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When does the brain really die? new study tracks the final moments

NCT ID NCT05306327

Knowledge-focused Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study watches brain activity in patients who are taken off life support in the ICU. Researchers want to see when the brain stops working compared to when the heart stops. It involves 158 adults expected to die within 24 hours of stopping life support. The goal is to better understand the dying process, not to test a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 158 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2022

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study will include all patients admitted to a participating ICU who fulfil all the inclusion criteria and for whom none of the exclusion criteria exist.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age ≥ 18 years 2. Plan for the withdrawal of life sustaining measures (WLSM) 3. Attending physician anticipates patient will die within 24 hours of the withdrawal of life sustaining measures 4. Patient has an indwelling arterial cannula for monitoring blood pressure Exclusion Criteria: 1. Brain death or plan for Neurologic Determination of Death (NDD) 2. Injuries that anatomically preclude the use of neurologic monitoring

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Conditions

The condition(s) this trial relates to.

Death

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Determination of death

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    5 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Centre hospitalier de l'Université de Montréal,

    RECRUITING

    Montreal, Quebec, H2X3E4, Canada

  • Kingston Health Sciences Centre

    RECRUITING

    Kingston, Ontario, K7L2V7, Canada

  • London Health Sciences Centre

    RECRUITING

    London, Ontario, N6A 5A5, Canada

  • Ottawa Hospital

    RECRUITING

    Ottawa, Ontario, K1H8L6, Canada

  • University of Calgary Foothills Campus

    RECRUITING

    Calgary, Alberta, T2N1N4, Canada