IVF lab test: when to hatch embryos for best genetic results?
NCT ID NCT07154875
First seen Jun 26, 2026 · Last updated Sep 11, 2026 · Updated 4 times
Summary
This study looks at whether doing a laser-assisted hatching procedure on Day 3 or Day 5 of embryo growth changes the genetic test results in IVF. About 200 people having IVF with genetic testing will take part. The goal is to see if timing affects embryo health and the accuracy of genetic screening.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Assisted hatching (laser procedure to thin the embryo's outer shell)
- What this could lead to
- If it works, this could help IVF labs choose the best timing for assisted hatching to improve embryo selection and genetic testing accuracy.
- What could go wrong
- This is a small, early-stage trial focused on lab outcomes, not pregnancy or live birth. The results may not directly improve success rates for patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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141 people
The number who actually took part.
- Started
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Jun 2025
- Finished
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Jul 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Female participants undergoing IVF-ICSI with an indication for PGT-A * Age ≥18 years; no prespecified upper age limit. Age was recorded for subsequent analyses * Anti-Müllerian hormone (AMH) level ≥1.0 ng/mL * Antral follicle count (AFC) ≥5 follicles * Controlled ovarian stimulation using an antagonist or progestin-primed ovarian stimulation (PPOS) protocol * Use of ejaculated sperm prepared by density-gradient centrifugation or swim-up * Written informed consent for participation Exclusion Criteria: * History of ≥3 failed IVF cycles or ≥3 consecutive miscarriages * Indication for PGT-M or PGT-SR, including monogenic disorders or structural chromosomal rearrangements * Severe uncontrolled medical or autoimmune conditions considered likely to affect oocyte or embryo development * No metaphase II (MII) oocytes available for ICSI * Use of surgically retrieved sperm * Use of advanced sperm-selection techniques, including IMSI, PICSI, or MACS * Polycystic ovary syndrome diagnosed according to the Rotterdam criteria
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Center for Reproductive Support, 16A Ha Dong General Hospital
Hanoi, Hanoi, 100000, Vietnam