, avoiding treatment failure and side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2020

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria for Visit 1 * Clinico-pathological diagnosis of heart failure * Age ≥ 18 years * Estimated GFR ≥ 15 mL/min/1.73m2 * Receiving loop diuretics for at least a week at ≥ 40 mg/day (furosemide) or 2 mg/day (bumetanide), either orally or intravenously * Willing and able to provide consent Inclusion Criteria for Visit 2 · Patients from visit 1 with diuretic resistance Exclusion Criteria for Visit 1 Direct contraindications to MR scanning (implanted materials etc.) * Additional diuretic types other than spironolactone/epleronone/metolazone/finerenone * Liver disease with hepato-renal syndrome * Pregnant, breastfeeding or intending pregnancy * Kidney malformation leading to chronic kidney disease (for example polycystic kidney) * Unable to provide consent Exclusion criteria for Visit 2 · Hypokalemia (serum potassium \<3.5 mmol/l)

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Conditions

The condition(s) this trial relates to.

cardio-renal syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardio-renal syndrome

Contacts and locations

Locations

  • Heart Failure Clinic | St. Joseph's Health Care London

    London, Ontario, N6A 3N3, Canada

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