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Minimally invasive surgery vs. open surgery for cervical cancer: which is better?

NCT ID NCT07626996

Disease control Sponsor: Zagazig University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compared two surgical approaches for early-stage cervical cancer: laparoscopic-assisted (minimally invasive) and open abdominal hysterectomy. Sixty women with stage IA1 to IB1 cervical cancer were randomly assigned to one of the two surgeries. Researchers measured surgery time, blood loss, hospital stay, and cancer recurrence over three years to see which method is safer and more effective.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Laparoscopic-assisted radical hysterectomy (minimally invasive surgery) vs open radical hysterectomy
What this could lead to
If successful, this could show that laparoscopic surgery is as safe and effective as open surgery for early-stage cervical cancer, with shorter recovery and fewer complications.
What could go wrong
This is a small, single-center study with only 60 patients, so results may not apply to everyone. Long-term outcomes like recurrence are still being tracked, and laparoscopic surgery may have a learning curve for surgeons.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

60 people

The number who actually took part.

Started

Mar 2021

Finished

Jan 2024

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

38 to 65 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * FIGO stage IA1, IA2, IB1 * patients with a tumor size \< 2 cm by MRI or pathological assessment after conization * tumours with histopathological subtypes: squamous cell carcinoma, adenocarcinoma and adeno-squamous carcinoma ( * patients with adequate; hematopoietic, renal and liver functions: * patients with BMI \< 35 ( * patients with age range 38 - 65 years old. Exclusion Criteria: * patients with mental, heart, bladder, liver, or kidney illness * patients who had received pre-operative chemotherapy or radiotherapy pregnant patients * patients with incomplete data or lost follow-up * patients with radiological evidence of invasion of the outer 1/3 of the cervical stroma or the lower uterine segment.

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Conditions

The condition(s) this trial relates to.

cervical cancer cervical carcinoma Uterine Cervical Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cervical cancer

Contacts and locations

Locations

  • Zagazig University Hospitals

    Zagazig, Sharqia Province, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.