Can brain tests unlock the social struggles of turner syndrome?

NCT ID NCT03812913

Knowledge-focused Sponsor: University Hospital, Angers Source: ClinicalTrials.gov ↗

First seen Aug 18, 2026 · Last updated Aug 19, 2026 · Updated 1 time

Summary

This study investigates why some girls with Turner syndrome find it hard to make friends, read emotions, and control their feelings. Researchers will compare 35 girls with Turner syndrome to 35 girls with isolated growth hormone deficiency, all aged 7 to 16. Through puzzles, memory tasks, and questionnaires, they aim to pinpoint which cognitive and social abilities are affected. The goal is to better understand these challenges to improve support and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: Neuropsychological and experimental tasks, plus questionnaires
What this could lead to: If successful, this could identify specific cognitive and social challenges in Turner syndrome, guiding targeted support and interventions.
What could go wrong: This is an observational study with a small sample size, so findings may not apply to all individuals. It does not test a treatment, so direct benefits are uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

70 people

The number who actually took part.

Started

Sep 2019

Finished

May 2025

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

* 35 patients with Turner syndrome * 35 patients with isolated growth hormone deficiency

Ages

7 to 16 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

INCLUSION CRITERIA Turner syndrome group : * girls with diagnosed Turner syndrome. Isolated GHD group : * girls with diagnosed isolated growth hormone deficiency All participants : * age between 7 years to 16 years and 11 months. * informed consent signed by the participant and her parents (or her legal representatives) * being registered in the national social security system EXCLUSION CRITERIA : Turner syndrome group : * patients with chronic pathology other than Turner syndrome. * karyotype : part of a Y chromosome and r(X) cases. * medical treatment other than those usually prescribed in patients with Turner syndrome. Isolated GHD group : * patients with chronic pathology other than isolated growth hormone deficiency. * medical treatment other than those usually prescribed in patients with isolated growth hormone deficiency. All participants : * diagnosed intellectual disability (IQ\<70) or intellectual giftedness * history of acquired brain injury * sensory disturbances (auditory or visual) incompatible with the achievement of neuropsychological tasks. * insufficient French language proficiency

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Conditions

The condition(s) this trial relates to.

CGF1 isolated congenital growth hormone deficiency pituitary dwarfism Turner syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cognitive functions Isolated growth hormone deficiency Pediatrics Social cognition Turner syndrome

Can brain tests unlock the social struggles of turner syndrome?

What the study statuses mean