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Smart pain monitor may reduce opioid use in endometriosis surgery

NCT ID NCT06732050

Symptom relief Sponsor: Prof Urs Zingg Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This completed study tested whether a special pain monitor (NOL index) could help doctors give the right amount of pain medication during laparoscopic endometriosis surgery. The goal was to reduce total painkiller use and improve recovery. The study included 125 premenopausal women undergoing surgery for endometriosis or adenomyosis.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Nociception Level (NOL) index monitor
What this could lead to
If successful, this could help doctors give just the right amount of pain medication during surgery, reducing side effects and improving recovery for endometriosis patients.
What could go wrong
This is a small, completed study, so results may not apply to all patients. The device may not significantly reduce painkiller use or improve outcomes compared to standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

125 people

The number who actually took part.

Started

Aug 2024

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years * Premenopausal females * Undergoes any type of laparoscopic surgery for suspected endometriosis or adenomyosis (diagnostic/therapeutic and/or hysterectomy) Exclusion Criteria: * Age \< 18 years * Patients with contraindications for opioids and/or ketamine/clonidine (standard medications) * Pregnant or breastfeeding women * Lack of ability to follow the study procedure, e.g. due to severe language barriers, mental disorders, dementia * Patients requiring preoperative or postoperative treatment in the intensive care unit * Patients with conditions precluding the use of the NOL® sensor, such as neuromuscular deficits affecting hand function * Regular consumption of opioids (Mankoski Score ≥6)

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Conditions

The condition(s) this trial relates to.

adenomyosis endometriosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Perioperative analgesia in endometriosis

Contacts and locations

Locations

  • Spital Limmattal

    Schlieren, Canton of Zurich, 8952, Switzerland

More trials for these conditions

Other studies related to the condition(s) this trial covers.