Reproductive system disorder

Researchers are testing a vaccine called BNT113 in people whose cancers are driven by HPV16, a common virus linked to head and neck, cervical, and anogenital tumors. The trial enrolls two groups: one with head and neck cancer that has been treated and shows no signs of disease, a…

Researchers are testing whether injecting a woman's own bone marrow cells into her ovaries can restore ovarian function in premature ovarian insufficiency, a condition where the ovaries stop working before age 40. Ten women with the diagnosis will receive the treatment, which inv…

Researchers are testing a treatment called TOOKAD Soluble vascular targeted photodynamic therapy in men with localized intermediate-risk prostate cancer. The approach uses a drug activated by light to destroy cancer tissue in the prostate. The trial follows 50 men for up to 60 mo…

This early-stage trial tested whether a new herpes vaccine called HSV529 is safe for people. Researchers gave the vaccine or a placebo to 69 healthy adults aged 18 to 40, some of whom had herpes and some who did not. Participants received three shots over six months and were moni…

This study tested an experimental HIV vaccine in 132 healthy, HIV-negative adults. The vaccine uses a harmless virus (ALVAC) to deliver HIV proteins, plus a protein boost (gp120) with an adjuvant to strengthen the immune response. The main goals were to check safety and measure w…

This study tests an RSV vaccine in pregnant women living with HIV. The goal is to see if the vaccine is safe and helps mothers pass protective antibodies to their babies, potentially preventing severe RSV lung infections in infants. The trial involves about 681 pregnant participa…

This Phase 1 trial tested a new HIV vaccine in 68 healthy adults to see if it is safe and triggers an immune response. The vaccine uses a DNA-based approach combined with an HIV protein to train the body to fight the virus. While early results are encouraging, this is just the fi…

This early-stage study tested a vaccine called DCP-001 in 17 women with a serious type of ovarian cancer who had already completed standard treatment. The goal was to see if the vaccine is safe and can boost the immune system to recognize and fight cancer cells. Researchers measu…

This study tested two different schedules of an experimental HIV vaccine in 147 healthy adults to see which one triggers a stronger immune response. Volunteers received either three DNA shots followed by one booster, or two DNA shots followed by two boosters. The goal was to find…

Researchers test whether they can place sutures inside the uterus using a hysteroscope and the X-Tack device. The pilot enrolls women who are already scheduled for laparoscopic hysterectomy for benign conditions. After the sutures are placed, surgeons open the removed uterus to c…

This study adapts a wellness program called Chetana to help men who have sex with men (MSM) and transgender women (TGW) in India who are living with HIV stay engaged in care. The program includes yoga, nutrition, legal advice, mental health support, and peer navigators who provid…

This study tested whether monthly injections of two HIV drugs (cabotegravir and rilpivirine) work better than daily oral pills for people with HIV who have a history of missing doses. Over 450 participants were enrolled. The goal was to see if the long-acting shots reduce the cha…

This study tested whether taking the drug abiraterone on an on-and-off schedule could help it work longer for men with advanced prostate cancer that no longer responds to hormone therapy. Nineteen men whose cancer had already responded to standard daily abiraterone were enrolled.…

This study looked at whether a special care plan led by a geriatrician and a nurse could improve survival and quality of life for older adults (70+) with advanced cancer. 792 patients with breast, colorectal, lung, prostate, bladder, ovarian cancer, or lymphoma took part. The app…

Researchers are testing two ways to give the HIV drug dolutegravir to people who also have tuberculosis and are taking rifampin-based TB therapy. Rifampin can lower dolutegravir levels in the body, so the trial compares taking 50 mg once daily with food against taking 50 mg twice…

Researchers are testing a radiation technique called PULSAR in people with metastatic cervical cancer. PULSAR delivers radiation in short bursts to pelvic tumors, guided by imaging, alongside standard systemic therapy. The trial aims to see whether this approach improves overall …

Researchers at the University of Miami are testing two ways to help men who have sex with men take their HIV prevention medication, known as PrEP, more consistently. One group receives four weekly counseling sessions with a nurse, using techniques from cognitive behavioral therap…

This early-phase trial tested a combination of two chemotherapy drugs (gemcitabine and carboplatin) plus lenalidomide, a drug that blocks blood vessel growth in tumors, in 18 adults with advanced solid tumors, especially urothelial (bladder) cancer. The main goal was to find the …

Researchers are studying whether trained community workers can safely deliver HIV treatment outside clinics in Cambodia. The trial enrolls about 4,000 people living with HIV who have stable treatment and no complications. Community action workers receive training to dispense drug…

This study tests whether adding the immunotherapy drug nivolumab (Opdivo) to standard radiation and hormone therapy is safe and effective for men with a very aggressive form of prostate cancer (Gleason grade group 5). About 44 men will receive the drug combination. The goal is to…

This study tests a new program to help people with HIV who also use substances stick to their HIV medications and stay in care. The program teaches coping skills and ways to manage substance use. Researchers want to see if the program is practical and acceptable to participants. …

Researchers at UT Health San Antonio are testing a mobile app called PL4Y to see if it helps young people recently diagnosed with HIV stay connected to medical care. The pilot study enrolls 29 participants who either have a recent diagnosis, a high viral load, or have missed HIV …

This study tests whether adding darolutamide to standard hormone therapy (ADT) can delay cancer worsening in men with metastatic hormone-sensitive prostate cancer. About 223 men will receive darolutamide plus ADT, and their results will be compared to men from an earlier study wh…

This Phase 2 trial tests whether a combination of dasatinib and quercetin (D+Q) can safely improve physical function in 82 older adults with HIV who are frail or prefrail. Participants take D+Q or a placebo in six 2-day cycles over 12 weeks, then are monitored for another 12 week…

This study tested a radioactive drug called 177Lu-PSMA-617 in 62 Chinese men with advanced prostate cancer that had spread and stopped responding to hormone therapy and chemotherapy. The drug targets a protein on cancer cells and delivers radiation directly to them. Researchers m…

This trial compares two surgical methods—carbon dioxide laser ablation and electrocoagulation—for removing genital warts in women. The main goal is to see which technique gives a better cosmetic result six weeks after treatment. Researchers also track operation time, complication…

This phase II trial is testing an oral drug called giredestrant in 30 people with grade 1 endometrial cancer. The goal is to see if the drug can shrink or control the cancer over 6 months. Participants take one pill daily for up to 24 cycles, and doctors monitor tumor changes and…

This study tests a radioactive drug called 177Lu-PSMA-617 in men with advanced prostate cancer that has stopped responding to hormone therapy. The drug seeks out and delivers radiation directly to cancer cells. The trial aims to find the safest effective dose and see if it can lo…

Researchers are testing an oral form of native testosterone called DITEST in men with primary or secondary hypogonadism. The trial measures how much testosterone reaches the blood after a single dose, both with and without food, and compares it to an existing oral testosterone tr…

This early-phase trial tests a new drug called AI-061, which combines two immune-boosting antibodies (anti-PD-1 and anti-CTLA-4) into one treatment. The study will enroll 18 adults with advanced solid tumors that have spread or cannot be removed. The main goals are to find a safe…

Researchers are testing whether a once-daily form of raltegravir can keep HIV suppressed in adults who already have the virus under control with standard antiretroviral therapy. The trial enrolls about 100 adults with HIV-1 who have been on stable treatment for at least six month…

This Phase 2 trial tests two experimental drug combinations in 63 women with a specific type of ovarian cancer (BRCA-mutant or HRD-positive) that has worsened after prior PARP inhibitor treatment. Participants receive either tuvusertib plus niraparib or tuvusertib plus larteserti…

This early-stage trial is testing a new drug called tuvusertib, given together with either lartesertib or avelumab, in people with advanced solid tumors that have not responded to standard treatments. The main goals are to check safety, find the best dose, and see how the body pr…

Acromegaly is a rare condition where the pituitary gland makes too much growth hormone, causing bones and tissues to enlarge. Researchers are testing a long-acting octreotide injection called SYHX2008 in 78 adults with active acromegaly. Participants receive either the new inject…

Researchers are testing whether giving radiation therapy before sipuleucel-T, a personalized immunotherapy vaccine, works better than the vaccine alone in men with hormone-resistant prostate cancer that has spread. The trial enrolls about 51 participants and randomly assigns them…

Researchers are studying whether an enhanced package of care helps people with advanced HIV in Malawi stay in treatment and keep the virus suppressed. The package adds CD4 and TB-LAM tests and starts patients on TB preventive therapy, delivered through a hub-and-spoke system of c…

This early-phase trial tested a new drug called vilastobart, alone or with another drug (atezolizumab), in 125 people with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check safety and find the right dose. Researchers also looke…

This study tested a new oral drug called atumelnant in 38 adults with classic congenital adrenal hyperplasia, a genetic condition causing hormone imbalances. The drug works by blocking a hormone receptor to lower excess adrenal hormones. Researchers measured safety, side effects,…

This study tests whether boric acid vaginal inserts (600 mg) taken for 7 or 14 days can safely and effectively treat yeast infections. About 400 women aged 12 and older with active symptoms will participate. The goal is to see if all signs and symptoms disappear without needing m…

In sub-Saharan Africa, tuberculosis often causes sepsis in people living with HIV, and many die within days. This phase 3 trial tests two changes to standard care: starting anti-TB therapy right away instead of waiting for test results, and using a higher, sepsis-specific dose in…

Researchers are testing whether a daily pill combining dolutegravir and lamivudine keeps HIV suppressed in adults whose virus is already under control but who have a history of resistance to lamivudine. The study enrolls 167 participants who switch from their current HIV treatmen…

This study tested two ways to offer HIV treatment, hepatitis C treatment, and substance use disorder medications to people who inject drugs. One group received a telehealth-enhanced program with on-demand services like mobile blood draws and counseling, while the other group got …

This trial tests whether silodosin, a medication that relaxes prostate and bladder muscles, works better than tamsulosin for men with an enlarged prostate and bothersome urinary symptoms. About 110 men aged 60 to 80 will take one of the two drugs for 12 weeks. Researchers will me…

This study looked at whether inositol, a natural supplement, can improve ovulation in women with polycystic ovary syndrome (PCOS) who did not respond to the fertility drug letrozole. 36 women aged 18-35 took part. The researchers compared inositol to metformin, another common tre…

This phase 2 trial tests an oral drug called ARD-101 in adults with Prader-Willi syndrome, a genetic condition that causes an unrelenting feeling of hunger. Researchers give the drug twice daily for 28 days to see if it safely reduces hyperphagia, the intense drive to eat, using …

This study evaluates a program for HIV-positive adolescent girls and young women who are pregnant or parenting. The program offers education on sexual health, support groups, skills development, mentorship, and involvement of young fathers. Researchers will measure resilience and…

This trial tests whether a steam-based treatment called Rezūm can work as well as standard surgery (TURP) for men with an enlarged prostate who need a catheter to urinate. Men aged 50 to 80 with this condition will be randomly assigned to receive either Rezūm or TURP. The main go…

This Phase 3 trial tests an oral drug called QLG1080 in men with hormone-sensitive advanced prostate cancer. The goal is to see if the drug can safely lower testosterone to castration levels, which helps slow cancer growth. Participants must be eligible for endocrine therapy and …

This trial tests whether kidneys from deceased HIV-positive donors can be safely transplanted into people living with HIV. Researchers track major complications like graft failure, serious side effects, and HIV progression. The goal is to see if using these organs is a safe way t…

This study compares two follicle-stimulating hormones, follitropin delta and follitropin alfa, used to stimulate the ovaries in Indonesian women under 40 undergoing intrauterine insemination (IUI) for infertility. Researchers will review medical records from a fertility center to…

This trial tests an experimental drug called FLX475, given alone or with the immunotherapy pembrolizumab, in people with advanced cancers that have not responded to standard treatments. The study aims to find the safest dose and to see whether the combination can shrink tumors. P…

This trial tests whether a daily fish-derived lipid supplement, taken for 12 weeks alongside standard dietary advice, can reduce inflammation and pain in women with endometriosis. Researchers will randomly assign 46 women aged 18 to 55 with a confirmed diagnosis to either the sup…

This trial tests whether a three-month course of the dietary supplement Stemregen can improve sperm quality in men with severe oligoasthenozoospermia, a condition marked by very low sperm count and poor movement. Researchers will compare semen parameters, sperm DNA damage, and ou…

This study tested whether adding the immunotherapy drug pembrolizumab to standard hormone therapy (enzalutamide plus ADT) could help men with metastatic hormone-sensitive prostate cancer live longer or delay cancer growth. The trial enrolled 186 Chinese men and was stopped early …

This trial tests whether injections of platelet-rich plasma from cord blood can ease vulvar lichen sclerosus, a chronic skin condition causing itching, burning, and pain. Researchers will compare CB-PRP against a placebo in 100 women, giving three treatments four weeks apart. The…

This trial tests an experimental drug called SNS-101, which targets a protein called VISTA that may help tumors evade the immune system. Researchers give SNS-101 alone or with another immunotherapy, cemiplimab, to adults with advanced solid tumors that have not responded to stand…

This trial tests whether adding a zinc-containing vaginal gel to the standard yeast infection pill can lower the chance of the infection returning. About 64 women with a current yeast infection will receive either the standard single dose of fluconazole alone or fluconazole follo…

This study compares three treatments for early HIV infection: zidovudine (AZT) alone, alpha-interferon alone, or both together. It aims to see which best lowers viral load, protects the immune system, and delays the first serious infection. About 180 adults with early HIV and hea…

This trial tests whether giving a higher radiation dose during brachytherapy, a type of internal radiation, can improve local control in patients with locally advanced cervical cancer. Participants receive standard external beam radiation and chemotherapy, plus a boosted brachyth…

This study tested whether thumbtack needle acupuncture can improve ovarian function in 240 women aged 18-40 with diminished ovarian reserve (low egg supply). Participants received acupuncture at specific points for up to 4 weeks. The main goals were to see changes in anti-Mülleri…

This trial compares two types of radiation therapy for prostate cancer: proton therapy and standard photon therapy. The main question is whether proton therapy reduces moderate to severe urinary or intestinal side effects. Researchers will also track quality of life, cancer recur…

This trial tests whether an individualized pelvic floor physiotherapy program combined with lifestyle education can reduce symptoms and improve daily life for women with stage I or II pelvic organ prolapse. Researchers will compare this approach to lifestyle education alone in 12…

Researchers are testing a smartphone game called MyGoals to see if it can help adolescents living with HIV in Kenya stay engaged in their care. The game includes role-playing, mini-games, and personal goal-setting to boost knowledge, attitudes, and confidence around treatment and…

This study tests a device called Materna Prep, which is used for 30-90 minutes during early labor to gently stretch the vaginal canal and pelvic floor. The goal is to reduce muscle injuries that can happen during vaginal birth. 420 first-time mothers or those with a prior early p…

This study tested a mobile phone-based wellness program (WISH) to help veterans with HIV quit smoking. 234 participants were split into two groups: one received the WISH program, the other got standard care (quitline and text support). The goal was to see if the wellness program …

This study is testing two mobile health tools—a computer-delivered program and motivational text messages—to help young adults (ages 18-24) in Zambia better manage their HIV and cut down on alcohol use. The goal is to see if these tools are easy to use and acceptable to participa…

This trial tests whether Impryl, a nutritional supplement with B vitamins and zinc, can increase the chance of an ongoing pregnancy in couples where the male partner has subfertility. About 1,200 couples will take either Impryl or a placebo while starting fertility treatments lik…

This pilot study tests whether people with HIV who receive routine care at a community center, instead of a hospital, feel more satisfied with their care. Researchers will compare satisfaction between two groups: one getting care at the community facility and one continuing usual…

This trial tests a counseling program called ImpACT+ for women in South Africa who have HIV and a history of sexual trauma. The program combines HIV treatment adherence support with coping skills to address traumatic stress. Researchers will compare viral suppression rates and ca…

Researchers are studying whether adding a perineorrhaphy, a repair of the perineum, during vaginal prolapse surgery lowers the need for repeat surgery and eases symptoms. The study uses Swedish registry data to compare women who had the extra procedure with those who did not. It …

This trial tests a modified version of a minimally invasive procedure called prostatic urethral lift (PUL) for men with an enlarged prostate causing bothersome urinary symptoms. The new approach uses a zero-angle firing and needle-guided puncture technique to place implants more …

This trial tests whether a modified laser surgery for an enlarged prostate can relieve urinary blockage while preserving ejaculation. Men aged 50 and older with urinary symptoms are randomly assigned to either the standard laser vaporization or a version that leaves small tissue …

This study tests whether a structured transition-of-care program can improve support for adults in Malawi who are hospitalized with both HIV and a chronic condition like high blood pressure. The program includes discharge planning, nurse home visits within a week, and community f…

This trial is testing whether a new, once-monthly injection of octreotide (CAM2029) can help people with acromegaly, a condition where the body makes too much growth hormone. Participants will receive either the study drug or a placebo for six months. The main goal is to see if t…

This study is testing a device called the Optilume Catheter System, a drug-coated balloon that is inflated in the prostate to widen the urinary passage. It is designed for men with symptomatic benign prostatic hyperplasia (BPH), an enlarged prostate that causes bothersome urinary…

This trial compares two methods of amnioinfusion—adding fluid to the womb—in pregnant women with preterm premature rupture of membranes (PPROM) and very low amniotic fluid. One method uses a central venous pressure (CVP) set for controlled fluid delivery, while the other uses the…

This trial tests whether a daily dienogest tablet can shrink endometriomas (ovarian cysts caused by endometriosis) and ease period pain better than a combined oral contraceptive pill. Women aged 18 to 40 with symptomatic endometriomas will take one of the two treatments for three…

This trial investigates whether adding DHEA to coenzyme Q10 improves sperm concentration in men with low sperm count (oligospermia). Half the participants will take DHEA plus CoQ10, while the other half takes CoQ10 alone, for three months. The study measures sperm concentration b…

This trial asks men with advanced prostate cancer which of two oral medications they prefer: the experimental drug ODM-201 or the approved drug enzalutamide. Both work by blocking male hormones that fuel cancer growth. Participants will take each drug for a period and then answer…

This study looks at whether a traditional Chinese herbal formula, Guishen Yijing, can help women with diminished ovarian reserve (DOR) — a condition where the ovaries have fewer eggs than expected for a woman's age. Researchers will review medical records of 126 women who took th…

This trial tests whether offering small cash payments to people living with HIV, when they attend counseling sessions and clinic visits, can help them stay engaged in care and achieve viral suppression. Participants are adults identified as high risk for dropping out of care at t…

This trial tests whether elagolix, a hormone-blocking drug, can shrink endometriomas (ovarian cysts caused by endometriosis) and ease severe period pain better than the combined birth control pill. Women aged 18-40 with symptomatic endometriomas (2-5 cm) will take either elagolix…

This trial is testing a procedure called HIPEC, where a heated chemotherapy drug (cisplatin) is delivered directly into the abdomen after surgery to remove visible cancer. The goal is to find the safest dose that can be used in patients with advanced ovarian, fallopian tube, or p…

This phase 1 trial is testing whether adding the antiviral drug Vistide (cidofovir) to the standard combination of radiation and chemotherapy can improve outcomes for people with HPV-positive cervical cancer. The idea is that Vistide may make cancer cells more sensitive to radiat…

This study in Zambia is testing whether community-based and streamlined models of antiretroviral therapy (ART) care can help people living with HIV stay in treatment. It involves about 3,100 HIV-positive adolescents and adults who are not acutely ill. Participants may receive car…

This trial tests whether a structured, pharmacist-led medication management program can help HIV patients at high risk of drug-related problems take their medications more consistently. Participants are randomly assigned to usual care, a basic program, or an enhanced program with…

This trial tests a community-based program called VINA STEAM, designed to help gay and bisexual men in Ho Chi Minh City cope with stress and HIV-related stigma. Participants join small peer-led groups to build skills that may reduce minority stress and stigma. The study measures …

This phase II trial is testing whether the chemotherapy drug eribulin, given alone or combined with the immunotherapy pembrolizumab, can help people with ovarian or uterine carcinosarcoma that has returned or progressed. The study aims to see if these treatments can shrink tumors…

This trial investigates whether combining two laparoscopic procedures—resection rectopexy and sacrocolpopexy—can safely and effectively treat women who have both pelvic organ prolapse and obstructive defecation syndrome (a type of chronic constipation). The study will enroll 35 w…

This phase 3 trial asks whether a dolutegravir-based HIV regimen works as well as or better than an efavirenz-based regimen in pregnant women living with HIV-1. The study compares how well each treatment suppresses the virus at delivery and checks safety for both mothers and thei…

This phase 2 trial tests the drug cabozantinib in women with advanced or metastatic cervical cancer that has worsened after platinum-based chemotherapy. The study aims to see if cabozantinib can control the disease and how safe it is, particularly regarding risks like fistulas. P…

This trial compares two surgical procedures—bipolar enucleation of the prostate (BEEP) and bipolar TURP (bTURP)—for treating benign prostatic hyperplasia (BPH) in men with prostates larger than 80 grams. Researchers measure how much prostate tissue remains after surgery, changes …

This trial compares two ways to make the first incision for laparoscopic surgery in women with endometrial cancer: the standard umbilical entry versus entry through the Lee-Huang point, a spot on the upper left abdomen. The goal is to see which approach leads to fewer complicatio…

This trial tests whether a soft balloon (Cook's balloon) placed in the cervix is better than a vaginal medication (dinoprostone) for starting labor in full-term pregnancies where the baby is growing slowly. The main goal is to see which method leads to more vaginal deliveries and…

This study monitors the safety and effectiveness of the drug olaparib (Lynparza) in people with ovarian, breast, prostate, or pancreatic cancer who are prescribed it as part of routine care in South Korea. Researchers will track side effects and how long the cancer stays under co…

This study tested a new strategy: giving TB prevention medicine at the same time as TB testing to people with HIV starting or restarting antiretroviral therapy. The goal was to see if this approach gets more people on TB prevention quickly without missing active TB cases. The tri…

This trial investigates whether a single injection of platelet-rich plasma (PRP), made from a person's own blood, can reduce pain and improve function in chronic patellar tendinopathy (knee tendon pain). The study includes 29 adults aged 18–65 who have had tendon pain for over th…

This study tested a special digital pill and smartphone app to help HIV-negative men who have sex with men and who also have substance use disorder take their daily HIV prevention medication (PrEP) consistently. Forty participants took a PrEP pill with a sensor that recorded when…

This clinical trial investigates whether different dosing schedules of tadalafil or tamsulosin, when combined with a 5-alpha reductase inhibitor, can better manage urinary symptoms and preserve sexual function in men with benign prostatic hyperplasia (BPH). The study includes 240…

This study tests whether a virtual environment (VE) can help minority men who have sex with men and are living with HIV adopt healthier behaviors to prevent cardiovascular disease. Participants use a computer-based virtual world to access educational quests and other features. Th…

This phase 3 trial investigates whether the antibiotic linezolid can cure yaws, a bacterial skin infection that causes ulcers, as effectively as the standard treatment azithromycin. The study involves 384 children aged 5 to 18 with confirmed yaws. Participants receive either line…

This study looks at whether CABENUVA, a long-acting injectable HIV medication, is safe and effective for people with HIV who also have severe kidney impairment, including those on dialysis. Participants receive the drug as monthly or every-2-month injections. The goal is to see h…

This study tests a care model where hospitalized adults with opioid use disorder and a serious infection receive long-acting injectable buprenorphine from their infectious disease doctors, alongside infection treatment. The goal is to keep patients on effective medication for opi…

This phase 3 trial investigates whether the drug tolvaptan can safely and effectively correct low sodium levels in patients with hyponatremia, a condition where the body's sodium-water balance is off. The study enrolls adults with mild to moderate hyponatremia who are either euvo…

This study tests a new drug called pegilodecakin, a lab-made version of a natural immune protein (interleukin-10), in people with advanced solid tumors such as melanoma, lung, breast, prostate, ovarian, kidney, colorectal, and pancreatic cancers. The drug is given as a daily shot…

This study tests a long-acting growth hormone called TransCon hGH, given as a once-weekly injection, in children with growth hormone deficiency who have already completed a prior TransCon trial. The goal is to see if the weekly shot remains safe and effective over the long term. …

This phase 3 trial investigates whether a once-weekly injection of lonapegsomatropin, a long-acting growth hormone, can safely and effectively treat adults with growth hormone deficiency. The study compares the weekly drug against a placebo and a standard daily growth hormone pro…

This study tests different ways to help people with HIV take their medication regularly. Researchers will enroll 534 people starting HIV treatment in Cape Town. They will use a device to track pill-taking and try different outreach methods, like calls or texts, to support adheren…

This study tests a program called Maisha (Swahili for 'life') that aims to reduce HIV stigma among pregnant women and their male partners entering antenatal care in Tanzania. The program includes a video and counseling session before HIV testing, plus extra support for those who …

This study tests whether a secure website with educational sessions, goal-setting, and tracking tools can help survivors of several cancers (including breast, prostate, colorectal, and others) improve their diet, increase physical activity, and manage weight. Participants are age…

This trial tests whether combining a hormone-releasing IUD with an anchoring IUD can prevent the device from slipping out of place in women with adenomyosis, a condition that causes pelvic pain and heavy bleeding. The study includes 270 women with different uterine cavity depths,…

This trial compares three modern radiotherapy techniques—helical tomotherapy and two types of dynamic arc therapy (RapidArc and VMAT)—for treating prostate, cervical, and anal canal cancers that require pelvic lymph node irradiation. The goal is to determine which method is most …

This study tests whether using continuous positive airway pressure (CPAP) or positive end-expiratory pressure (PEEP) during resuscitation helps extremely low birth weight infants (born before 28 weeks) breathe better and avoid lung damage. Half of the babies receive standard care…

This study tests a new way to help vulnerable people with HIV get diagnosed and start treatment right away using a mobile screening unit. Participants receive the once-daily pill Biktarvy on the same day they are enrolled. The goal is to see if this approach helps them stay in ca…

This trial tests a package of services called TASKPEN, which combines HIV care with screening and treatment for high blood pressure, diabetes, and tobacco use. It involves over 5,700 adults living with HIV in Lusaka, Zambia. The goal is to see if this integrated approach helps mo…

This study tested the drug pembrolizumab (Keytruda) as a follow-up treatment for one patient with a rare type of ovarian cancer called small cell carcinoma of the ovary, hypercalcemic type (SCCOHT). The goal was to see if the drug could help keep the cancer from coming back. Beca…

This study tested a herbal extract from a Himalayan plant (Nepeta adenophyta) in 116 women with PCOS. Participants took either the herb, the standard drug metformin, or both for 4 months. The goal was to see if the herb could help restore regular menstrual cycles and improve meta…

This study tested a new type of PET/MRI scan that uses a special tracer to find small spots of prostate cancer that standard scans miss. Men with a rising PSA after prostate surgery and radiation received targeted radiation to those spots. The goal was to see if this approach can…

This study tests an oral medication called LUM-201 in children with growth hormone deficiency who have not yet received treatment. The goal is to see if taking a pill daily can improve growth as effectively as standard daily injections. The trial also looks for a way to identify …

This completed phase 2 trial tested whether the drug cediranib, given with chemotherapy, is safe for women with advanced ovarian cancer who are at risk of bowel obstruction. 30 participants received the combination. The study focused on whether the treatment caused serious bowel …

This Phase 3 trial tested whether taking Elagolix (a hormone-blocking pill) for two months before IVF could improve live birth rates in women with endometriosis. 103 women participated, and the main goal was to see if more babies were born after this pre-treatment. The study comp…

This study compares two ways of injecting BOTOX into the prostate for men with benign prostatic hyperplasia (BPH) who still have bothersome urinary symptoms despite medication. One group receives BOTOX only in the prostate gland, while the other gets injections in the prostate, b…

This study tested a drug called SB-UF, which combines hormones and a plant extract, to see if it can shrink uterine fibroids in pregnant women. 66 women took the drug or a placebo throughout their pregnancy. The goal was to reduce fibroid size and help them disappear, which could…

This early-phase trial tested a new type of vaccine made from a patient's own immune cells (dendritic cells) that are engineered to target a protein called WT1 found in many cancers. Ten people with advanced esophageal, pancreatic, ovarian, or liver cancer received six vaccines o…

This early-phase study tested whether adding indomethacin, a common anti-inflammatory drug, to standard platinum-based chemotherapy is safe for people with colorectal, esophageal, or ovarian cancers. The 13 participants received escalating doses of indomethacin alongside their ch…

This study compared two surgical approaches for early-stage cervical cancer: laparoscopic-assisted (minimally invasive) and open abdominal hysterectomy. Sixty women with stage IA1 to IB1 cervical cancer were randomly assigned to one of the two surgeries. Researchers measured surg…

This study tested three different ways to help people living with HIV stop smoking. Over 670 patients from 13 HIV clinics in Hanoi took part. Nurses either referred patients to a quitline, provided counseling, or offered counseling plus nicotine gum. The goal was to see which met…

This study tested a device called NanoKnife to treat prostate cancer in 121 men with intermediate-risk disease. The goal was to safely destroy cancer tissue while avoiding major side effects. Researchers checked if the treated area was cancer-free after 12 months and tracked any …

This study compared two common antibiotics—azithromycin (single dose) and doxycycline (7-day course)—for treating anal chlamydia in women who also had a vaginal chlamydia infection. The goal was to see which treatment clears the anal infection better, since anal chlamydia often g…

This study tested a new technique to help women with primary ovarian insufficiency (early ovarian failure) become pregnant. Doctors removed one ovary, treated small pieces of it with drugs to wake up dormant eggs, and then transplanted the tissue back into the patient. After moni…

This early-phase trial tested whether combining shockwave therapy with platelet-rich plasma (PRP) injections can improve erectile function in men with microvascular erectile dysfunction. Fifty-nine men received either the combination treatment or a sham procedure. The main goal w…

This study tested a new X-ray monitoring technique (KIM) during prostate cancer radiation therapy. The goal was to see if it helps doctors aim more precisely at the tumor while reducing harm to healthy tissue. 49 men with low- or intermediate-risk prostate cancer took part. The a…

This phase 2 trial tested whether the immunotherapy drug pembrolizumab (Keytruda) could help keep cancer from growing in people with platinum-resistant ovarian, fallopian tube, or peritoneal cancer. After initial chemotherapy with paclitaxel, 20 participants received pembrolizuma…

This study tested a combination of peginterferon alfa2a and ribavirin in 17 HIV-positive people with chronic hepatitis C who had not responded to earlier treatment. Participants received weekly injections and daily pills for 48 weeks. The main goal was to see if the virus became …

This trial tested whether a precise type of radiation called SBRT could slow the growth of metastatic prostate cancer in men whose disease was starting to worsen despite hormone therapy. 86 men with one or two growing tumors received SBRT while continuing their current hormone dr…

This study tested whether adding platelet-rich plasma (PRP) from a man's own blood to his sperm sample could improve embryo development during IVF. Researchers compared embryos from 66 men with severe sperm disorders, half treated with PRP and half without. The goal was to see if…

This study tested a new way to manage high blood pressure and heart disease risk in people living with HIV in Botswana. Over 4,600 adults on HIV treatment took part. The goal was to see if adding heart health checks and treatment to regular HIV clinic visits helps more people con…

This pilot study tested a text-message game called iTAG that uses points, a scoreboard, and motivational messages to encourage young people with HIV in Ghana to take their medication regularly. Twenty-one participants aged 18-24 received the game for 90 days. Researchers measured…

This study looked at 60 men with metabolic syndrome who also had erectile dysfunction and early signs of heart stiffness. Researchers compared three treatments: tadalafil (a common ED drug), an SGLT2 inhibitor (a diabetes drug), and a combination of both, given for three months. …

This study tested a new way to care for people who inject drugs and have hepatitis C. Along with standard hepatitis C treatment, participants were offered HIV prevention medication and buprenorphine for opioid use disorder. The goal was to see if this combined approach could cure…

This study tested whether the BCG vaccine, normally used to prevent tuberculosis, could reduce the hidden HIV reservoir in people living with HIV who are on antiretroviral therapy. Sixty participants received either a single BCG shot or a placebo. Researchers measured changes in …

This study tested a new, cross-shaped silicone pessary for women with pelvic organ prolapse. 51 women who already used a traditional pessary tried the new device for 6 months. Researchers measured symptom distress and how many women kept using it. The goal was to see if the new s…

This study tested a device that uses water vapor (steam) to destroy cancerous tissue in the prostate. 32 men with prostate cancer received the treatment just before their scheduled prostate removal surgery. Researchers checked how well the steam destroyed the targeted tissue and …

This study looked at 160 women with pelvic organ prolapse who had a hysterectomy and then one of two surgical repairs. The goal was to see if repairing one side or both sides of the supporting ligaments works better and is safer. Results may help doctors choose the best approach …

This phase 3 trial tested whether adding the immunotherapy drug atezolizumab to standard chemotherapy and bevacizumab helps women with advanced, persistent, or recurrent cervical cancer live longer. The study enrolled 410 participants and compared the new combination against the …

This study tested a single, high-dose radiation treatment for men with low-risk or low intermediate-risk prostate cancer. The goal was to see how well the body tolerates this one-time treatment by tracking side effects in the bladder and digestive system within the first 6 months…

This study compared two surgical techniques—laparoscopic sacropexy and vaginal mesh surgery—for repairing a cystocele (a type of pelvic organ prolapse). Researchers followed 220 women for four years to see which approach provided better symptom relief and fewer complications. The…

This study tested a program that combined mobile health tools and peer support to help 541 Nigerian adolescents with HIV stick to their treatment and keep the virus under control. Participants were already on antiretroviral therapy and received the program for up to 48 weeks. The…

This study compared two surgical techniques for repairing a cystocele, a type of pelvic organ prolapse where the bladder bulges into the vagina. The two methods were laparoscopic sacropexy (keyhole surgery using a mesh) and vaginal mesh surgery. The trial enrolled 262 women and l…

This phase 2 trial tested a high-dose chemotherapy regimen called TICE in 101 patients with germ cell tumors that had relapsed or were not responding to standard treatment. The approach uses two cycles of paclitaxel and ifosfamide followed by three cycles of carboplatin and etopo…

This study tested whether applying Lugol's iodine during LLETZ surgery helps doctors remove all precancerous cervical tissue. Iodine stains healthy tissue brown, making abnormal areas easier to see. The trial involved 230 women with cervical dysplasia and compared standard surger…

This study looked at whether a fast blood test (ROTEM) done during surgery for placenta accreta can help doctors decide when to give blood transfusions. 32 women took part, with half getting the rapid test and half getting standard lab tests. The goal was to see if the rapid test…

This study looked at 99 IVF patients with endometriosis (a condition where uterine-like tissue grows elsewhere) and a positive BCL6 test. It compared a cheap oral pill (norethindrone acetate) to an expensive injection (Depo Lupron) given before embryo transfer. The goal was to se…

This study compared two surgical methods for repairing distal hypospadias, a birth defect where the urinary opening is on the underside of the penis. 120 boys aged 2-12 received either a standard double dartos flap or that plus a Byar's flap. The goal was to see which technique l…

This study tested whether people with well-controlled HIV can safely take their antiretroviral drugs only 4 days in a row each week, instead of every day. Over 600 adults with stable HIV participated. The main goal was to see if the 4-day schedule kept the virus suppressed just a…

This Phase 3 trial tested whether taking the drug selinexor as a maintenance pill after chemotherapy can help delay cancer progression in people with advanced or recurrent endometrial cancer. 263 participants who had responded to initial chemo were randomly assigned to receive ei…

This study followed 27 HIV-positive people with kidney failure who received a kidney transplant. All were on a three-drug HIV treatment including Raltegravir. The goal was to see how many had graft rejection within 6 months, using blood tests and kidney biopsies.

This study tested the safety and effectiveness of a new robotic system (Dexter) for repairing pelvic organ prolapse in 35 women. The surgery aimed to restore support to the pelvic organs using a robot-assisted approach. The main goals were to see if the procedure could be complet…

This study tested whether adding the drug maraviroc to standard HIV treatment could help improve immune function in people whose CD4 counts remain low even when the virus is well-controlled. It involved 60 HIV-positive adults with low CD4 counts and little recent immune improveme…

This study tested a more intensive hepatitis C treatment in 58 adults who have both HIV and hepatitis C (genotypes 1 or 4) and had not responded to previous therapy. Participants received higher doses of two drugs, peginterferon alfa-2a and ribavirin, for up to 18 months. The goa…

This study tested whether a single HIV drug, darunavir/ritonavir, could replace the usual combination therapy in pregnant women with well-controlled HIV. The goal was to prevent mother-to-child transmission without using a class of drugs called NRTIs. 91 pregnant women already on…

This study tested a new way to treat intermediate-risk prostate cancer using a 3D map to guide microwaves directly to the main tumor. 76 men across Europe received the treatment, and researchers checked if the cancer was gone after 12 months. The goal is to destroy the cancer whi…

This study tested whether people with HIV who have high immune cell counts (CD4 above 500) can safely take antiretroviral drugs in 6-month cycles—6 months on treatment, then 6 months off—instead of taking them every day. The goal was to see if this approach could keep their immun…

Researchers are testing whether a combination of PET scans with a radioactive tracer called [18F]PSMA-1007, sodium MRI, and multiparametric MRI can accurately predict where prostate cancer is and how aggressive it is. The study enrolls men who are scheduled to have their prostate…

Researchers are studying whether a point-of-care nucleic acid test can diagnose HIV faster than standard lab testing and help people get into care or prevention services sooner. The trial enrolls adults at a Seattle HIV clinic, including people living with HIV and those seeking t…

Researchers in Cameroon are comparing a new smart speculum with a standard speculum to see which gives better comfort for women and clearer views of the cervix. Each participant receives both exams in random order, and clinicians use the smart speculum's images to make remote dia…

This study tests Cellvizio, a device that provides real-time, high-resolution views of tissues during gynecological surgery. Researchers want to see if it can help diagnose lesions and check surgical margins more accurately. The study will enroll 80 women undergoing laparoscopic …

This study is testing three new diagnostic tests to see if they can correctly identify a gene mutation that makes gonorrhea resistant to the antibiotic ciprofloxacin. Researchers will use leftover samples from over 3,000 people who already tested positive for gonorrhea. If the te…

This trial tests whether indocyanine green, a dye injected before surgery, can find sentinel lymph nodes as reliably as the standard technetium-99 radioactive tracer. About 744 adults with various cancers will receive both agents, and surgeons will compare detection rates using a…

This study explores whether using only MRI-targeted prostate biopsies—instead of combining them with standard systematic biopsies—can provide enough information for doctors to decide on treatment. Men aged 50 to 75 with suspected prostate cancer and a single suspicious lesion on …

This trial tests whether a vaginal self-sampling device can accurately detect high-risk human papillomavirus (HPV) compared to samples collected by a clinician. About 1,000 women aged 30-64, either regular screening attendees or those who haven't been screened in 3+ years, will p…

This trial tests whether a new PET/CT tracer, 64Cu-SAR-bisPSMA, can find more sites of prostate cancer recurrence than the standard 68Ga PSMA-11 scan in men whose PSA rises after prostate removal. Fifty men will receive both scans, and researchers will compare how many lesions ea…

This study is testing whether a simple blood test can help doctors tell apart two main causes of intrauterine growth restriction (IUGR) — a condition where a baby grows slower than expected in the womb. The test measures the ratio of two proteins, sFlt-1 and PlGF, which are linke…

This trial tests whether a green dye, injected during keyhole surgery to remove benign ovarian cysts, can show how well the ovary is still getting blood flow. The idea is that better blood flow might mean the ovary is healthier and more likely to support a future pregnancy. Women…

This trial tests whether a new hybrid tracer, ICG-99mTc-nanoscan, can replace the standard tracer for sentinel node biopsy in people with penile cancer, melanoma, or oral cancer. The hybrid tracer combines a fluorescent dye with a radioactive marker, potentially allowing surgeons…

This large registry study is testing whether a special type of PET scan, called PSMA-PET, can better detect where prostate cancer has returned after initial treatment. Thousands of men with suspected recurrent prostate cancer across Ontario will receive this scan. The goal is to …

This study tested two new technologies—optical genome mapping and long-read DNA sequencing—against standard chromosome tests in 350 people with infertility, intellectual disability, birth defects, or miscarriage. The goal was to see if these newer methods can find more chromosome…

This study tested whether a special MRI technique called susceptibility weighted imaging (SWI) can better detect endometriosis lesions before surgery. Endometriosis spots often contain old blood, which SWI is good at seeing. Researchers compared SWI-MRI findings with what surgeon…

This study looked at whether women would be willing to collect their own urine sample for cervical cancer screening instead of a traditional swab. 173 women aged 31-49 at a French hospital tried it and answered questions about their experience. The goal was to see how acceptable …

This study tested a new MRI method that measures temperature changes in the prostate. The goal is to help doctors find cancer more accurately and guide laser treatments. Researchers scanned 70 men who already needed an MRI for prostate cancer diagnosis. The focus was on checking …

This study tested an AI software called Quantib Prostate to see if it can detect prostate cancer on MRI scans as accurately as expert radiologists. Researchers looked at 200 men who had prostate MRIs and biopsies. The AI's readings were compared to the radiologist's readings, usi…

This completed study looked at 251 women with infertility who had a hysterosalpingography (HSG) — an X-ray test that checks if the fallopian tubes are open. The researchers compared three different ways of doing the test: using a metal cannula, an active balloon, or a passive bal…

This study tested two different radioactive tracers (68Ga-RM2 and 68Ga-PSMA-617) used in PET/CT scans to see which one better detects prostate cancer in men scheduled for prostate removal surgery. Twenty-two men with low, intermediate, or high-risk prostate cancer received both s…

This study looked at whether PET scans can better detect endometriosis lesions before surgery compared to standard MRI and ultrasound. Fifteen women with symptomatic endometriosis scheduled for surgery received a PET scan, and the results were compared with what surgeons actually…

This study looked at two methods of taking prostate tissue samples to diagnose cancer: one through the rectum and one through the skin between the scrotum and anus. Researchers wanted to see which method causes fewer infections and less bleeding. 101 men with suspected prostate c…

This pilot study tested whether low-dose CT scans can help find lung cancer early in HIV-positive people who are heavy smokers. Researchers scanned 450 participants to see how many had lung cancer and what types were found. The goal was to learn if this screening method is useful…

This study tested a new type of PET-CT scanner that can scan a tumor right after it is removed from the body. Patients with prostate or head and neck cancer received a small amount of radioactive tracer before surgery, which sticks to cancer cells. After removal, the specimen was…

This study tested whether a rapid point-of-care test (Xpert® Xpress MVP) helps doctors diagnose vaginal infections more accurately than usual methods. 351 women with symptoms like discharge or itching were randomly assigned to either usual care or the rapid test. Researchers then…

Researchers are testing a field-based sexual health program for people recently exposed to HIV who were notified by New York City's partner services program. The program adds four services to standard contact tracing: HIV and STI testing in the field, same-day start of HIV preven…

Researchers follow more than 1,200 HIV-positive pregnant and postpartum women in Kigali, Rwanda, who receive standard HIV care through prevention of mother-to-child transmission programs. The study tracks whether their babies remain HIV-free through 18 to 24 months of age while m…

This trial tests whether mobile phone communication helps HIV-positive pregnant women in Kenya complete the steps that prevent passing HIV to their babies. Twenty-six health facilities are assigned to either standard care or standard care plus phone-based support for mothers, mal…

This study tests two ways to prevent HIV: a rectal gel used before sex and daily pills. About 150 men will try each method for 8 weeks to see which is safer, easier to use, and more acceptable. The goal is to give people more choices for on-demand HIV prevention.

Researchers are testing two lab-made antibodies, CAP256V2LS and VRC07-523LS, given as shots under the skin to young women who do not have HIV. The phase II trial enrolls about 990 women aged 18 to 30 in Zambia and nearby countries. It measures whether the shots cause serious reac…

Researchers at George Washington University are testing a program called Juntas Adelante to see if it helps Latina transgender women in the Washington DC area learn about and use HIV prevention medicines. The program includes five short online videos and up to two virtual coachin…

Researchers at the University of Washington are adapting a brief narrative therapy session for use in a low-barrier primary care clinic that serves people experiencing homelessness in North Seattle. The study enrolls 64 adults who have had at least one therapy appointment at the …

This study is testing a computer-based program called MES-PrEP to help young transgender women in Thailand start and stick with HIV pre-exposure prophylaxis (PrEP). The program provides personalized feedback and information based on each person's confidence and motivation. Resear…

This trial tests whether a software tool called the hypotension prediction index (HPI) can help prevent acute kidney injury after robotic-assisted urologic surgery. The tool uses arterial pressure data to forecast drops in blood pressure during the operation, allowing doctors to …

Researchers are testing whether a brief educational session helps Latina women who are overdue for cervical cancer screening use a mailed HPV self-sampling kit. Half of the participants receive the kit alone, and the other half also join a small-group session with a bilingual hea…

Researchers are testing whether a four-week group program can help people who inject drugs and are in methadone treatment reduce their risk of HIV. The program teaches skills like cleaning needles and using condoms, and it is compared with a support group that does not focus on t…

This trial tests a strategy called expedited partner therapy (EPT) for men who have sex with men in Peru. When a participant is diagnosed with gonorrhea or chlamydia, they receive antibiotic packets to give to their recent sexual partners, so those partners can get treated withou…

This trial tests whether a one-hour group discussion helps Latino men aged 50 to 70 make informed decisions about PSA screening for prostate cancer. Participants receive either a printed pamphlet or an interactive session covering the benefits, risks, and controversy around PSA t…

This study tests whether women in Kazakhstan will accept self-sampling kits for HPV detection, a key step in preventing cervical cancer. Researchers will distribute three different self-sampling devices to 1,000 women and survey their willingness to use them. The goal is to see i…

This trial tests whether a community-based program can help reduce HIV infections among people who move into rural Ugandan communities. Migrants often have higher HIV rates but are less likely to use prevention and care services. The program, called WIN, trains community voluntee…

This trial tests a workshop called Floreciendo, designed for Latina teens aged 14-18 and their female caregivers. The workshop covers sexual health basics, condoms and contraception, family communication, and gender relationships. The study aims to see if the program is feasible …

This trial tests a program designed for Latino fathers to help them reduce risky sexual behaviors, substance abuse, and domestic violence, and improve communication with their sons. The program combines two behavioral interventions: one that teaches fathers about HIV prevention a…

This study tests a culturally tailored program to prevent chronic diseases like diabetes, high blood pressure, and obesity in Latino men over 50 living with HIV. Participants meet with a community health worker, join group walking sessions three times a week, and discuss pleasant…

This study tests whether training influential members of social networks to talk about PrEP can encourage more African-American men who have sex with men to use it. Half of the recruited networks will have their leaders trained to share accurate PrEP information and counter misco…

This study tests whether limiting daily eating to an 8–10 hour window can improve metabolic health and potentially lower the risk of endometrial cancer. Overweight or obese Native Hawaiian/Pacific Islander women at elevated risk will follow a time-restricted eating schedule for s…

This study looked at 363 women with a history of three or more miscarriages who carry a specific gene mutation (MTHFR C677T). Researchers compared two treatments during pregnancy: aspirin plus folic acid, or the same plus a blood thinner (enoxaparin). The goal was to see which ap…

This large study tested an experimental HIV vaccine in over 5,400 healthy South African adults at risk of HIV. The vaccine was designed to teach the immune system to fight HIV. Unfortunately, the vaccine did not prevent HIV infection, and the trial was stopped early. The results …

This study tested whether giving albumin and furosemide right after egg retrieval can prevent severe ovarian hyperstimulation syndrome (OHSS) in women at high risk during ICSI. OHSS can cause swelling, fluid buildup, and sometimes hospitalization. The trial involved 200 women and…

This study tested whether offering a vaginal self-sampling kit directly to women aged 50-65 who had not had a cervical smear in over three years would increase screening participation. Women received a kit to use at home and mail to a lab for HPV testing. The goal was to see how …

This study tested whether a quarterly HIV prevention program is practical and helpful for men who have sex with men in four African countries. Over 800 men received regular check-ups, STI testing and treatment, counseling, and condoms. The goal was to see if this approach could l…

This large study in South Africa tested whether offering HIV treatment to everyone right after diagnosis, instead of waiting until their immune system weakened, could reduce new HIV infections across entire communities. Over 28,000 people from 22 communities took part. The idea i…

This study tested a two-step screening process to find postmenopausal women at higher risk for endometrial cancer. Those identified as high-risk received a hormone challenge test and, if positive, standard care plus a lifestyle program. The goal was to see if this approach is pra…

This trial tests whether drinking lavender herbal tea twice daily for nine days around each menstrual cycle can reduce the emotional and physical symptoms of premenstrual syndrome (PMS), such as anxiety, depression, stress, and pain. Sixty women with PMS will be randomly assigned…

This trial examines whether pelvic floor muscle exercises can improve vaginal and sexual health in postmenopausal women. Twenty women who are sexually active and have gone through menopause join the study. One group receives training from a physiotherapist and does home exercises…

This study tests whether a personalized 4-week exercise program can improve quality of life and physical function in men with metastatic prostate cancer who are receiving radiation therapy. Eighty participants will either exercise or not, and researchers will track changes in wel…

Researchers at the University of Oklahoma are testing a mobile health program designed to help adults receiving chemotherapy for metastatic breast or gynecologic cancer stay physically active. The program combines a wearable activity tracker, behavior change techniques, acceptanc…

Researchers at the University of Alcala are testing whether a three-month strength and balance training program changes walking patterns and pelvic floor muscle activity in sedentary menopausal women. Thirty-four women aged 45 to 77 will either join guided training sessions twice…

This study tests a new way to give radiotherapy for men with intermediate-risk prostate cancer. The goal is to lower the dose to healthy parts of the prostate while boosting the dose to the tumor, using a special MRI-guided machine (MR-linac). Twenty men will take part to see if …

Researchers are testing whether adding pain neuroscience education to a six-week exercise program helps women with primary dysmenorrhea, the recurring menstrual pain that is not caused by another condition. Sixty-two women aged 18 to 35 join the trial and are split into two group…

Researchers are testing whether adding alpha-lipoic acid, an antioxidant supplement, to standard letrozole treatment helps infertile women with polycystic ovary syndrome ovulate and become pregnant. The trial enrolls 150 women aged 18 to 35 who are trying to conceive. Both groups…

Ataxia-telangiectasia is a rare, inherited disease that damages the nervous system, skin, and immune system, and it has no cure. Researchers are testing sirolimus, an immune-suppressing drug, in children under 17 with the condition. The six participants take sirolimus by mouth fo…

Researchers at Mansoura University are tracking 46 men who had GreenLight laser surgery for an enlarged prostate, a procedure that preserves the ejaculatory hood. The study measures urinary symptom scores five years later to see whether symptoms return and how sexual function hol…

This study tests whether adding a special yoga and physiotherapy program to standard care can lower stress in women receiving brachytherapy for cervical cancer. About 98 women will take part. The program includes gentle movement and breathing exercises designed to be safe during …

Bariatric surgery helps people with severe obesity lose weight, but it also strips away muscle and bone. Many men who have the surgery also have low testosterone, which worsens muscle loss. This trial tests whether testosterone replacement, combined with exercise and diet counsel…

This study tested whether adding a magnetic chair (extracorporeal magnetic innervation) to standard pelvic floor exercises helps men with premature ejaculation more than exercises alone. Forty-one men aged 25-45 took part over 8 weeks. Researchers measured pelvic floor muscle mov…

This pilot study compares two types of surgical mesh, biological and synthetic, used during a combined operation for pelvic organ prolapse and rectal prolapse. Thirty participants with obstructed defecation syndrome and pelvic organ prolapse undergo laparoscopic mesh sacropexy pl…

Researchers at Mansoura University are comparing two settings of holmium laser enucleation of the prostate (HoLEP) in men with symptomatic benign prostatic hyperplasia (BPH) and prostates of at least 80 cc. One group receives the standard laser setting, while the other receives a…

This study tests whether a single session of physical activity, physical therapy, or a combination of both can improve how women with endometriosis perceive their bodies and physical abilities, with the goal of boosting overall quality of life. Researchers will enroll 52 menstrua…

This pilot study tests whether a single session of narrative therapy, a type of talk therapy, can help reduce depression and anxiety in people living with HIV. Researchers will enroll 64 adults from a primary care HIV clinic to see if the therapy is acceptable, feasible, and bene…

This study tests whether Prospidol, a rectal suppository containing natural ingredients like hyaluronic acid and Boswellia extract, can reduce pain and urinary symptoms in men with chronic prostatitis/chronic pelvic pain syndrome. Forty adult men will use one suppository daily fo…

This study tested a resilience-building program called RISE+ in 106 people over 50 living with HIV. Participants watched videos and did activities to improve coping skills, optimism, and social connections. The goal was to see if the program helps them handle daily stress better …

This study looks at two different ways to numb the belly area in children aged 1 to 7 who are having surgery for an undescended testicle. The goal is to see which method reduces pain and the need for extra pain medicine after the operation. About 70 children will take part, and n…

This study tests whether a 5-minute educational video about uterine fibroids and their treatments can help patients feel less conflicted when deciding on a treatment plan. About 154 women with fibroids will be randomly assigned to watch the video before their appointment or recei…

This study tested two treatments for erectile dysfunction (ED) in 185 men: a daily tadalafil pill (5 mg) and a nerve stimulation device (TENS) that sends mild electrical pulses to the penis. The goal was to see if these treatments improve blood flow and erection hardness. The tri…

This trial tests whether suspended moxibustion, a traditional therapy that holds a burning moxa stick near the skin, can reduce pain from primary dysmenorrhea, or period cramps without an underlying disease. Researchers plan to enroll 48 female students aged 18 to 35 who have mod…

This completed Phase 2 trial tested whether formal hypnosis, alongside standard care, could reduce anxiety and pain in 68 cancer patients undergoing brachytherapy. Patients received either standard care with Kalinox or standard care plus formal hypnosis. The study measured anxiet…

This trial tests whether peer education based on the Health Belief Model helps female university students cope with premenstrual syndrome (PMS). About 50 students with PMS will be randomly assigned to either receive two biweekly classroom sessions led by peers, covering PMS cause…

This trial tests whether regular electronic questionnaires after prostate cancer surgery can improve recovery. Men who have their prostate removed will report symptoms like incontinence and mood through an app or computer. If scores hit certain levels, a nurse calls to offer a ur…

This study asks whether adding acupuncture to a multidisciplinary treatment plan can reduce pain and improve quality of life for women with vulvodynia or chronic pelvic pain lasting at least six months. Half of the participants will receive acupuncture sessions, while the other h…

This trial tests whether a 12-week structured physiotherapy program—including stretching, aerobic jogging, Kegel exercises, and relaxation—can reduce the severity of period pain in 360 female physical therapy students with primary dysmenorrhea. Participants are randomly assigned …

This study tests four different vaginal treatments (estrogen, DHEA, estrogen with probiotics, and a moisturizer) in 160 breast cancer patients who have vaginal atrophy due to hormone therapy. The goal is to see which treatment best relieves symptoms like dryness and pain, and imp…

This trial tests whether adding two surgical steps—suspending the urethra and rebuilding pelvic fascia—during robot-assisted prostate removal can help men regain urinary continence sooner. About 60 prostate cancer patients will receive the modified procedure and be followed for t…

This phase II trial tests whether flibanserin, a drug approved for low sexual desire in women, can increase sexual interest in men with prostate cancer who are receiving androgen deprivation therapy (hormone therapy). About 44 men will be randomly assigned to take flibanserin or …

This study tested a counseling program called the Friendship Bench for 106 teens aged 13-18 who have HIV and feel depressed or anxious. The program aims to improve their mood and help them stay engaged in their HIV care. Researchers measured how well the program worked by looking…

This study investigates whether a 12-week program of tai chi and qigong (called Body Mind Training) can reduce fatigue in male cancer survivors aged 55 and older. Participants are randomly assigned to the mind-body training, a light exercise-only group, or a usual-care group. Res…

This study tests whether high-intensity laser therapy (HILT) can reduce pain during intercourse for women with provoked vestibulodynia, a condition causing severe pain at the vaginal opening. About 145 women with moderate to severe pain will receive either real or sham laser trea…

This study tests whether a podcast-based education program can reduce the severity of premenstrual syndrome (PMS) symptoms and improve quality of life in female university students. Participants listen to eight podcast episodes over four weeks that cover topics like understanding…

This trial tests whether a shorter-acting spinal anesthetic (prilocaine) helps pregnant women recover feeling and movement faster after a cervical stitch procedure compared to the standard drug (bupivacaine). About 129 healthy pregnant women at risk of preterm loss will receive o…

This study looked at whether high-intensity interval training (short bursts of hard exercise) can improve physical function and reduce fatigue in adults aged 50-80 living with HIV who are sedentary and tired. Participants were randomly assigned to either high-intensity training o…

This study tested whether laughter yoga and sleep hygiene training could help university students with premenstrual syndrome (PMS). 45 female students took part in 4 weekly 45-minute laughter yoga sessions plus sleep hygiene advice. Researchers measured changes in PMS symptoms, s…

This study tested whether a structured cognitive behavioral therapy (CBT) program could reduce psychological distress and improve problem-solving skills in women with vaginismus. Sixty women were randomly assigned to either CBT sessions over three months or routine care. The resu…

This study looked at whether a one-hour hypnosis session, done 5 to 15 days before a hysterectomy for pelvic gynecological cancer, could lower anxiety around the time of surgery. Twenty-nine women participated, and the hypnosis was guided by a trained nurse. The main goal was to …

This study tested whether one-on-one sessions with a trained nurse could help people with resistant hypertension better handle side effects like sexual problems and bladder control issues caused by their blood pressure medications. The goal was to see if this education helps pati…

This study tested a new medication called OG-6219 in 354 women aged 18 to 49 with moderate to severe endometriosis-related pain. The goal was to see if three different doses could safely reduce pelvic pain compared to a placebo. The trial is complete, and results will show how we…

This study tested a 3-month treatment with a combination of vitamin D, green tea extract (EGCG), vitamin B6, and D-Chiro-inositol in 108 women with uterine fibroids who were planning surgery. The goal was to see if the supplement could ease symptoms and possibly help some women a…

This study tested a training program for people living with HIV to help them become more active in managing their health. The program was delivered by psychologists and aimed to improve treatment adherence, quality of life, and emotional well-being. 75 participants took part in t…

This completed study tested whether a special pain monitor (NOL index) could help doctors give the right amount of pain medication during laparoscopic endometriosis surgery. The goal was to reduce total painkiller use and improve recovery. The study included 125 premenopausal wom…

This study tested an online program called ORCHID that helps people with HIV feel more positive emotions. The goal was to see if it could reduce depression and improve HIV care. 29 adults from Chicago clinics took part. The program was designed to be used on a phone or computer.

This study looked at whether a 16-week program of aerobic and resistance exercise could improve physical function and reduce inflammation in HIV-infected veterans aged 50 and older. Thirty-three participants completed the program, and researchers measured changes in heart and mus…

This study compared progressive relaxation exercises (tensing and relaxing muscles while breathing) with isometric exercises (holding muscle contractions) for managing period pain. Sixty women with moderate to severe primary dysmenorrhea took part. Researchers measured pain, othe…

This pilot study tested a portable TENS device for reducing menstrual pain in 34 women with primary dysmenorrhea. Participants used the device on their lower abdomen during pain episodes for up to three cycles. The goal was to see if this drug-free approach could ease pain and im…

This study tested a program to help men prepare for and manage side effects from prostate cancer treatments like surgery or radiation. The program used daily texts and emails, plus support from other men, to encourage healthy habits before treatment. The goal was to reduce distre…

This study gives questionnaires to patients, interpreters, and healthcare professionals to understand how language and cultural differences impact care for women with gynecologic cancer. The goal is to identify barriers and improve the patient experience. About 45 people will tak…

This study checks for muscle loss (sarcopenia) in 25 women with advanced ovarian cancer before they start chemotherapy. Using CT scans, researchers want to see how common this condition is and if it affects treatment timing. The goal is to better understand how muscle health rela…

This completed study enrolled 377 individuals and families with a high risk of breast or ovarian cancer due to known or suspected genetic factors. Researchers collected medical records, questionnaires, and biological samples to better understand the disease's natural history and …

This study aims to understand why testicular cancer sometimes runs in families. Researchers will collect DNA samples and medical information from about 750 people in families with multiple cases of testicular cancer. No treatment is given; the goal is to find genes that increase …

This study looked at 190 HIV-positive women starting HIV medicines to see how often herpes virus symptoms appear or get worse. Researchers collected blood, urine, and vaginal samples over a year to track virus activity. The goal was to understand why some women have herpes flare-…

This study followed 1,377 people living with HIV in Liberia over three years to track how the disease progresses and affects their health. Researchers collected blood and urine samples, conducted physical exams, and asked about medications and risk behaviors. The goal was to gath…

This study looks at whether the mobility of a cesarean scar is related to the severity of menstrual pain in women who have had a C-section. Researchers will measure scar mobility, pain levels, and pressure sensitivity in 34 women aged 20–35 with regular cycles and period pain. Th…

Researchers want to know whether the amount, location, and behavior of body fat contribute to two hormone conditions in women: hypothalamic amenorrhea, where menstrual periods stop, and polycystic ovary syndrome (PCOS). The study enrolls 50 women across five groups, including ath…

This early-stage trial in 18 healthy adults compares a new octreotide tablet (T25) with an existing capsule (MYCAPSSA) to see how much drug gets into the blood. It also checks whether a high-fat meal changes absorption of the tablet. Participants take single doses under fasting o…

Researchers at a large hospital in Seoul reviewed records from nearly 33,000 adults who had curative-intent surgery for one of seven cancers in the abdomen or pelvis: pancreatic, gastric, rectal, cervical, endometrial, kidney, or prostate. They grouped patients by whether they re…

This study looks at how Spanish-speaking Latiné men cope after prostate cancer treatment, especially with issues like erectile dysfunction and urinary problems. Researchers will survey and interview 55 survivors to understand their needs and cultural barriers. The goal is to crea…

This phase 3 trial compares a less invasive sentinel node biopsy approach to standard staging methods in 262 women with early-stage endometrial cancer at intermediate or high risk of recurrence. The goal is to see if the sentinel node policy reduces surgical complications while s…

Researchers at the University of California, San Francisco, are studying how genes and environment affect the rate at which women's ovaries age. They will measure antral follicle counts by ultrasound and collect DNA from 1,080 women aged 25 to 45 with regular menstrual cycles. Th…

This study followed over 46,000 women in the Netherlands who tested positive for HPV and had mild abnormal Pap results. Researchers tracked how many developed cervical cancer within five years. The goal was to see if these women could safely have fewer follow-up tests, making scr…

Researchers want to learn which molecules on cancer cells the immune system attacks when checkpoint inhibitor drugs work well. They collect tumor and blood samples from adults with solid tumors who respond to these drugs, either during treatment or after surgery. The team then se…

Researchers at the University of California, San Francisco are running a long-term study to see whether children conceived through infertility treatment have different metabolic profiles than other children. The study has two parts: one looks back at children already born, and th…

This trial tests whether an AI-supported chatbot can boost nursing students' knowledge of gynecologic cancers and their clinical decision-making skills. Third-year nursing students who have completed their obstetrics and gynecology course will be randomly assigned to either use t…

This study looks at whether doing a laser-assisted hatching procedure on Day 3 or Day 5 of embryo growth changes the genetic test results in IVF. About 200 people having IVF with genetic testing will take part. The goal is to see if timing affects embryo health and the accuracy o…

This study follows nearly 600 people with Smith-Magenis syndrome (SMS), a rare genetic condition, to track how their health, behavior, and development change over time. Researchers will perform detailed medical exams, genetic tests, and surveys to better understand the syndrome's…

Researchers are collecting health records from young people with HIV in ten African countries who have taken the drugs darunavir, etravirine, or both. The study follows their demographics, clinical and laboratory profiles, and HIV drug resistance over time. The goal is to underst…

This study looks at how giving fluids during robotic prostatectomy affects patient outcomes. It compares two approaches: one guided by a special monitor (LiDCO) that tracks blood flow in real time, and the other using standard clinical judgment. The researchers will measure the t…

This pilot study tests a streamlined ovarian stimulation protocol for women undergoing fertility treatment. Participants receive a single injection of corifollitropin alfa plus daily oral clomiphene citrate, instead of the usual multiple daily injections. Researchers will measure…

This study collected tissue samples from the tonsils, lymph nodes, bowel, and lungs of HIV patients and healthy volunteers. The goal was to measure the amount of virus and certain immune cells in these tissues during treatment. By comparing samples, researchers hoped to learn mor…

This study asks whether measuring circulating endothelial cells (CECs), cells shed from blood vessel walls, can predict how well ovarian cancer patients respond to standard chemotherapy with or without bevacizumab. Researchers will use a standardized flow cytometry method to coun…

This study looked at people with low or no GnRH, a hormone that controls puberty and fertility. Researchers studied 111 adults and teens to understand how GnRH problems affect the body. The goal was to find new hormone patterns and genetic causes, not to test a treatment.

This study looked at 492 women after menopause to see how often signs of endometriosis show up on routine ultrasound exams. Researchers used a standard method to check for deep endometriosis and cysts. The goal was to learn more about this condition in older women, which is not w…

This study looked at whether a simple home semen test can help couples find male fertility problems sooner. About 200 couples who were just starting to try for a baby used a home testing device. The goal was to see if it was easy to use and if it reduced stress while helping coup…

This survey follows people who use the REKOVELLE pen, which contains the hormone follitropin delta, to stimulate the ovaries during assisted reproduction like IVF or ICSI. The goal is to track how often side effects occur when the drug is used in everyday clinical practice. Resea…

Researchers in Ethiopia are studying how HIV spreads among people with different treatment histories. They compare newly diagnosed individuals who have never taken antiretroviral therapy with those on therapy who have not achieved viral suppression, and with those who are virally…

This study looks at whether providing cancer care at home is a good option for Black men with advanced prostate cancer. Researchers want to see if this approach can reduce healthcare disparities and improve quality of life. Participants will fill out questionnaires about their pr…

Researchers at Deraya University are studying whether premenstrual syndrome (PMS) affects a woman's ability to keep balance while doing two things at once, like standing and spelling. They plan to compare 40 women aged 18 to 27 during their PMS phase and their non-PMS phase, usin…

Endometriosis causes severe pelvic pain, and many people still hurt even after treatment. Researchers suspect the nervous system amplifies pain signals, a process called central sensitization. This study tests whether six patient questionnaires can reliably measure central sensit…

This study looks at medical records from 584 men in Brazil with castration-resistant metastatic prostate cancer, a form of the disease that no longer responds to hormone therapy. Researchers aim to describe how long these patients survive and to identify their individual characte…

Researchers are collecting images of eggs and embryos from time-lapse incubators to train an AI system called CHLOE. The goal is to see if the AI can accurately predict which embryos will reach the blastocyst stage, a key step in IVF. This study involves women aged 18 and older w…

This observational study measures how often HPV infections and other sexually transmitted infections occur in transgender adults. Researchers will check for HPV at genital, anal, and oral sites, and also look for anal dysplasia, which can be a precursor to cancer. The study inclu…

This study tested whether using virtual reality (VR) to teach patients about post-surgery care helps them feel more ready to go home after a prostatectomy. 46 adults were split into two groups: one received standard discharge instructions, and the other used a VR program. The VR …

This study tests a patient navigator program for 28 underserved people struggling with infertility. The navigator helps with insurance, appointments, and tests to speed up care. Researchers compare their progress to similar patients from the year before. The goal is to see if thi…

This study looks at whether a blood test measuring the 'atherogenic index' can predict how well the drug tadalafil works for men with erectile dysfunction caused by blood vessel problems. Researchers will give 132 men tadalafil daily for one month and compare their symptom scores…

This study looks at proteins in the blood of women with ovarian, peritoneal, or fallopian tube cancer who are in remission. The goal is to find a protein pattern, or 'fingerprint,' that signals when the cancer might come back. Researchers followed 119 women with stage III or IV c…

This study tested a document called Voicing My CHOiCES, designed to help young adults (ages 18-39) with serious illnesses like cancer or HIV discuss their care preferences. Participants filled out questionnaires about anxiety, social support, and communication, then reviewed the …

This study looked at 200 people living with HIV in Liberia to compare two tests for latent tuberculosis (TB) infection: a blood test (IGRA) and a skin test (TST). The goal was to see which test works better in this population. Participants had a skin test and their results were c…

This study looks at how cumulative stress and trauma influence alcohol use and HIV self-management in young people living with HIV, ages 18 to 29. Researchers will track drinking patterns and viral load to identify modifiable targets for future interventions. The goal is to find …

This study explores whether men with early prostate cancer on active surveillance would be willing to take dietary fibre supplements, such as inulin or psyllium. Previous research hints these fibres may reduce inflammation and slow tumour growth, but no one has asked patients abo…

This study looked at liver fibrosis (scarring) in 127 HIV patients who had high liver enzymes while on antiretroviral therapy. Participants underwent tests like liver biopsy, ultrasound, and CT scans to measure liver damage. The goal was to understand how common and severe liver …

This completed study tested whether analyzing social media messages (like WhatsApp and Instagram) from 400 young women aged 18-24 in Kisumu, Kenya could help identify those at risk for HIV. Researchers used AI to look at language patterns and compared them to standard HIV risk sc…

This pilot study tests a program to help young female cancer survivors in rural Imperial County, California, get reproductive health care that matches their personal goals. The program includes a quick needs assessment during oncology visits, followed by a session with a social w…

This study looks at why babies born with restricted growth (IUGR) have a higher risk of childhood obesity. Researchers will track 400 mother-infant pairs for two years, analyzing T-cell changes and DNA methylation. The goal is to uncover early biological signs that could lead to …

This study builds a global registry of adults with anal squamous cell carcinoma, both with and without HIV infection. Researchers will collect real-world data on treatments, lab results, and outcomes to compare how the disease progresses in each group. The goal is to identify fac…

This study will check 300 people living with HIV for oral HPV infection and mouth lesions using a simple swish-and-spit sample. Researchers will compare those who test positive and negative, and look at factors like age, sex, tobacco use, and HIV lab results to see what might pre…

This observational study will examine the molecular and epidemiological characteristics of endometrial cancer in Brazil, focusing on women diagnosed between 2016 and 2019. Researchers will analyze tumor samples for genetic mutations and biomarkers, and collect data on demographic…

This trial tests whether a 15-minute educational video and a list of suggested questions can improve understanding of immunotherapy among patients with advanced cancer and their caregivers. Participants are randomly assigned to receive the educational materials or usual care, and…

This pilot study is testing whether a noninvasive ultrasound device, called USCOM, can measure how well the heart is pumping blood in pregnant people who have just been diagnosed with fetal growth restriction (FGR). FGR means the baby is smaller than expected, and this condition …

This study tests whether giving gynecologic cancer patients a list of questions to ask their doctor improves their confidence, reduces distress, and builds trust. About 70 adults with newly diagnosed or suspected gynecologic cancer will either receive the question list or usual c…

This study follows 140 adults who have been treated for uncomplicated chlamydia or gonorrhea infections. Participants will have weekly swabs or urine tests to check when the bacteria's genetic material (RNA) disappears from the body, up to 4 weeks after starting treatment. The go…

This study investigates why some girls with Turner syndrome find it hard to make friends, read emotions, and control their feelings. Researchers will compare 35 girls with Turner syndrome to 35 girls with isolated growth hormone deficiency, all aged 7 to 16. Through puzzles, memo…

This study aims to develop a program to help people living with HIV in Zambia re-engage with care after they have missed appointments or stopped taking their medication. Many people cycle in and out of HIV care, and returning is a critical moment to prevent future lapses. Researc…

This study looks at how psychological and social factors might help people living with HIV resist self-stigma—the negative feelings and beliefs they may hold about themselves due to their condition. Researchers will survey both patients and their healthcare providers to understan…

This study investigates whether lymph nodes in the lower abdomen, called the inferior epigastric lymph node basin, might be an early stop for ovarian cancer spreading from the peritoneum. Researchers will biopsy these nodes in 20 patients undergoing surgery for ovarian peritoneal…

This study looks at whether levels of a protein called zonulin, found in blood and semen, differ between infertile men with and without varicocele (enlarged veins in the scrotum). Researchers will measure zonulin in 119 men and compare it with standard semen quality measures like…

This study follows about 1,000 adults in South Africa and Uganda who are switching to a common HIV treatment called TLD, which combines three drugs into one pill. The goal is to see how effective TLD is in everyday conditions, not just in controlled trials. If the treatment stops…

This study looks at whether the virus that causes COVID-19 can be found in the semen of men with cancer who are storing sperm before treatment. Researchers will test both the fluid and the sperm cells for the virus and compare results with nasal swabs and blood tests. The goal is…

This study looks at women who have had one cesarean section and are now deciding how to give birth again: trying a vaginal delivery (TOLAC) or scheduling another C-section (ERCD). The goal is to compare the safety of both options for the baby and the mother. Researchers will foll…

This study looked at 14 men with intermediate-risk prostate cancer who were scheduled for prostate removal surgery. Each man received two different types of PET scans to see which one better highlights cancer cells. The goal was to compare the scans' ability to detect and measure…

This completed study tested an online program designed to encourage HIV and syphilis testing, condom use, and PrEP uptake among young American Indian men and gay/bisexual men in rural Oklahoma. Researchers worked with community advisors to tailor health materials to local culture…

This study investigates whether telling others about an HIV diagnosis affects how consistently people take their HIV medications. Researchers believe that disclosure might lead to social support, which could improve adherence. The study follows 120 people with HIV who are already…

This study looks at whether a woman's expectations before endometriosis surgery influence her pain, disability, and well-being afterward. Researchers follow about 300 women for a year, tracking their symptoms and psychological factors. The goal is to understand why some women sti…

This study tests whether a structured face-to-face education program can improve women's knowledge about cervical cancer and their attitudes toward the HPV vaccine. One hundred women aged 18-49 in Turkey will be split into two groups: one receives the education, the other gets ro…

This study follows 67 women with cervical cancer for one year after they finish radiation therapy. Researchers want to see how their quality of life, including physical and emotional well-being, changes over time. Participants fill out questionnaires about symptoms like fatigue, …

This study looks at how proteins in the blood change in women with ovarian cancer as they go through standard treatment. Researchers collected blood samples before surgery, after surgery, and after chemotherapy to see if these protein shifts could give a fuller picture of how the…

This study looks at cerebral small vessel disease (CSVD) — damage to tiny blood vessels in the brain that can cause memory loss and disability — in people with HIV over age 50. Researchers want to see if CSVD is linked to blood vessel problems in the eyes and kidneys, which could…

This study looks at how sleep length and quality may affect the success of in vitro fertilization (IVF) in women. Participants will wear a ring-shaped device that tracks sleep patterns before and after a frozen embryo transfer. The goal is to see if sleep parameters like total sl…

This study looked at how certain enzymes called matrix metalloproteinases (MMPs) and their inhibitors relate to human papillomavirus (HPV) in cervical dysplasia and cancer. Researchers collected tissue and cell samples from 216 women with different stages of cervical lesions. The…

This completed study looked at whether a simple blood test (liquid biopsy) can help track breast, ovarian, and endometrial cancers. Researchers analyzed circulating tumor cells in 150 women to see if these cells could predict the risk of cancer spreading or how well treatment wor…

This study tested whether Pluvicto, a radioactive drug for prostate cancer, can be safely given through a permanently implanted port (TIVAP) instead of a standard IV. Researchers measured if any drug got stuck in the port in 107 patients. The goal was to see if using the port is …

This completed study looked at a new antibody called anti-SIRPα as a potential immunotherapy for liver cancer. Researchers used blood and tissue samples from 30 liver cancer patients to see how the antibody affects immune cells. The goal was to understand whether blocking the SIR…

This study looked at two ways to help breast and ovarian cancer survivors get genetic counseling: a mailed brochure or a phone call with a health coach. About 668 women took part. The goal was to see which method led more people to actually get genetic counseling or testing. The …

This study looks at whether a score called KELIM can predict how well ovarian cancer patients respond to maintenance treatment with PARP inhibitors after initial chemotherapy. Researchers will analyze data from 243 patients who took part in the PAOLA-1 trial. If KELIM proves usef…

This completed study looked at 80 patients with advanced prostate cancer that had stopped responding to chemotherapy. All patients received a radioactive drug called 177Lu-PSMA-617. Researchers compared two types of scans—PET and SPECT—to see which better tracks changes in tumor …

This study tested two peer education programs to see which better improves nursing students' knowledge, attitudes, and behaviors about sexually transmitted infections (STIs). Thirty-six first-year nursing students were split into two groups: one received a program based on a beha…

This study looked at 294 women with deep endometriosis affecting the rectum. Researchers compared how patients felt after conservative surgery versus more radical bowel removal. The goal was to see which approach leads to fewer bowel and bladder problems and to find factors that …

This study looked at how two types of exercise—high-intensity interval training (HIIT) and continuous moderate exercise—affect sleep and inflammation in 52 older adults with HIV. Participants exercised three times a week for 16 weeks. Researchers measured sleep quality through su…

This study tested whether injecting a fluorescent dye called indocyanine green (ICG) into the ureters helps surgeons see them more clearly during laparoscopic surgery for deep infiltrating endometriosis. 51 women with suspected or confirmed deep endometriosis took part. The goal …

This study tested a device called the Alife Hera System, which uses a computer algorithm to score embryos based on images and patient information. The goal was to see if using this score alongside standard methods helps doctors choose the embryo most likely to result in a pregnan…

This study reviewed 1251 intrauterine insemination (IUI) cycles at one hospital to see if the type of fertility drug used or the cause of infertility affected pregnancy rates. Participants were women aged 20-44 with normal ovulation and their partners with adequate sperm. The res…

This study looked at 107 women having a first-time cervical procedure (LEEP) for abnormal cells. Researchers compared how local anesthesia (cervical block) versus general or spinal anesthesia affected the size of the removed tissue. The goal was to see if the anesthesia method in…

This study looked at 777 people with HIV in Brazil who failed their first treatment with tenofovir, lamivudine, and dolutegravir. Researchers wanted to understand what types of drug resistance and virus subtypes were involved. The goal is to improve treatment choices for people i…

This study followed 40 women with cervical, uterine, or ovarian cancer to see how their relationship and sexual communication changed from diagnosis to 3 months after treatment. Participants filled out questionnaires about their sexual activity, desire, and discomfort. The goal w…

This study looks at why certain immune cells (CD4 and CD8 T cells) remain activated in people with HIV whose viral load has been undetectable on antiretroviral therapy for at least two years. Researchers are investigating whether a common virus called cytomegalovirus (CMV) or an …

This early-stage trial tested a single injection of JL18008, a lab-made protein designed to boost immune cells, in 40 healthy adults. The main goal was to check safety and how the body handles the drug. Researchers also measured changes in immune cell counts over 56 days. This is…

This study looked at how often thyroid problems (specifically an underactive thyroid) occur in people with HIV. Researchers reviewed medical records of 154 HIV-positive adults who were treated at a French hospital between 2001 and 2012. The goal was to get a clearer picture of th…

This completed study looked at 59 men who have sex with men and use methamphetamine. Researchers used a program that gives rewards for drug-free urine samples to help them cut back. They measured inflammation in the rectum and tracked STI/HIV risk behaviors over 8 weeks. The goal…

This study looked at 200 men with sperm abnormalities to see if vacuoles (tiny holes) in the sperm head are linked to DNA damage. Researchers used high-powered microscopes and genetic tests to measure vacuole size and chromosome errors. The goal is to help doctors pick healthier …

This study looked at a protein called osteopontin in the blood of pregnant women whose water broke too early (PPROM). Researchers compared 71 women with early rupture to those with normal-term rupture to see if protein levels differ. The goal was to learn more about the biology b…

This study tested a device called Seedchrony that measures a natural chemical in the uterus to see if it can predict whether an embryo transfer will lead to pregnancy. The study involved 92 women undergoing their first IVF cycle. The goal is to find a way to improve the low succe…

This study looked at how not having enough healthy food (food insecurity) can lead to insulin resistance in people living with HIV. Researchers tested a community-based "food as medicine" program that provided healthy food and taught cooking and self-care skills. The goal was to …

This study looked at whether measuring the stiffness of uterine fibroids can help predict how well they respond to a non-invasive treatment called MR-HIFU. Forty women with symptomatic fibroids were enrolled. The goal was to improve patient selection so that only those likely to …

This pilot study tested a new device that measures cervical stiffness in 21 pregnant women at high risk for preterm birth. The goal was to see if stiffness measurements could improve risk assessment beyond standard ultrasound checks. Researchers hope this could lead to better pre…

This study tested whether a two-hour, peer-led workshop with religious messages could encourage Muslim women in North East England and Scotland to get screened for breast, bowel, and cervical cancer. 169 women aged 25-74 who were not up-to-date with all eligible screenings took p…

This study collected ultrasound and MRI images from 100 women with endometriosis who were scheduled for surgery. The goal was to create a database that helps doctors better identify and stage the disease using these scans. Participants were aged 18-40, had a clinical diagnosis, a…

This study looked at how doctors in Russia treat a specific type of ovarian cancer called HRD-positive. Researchers collected information from 414 patients to understand what treatments they received and how they fared. The goal was to describe real-world practice, not to test a …

This study looked at genetic changes in prostate cancer samples from 84 men who had surgery. The goal was to find DNA markers that could predict if the cancer would come back or spread. By identifying these markers, doctors may one day better tailor follow-up care and treatment f…

This completed study looked at ways to increase diversity in cancer clinical trials, focusing on breast, liver, and prostate cancers. Researchers worked with communities, doctors, and scientists in New York City to find better ways to include people of color and underserved group…

This study looked at whether a special PET/CT scan, done within two months after treatment, helps doctors make better decisions for patients with advanced cervical cancer. Researchers compared what doctors would decide without the scan versus with it. The study involved 40 patien…

This study tested a digital health platform to help people with a hereditary risk of breast and ovarian cancer share their genetic test results with family members. Researchers worked with 128 participants in Switzerland and Korea to see if the tool reduced distress and improved …

This study looks at how radiation therapy for brain tumors like meningioma or pituitary adenoma might affect autobiographical memory—the memories of your life events. Researchers will ask 17 patients to complete memory tests one and two years after treatment. The goal is to see i…

This study aimed to improve how doctors predict whether prostate cancer has spread to nearby lymph nodes. Researchers combined patient information, MRI scans, and genetic data from 367 men who had their prostate removed. The goal was to create a more accurate tool to help decide …

This study looked back at 388 women with advanced ovarian, fallopian tube, or peritoneal cancer who were taking the drug niraparib as maintenance therapy. Researchers wanted to see how often serious side effects happened and how patients used the drug in real-life UK clinics. No …

This study looked at 30 women with PCOS who had trouble ovulating. Researchers measured a hormone called AMH while giving low doses of FSH to see if a drop in AMH happens when an egg follicle starts to grow. The goal was to better understand why ovulation fails in PCOS, not to te…

This study looked at 40 women with symptomatic uterine fibroids to understand why MR-guided focused ultrasound (HIFU) works better for some than others. Researchers used MRI and contrast-enhanced ultrasound to measure fibroid blood flow, stiffness, and other features before treat…

This study looked at a new device called AE05ML that helps surgeons place clips on blood vessels and other tissues during keyhole surgery. The goal was to see if the device is safe and works well. A total of 161 adults took part in the study.

This study looked at whether a common vaginal yeast, Candida albicans, plays a role in endometriosis. Researchers compared 48 women with and without endometriosis to see if yeast overgrowth was more common in those with the disease. The goal was to better understand what causes e…

This completed study looked at 172 people with and without HIV to understand why those with HIV have a higher risk of diabetes. Researchers examined fat tissue and immune cells to see if chronic immune activation in fat contributes to insulin resistance. The goal was to learn how…

This study tested whether a family history app can help doctors collect and use information about patients' family health risks. Over 600 adults aged 30-69 took part. The goal was to see if the app leads to better screening and genetic referrals for conditions like cancer, heart …

This study reviewed over 11,000 patients with advanced ovarian cancer to see if hospitals that follow ten specific quality standards for surgery have better outcomes. The research looked at how long patients lived without their cancer getting worse and overall survival. The goal …

This completed study looked at how often joint pain occurs in 71 people with ovarian, colorectal, or lung cancer who were taking the drug bevacizumab. Participants filled out a questionnaire about their joint pain over 6 months. The goal was to better understand this side effect.

This study looked at 90 children and teens (ages 7-18) taking antipsychotic medication to see how it affects their hormones, growth, and metabolism. Researchers measured prolactin levels and checked for links to sex hormones, metabolic health, and puberty development. The goal wa…

This completed study from the University of Aberdeen looked at how dietary fiber supplements might influence prostate cancer. Researchers gave mice different fibers (inulin, pectin, hemp hull) along with stool samples from healthy men over 60. They then measured changes in gut ba…

This study tested whether a flexible, personalized exercise program is practical for cancer patients receiving chemotherapy. Twenty-one adults with breast, ovarian, or colorectal cancer took part. The main goal was to see if patients would join, attend, and stick with the exercis…

This study tested different ways to teach physical activity-related health competence to nursing students in Bavaria. Over 300 students from 16 schools participated, with some schools using new teaching methods and others serving as controls. The goal was to see which approach be…

This study follows over 1,700 women who previously took part in a cervical cancer screening trial. Researchers want to see if testing for HPV alone is as safe and effective as combining it with a Pap smear over 10 years. Participants provide a cervical sample for both tests, and …

This completed study tested a small-group discussion program called SISTA-P for Black women at high risk for HIV. The program covered self-care, HIV and PrEP education, and assertiveness skills. Researchers enrolled 23 women in Washington D.C., Atlanta, and New Orleans to see if …

This study looked at how prostate and colorectal cancer affect mitochondria—the energy factories in cells—and whether a 4-week home exercise program could improve them. Fifteen men awaiting surgery did either resistance or high-intensity interval training at home. Researchers mea…

This study tested simple toolkits to encourage women living with HIV in Ghana to collect their own samples for HPV testing, which can help prevent cervical cancer. About 108 women took part, and the researchers checked if they completed and returned the self-sampling kit or got a…

This study looked at 172 kidney transplant recipients who were on stable anti-rejection medication for at least 3 months. Researchers measured levels of a common, harmless virus (Torque Teno Virus) in their blood to see if it could predict serious infections or organ rejection. T…

This study followed 516 HIV-positive men who have sex with men over two years to track anal HPV infection and related lesions. Researchers used exams and anoscopy to see how often high-grade lesions appear or go away on their own. The goal is to gather evidence to better prevent …

This study investigates why the gut immune barrier remains damaged in people with HIV even after successful antiretroviral therapy. Researchers collected blood and intestinal biopsies from 80 participants to measure immune cells and inflammation. The goal is to understand why the…

This study looked at 167 men who have sex with men and are on HIV treatment with undetectable virus in their blood. Researchers took blood and semen samples to see if the virus could still be found in semen. The goal was to understand if there is still a risk of passing HIV to ot…

This study tested whether less invasive methods—a vaginal swab or a fluid sample from the uterus—can accurately measure the microbiome (bacteria) in the womb, compared to the standard endometrial biopsy. Fifty-seven women provided samples at two time points. The goal is to find a…

This study looked at a genetic variation in the TLR7 gene, which helps the immune system detect viruses like HIV-1. Researchers compared 90 women—some with HIV and some without—to see if this gene difference is more common in infected women. The goal was to understand how this va…

This study looks at why HIV remains in the body even when standard treatment keeps virus levels undetectable in the blood. Researchers will take small tissue samples from the gut and blood of 30 HIV-positive adults on effective therapy. The goal is to understand how the virus per…

This study tested whether taking dasatinib alone or with darolutamide for 14 days can increase PSMA levels on PET scans in men with metastatic prostate cancer. Only 4 men participated, all with low PSMA uptake on their initial scan. The goal was to learn more about how PSMA expre…

This study looked at whether following national guidelines for ovarian cancer surgery is cost-effective. Researchers measured the cost per quality-adjusted life year (QALY) over three years in 200 women with advanced ovarian cancer. The goal was to understand the economic impact …

This study looked at how five common HIV drugs enter breast milk in 20 healthy women who were finishing breastfeeding. The goal was to find out if the drug levels could be too high (risking infant side effects) or too low (risking drug resistance if the baby gets HIV). Participan…

This study looked at whether it is possible and practical to offer rapid HIV testing to men who have sex with men (MSM) in community settings, rather than only at clinics. Researchers worked with teams in France and Canada to test this approach with 357 participants. The goal was…

This completed study tested whether giving families of children with long-term illnesses (like cancer, heart disease, or premature birth) a tablet computer with a special app helps them manage care at home. Researchers measured satisfaction, cost-effectiveness, and how well famil…