Reproductive system disorder

Researchers are testing whether a combination of two long-acting HIV antibodies and a low dose of the cancer immunotherapy nivolumab can help people with HIV control the virus without antiretroviral therapy. The trial enrolls 90 adults whose HIV is already well suppressed on stan…

This trial tests ADI-212, a type of cell therapy made from donor immune cells engineered to recognize and attack prostate cancer cells that carry a protein called PSMA. The study enrolls adults with metastatic castration-resistant prostate cancer, a form of the disease that has s…

This trial tests a new type of cell therapy for men with metastatic castration-resistant prostate cancer, a form of the disease that has spread and no longer responds to standard hormone therapy. The treatment uses the patient's own immune cells, called T cells, which are modifie…

This trial tests whether a single, outpatient treatment using low-thermal argon plasma can clear grade 2 cervical intraepithelial neoplasia (CIN2), a precancerous condition. Participants receive either the plasma treatment, a sham procedure, or standard active surveillance. The m…

This trial is testing whether a personalized cell therapy can help women with ovarian cancer that has returned. Doctors will remove a tumor, extract immune cells called tumor-infiltrating lymphocytes (TILs), and boost them in the lab before infusing them back into the patient. Af…

This study investigates whether combining two immune checkpoint inhibitors—one targeting GARP:TGF-β1 and another targeting PD-1—can better reactivate and eliminate dormant HIV-infected cells. Using blood samples from people with HIV-1 on suppressive antiretroviral therapy, resear…

This early-stage trial will test a new HIV vaccine in 22 infants who were exposed to HIV during birth but are not infected. The vaccine is designed to train the immune system to recognize and fight HIV. The main goal is to see if the vaccine is safe and whether it triggers an imm…

This phase 1 trial tests a higher dose of the experimental HIV vaccine VIR-1388 in about 12 adults aged 18 to 55 who already carry cytomegalovirus (CMV). The vaccine uses a weakened CMV virus to deliver HIV proteins, aiming to trigger a strong immune response. Participants receiv…

This trial tests whether the 9-valent HPV vaccine is safe and triggers a protective immune response in adults with HIV. People with HIV face higher risks of HPV infection and related cancers, but vaccine research in this group is limited. The study enrolls 60 HIV-infected adults …

This study tests a new drug called SX-682 (a tablet) combined with the chemotherapy docetaxel in people whose head/neck, salivary gland, or prostate cancer has spread or returned after treatment. The goal is to find the right dose and see if the combination shrinks tumors. About …

This phase 2 trial tests a combination of a vaccine (TriAdeno) and an immune-boosting drug (N-803) in 52 men with early-stage, low- or medium-risk prostate cancer who are currently on active surveillance. The vaccine targets three proteins found in prostate cancer cells, while N-…

Researchers are running a first-in-human Phase 1 trial of JUR-003, an intravenous biologic, in adults with metastatic prostate cancer. The study has two parts: a dose-escalation phase to find the highest dose people can tolerate, and a dose-expansion phase to look at early anti-t…

This Phase II trial tests whether an immune-boosting drug (N-803) alone or combined with a vaccine (ETBX-071) can lower PSA levels in men whose prostate cancer has returned after targeted radiation therapy. Participants receive up to eight cycles of treatment and are followed for…

This phase 2 trial is testing whether a lower dose of the immunotherapy drug nivolumab, given less often, can still control cancer in people with various advanced or metastatic cancers. The goal is to see if a cheaper, more accessible regimen works as well as the standard high-co…

This study will test whether living in a self-contained, AI-managed community (called a Microcity) can improve mental health and reduce addiction in adults with conditions like autism, ADHD, substance use disorders, and behavioral addictions. Up to 1 million participants will liv…

This study tests a new drug called zanzalitinib in people with a type of advanced prostate cancer that no longer responds to hormone therapy and has spread to soft tissues or organs. The goal is to see if the drug can slow or stop cancer growth. About 19 participants will receive…

This study tests whether a pharmacist-led electronic consultation can improve lung health for people with HIV who smoke or use certain medications that raise pneumonia risk. Pharmacists will review records and suggest changes like smoking cessation aids, vaccines, or stopping unn…

Researchers are testing whether a combination of semaglutide (Wegovy), a levonorgestrel-releasing intrauterine device (LNG-IUD), and a structured weight loss program can treat endometrial atypical hyperplasia or early-stage, grade 1 endometrioid endometrial cancer in women who wa…

Researchers are testing whether combining trastuzumab with retlirafusp alfa helps people with HER2-positive gastric or gastroesophageal junction cancer that has worsened after standard first-line treatment. The trial enrolls about 35 adults whose tumors test HER2 2+ or 3+. Partic…

When a kidney stone blocks urine flow and causes a severe infection, doctors must quickly relieve the blockage and control the infection. They can place a stent through the urinary tract, insert a drainage tube through the skin, or start antibiotics alone. This study observes 1,6…

Researchers are testing whether torvutatug samrotecan, alone or with bevacizumab, works better than standard care as maintenance therapy for people with platinum-sensitive relapsed ovarian, fallopian tube, or primary peritoneal cancer. The trial enrolls about 600 participants who…

This Phase 2 trial tests amivantamab, a targeted drug given as a shot under the skin, in adults with advanced penile cancer that has spread or returned after at least one round of platinum-based chemotherapy. The study includes two groups based on HPV status and measures how many…

This trial is testing whether a new drug called raludotatug deruxtecan (R-DXd), given alone or with bevacizumab, can help people with advanced ovarian cancer live longer and delay cancer growth compared to standard chemotherapy. The study includes adults with high-grade serous or…

This trial is testing whether a targeted therapy called raludotatug deruxtecan (R-DXd), given alone or with bevacizumab, can help people with newly diagnosed advanced ovarian cancer live longer without their cancer growing. Participants have already completed first-line platinum-…

Researchers are testing whether a two-drug injectable regimen can control HIV in adults who have not yet started treatment. The trial pairs an experimental drug called VH4011499 with cabotegravir, an existing injectable HIV medicine, and compares different dose combinations again…

Penile squamous cell carcinoma is a rare and aggressive cancer with limited options once it progresses after platinum-based chemotherapy. This phase 2 trial tests sacituzumab tirumotecan, an antibody-drug conjugate that targets the TROP-2 protein on cancer cells, in about 37 part…

Researchers are studying whether adding daily atorvastatin to standard chemotherapy and surgery changes the immune cells inside advanced high grade serous tumors of the ovary, fallopian tube, or peritoneum. The trial enrolls 40 adults with Stage III or IV disease who cannot have …

This phase 3 trial tests whether adding an experimental drug called BG-C9074 to bevacizumab helps adults with epithelial ovarian, fallopian tube, or primary peritoneal cancer whose disease has not worsened after initial platinum-based chemotherapy plus bevacizumab. Participants r…

Researchers are testing whether adding the immunotherapy drug adebrelimab to standard chemotherapy before and after surgery can improve outcomes for people with locally advanced cervical cancer. About 35 participants will receive three cycles of adebrelimab plus paclitaxel and ci…

Researchers are testing whether adding tirzepatide, a weekly drug that treats obesity and diabetes, to a standard levonorgestrel-releasing intrauterine device can help clear early endometrial cancer or a precancerous condition called endometrial intraepithelial neoplasia. The stu…

Researchers are testing a new drug called TS-104 in adults with advanced solid tumors, including lung, head and neck, ovarian, endometrial, esophageal, and gastric cancers. TS-104 is a peptide drug conjugate: it uses a targeting peptide to carry the chemotherapy drug MMAE directl…

Researchers are testing an oral drug called AL58805, which blocks two cancer-growth proteins, PI3K and mTOR, in adults with advanced endometrial, cervical, soft tissue sarcoma, or breast cancers that have worsened after at least one standard treatment. Participants receive AL5880…

This study tests whether adding precisely targeted radiation to standard hormone therapy helps men with metastatic hormone-sensitive prostate cancer. All participants first receive six months of darolutamide plus androgen deprivation therapy. Those whose cancer has not progressed…

People newly diagnosed with breast, colorectal, lung, or prostate cancer often also manage other long-term conditions and take multiple medications. This pilot study tests whether a pharmacist-led medication review plus the Medisafe mobile app helps them stick to those regimens. …

Researchers are testing whether a higher dose of proton beam therapy can normalise hormone levels better than standard radiotherapy in people with functioning pituitary tumours, including acromegaly and Cushing's disease. Participants receive about six weeks of either standard-do…

This study follows men in India with metastatic hormone-sensitive prostate cancer who are already receiving darolutamide plus androgen deprivation therapy as part of their routine care. Researchers will track side effects, treatment changes, and lab results over up to one year. T…

Researchers are testing an investigational oral drug called catequentinib hydrochloride (AL3818) in adults with advanced or metastatic endometrial cancer, low grade serous ovarian cancer, soft tissue sarcoma, or glioblastoma. The trial has two parts: a phase 1b part to find safe …

This trial tests whether adding an experimental drug called INCB123667 to the standard maintenance therapy bevacizumab can delay cancer recurrence in people with advanced ovarian, fallopian tube, or primary peritoneal cancer. Participants must have completed initial chemotherapy …

Researchers test whether a short, highly focused course of stereotactic body radiotherapy can safely treat prostate cancer that has come back in one small area after earlier radiation. The study enrolls 60 men under 80 whose cancer returned locally and who have not yet started ho…

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

This phase 3 trial tests whether adding enoxaparin, a blood thinner, to standard progesterone treatment increases the chance of a live birth in women who have had two or more unexplained miscarriages. Participants receive either progesterone alone or progesterone plus daily enoxa…

This trial tests whether B-OK bottles, which use beads to visually explain how HIV affects health and how treatment lowers viral load, can help people with HIV stick to their medication. Researchers will roll out the bottles across HIV case management agencies in Philadelphia and…

This trial tests whether radioguided surgery can help surgeons find and remove lymph nodes containing prostate cancer in men whose cancer has returned after initial treatment. Participants are randomly assigned to either radioguided surgery, where a radioactive tracer highlights …

This early-stage trial tests an experimental drug called STRO-006 in adults with advanced solid tumors, including head and neck, lung, esophageal, gastric, colorectal, endometrial, bladder, and breast cancers that have not responded to standard treatments. The study has three par…

This trial tests whether MRI-guided High-Intensity Focused Ultrasound (HIFU) can ease symptoms of adenomyosis, a condition where uterine tissue grows into the muscle wall, causing pain and heavy bleeding. Researchers plan to enroll 20 women aged 18 and older who have adenomyosis …

This early-stage trial tests an investigational drug called ABBV-253 in adults with advanced solid tumors, including lung, colorectal, and pancreatic cancers. The study aims to find safe doses and see whether the drug can shrink tumors. Participants receive the drug by infusion, …

This trial tests whether a smartphone app called PL4Y can help young adults aged 18 to 29 who have HIV stay engaged in their care. For the first 6 months, participants receive standard care. Then they get the app, which sends daily medication reminders, appointment alerts, secure…

This phase II trial tests whether sacituzumab tirumotecan (Sac-TMT) can shrink tumors in people with advanced or metastatic squamous cell carcinoma of the vagina or vulva. These cancers are rare, and there is no standard second-line treatment. Sac-TMT is an antibody-drug conjugat…

This study tests whether adding a glutaminase inhibitor (telaglenastat) to standard chemoradiation helps people with advanced cervical cancer live longer without the disease getting worse. About 42 adults with stage III–IVA cervical cancer will receive the drug alongside standard…

This phase 3 trial tests whether risvutatug rezetecan, an antibody-drug conjugate that delivers a toxin directly to prostate cancer cells, can slow or shrink tumors better than standard hormone therapy. About 684 men with metastatic castration-resistant prostate cancer will recei…

This trial tests whether pembrolizumab, an immunotherapy drug, is safe when combined with chemotherapy or chemoradiotherapy for people in India with advanced gastric or gastroesophageal junction cancer, advanced biliary tract cancer, or high-risk locally advanced cervical cancer.…

This phase 3 trial tests whether a new drug called mocertatug rezetecan (Mo-Rez) combined with bevacizumab works better than standard chemotherapy plus bevacizumab for women with platinum-sensitive ovarian cancer. The study includes about 690 participants whose cancer has returne…

This trial is testing whether a 10-week course of fluconazole works as well as the standard 24-week course for people with HIV who have a cryptococcal infection in their blood (antigenemia) but no symptoms. It also compares starting HIV medications right away versus waiting 14 da…

This trial tests whether a coordinated care pathway, involving oncologists, geriatricians, pharmacists, and pharmacologists, can reduce severe side effects in adults over 70 with certain cancers who are starting oral therapy. Participants receive extra monitoring, including blood…

This study looks at whether giving women living with HIV the option to collect their own HPV test samples at home or in their community, with help from health workers, increases how many get screened for cervical cancer. About 17,700 women will take part across multiple clinics. …

This pilot study tests whether injecting Botox into the prostate a few weeks before surgery can improve outcomes for men with high-risk localized prostate cancer. Thirty men will receive either a single Botox injection or a placebo, then undergo standard prostate removal surgery.…

This study tests whether a 10-day course of oral amoxicillin works as well as a single injected dose of penicillin to treat congenital syphilis in newborns up to 30 days old. About 374 infants across 12 U.S. sites will be randomly assigned to one of the two treatments. The goal i…

This trial asks whether two medications used for endometriosis symptoms, norethindrone acetate and elagolix, affect brain health. Researchers will measure blood flow in the brain and markers of inflammation in 45 women with endometriosis. Participants will be randomly assigned to…

This phase 3 trial tests whether adding an experimental drug (GSK5733584) to standard immunotherapy can help keep advanced or recurrent endometrial cancer from growing. About 610 adults who have already completed initial chemotherapy with immunotherapy will receive either the new…

This trial tests whether a small spring implant placed in the prostate can ease urinary symptoms as well as or better than the daily medication tamsulosin. Men with moderate to severe symptoms from an enlarged prostate, known as BPH, will be randomly assigned to receive either th…

This trial tests whether raludotatug deruxtecan, given alone or with bevacizumab, can delay cancer growth better than standard care in people with platinum-sensitive ovarian, primary peritoneal, or fallopian tube cancer that has returned after first treatment. About 600 adults as…

This trial compares an experimental drug called JSKN033 with standard chemotherapy in people whose cervical cancer has returned or spread and no longer responds to platinum-based chemotherapy or PD-1/L1 inhibitors. The study includes about 368 adults with recurrent or metastatic …

This early-stage trial tests an experimental medicine called BI 3822971 in adults with advanced or metastatic solid cancers, such as lung, head and neck, breast, esophageal, bladder, vulvar, or cervical cancer, who have no standard treatment options left. The goal is to find out …

Researchers in Peru are testing whether starting antiretroviral therapy on the same day as diagnosis can reduce the stigma that people with HIV face. The study involves developing a same-day treatment protocol with input from HIV experts, then piloting it with patients and their …

This phase Ib/II trial tests an investigational drug called BL-M08D1 in adults with recurrent or metastatic gynecological cancers and other solid tumors. The study aims to find the safest and most effective dose and to see whether the drug can shrink tumors. Participants receive …

This phase III trial tests whether adding a radioactive drug called 177Lu-NYM032 to standard care helps men with a specific type of advanced prostate cancer live longer. The drug targets a protein called PSMA found on many prostate cancer cells, delivering radiation directly to t…

This trial tests whether measuring the spinal canal with ultrasound before surgery can help doctors give the right amount of spinal anesthesia. The study includes men aged 40 and older having prostate surgery. Half receive a dose based on their individual spinal canal size, while…

This trial compares different HIV drug combinations in children and teens aged 4 weeks to under 15 years, including those starting treatment for the first time and those whose current drugs are failing. Researchers want to see which combinations best keep the virus at very low le…

This pilot study tests whether a surgeon located at a different hospital can safely perform parts of robotic prostate or colorectal cancer surgery using the Toumai robotic system. The local surgical team remains with the patient and can take over control at any moment. Researcher…

This study tests whether a self-applied cream (5-fluorouracil) after a heat procedure (thermal ablation) can clear HPV better than a placebo cream in 140 women with HIV in Kenya. Participants will use the cream every two weeks for 24 weeks and be followed for 48 weeks total. The …

This study looks at how long-acting injectable HIV drugs (cabotegravir and rilpivirine) work in the body during pregnancy and after childbirth. About 40 pregnant women with HIV will receive the shots every 4 weeks. The goal is to measure drug levels and see if they stay effective…

This early-stage trial is testing whether combining two chemotherapy drugs—liposomal irinotecan and cisplatin—can safely shrink or control advanced solid tumors that have not responded to standard treatments. The study will enroll about 44 adults aged 20 to 85 with various types …

This trial tests whether genistein, a natural compound found in soy, can reduce inflammation and improve blood vessel health in people living with HIV. Even with effective HIV treatment, the body stays inflamed, raising the risk of heart disease and other problems. The study give…

This early-phase trial explores whether PSMA PET scans can help doctors adjust radiation therapy for men with prostate cancer that has spread to 4 to 20 spots in the body. Participants receive standard hormone therapy plus a special PET scan, then targeted radiation to all visibl…

This trial investigates whether adding a special radiation technique called spatially fractionated radiation therapy (SFRT) to standard chemoradiation can improve outcomes for people with locally advanced cervical cancer. Participants with stage IIB to IVA disease will be randoml…

This trial tests whether adding mazdutide, a weekly injection that helps with weight loss, to a hormonal intrauterine device (IUD) can improve treatment for overweight or obese women with atypical endometrial hyperplasia or early-stage endometrioid endometrial cancer who wish to …

This trial tests whether adding targeted radiation to standard hormone therapy can help men with recurring prostate cancer stay off cancer drugs longer. Men with a rising PSA and 1 to 5 metastases will receive either hormone therapy alone or hormone therapy plus radiation to the …

This phase 2 trial tests a drug called sacituzumab tirumotecan in people with neuroendocrine prostate cancer, a rare and aggressive form that has progressed after platinum-based chemotherapy. The drug is given by IV infusion three times per 42-day cycle. The study measures how ma…

This study tests a weekly, image-guided radiation therapy (SBRT) for men with very high-risk prostate cancer that may have spread to nearby lymph nodes. The treatment uses weekly CT or MRI scans to adapt the radiation dose precisely to the tumor. The main goals are to see if this…

This trial tests whether adding a lab-made antibody (ePGT121v1-LS) to standard HIV medication can help infants under one year old achieve better viral suppression. About 87 infants in South Africa will receive either the antibody or a placebo injection every 12 weeks for 48 weeks…

This trial tests whether adding two lab-made antibodies (ePGT121v1-LS and VRC07-523-LS) to standard antiretroviral therapy can help infants living with HIV achieve viral suppression. Infants up to one year old in Mozambique and Cameroon receive four injections of the antibodies o…

This trial tests whether a higher starting dose of follicle-stimulating hormone (FSH) improves embryo development in women undergoing IVF. Participants with good fertility prognosis are randomly assigned to receive either 225 IU or 300 IU of FSH daily during ovarian stimulation. …

This trial tests whether electro-thumbtack needle (ETN) therapy, a form of acupuncture with mild electrical stimulation, can improve the live birth rate in women with diminished ovarian reserve (DOR) undergoing in vitro fertilization (IVF). About 406 women with DOR will be random…

This trial tests whether a 7-day course of doxycycline can effectively cure asymptomatic anal lymphogranuloma venereum (LGV), a sexually transmitted infection caused by Chlamydia trachomatis. Currently, treatment lasts 21 days, but recent studies suggest a shorter course may work…

This trial tests a six-session peer-led program called Gwan Enjoy Life for sexual minority men living with HIV in Jamaica. The program aims to reduce depression, anxiety, and loneliness while helping participants stay engaged in HIV care and take their medications. Sixty men will…

This phase 2 trial is testing whether adding relacorilant—a drug that blocks a stress-related hormone—to the chemotherapy nab-paclitaxel can shrink tumors in people with recurrent or metastatic cervical cancer. Participants have already tried platinum-based chemo and immunotherap…

This study tests a device called Vanquish that uses water vapor (steam) to destroy prostate cancer tissue in men with Grade Group 3 intermediate-risk prostate cancer. Fifty participants will receive the treatment and be followed for two years to see if the cancer is reduced and t…

This trial explores whether a single dose of psilocybin, combined with motivational support therapy, can help people with HIV who have moderate-to-severe methamphetamine use disorder reduce or stop their meth use. Participants will be randomly assigned to receive either a higher …

This study tests a program called Light Inside, designed to reduce stigma for women living with HIV who use drugs. The program involves five small-group sessions that teach coping skills and communication strategies to help participants stay engaged in HIV care and adhere to thei…

This study tests an experimental drug called TUB-040 in people with recurrent or progressive endometrial cancer that has not responded to platinum-based chemotherapy and immunotherapy. TUB-040 is an antibody-drug conjugate designed to bind to a protein called NaPi2B on cancer cel…

This trial tests whether testosterone therapy can help men with spinal cord injury who have low testosterone and difficulty walking. The goal is to see if it increases muscle and bone in the legs, reduces body fat, and improves strength. Some participants also receive finasteride…

This trial tests a new device called Vivifi that aims to reduce symptoms of an enlarged prostate (BPH) by gently altering the blood supply to the prostate through a small scrotal procedure. The study involves 20 men aged 45–80 with moderate-to-severe urinary symptoms. Researchers…

This pilot trial tests whether a daily drospirenone pill can replace standard daily injections during ovarian stimulation for women with poor ovarian reserve undergoing IVF. Participants take either drospirenone or the usual injection alongside their fertility hormones, then have…

This study will test whether a smartphone app can help people with HIV in Laos quit smoking. About 1,200 smokers from eight HIV clinics will be split into two groups: one gets the app with tailored messages and videos, the other gets printed self-help materials. The goal is to se…

This trial is testing whether using microultrasound to guide a radiation boost to cancerous spots inside the prostate can reduce side effects compared to standard radiation therapy. Men with intermediate-risk prostate cancer will receive stereotactic body radiation therapy (SBRT)…

This phase 3 trial investigates whether taking progesterone during the luteal phase of the menstrual cycle can increase the chance of a live birth for couples with unexplained infertility. Participants take either progesterone or a placebo twice daily for up to six months while t…

This trial is investigating whether an experimental drug called XNW5004, when combined with standard anti-tumor therapies, can help control advanced prostate cancer. The study involves men with prostate cancer that has spread. Researchers are looking at how safe the combination i…

This study tracks the safety and effectiveness of mirvetuximab soravtansine (MIRV), a drug that targets a protein called folate receptor alpha on cancer cells, in patients with advanced ovarian, fallopian tube, or primary peritoneal cancer. Researchers will observe 400 patients r…

This trial tests whether a package of support from a community health worker can help adults hospitalized with advanced HIV in Lusaka, Zambia, stay in care and survive longer. Participants are randomly assigned to receive the ARC intervention or standard care and are followed for…

This study looks at how effective the drug Pluvicto (177Lu-PSMA-617) is in treating men with a type of advanced prostate cancer that no longer responds to hormone therapy and has spread to other parts of the body. Researchers will analyze medical records from over 1,000 patients …

This phase II pilot trial is testing a three-drug combination—radium-223, darolutamide, and standard hormone therapy—in men with high-volume metastatic hormone-sensitive prostate cancer. The goal is to see if adding radium-223 as maintenance therapy after initial treatment can im…

This trial tests whether adding orlistat, a weight-loss drug that blocks fat absorption, to standard progestin therapy can improve treatment response in young women (45 or younger) with early-stage endometrial cancer or atypical endometrial hyperplasia who have low progesterone r…

People living with HIV have twice the risk of heart attacks and stroke compared to the general population. This trial tests whether integrating clinical pharmacists into HIV care can improve blood pressure control and reduce cardiovascular disease risk. The study enrolls 450 adul…

This study tests whether adding the experimental drug saruparib to standard hormone therapy can slow the growth of metastatic hormone-sensitive prostate cancer. It includes men whose cancer has not progressed after prior chemotherapy or a specific type of radiation therapy. Parti…

This trial tests a 24-week virtual care program called BRIDGE NET for people with serious mental illness who are starting cancer treatment. The program brings together oncology and mental health teams to plan care, provide early psychiatric support, and regularly check in with pa…

This trial tests two experimental treatments for erectile dysfunction in men who have had robotic prostate surgery for prostate cancer. One group receives an injection of urine-derived exosomes into the penis, while the other gets ozone gas delivered through the rectum. Researche…

This study tests whether a 12-week virtual cooking and nutrition program is practical and helpful for Hispanic prostate cancer survivors and their caregivers. Participants attend nutrition education, cooking classes, and health coaching sessions online. The goal is to see if the …

This study tests whether a vaginal ovule device, used alongside standard antibiotics or antifungals, improves vaginal health in women with bacterial vaginosis or yeast infections. Eighty women aged 18 to 60 receive either the active device or a placebo ovule over three treatment …

This study tests whether taking linzagolix (Yselty) for 3 to 6 months before an embryo transfer can improve live birth rates in women with adenomyosis who have experienced repeated implantation failure. Adenomyosis can make the womb lining less receptive to embryos, even when the…

This study tests whether adding Qiling Yiqi tablets, a Chinese herbal medicine, to standard HIV therapy can improve immune function in people whose CD4 counts remain low despite successful viral suppression. The trial involves 240 adults with HIV who have been on antiretroviral t…

This study tests whether adding Fuyang Jiedu Granules, a traditional Chinese herbal mixture, to standard antiretroviral therapy can improve immune function in people with HIV who have persistently low CD4 counts despite viral suppression. The trial includes 240 adults aged 18–60 …

This trial investigates whether a minimally invasive procedure using a special dye can better detect cancer spread in men with early-stage testicular cancer. About 20-30% of these patients have cancer cells in lymph nodes that standard scans miss. Participants are randomly assign…

This study looks at how well the chemotherapy drug temozolomide works for people with aggressive pituitary tumors or pituitary cancer that hasn't responded to standard treatments like surgery or radiation. Researchers are collecting data from medical records across multiple hospi…

This study tests a new drug, ubamatamab, combined with standard chemotherapy drugs (carboplatin, paclitaxel, and bevacizumab) in 43 people with advanced ovarian cancer that did not respond well to initial treatment. The goal is to see if the combination is safe and can shrink tum…

This study looks at whether the RSV vaccine given in late pregnancy can help protect babies born to mothers with HIV. RSV is a leading cause of infant hospitalization, and babies exposed to HIV are at higher risk. Researchers will measure antibody levels in mothers and infants to…

This study tests a new approach for treating high-grade cervical precancer (HSIL) using a cream called HAL that is activated by a special light, instead of standard surgery. About 230 women will be randomly assigned to receive either the light therapy or surgery. The main goal is…

This trial tests whether a single infusion of granulocyte colony-stimulating factor (G-CSF) into the uterus can improve pregnancy outcomes in women with thin endometrium (uterine lining) undergoing frozen embryo transfer. Thin endometrium can reduce the chance of pregnancy. The s…

This trial tests two different daily doses of fertility hormones (follitropin-delta and menotropin) during ovarian stimulation for IVF in women aged 35 and older. The goal is to see which dosing strategy leads to more good-quality embryos. The study involves 240 women with normal…

This study looks at whether switching to a daily pill containing bictegravir, emtricitabine, and tenofovir alafenamide (BIC/FTC/TAF) can help people with HIV who previously did not respond to a long-acting injectable treatment (CAB/RPV LAI). The study includes 30 adults and will …

This study tests an experimental drug, TAX2, in adults with advanced or metastatic solid tumors that have not responded to standard treatments. The trial has two parts: first, finding a safe dose, and then testing that dose in more people. Researchers will monitor side effects, h…

This trial tests whether a special mesh-like suture (Duramesh) can prevent incisional hernias better than a standard slowly-absorbable suture (PDS loop) in women having abdominal surgery for gynecological cancers. About 300 participants will be randomly assigned to one of the two…

This phase 1 trial tests whether giving a higher first dose of the radioactive drug Lu-177-PSMA-617 can improve treatment for men with metastatic castration-resistant prostate cancer. The drug targets a protein on prostate cancer cells and delivers radiation to kill them. Researc…

This trial tests whether combining an immune-boosting cream (imiquimod) with a low dose of an immunotherapy drug (nivolumab) can shrink vulvar squamous cell carcinoma tumors before surgery. About 50 women with resectable, early-to-moderate stage vulvar cancer will receive the dru…

This trial investigates whether combining a targeted radioactive drug (177Lu-PSMA-617) with a hormone therapy (darolutamide) before surgery can improve outcomes for men with high-risk localized prostate cancer. Participants receive two doses of the radioactive drug and daily horm…

This study tests whether offering rapid HIV testing during a dental visit leads more people to get tested than simply referring them to a lab. About 6,700 adult dental patients at four community health centers will be offered either a quick oral swab test on-site or a referral fo…

This trial explores whether a new type of radiotherapy called CT online-adaptive radiotherapy can safely deliver treatment for endometrial cancer in just 5 sessions over a week and a half, instead of the usual 25 sessions over 5 weeks. The study includes 30 adults who have had su…

This phase 3 trial compares a single intravenous dose of temocillin to the standard ceftriaxone shot for treating gonorrhea. The goal is to see if temocillin works just as well while having less impact on the gut's healthy bacteria, which can help prevent the rise of drug-resista…

This pilot study tests a program called Kisoboka Amaka for men living with HIV who drink heavily and have pregnant partners. The program combines counseling, financial training, and mobile savings to help men drink less and take their HIV medication consistently. Researchers will…

This study tests a personalized approach to hormone therapy for men with metastatic hormone-sensitive prostate cancer. The goal is to reduce treatment intensity for lower-risk patients to minimize side effects while still controlling the cancer. About 108 participants will receiv…

This study tests whether the drug elranatamab can help keep plasmablastic lymphoma, a rare and aggressive blood cancer, from returning after initial chemotherapy. About 17 adults with or without HIV who have already responded to first treatment will receive elranatamab injections…

This study tests whether a single, powerful dose of MRI-guided radiation can safely treat prostate cancer that has come back in a few lymph nodes after initial treatment. Forty-eight men will receive one 24 Gy radiation session aimed precisely at the affected nodes. The main goal…

This study tests whether giving radiotherapy to the prostate and to cancer spots seen on PET scans can help men with metastatic prostate cancer whose PSA levels remain high after six months of hormone therapy. Participants continue their hormone treatment and receive three PSMA-P…

This study tests whether tamoxifen, a drug commonly used for breast cancer, can speed up testosterone recovery in men with prostate cancer who have completed hormone therapy (ADT). Many men experience low testosterone for months or years after stopping ADT, causing fatigue, depre…

This study tests whether Sanghe Jianghuo Granules, a traditional Chinese herbal medicine, can safely slow down early puberty in girls aged 5 to 8.5 years. The trial will involve 200 participants who will take the granules or a placebo twice daily for 3 months. The main goal is to…

This study follows 100 adults with congenital adrenal hyperplasia (CAH) who switch from standard steroids to a timed-release hydrocortisone (Efmody). The goal is to see if better mimicking the body's natural cortisol rhythm improves hormone levels, metabolic health, and quality o…

This study compares myo-inositol alone versus myo-inositol plus alpha-lactalbumin in 82 women with PCOS who want to conceive. Over 12 weeks, researchers will track pregnancy rates, menstrual regularity, and metabolic changes. The goal is to see if adding alpha-lactalbumin improve…

This study tests a program that combines group counseling, financial literacy training, and savings accounts to help Ugandan teens with HIV manage depression and stick to their medication. About 588 adolescents aged 15-19 will take part. The goal is to see if this approach can re…

This study will compare two different HIV medication combinations in 60 people who also have active tuberculosis. Participants will receive either a newer drug (Ainuovirine) or a standard one (Efavirenz), along with their TB meds. The goal is to see which regimen better suppresse…

This study tests a daily pill called zanzalintinib in men with advanced prostate cancer that has stopped responding to hormone therapy and has already been treated with Pluvicto. The goal is to see if the drug can delay cancer growth or shrinkage. About 30 participants will take …

This study looks at whether a long-acting injectable HIV prevention drug (cabotegravir) can be delivered fairly and effectively in NHS sexual health clinics. Researchers will follow 200 people taking the drug for 12 months, along with 20 healthcare professionals, to see how well …

This study tests whether infusing fluid into the uterus during labor (amnioinfusion) can reduce brain injury in newborns whose mothers have a uterine infection called chorioamnionitis. The infection can cause inflammation and fever that may stress the baby's brain before birth. R…

This study compares two procedures for men with erectile dysfunction caused by a vein leak. One procedure blocks the leaking veins, and the other reroutes the main vein. The goal is to see which works better and is safer. About 60 men will take part.

This study tests whether adding a weight-loss shot (tirzepatide) to standard hormone therapy can better treat early-stage uterine cancer or pre-cancer in overweight women. About 30 participants will either get the standard progesterone IUD alone or the IUD plus tirzepatide. The g…

This study tests proton beam therapy for stage II seminoma, a testicular cancer that is highly curable. The goal is to see if this more targeted radiation can treat the cancer effectively while reducing long-term side effects and the risk of developing another cancer later in lif…

This phase 3 trial tests whether daily vitamin D supplements can improve immune function and quality of life in Black/West African men with prostate cancer who have low vitamin D levels. Researchers will compare men with localized disease to those with advanced cancer, tracking i…

This phase 2 trial tests whether adding mevrometostat to enzalutamide can slow cancer growth in 60 men with metastatic castration-resistant prostate cancer who have already been treated with similar drugs. Participants will take both drugs orally. The main goal is to see how long…

This study tests a new device that uses pulsed energy to shrink the prostate in men with bothersome urinary symptoms from an enlarged prostate (BPH). About 250 men over age 45 will either get the new treatment or a standard scope procedure. The goal is to see if the new device sa…

This phase 2 trial tests whether transferring vaginal fluid from healthy donors can help women aged 18-25 with recurrent bacterial vaginosis (BV). Participants first receive standard antibiotics, then the transplant. The goal is to see if this restores a healthy vaginal microbiom…

This study will observe 500 women with ovarian, fallopian tube, or primary peritoneal cancer who are taking the drug senaparib. Researchers will track side effects and how well the drug controls the cancer in real-world conditions, outside of a strict clinical trial. The goal is …

This phase 3 trial tests whether adding carboplatin to standard therapy can delay cancer growth in men with aggressive prostate cancer that has spread and has either a BRCA gene mutation or neuroendocrine features. About 330 participants will receive either standard care alone or…

This study looks at whether surgically removing uterine fibroids (myomectomy) before in vitro fertilization (IVF) helps women with infertility have a baby. About 792 women aged 20-39 with fibroids 4-6 cm that do not distort the uterine cavity will be randomly assigned to either h…

This study looks at whether people with HIV who are already well-controlled on daily pills can switch to a long-acting injection given every two months. The goal is to see how many stay on the injection without stopping or needing to change treatment over 48 weeks. The study will…

This early study tests a drug called leflutrozole in 15 men who have no sperm in their semen due to a blockage-free cause. The drug is taken as a weekly capsule and aims to boost sperm production. Researchers will check if sperm appear in the semen after 12-20 weeks of treatment.

This study looks at whether making small punctures in the ovary during egg retrieval can help women with low ovarian reserve (DOR) produce more eggs in a later cycle. About 214 women undergoing IVF will be randomly assigned to get the puncture procedure or standard care. The main…

This study tests whether a one-visit, point-of-care test and treat approach helps more people with HIV, hepatitis B, or hepatitis C complete hepatitis C treatment within 24 weeks compared to standard care. About 1,280 participants will be randomly assigned to either the simplifie…

This study looks at whether giving two antibiotics (ampicillin and gentamicin) instead of one (ampicillin alone) can better prevent infections in pregnant women whose water breaks before labor starts. About 320 women at term will be randomly assigned to one of the two treatments.…

The ROOT study is testing a personalized nutrition program for pregnant women. Participants receive standard prenatal care plus customized diet and lifestyle plans based on their genes and nutrient levels. The goal is to see if this approach can lower the chances of preterm birth…

This study compares two ways to drain urine in men with blocked bladders before prostate surgery: self-catheterization (done by the patient several times a day) versus a permanent tube. The goal is to see if self-catheterization leads to fewer infections. About 106 men over 50 wi…

This early-stage trial tests a single injection of stem cells from donated umbilical cords in 21 women with primary ovarian insufficiency (early menopause). The goal is to see if the treatment is safe and if it can improve hormone levels. Participants will be monitored for 24 wee…

This study tests whether pharmacy technicians can help people with HIV get long-acting injectable medication more easily at community clinics in Chicago. About 465 participants will be observed and may complete surveys or interviews. The goal is to improve access to modern HIV tr…

This study tests whether a special high-energy formula called InfaCore can help undernourished infants (1-12 months old) gain weight and tolerate feeding better. About 35 babies who are not growing well or are at risk will receive the formula. The main goal is to see if their wei…

This study tests whether giving men with low testosterone and no sperm in their ejaculate a combination of two hormones (hCG and FSH) can help them produce usable sperm for IVF. About 860 men will either receive the hormone therapy or standard care for 16 weeks. The goal is to se…

This study tests whether a natural blood product called i-PRF can help heal the womb lining after surgery for moderate to severe uterine adhesions (scarring). The trial will involve 200 women aged 20-40 who want to have children. After surgery, some will receive i-PRF and others …

This study tests whether a probiotic called Lactobacillus gasseri KABP®064 can prevent bacterial vaginosis (BV) from returning after standard antibiotic treatment. BV is a common vaginal infection that often comes back within a year. The trial will involve 160 women with a histor…

This phase 2 trial is testing a daily pill called Inavolisib in about 48 people with advanced endometrial cancer that has a specific genetic change (PIK3CA mutation). The drug targets that mutation to try to shrink tumors or stop them from growing. Researchers will measure how ma…

This study tests a new approach called Bioblation, which combines a prostate biopsy with laser ablation in a single session under local anesthesia. It is for men with severe urinary symptoms and suspected low- to intermediate-risk prostate cancer. The goal is to see if this one-s…

This study tests a personalized radiation approach for men whose prostate cancer has returned after surgery. Using PSMA PET scans, doctors will give higher radiation doses to active cancer spots and lower doses to healthy areas, all in just 5 treatments over two weeks. The goal i…

This study tests whether daily adaptive radiotherapy (ART) can safely deliver shorter, more intense radiation treatments for prostate, endometrial, cervical, and rectal cancers. About 264 participants will be randomly assigned to standard radiation or ART, which uses daily imagin…

This study tests a new way to deliver radiotherapy for endometrial cancer after surgery. Using real-time MRI guidance, doctors can target radiation more accurately and reduce damage to nearby organs like the bowel and bladder. About 61 women will receive five high-dose sessions o…

This study will test a new mesh implant called ProGYNious for repairing pelvic organ prolapse in 100 women. The goal is to see how well it works and if it is safe. Participants will be followed for complications and quality of life after surgery.

This study tests a combination of three drugs (Benmelstobart, Anlotinib, and low-dose Cyclophosphamide) in 40 women whose ovarian, fallopian tube, or peritoneal cancer has come back. The goal is to see if this mix can keep the cancer from growing for longer. Participants must be …

This study tests a daily pill called upadacitinib for people with severe forms of lichen planus, a skin disease causing painful mouth sores or hair loss. About 56 adults will receive either the drug or a placebo for 16 weeks to see if it reduces symptoms. The goal is to control t…

This study tests whether adding surgery and targeted radiation to a new hormone-blocking drug (rezvilutamide) can help men whose prostate cancer has spread to a few spots (oligometastatic). 300 men will be split into three groups: one gets the drug alone, one gets drug plus surge…

Researchers are testing a new PET/CT imaging tracer called [68Ga]-LY4257529 that targets a protein called GRPR, which some cancers make in large amounts. The study includes up to 60 adults with breast cancer or other tumors known or suspected to express GRPR, such as prostate, ov…

Researchers are testing whether sex work managers, called queen mothers, can hand out and collect HIV self-tests and self-collected STI test kits at places where female sex workers meet and work in Lusaka. The study compares this peer-supported approach with the current standard …

Researchers are reviewing medical records from about 1,125 women in Italy with newly diagnosed advanced high-grade epithelial ovarian cancer. The study focuses on how hospitals test tumors for homologous recombination deficiency (HRD), a DNA repair flaw that can make PARP inhibit…

Placenta accreta spectrum is a serious pregnancy complication where the placenta grows too deeply into the uterus, risking severe bleeding during delivery. Doctors usually rely on ultrasound to detect it, but ultrasound accuracy varies. This study checks whether simple blood test…

This pilot study tests a one-stage approach for men with a high probability of clinically significant prostate cancer. Instead of a separate preoperative biopsy, participants have a targeted prostate biopsy under general anesthesia, and the tissue is examined immediately with fro…

This study compares two ways of taking prostate biopsies in men with suspected prostate cancer. The new method takes samples from the MRI-visible spot and nearby areas, while the standard method also samples random spots across the prostate. The goal is to see if the new approach…

Researchers are testing a new imaging agent called 111In-TJD-31 that targets placental alkaline phosphatase (ALPP), a protein found on many solid tumor cells but rarely in healthy adult tissue. The study enrolls 8 participants: 2 healthy volunteers who give blood samples and 6 pa…

Many cancer trials require patients to have specific molecular markers, so researchers test large numbers of people to find the few who qualify. This study evaluates FATHOM, an AI system that reads clinical trial records and routine tumor slides to predict which patients carry th…

This study is looking at whether a blood test called Galleri can help detect ovarian cancer early in people with BRCA1 or BRCA2 gene changes, who are at higher risk. Participants will give a blood sample and answer questionnaires about their experience. The study will also check …

This trial tests whether a fluorescent dye called zopocianine can make prostate cancer cells glow under near-infrared light during surgery. Men with prostate cancer scheduled for prostatectomy receive a single dose of the dye before surgery. The goal is to see if the dye helps su…

Researchers at Assiut University are investigating whether the severity of erectile dysfunction mirrors the severity of coronary artery disease in men aged 18 to 50. The study enrolls 120 men who are undergoing coronary angiography for suspected or confirmed heart conditions. Par…

Researchers are testing three advanced diffusion MRI sequences to see which one best identifies men who can safely skip a prostate biopsy. The study includes men with suspicious prostate MRI results and those already scheduled for a routine MRI. By comparing these new scans again…

This study tests whether machine learning can analyze ultrasound images to distinguish benign from malignant adnexal masses, growths near the ovaries that are common but hard to classify. Researchers will develop and validate AI models using images from 12,000 patients across mul…

Researchers are testing whether a urine-based self-test can accurately detect tenofovir, a drug used in PrEP for HIV prevention. The study enrolls HIV-negative women in North Carolina who use stimulants and are either on PrEP or eligible for it. Participants will complete the sel…

This trial is testing an experimental imaging agent called [⁶⁴Cu]Cu-RAX301, which is designed to bind to prostate cancer cells and show up on PET/CT scans. The study includes men with prostate cancer who are either about to have surgery to remove the prostate or who may have a re…

This pilot study investigates whether a PSMA PET scan, using an injected radiotracer, can detect clinically significant prostate cancer recurrence one year after focal HIFU treatment, compared with the standard MRI. About 30 men with prostate cancer who meet specific criteria wil…

This study is testing whether a new scoring system, called the Fusion CEMEP score, can safely guide prostate biopsy decisions. The goal is to see if men with suspected prostate cancer can skip the extra systematic biopsies and only have targeted biopsies based on MRI findings. Th…

This pilot study is testing whether a special PET/MRI scan using a radioactive tracer called 68Ga-PSMA-11 can better identify all areas of significant prostate cancer in men with localized disease. The goal is to improve selection for focal therapy, a treatment that targets only …

This study tests a community-based screening strategy for tuberculosis (TB) in migrant communities in New York City. A mobile van offers digital chest X-rays with AI interpretation, along with TB symptom checks, blood tests for latent TB, and HIV testing. The goal is to see wheth…

This study tests a new imaging tracer called [18F]FAPI-74, which attaches to a protein found on cells in tumors and scarred or inflamed tissue. Researchers want to see if it can show these areas more clearly than current scans. About 770 adults with various cancers or non-cancer …

This study tests a new imaging technique that could help surgeons see if cancer has spread to lymph nodes during surgery for gynecologic cancers like ovarian, endometrial, cervical, and vulvar cancer. The method uses a special microscope to examine lymph node tissue right after i…

This study evaluates several experimental blood tests designed to detect ovarian cancer earlier. Researchers compare results from people with ovarian cancer to those without cancer to see how well the tests distinguish between the two. The tests look for specific changes in the b…

This study compares an AI algorithm to radiologists in reading prostate MRI scans to detect clinically significant prostate cancer. About 500 men with suspected prostate cancer will have their MRI read by both AI and a radiologist, and results will be compared. If the AI performs…

This study will test a new urine test called My Prostate Score 2 (MPS2) combined with MRI to detect aggressive prostate cancer in men aged 50-75 with elevated PSA levels. The goal is to find only the cancers that need treatment and avoid unnecessary biopsies. The trial plans to e…

This study tests a workshop led by peers and a Black GP to encourage Black men aged 45 and over to talk to their doctor about prostate cancer risk and get a PSA test. About 300 men from three UK regions will take part. Half attend the workshop right away, the other half wait six …

This study will test whether analyzing stool and urine samples using a technique called metagenomics can find infections in people with weakened immune systems (due to HIV, chemotherapy, or immunosuppressive drugs). Currently, doctors often need to take invasive samples like bloo…

The PRIORITY study is testing a new approach to diagnose cervical cancer earlier by combining self-sampling at home with digital colposcopy and telemedicine. Researchers will enroll 700 women aged 30 to 65 to see if this method is more accurate and faster than current care. The g…

This study aims to develop a non-invasive diagnostic test for endometriosis, a painful condition affecting 1 in 10 women. Researchers will combine AI-enhanced ultrasound with blood, saliva, and tissue markers to detect the disease without surgery. 365 women aged 18-45 with suspec…

This study tests a non-invasive light-based device (SR-NIRS) to measure blood flow and oxygen in the testicles of children. It includes 74 boys aged 1 month to 18 years, both healthy and those with sudden scrotal pain. The goal is to see if this device can help tell if testicular…

This study tests a new PET scanner built specifically to image the prostate. Researchers want to see if it can detect prostate cancer more clearly than standard whole-body PET scans. About 25 men with known or suspected prostate cancer will receive both scans, and the images will…

This study tests whether a mobile app using artificial intelligence can help frontline health workers in sub-Saharan Africa better diagnose skin-related neglected tropical diseases, like leprosy and scabies. Researchers will collect images from dermatologists to train the AI, the…

This study explores whether analyzing tumor DNA in urine can be a simple, non-invasive way to monitor prostate and bladder cancer. Researchers will collect urine samples from 25 patients at different treatment stages to see if the test can detect cancer mutations and track change…

Researchers at the University of Washington are studying whether an online community of practice helps pharmacists learn to prescribe PrEP, a daily pill that prevents HIV. The study enrolls about 500 pharmacists and pharmacy staff across the United States whose pharmacies do not …

Researchers at Emory University are running a rapid randomized controlled trial to see if small changes to digital messages and website design can help more people start and stay on HIV prevention medication (PrEP) through telehealth. The study includes adults in the United State…

This study will test if using two heat probes instead of one can better prevent cervical cancer in 300 women with HIV in Zimbabwe. The standard single-probe treatment often fails in these women. The goal is to see if the two-probe method is safe, acceptable, and more effective at…

Researchers are testing a new injectable drug called VH5356136 to see if it is safe and how the body processes it. The trial enrolls about 160 healthy adults without HIV, ages 18 to 55. Participants receive a single dose of the drug or a placebo, and researchers monitor side effe…

This trial tests whether an animated health coach on a smartphone can help people who have abnormal cervical cancer screening results get the follow-up care they need. Many people skip these appointments, which can lead to preventable cancer. The study will enroll 750 adults aged…

Researchers are testing an experimental injectable drug called VH4367310 in healthy adults aged 18 to 55. The drug is a long-acting form of cabotegravir, a medicine already used to prevent HIV. This phase 1 trial gives a single increasing dose to measure how the body processes th…

This study looks at how to keep HIV self-test kits available for adolescent girls and young women in sub-Saharan Africa. Researchers will test two subsidy levels (high and low) for shopkeepers, with decreasing support over time. The goal is to find a sustainable way for private d…

This study tests whether using two probes during a heat-based treatment (thermal ablation) works better than the usual one-probe method to prevent cervical cancer in women living with HIV. About 200 women aged 25-49 with HIV and cervical precancer will be enrolled. The goal is to…

This study will test whether using two heat probes instead of one to treat cervical precancer works better for women living with HIV. Researchers in Rwanda will enroll 300 women to see if the two-probe approach is safe, acceptable, and more effective at clearing HPV. The goal is …

This study aims to see if watching video logs and receiving personalized messages can make Black women more willing to use PrEP, a daily pill that prevents HIV. It also looks at whether healthcare providers become more willing to prescribe PrEP. About 78 participants in Texas wil…

This study tests whether using two heat probes instead of one can better prevent cervical cancer in women living with HIV, who face a much higher risk. Researchers will enroll 300 women in Kenya to see if the two-probe method is safe, acceptable, and more effective at clearing HP…

This study looks at how to make HIV prevention pills (PrEP) easier for young people to get and keep using. Researchers will follow 1000 current or eligible PrEP users in Alabama and Botswana for 2 years. They will also create and test a decision-support toolkit to help patients a…

This trial tests whether a peer-led program that lets women choose and switch HIV prevention methods can increase consistent use compared to standard care. The program includes peer mentor support, HIV testing, access to PEP, and STI care. It enrolls HIV-negative women at elevate…

This pilot trial tests a two-hour educational workshop called SCREEN, designed to raise awareness of prostate cancer, its symptoms, and the benefits of early screening. The study enrolls men aged 18 to 79 who are not up to date with their prostate cancer screening. Researchers wi…

This study tests a 6-session telehealth program called EMPOWER for African American women in the South. The program helps women make informed choices about HIV prevention, including PrEP. Researchers will enroll 80 women to see if the program is feasible and acceptable.

Researchers are testing a 10-session bilingual therapy program called PrEPared Minds/Mentes PrEParadas. The program uses cognitive behavioral therapy to reduce anxiety and depression in men who have sex with men. The goal is to see if improving mental health helps these men learn…

This trial tests whether a self-administered vaginal swab, analyzed with advanced molecular technology, can detect and treat bacterial imbalances early in pregnancy. Pregnant women at high risk of preterm birth will either receive this screening plus targeted antibiotics or stand…

This study tests whether a nurse-led program can help incarcerated individuals start and stay on HIV pre-exposure prophylaxis (PrEP) after they return to the community. Participants receive behavioral sessions during incarceration to boost motivation, and some get extra navigatio…

This trial asks whether taking 50 mL of extra virgin olive oil every day can reduce the chance of heart attacks, strokes, and related deaths in people living with HIV. About 1,300 adults aged 50–75 with well-controlled HIV and at least one heart risk factor will be randomly assig…

This study compares monitoring by nurses versus physicians for people taking HIV pre-exposure prophylaxis (PrEP). It looks at how well patients follow their PrEP schedule, their satisfaction with care, and the cost of each approach. The goal is to see if nurse-led care can be a s…

This study is developing a prediction model to identify pregnancies at increased risk of stillbirth or fetal growth restriction, often caused by placental problems. Researchers will follow 7,000 pregnant individuals, collecting data from early pregnancy through delivery and postp…

This pilot trial tests a mobile app called Bandi, designed to support HIV prevention among young men who have sex with men in South Korea. Participants are randomly assigned to either the full app, which includes interactive health content, peer forums, a sexual health log, and a…

This pilot study tests whether training popular opinion leaders in rural South Africa can increase uptake of HIV prevention tools. Researchers will select and train young adults to share sexual health information and distribute HIV self-tests to their peers. The study will assess…

This study explores whether offering HIV prevention medication (PrEP) through pharmacies can help more young women aged 18-24 in Tanzania access and consistently use it. Researchers compare four different pharmacy-based service models to standard care, and later test cost-sharing…

This study tests a mobile health program called PrEP Choice to help young people ages 13-24 start and stick with HIV prevention pills or shots. It also looks at whether taking the antibiotic doxycycline after sex (DoxyPEP) can prevent other sexually transmitted infections. About …

This study tests a mobile health app called mSYNC designed to help prevent HIV in people who use drugs and visit the emergency department. The app provides counseling and support for risk behaviors, mental health, and access to care. Researchers want to see if the app is acceptab…

This study tests a 5-month text-messaging program called #TranscendentHealth, created specifically for transgender boys and gender-diverse youth assigned female at birth, ages 14 to 18. The program aims to improve condom use, birth control use, and HIV/STI testing by addressing t…

This study adapts a program called CARES to help 2,100 adolescent girls and young women (ages 16-24) in South Africa and Zimbabwe consistently use HIV prevention methods like pills, rings, or injections. The program includes counseling, text reminders, and peer support. Researche…

This study tests a mobile app called LOTUS designed to help people who use drugs engage with HIV prevention services like testing and PrEP. The app provides tips, reminders, peer support, and a way to ask healthcare professionals questions. The trial will enroll 40 participants t…

This study aims to help outpatient clinics provide HIV prevention medication (PrEP) and sterile injection equipment to people who inject drugs. Researchers will work with clinics to develop and test a bundle of strategies, including patient education, provider training, and syste…

This pilot study will test a program called INSPIRE, designed to reduce stigma and increase HIV testing among Chinese immigrant women who work in massage parlors in Queens, NYC. The program involves four one-on-one conversations with a peer advocate over six weeks, plus weekly te…

This study tests Project LYNX, a program that helps young adults (ages 18-29) who have recently been involved with the criminal legal system find and connect to substance use treatment and HIV-prevention services. The program pairs each participant with a trained peer navigator a…

This study aims to help 400 male commercial minibus drivers in Nigeria use HIV self-testing and long-acting injectable medications for both HIV treatment and prevention. Drivers will be trained as peer educators to promote these tools among their community. The goal is to make it…

This study tests whether a 12-week program of diet changes, supplements, exercise, and better sleep can improve fertility scores in women aged 20-40 who show early signs of fertility decline. Researchers will enroll 384 women across six medical centers in China, using the OvaRePr…

This study tests whether trained young mentor mothers (YMMs) can help pregnant and breastfeeding teenage girls and young women (ages 15-24) in Zimbabwe use HIV prevention tools like PrEP and contraception. About 600 participants will be assigned to either receive support from YMM…

This study tests a digital teleconsultation program called E-PrevenT to help transgender sex workers and their clients access HIV and STI prevention services. The program aims to reach people who are often left out of traditional prevention efforts. Researchers will enroll 250 pa…

Endometriosis causes chronic pelvic pain and painful periods, and current treatments do not work for everyone. Researchers are testing whether desloratadine, an antihistamine usually taken for allergies, can reduce pain and improve quality of life. The trial enrolls 60 women aged…

Endometriosis is a long-term condition where tissue like the uterine lining grows outside the uterus, often causing lasting pelvic pain. Surgery can help, but pain sometimes remains afterward. Researchers are testing whether a structured pelvic floor physiotherapy program done be…

This trial tests whether an artificial intelligence chatbot can help men with prostate cancer better understand radiation therapy. Participants will use a plain-language chatbot alongside standard education from their care team. Researchers will measure changes in patients' confi…

Researchers are testing whether time-restricted eating, where all food is eaten within a 10-hour window each day, can reduce fatigue and slow frailty in older adults living with prostate cancer or metastatic breast cancer. The trial enrolls 132 people aged 55 and older who typica…

This study tests whether an 8-week home exercise program can reduce pain and improve walking and brain function in young women with painful periods. Eighty-six single women aged 18-25 with moderate to severe period pain will do 30-minute sessions three times a week, including rel…

This study looks at whether bringing in palliative care early during an unplanned hospital stay can reduce aggressive treatments at the end of life for people with advanced cancer. About 493 adults with metastatic digestive, gynecological, ENT, or sarcoma cancers will be randomly…

This trial asks whether removing a normal-looking appendix during endometriosis surgery reduces pelvic pain and the return of endometriosis lesions. Participants are adults aged 18 to 50 with endometriosis and significant pain who are scheduled for surgical excision. They are ran…

Researchers are testing a culturally adapted physiotherapy program for Somali women in Norway who have chronic pelvic pain. The program combines guided exercise, home exercise three times a week, pelvic floor muscle training, and pain education. Thirty women aged 18 to 45 will ta…

This study tests whether suzetrigine, a new painkiller that works on nerves without affecting the brain, can control pain after pelvic surgery as well as standard opioids. 120 women will receive either suzetrigine or opioids, along with common pain relievers. The goal is to see i…

Researchers are testing whether laser acupuncture tailored to each woman's meridian readings eases period pain better than the same fixed acupoints for everyone. The pilot study enrolls 40 women aged 18 to 30, including 20 with primary dysmenorrhea and 20 without significant symp…

This trial investigates whether low-intensity extracorporeal shockwave therapy can help men recover erectile function after nerve-sparing prostate cancer surgery. It enrolls 80 men who are scheduled for this surgery and have good erectile function beforehand. Participants are ran…

Researchers are testing whether a psilocybin-based drug called MLS101 is safe and tolerable for premenopausal women with premenstrual dysphoric disorder (PMDD), a condition that causes intense mood and physical symptoms before menstruation. The trial enrolls 32 women aged 18 to 5…

Researchers are testing whether virtual reality goggles can reduce pain, anxiety, and stress during hysterosalpingo-foam sonography (HyFoSy), an ultrasound exam that checks the uterus and whether the fallopian tubes are open. The study enrolls 68 women aged 18 and older who are h…

Researchers are testing whether finerenone, a medicine used for kidney and heart protection, can help women with premature ovarian insufficiency grow ovarian follicles and produce eggs for IVF. About 46 women under 40 with POI will take finerenone or a placebo twice weekly for 24…

This study tests a web-based mind-body awareness program for women undergoing infertility treatment. The program includes education and relaxation practices over 3 sessions in 2 weeks. Researchers will measure if it improves fertility awareness and feelings of preparedness in 78 …

Researchers are testing whether manual lymphatic drainage, a gentle massage that supports lymph flow, can ease premenstrual symptoms and change autonomic nervous system activity in women with PMS. Sixty women aged 18 to 40 will be assigned to one of three groups: drainage perform…

This trial tests whether an AI-powered support tool, accessed through a WeChat Mini Program, can reduce anxiety in men recently diagnosed with metastatic prostate cancer. Participants are randomly assigned to use the platform with the AI agent or without it for the first two week…

Researchers are testing whether regular foot reflexology can reduce premenstrual syndrome (PMS) symptoms and improve quality of life in female university students aged 18 to 25. Half the participants will receive 30-minute foot reflexology sessions four times a month for three mo…

This study tests whether adding telehealth sex therapy to standard pelvic floor physical therapy helps men recover urinary and sexual function after prostate cancer treatment. All participants receive pelvic floor therapy and education on using a vacuum erection device. Half are …

This phase II trial tests whether rimegepant, a drug used for migraines, can reduce pelvic pain in women with endometriosis. The study enrolls 132 women aged 18 to 45 with surgically confirmed endometriosis and moderate-to-severe pain. Participants take either rimegepant or a pla…

This study tests whether a smartphone app that plays personalized music can help people with HIV manage chronic pain. Sixty participants will either use the music app daily for 3 months or receive educational materials about pain. The main goal is to see if the app is practical a…

This study tests whether adding estrogen to standard prostate cancer treatment can improve quality of life for 60 men with metastatic hormone-sensitive prostate cancer. Standard therapy often causes hot flashes and other side effects by lowering estrogen. The study compares estro…

This trial tests two pain-relief options for hysterosalpingography (HSG), an X-ray test that checks the fallopian tubes and can be painful. Researchers will compare a rectal indomethacin suppository, a lidocaine injection around the cervix, and no pain medication in 180 women age…

This trial tests whether adding a structured yoga therapy program to standard surgery for endometriosis can reduce chronic pain and improve quality of life. About 188 women scheduled for endometriosis surgery will either receive standard care alone or standard care plus 32 guided…

This trial tests whether a single virtual reality exposure session, added to standard care, can help women with vaginismus—a condition causing involuntary pelvic muscle tightening due to fear of vaginal penetration. Participants will experience a virtual environment designed to g…

This study tests a mobile health app called OPUCARE designed to support women with infertility who are about to undergo egg retrieval. The app provides medication reminders, treatment information, side-effect tips, and motivational messages. Researchers want to see if using the a…

This trial tests an 8-week eHealth program called eMindExCare that combines mindfulness practices with home-based aerobic and resistance exercises for prostate cancer patients undergoing active treatment. The study aims to see if the program is feasible and acceptable, and whethe…

This trial tests whether a wearable device that delivers a cooling sensation on the wrist can reduce the burden of hot flashes in men with prostate cancer who are on androgen deprivation therapy (ADT). About 66 participants will be randomly assigned to use the device right away o…

This pilot study tests whether a Patient Empowerment Project (PEP) can improve the experience of people seeking fertility treatment. Patients complete a brief questionnaire about their sensitivities and preferences before their first visit, and clinic staff use the responses to t…

This study tests a laser surgery for men with small prostates that still cause bothersome urinary symptoms. It compares three surgical methods to see which best prevents bladder neck scarring and improves urine flow. 426 men aged 40 to 80 will take part. The goal is to find the s…

This trial investigates whether acupuncture can help women who have trouble urinating after a radical hysterectomy for cervical cancer. Participants receive either real acupuncture or a sham version (using non-penetrating needles) alongside standard care with a catheter and medic…

This trial tests F-GYN, a single-use injectable gel made of non-crosslinked hyaluronic acid, for women with moderate to severe vaginal dryness and atrophy. Participants either receive the injection right away or continue standard non-hormonal care for 4 weeks before getting the i…

This trial investigates whether a supervised program of aerobic and strength training can improve quality of life, heart function, and body composition in men with prostate cancer who are receiving androgen deprivation therapy (hormone therapy). The study involves 46 men aged 40 …

This study will compare two treatments for moderate to severe urinary symptoms caused by an enlarged prostate. One group takes a standard drug (alfalitic) plus a natural supplement (Serenoa repens, or saw palmetto), while the other takes the same drug plus another standard medica…

This study tests whether Pilates or gym exercises better relieve pain from primary dysmenorrhea (period pain) in young women aged 17-25. Fifty-two participants will do either Pilates or gym workouts three times a week for three months. Researchers will measure pain intensity, sym…

This study tests a procedure called irreversible electroporation (IRE) to treat urinary symptoms caused by an enlarged prostate. About 40 men aged 50 and older with moderate to severe symptoms will receive the treatment. The goal is to see if IRE safely improves urine flow and re…

This study tests whether a 12-week exercise program, delivered via Zoom, is practical and helpful for older adults (65+) with cancer who live in rural areas. Participants will do two supervised exercise sessions per week. The goal is to see if the program improves quality of life…

This study tests whether a single hypnosis session during chemotherapy can reduce anxiety and other side effects like nausea in young people with cancer. It includes 70 participants aged 15-49 with sarcoma, germ cell tumors, or breast cancer. Researchers will compare anxiety leve…

This pilot trial will test whether a prehabilitation program (exercise, protein drinks, breathing exercises, and coaching) is feasible for women awaiting ovarian cancer surgery. It compares in-person delivery, remote delivery via a web app, and standard education-only care. The s…

This study tests a psychological program for teens aged 15-19 with painful periods. The program uses cognitive restructuring and psychoeducation to help them change negative thoughts and improve emotional control. Researchers will measure pain and coping skills before and after t…

This study looks at whether a natural supplement called D-Chiro-inositol can help men aged 50 to 75 who have low testosterone (functional hypogonadism) and related sexual issues. Over 3 months, 35 men will take the supplement to see if their hormone levels and sexual function imp…

This study compares two types of IV catheters in 104 newborns with congenital syphilis who need 10 days of antibiotics. One group gets a standard short catheter, the other a longer catheter placed using ultrasound by a specialized nurse. The goal is to see which lasts longer and …

This study tests whether a special care plan called Enhanced Recovery After Surgery (ERAS) helps women recover faster after a hysterectomy. About 78 women will be randomly assigned to either ERAS or standard care. The goal is to see if ERAS shortens hospital stays and reduces pai…

This study tests a brief sleep-focused workshop for people with PMDD who have trouble sleeping. The workshop teaches about sleep and simple strategies to improve it. Researchers want to see if it's practical and helpful, using sleep diaries and activity watches. 72 participants w…

This study tests whether acupuncture, with or without daily self-acupressure, can reduce hot flashes in women with BRCA gene mutations who had their ovaries removed. About 200 participants will receive 8 weekly acupuncture sessions, then half will also practice acupressure at hom…

This study tests whether guided imagery exercises can reduce fear and improve comfort in men undergoing a common prostate surgery (TURP). Seventy participants will be randomly assigned to either listen to guided imagery sessions before and after surgery or receive standard care a…

This study develops and tests a support program for cancer survivors who worry about their cancer returning. 150 adults who finished treatment for breast, head and neck, colon-rectal, or prostate cancer will join. Depending on their level of fear, they will receive education, psy…

This study tests whether a dietary supplement called CL25216 can help women with painful periods (primary dysmenorrhea). Eighty healthy women aged 25-40 will take either CL25216 or a placebo daily for 84 days. Researchers will measure changes in menstrual pain, pain duration, and…

This study compares two types of prehabilitation (exercise, nutrition, and psychological support) for 225 women with advanced ovarian cancer. One group starts prehab early during chemotherapy, while the other starts just before surgery. The goal is to see if early prehab reduces …

This early-stage trial tests whether a single vaginal dose of sildenafil (100 mg) can reduce painful uterine contractions during menstruation. About 50 adults with moderate-to-severe period pain will receive the drug or a placebo in two separate cycles. The study uses MRI to meas…

This study tests a device called TUNES, which delivers gentle electrical stimulation through a menstrual disc to nerves near the uterus. The goal is to see if it can reduce pain and the need for pain medication in 60 women after uterine fibroid embolization. Participants will be …

This study tests whether a supervised exercise program can help women who have had breast or gynecological cancer and now suffer from muscle loss (sarcopenia). The 78 participants will do resistance, aerobic, balance, and stretching exercises. Researchers will measure changes in …

This study tests whether an 8-week online mindfulness program can improve hope, emotional coping, quality of life, and psychological well-being in women with gynecological cancer. About 96 women currently receiving treatment will be randomly assigned to either the mindfulness pro…

This study looks at how HIV and substance use disorder (SUD) affect the sense of smell and decision-making. Researchers will test 120 adults aged 18–65, including people with HIV, SUD, both, or neither. Participants will complete smell tests and computer tasks over two visits, an…

This study is testing a new questionnaire (called the QLQ-OV39) to see how well it measures quality of life in people with ovarian cancer. About 50 adults with early or advanced ovarian cancer will fill out the questionnaire and give feedback. The goal is to make sure the questio…

Researchers want to understand why most IVF embryo transfers fail to implant and what goes wrong in pregnancies complicated by preeclampsia. They will collect small tissue samples from the womb lining of up to 500 women aged 18 to 50 who are already scheduled for a diagnostic hys…

This study tests better ways to screen and treat cervical cancer in women living with HIV in Kenya, who face a much higher risk. Researchers will use HPV self-testing, care navigators, and a mobile app to help more women get diagnosed and treated. The goal is to find strategies t…

This study tests whether a video app that explains 'Undetectable = Untransmittable' (U=U) can help people with HIV stay on treatment and keep the virus under control. About 880 people from clinics in South Africa will use the app during counseling. The goal is to see if better un…

This study will investigate whether exposure to persistent organic pollutants (POPs) like dioxins and PCBs is linked to more severe endometriosis. Researchers will analyze blood samples from 650 women with endometriosis living in the Ile-de-France region of France. The goal is to…

This study explores whether artificial intelligence can help perform high-field whole-body MRI scans faster while keeping image quality high. Researchers will compare standard MRI sequences with AI-accelerated versions in 600 adults undergoing screening for prostate, lung, or vas…

This study will compare two types of robot-assisted surgery for prostate or kidney cancer: single-port (one small incision) and multi-port (several incisions). Researchers will track 376 adults to see which approach leads to a shorter hospital stay and better recovery. The study …

Researchers at Anhui Medical University are studying bacteria found inside prostate tumors and how they relate to the immune system. The study uses leftover tissue samples and archived slides from about 100 men with prostate cancer or benign prostate disease. Scientists will sequ…

Researchers at Anhui Medical University are studying how prostate cancer invades nerves, a feature linked to aggressive tumors and recurrence after surgery. They plan to collect tissue and clinical data from about 120 prostate cancer patients and compare nerve-invaded areas, ordi…

Researchers are studying whether the mix of bacteria in a person's gut can predict how well they respond to immunotherapy drugs called immune checkpoint inhibitors. The trial enrolls about 360 adults with advanced non-small cell lung cancer, melanoma, endometrial cancer, or cervi…

This study looks at whether taking bicalutamide for two weeks can make PSMA PET/CT scans better at finding small amounts of prostate cancer that standard scans might miss. It involves 20 men with recurrent prostate cancer and very low PSA levels. Participants are randomly assigne…

This study looks at whether an educational video can help people with certain cancers make informed choices about genetic testing. Participants will take a survey, watch a short video, and then take another survey to see if their knowledge and attitudes changed. The goal is to se…

This study looks at blood health in children with numerical chromosomal disorders, such as Down syndrome, Turner syndrome, Klinefelter syndrome, Edwards syndrome, and Patau syndrome. Researchers will measure blood counts and check for issues like anemia, low platelets, or abnorma…

Researchers are studying how the HIV combination pill Descovy, which contains tenofovir alafenamide and emtricitabine, moves through the bodies of people with HIV who also have advanced chronic kidney disease. About 50 adults with stage 3b or stage 4 kidney disease will take part…

This study aims to develop and pilot a program for people with HIV in South Africa who also face depression, trauma, and food insecurity. Researchers will first explore how these problems interact, then create a treatment called CBT-SA that combines therapy, nutrition support, an…

This study tests whether a standardized ultrasound approach can reliably classify how ovarian cancer involves the liver area before surgery. Researchers will compare ultrasound images with what surgeons actually find during operations, using tissue samples as an extra check when …

This registry study collects real-world data from about 300 adults treated with urinary bladder matrix (UBM) products for various wounds, including pressure ulcers, surgical incisions, and infections like Fournier's gangrene. Researchers track patient characteristics, treatment p…

This study tests whether a multi-day training program can reduce stigma that doctors in Vietnam show toward people with HIV and men who have sex with men. Researchers will send trained actors ("standardized patients") to clinics to pose as real patients and measure how doctors tr…

This study looks at men with an enlarged prostate who previously used the ProVee urethral expander device. Researchers want to see if these men needed any additional surgical treatments after the device was removed. The goal is to understand how well the device works over the lon…

This study tests whether teaching people practical ways to avoid everyday chemicals, like those in food packaging and cookware, can lower toxin levels in the body. Researchers will measure bisphenols and PFAS in blood, urine, and reproductive fluids of 60 IVF patients who receive…

This study will test whether a special MRI scan (CSE-MRI) can accurately measure active bone marrow in men with metastatic prostate cancer, compared to a standard PET scan using a radioactive tracer (FLT). Fifteen participants will receive both scans at the same time using a comb…

This study asks whether women with lipodystrophy syndromes or Turner syndrome experience lower sexual quality of life than women in the general population. Researchers will compare survey responses from affected women with those from a large French cohort. The goal is to understa…

This study looks at how to make cervical cancer screening easier for women with HIV, who are at higher risk for this cancer. Researchers will talk to patients and doctors to find out what gets in the way of screening and follow-up care. They will also explore using HPV self-testi…

This study investigates whether detailed molecular mapping of prostate tumors can predict how well men with metastatic hormone-sensitive prostate cancer respond to androgen deprivation therapy (ADT) combined with second-generation hormonal agents like abiraterone or enzalutamide.…

This study looks at a new way to classify ovarian cysts found in unborn babies using detailed ultrasound features. Researchers will follow 100 pregnant women whose fetuses have an ovarian cyst, tracking the cyst's size and appearance over time. The goal is to see if this classifi…

This trial tests whether people living with HIV can collect their own anal swabs for anal cancer screening, compared with swabs taken by a clinician. About 700 participants in Australia will provide both types of swabs, which will be checked for high-risk HPV and precancerous cel…

This study explores whether providing home self-sampling kits for six sexually transmitted infections (STIs) can help sex workers get tested more easily. Participants receive a kit to collect samples at home and return them by mail, along with a questionnaire about their backgrou…

This study examines tumor samples from 320 Latin American women with advanced ovarian, fallopian tube, or peritoneal cancer to describe the presence of certain markers (FRα, HER2, PD-L1, HRD, and BRCA). Researchers will collect medical history and test archived tumor tissue to se…

This study is a large registry that will collect detailed information from thousands of women undergoing surgery for non-cancerous gynecologic conditions like fibroids, endometriosis, and ovarian cysts. The goal is to track surgical techniques, complications, and recovery in real…

This study tests a mobile health program called SAMU to help adults in Uganda who have HIV, high blood pressure, and mental health issues like depression or anxiety. About 1,500 participants will use their phones for mental health screening and get connected to care. The goal is …

This study looks at blood samples from children with HIV who started treatment very early in life, comparing them to children without HIV. Even with early treatment, these children often have lower cognitive test scores. The goal is to see if certain metabolic patterns in the blo…

This study explores whether inflammation in the body is linked to the mood and psychological symptoms of Premenstrual Dysphoric Disorder (PMDD). Researchers will compare women with PMDD to healthy controls, tracking daily emotions and behaviors over two menstrual cycles and takin…

This study will give a single dose of oral methamphetamine to 20 people with HIV who are on effective antiretroviral therapy and have undetectable virus levels. The goal is to see if the drug can temporarily wake up dormant HIV hiding in cells, which could help researchers find n…

This study looks at the long-term urinary, sexual, and bowel health of people aged 7 to 25 who had surgery for Hirschsprung disease as young children. Hirschsprung disease is a rare birth defect where part of the large intestine lacks nerve cells, causing blockages. Surgery remov…

This pilot trial tests whether a risk calculator designed for Nigerian men can help primary care providers better identify those with clinically significant prostate cancer. Researchers will train healthcare workers at community hospitals and then support them in using the tool f…

This trial explores whether a whole-body bone scan (SPECT/CT) taken in the treatment position can help doctors plan stereotactic radiotherapy more precisely for prostate cancer that has spread to the bones. Thirty patients will receive the scan in addition to standard imaging, an…

This study looks at whether artificial intelligence and detailed molecular analysis can help predict how high-grade serous ovarian cancer will behave after surgery. Researchers will analyze tumor images, genetic data, and patient records from 1,300 women to build a model that for…

This study investigates whether erectile dysfunction (ED) in men being treated for high blood pressure is linked to a hidden heart condition called subendocardial ischemia, where the heart muscle doesn't get enough oxygen. Researchers will compare a noninvasive heart test called …

This study explores whether at-home saliva samples can reliably measure key steroid hormones in people with congenital adrenal hyperplasia (CAH), a condition requiring lifelong hormone therapy. Currently, monitoring involves morning blood tests that miss daily hormone fluctuation…

This study looks at how a long-acting injectable HIV prevention drug (CAB-LA) and hormonal birth control methods (like the shot or implant) affect each other in women. About 105 women who already use CAB-LA or no HIV prevention will join groups based on their contraceptive choice…

This study follows women aged 70 and older with ovarian cancer to understand why some experience cognitive decline or delirium during treatment. Researchers will track memory, thinking skills, frailty, and quality of life over 12 months, and analyze blood samples for markers of b…

This study looks at how a short, home-based high-intensity workout affects steroid hormones in men with low-grade prostate cancer who are on active surveillance. About 49 men will do one supervised bodyweight HIIT session and provide saliva samples. The goal is to see if the exer…

This study follows babies and young children (up to age 5) who have a genetic diagnosis of ataxia telangiectasia (A-T), a rare disease that affects movement and immunity. Researchers use brain and lung scans, blood tests, and movement analysis to spot early signs of disease progr…

This study tests whether a behavioral education program can help men with low sperm quality reduce their exposure to endocrine disrupting chemicals (EDCs) found in everyday products. Participants complete 14 online modules over 8 weeks, and researchers measure changes in environm…

This study looks at whether primary dysmenorrhea (painful periods) is linked to changes in the biomechanics of the lower back and pelvis. Researchers will compare female university students aged 18-24 who have moderate to severe menstrual pain with those who have little or no pai…

This study follows men aged 45 and older who are scheduled for surgery that removes only the middle part of an enlarged prostate (the median lobe). The goal is to see which factors before surgery—like symptoms, urine flow, and prostate shape—are linked to success one year later. …

This study brings together data from multiple previous trials to investigate a rare group of people with HIV who can keep the virus under control even after stopping antiretroviral therapy. Researchers will analyze stored blood samples and clinical records to look for biological …

This study looks at how a person's migration history and social situation affect how well HIV treatment works. Researchers will compare the health outcomes of 150 migrants living with HIV in France, based on their social and administrative status. The goal is to understand whethe…

This study explores whether ovulation can be detected using non-invasive methods like saliva, hair samples, and smartwatch data instead of standard blood tests. Researchers will monitor 30 women with regular menstrual cycles over three cycles, collecting saliva and hair for proge…

This study will include about 2,748 people with breast, gynecologic, or pancreatic cancer. Researchers want to see if adding patient-reported outcomes—like symptoms, preferences, and travel distance—to tumor board discussions helps doctors make better treatment decisions. The goa…

This study looks at 200 people with pneumonia to find out how many actually have an infection caused by Chlamydia pneumoniae, a type of bacteria. Researchers will use PCR tests to check for the germ and compare results with standard care. The goal is to see if this infection is o…

This study observes how well a combination of two drugs, olaparib and abiraterone, works as a first treatment for men with metastatic castration-resistant prostate cancer who have already tried other hormone therapies. Researchers will track how long patients stay on the treatmen…

This study looks at sleep health in people with HIV who are on different antiretroviral therapies. Some participants switch from a dolutegravir-based regimen to a doravirine-based one, while others stay on dolutegravir. Sleep is measured using questionnaires, wrist-worn activity …

This study will follow 5,500 first-time pregnant women to see if blood tests and eye scans can predict complications like preeclampsia, fetal growth restriction, and gestational diabetes. Researchers will collect samples and images at different points during pregnancy and compare…

This pilot study looks at how migration experiences and social bonds influence HIV prevention decisions among first-generation African immigrants aged 18-50 in New York and Massachusetts. Researchers will work with the community to develop a relationship-tailored behavioral inter…

This study looks at how feeling anxious or scared before prostate surgery affects recovery and satisfaction in men with an enlarged prostate. Researchers will follow 80 men who are having either laser or standard surgery. They will use questionnaires to measure anxiety, depressio…

This study investigates whether a simple coronary CT scan can detect early signs of heart disease in people with HIV. Researchers will measure calcium buildup in the heart arteries of 384 Mexican adults with HIV who have undetectable viral loads. The goal is to better understand …

This study looks at women with diminished ovarian reserve (DOR) — a condition where the ovaries have fewer eggs, making IVF harder. Researchers are examining specific RNA molecules in the fluid around eggs to see how they relate to egg quality and embryo development. The goal is …

This study looks at how to safely place a breathing tube in people with acromegaly, a condition that can cause changes in the face and airway. It compares two methods: direct laryngoscopy and video laryngoscopy. The goal is to find which method gives a better view of the airway a…

This study looks at how HIV-1 hides in immune cells in the gut of people on effective antiretroviral therapy. Researchers will collect blood and colon tissue from 30 HIV-positive volunteers and healthy controls during routine colonoscopies. The goal is to understand why these gut…

This study compares immune cells, specifically natural killer cells, in women with deep endometriosis and those without the condition. Researchers will collect blood, tissue, and vaginal samples from 50 participants to look for differences that might explain the disease. The goal…

This study tests whether injecting a radioactive tracer directly into the prostate artery improves imaging compared to standard arm injection in 10 men with high-risk prostate cancer. The goal is to see if this method gives clearer pictures and helps predict the right radiation d…

This study tests whether a safe dose of ivermectin, a common deworming drug, can make human feces deadly to flies that spread trachoma. Trachoma is a leading cause of blindness, and these flies carry the bacteria from person to person. Twelve healthy adults will take ivermectin, …

This study will look at whether SPECT scans taken after Lu-PSMA therapy can help predict how well patients with metastatic castration-resistant prostate cancer (mCRPC) are doing. Researchers will measure tumor activity and volume on the scans and compare them to standard PET-base…

This study looks at how HIV might change the way the body handles fats in the liver, leading to fatty liver disease. Researchers will collect one blood sample from 120 adults: people with HIV and fatty liver, people without HIV but with fatty liver, and healthy controls. By analy…

This study will check if menstrual blood can give the same health information as regular blood tests, uterine biopsies, and vaginal swabs. One hundred menstruating women aged 18 and over will provide samples during their period. The goal is to see if menstrual blood is a useful, …

This study looks at how doctors in tumor board meetings work together when discussing ovarian and uterine cancer cases. About 400 physicians will fill out surveys after each meeting to measure things like communication, teamwork, and decision-making. The goal is to understand wha…

This pilot study investigates how well a dual-wavelength diode laser can destroy endometriotic tissue inside ovarian cysts (endometriomas). Researchers will apply the laser to cyst walls removed during surgery and examine the tissue under a microscope to see if all abnormal cells…

This study will follow about 484 couples undergoing a type of IVF called ICSI to see if sperm DNA damage affects their chances of having a baby. Researchers will measure DNA breaks in sperm before and after a washing step, then track pregnancy and live birth rates. The goal is to…

This large observational study will follow 4,000 young cancer survivors (ages 15-39) across Europe to understand how different cancer treatments impact fertility, hormone function, and pregnancy outcomes. Researchers will also evaluate the safety and success of fertility preserva…

This study will follow 100 people with advanced cervical cancer who are getting radiation and chemo. Researchers want to see if checking for HPV and other markers in the blood and cervix can better predict if the cancer will come back. The goal is to find recurrences earlier and …

This study will follow 3,000 young women (ages 15-39) with cancer to understand how treatments like chemotherapy and immunotherapy impact their fertility, pregnancy outcomes, and quality of life. Researchers will also look at the safety and success of fertility preservation metho…

This study looks at the best way to help prostate cancer survivors learn about and get genetic testing for inherited cancer risks. About 500 participants will be randomly assigned to a digital guide, a printed guide, or standard care. Researchers will track who requests testing a…

This study follows 1,000 young men (ages 15-39) diagnosed with cancer to understand how treatments affect their fertility and hormone levels over time. Researchers will collect medical history, semen samples, and blood tests before and after therapy to identify who is at risk for…

Denys-Drash syndrome is a rare genetic condition that causes kidney failure in early childhood, often requiring a transplant. Past research suggests these children have a much higher chance of developing a type of lymphoma after transplant compared to other kids. This study will …

This study looks at whether a testosterone lotion applied to men's skin can transfer to women through casual contact. Researchers will measure testosterone levels in the blood of female partners after skin-to-skin contact. The goal is to understand if the lotion is safe for use a…

This study checks on children who had a moderate to severe head injury years ago to see if they have any lasting hormone or growth problems. Researchers will call participants for a 15-minute interview to measure their height and ask about symptoms. The goal is to learn how commo…

This study will survey about 950 men who stored sperm at a French fertility center before cancer treatment between 2010 and 2024. Researchers want to know how many later became fathers, whether naturally or with medical help, and if they used their frozen sperm. The goal is to be…

This study compares two minimally invasive surgical methods for early-stage endometrial cancer: standard laparoscopy (small abdominal cuts) and vNOTES (surgery through the vagina with no visible scars). Researchers will enroll 160 women to see how well each method finds sentinel …

This study tests whether a new real-time imaging method can make radiation therapy more accurate for cancer patients. About 40 adults with various cancers will receive their normal radiation treatment while the new imaging tracks the tumor in real time. The goal is to see if the …

This study looks at how a person's body composition—like muscle and fat levels—affects the radiation dose delivered to tumors and healthy organs during a targeted therapy for advanced prostate cancer. About 100 men with a specific type of prostate cancer will receive the standard…

This study will compare how much pain men expect versus actually feel during two common prostate biopsy methods: transrectal and transperineal. About 200 men having their first prostate biopsy will rate their pain before and after the procedure. The goal is to help doctors choose…

This study will ask 50 people aged 35 and older with abnormal uterine bleeding to collect daily urine samples and track their bleeding at home for several months. Researchers will use a home monitor to measure hormone levels and see if certain patterns are linked to uterine cance…

This study looks at whether recommending bed rest to pregnant women with a short cervix actually helps prevent preterm birth. Researchers will compare women who are told to rest with those who continue normal daily activities. The goal is to see if avoiding bed rest is just as sa…

This study tests a plastic scintillation detector that can monitor radiation dose and source position in real time during brachytherapy for prostate and gynecologic cancers. The goal is to see if the device can be used without disrupting the treatment workflow. If it works, it co…

This study looks at how emotional regulation varies across the menstrual cycle in autistic women. Researchers will compare them to women with borderline personality disorder, premenstrual dysphoric disorder, and those without any diagnosed condition. The goal is to better underst…

This study tests two different calcium treatments (ionophores) to help eggs fertilize during IVF when previous attempts failed. Researchers will compare which treatment works better and check embryo health. The study involves 20 couples with a history of low fertilization.

This study tests a digital tool called TRANSCEND-XR that uses extended reality (like virtual reality) to help adolescents and young adults who have finished treatment for testicular cancer. The tool aims to teach them about long-term side effects, when to see a doctor, and how to…

This study aims to learn about genetic changes in metastatic prostate cancer and how they affect patient outcomes. Researchers will collect and analyze tissue and blood samples from 100 adults in Brazil who are receiving standard palliative therapy. The goal is to better understa…

This study looks at whether one session of magnetic brain stimulation can temporarily change how the heart and brain communicate in women who have had multiple pregnancy losses and are overweight. Sixty women will receive either real or fake stimulation while their heart activity…

This study will measure microplastics in semen, follicular fluid, and other samples from 1000 men and women seeking fertility treatment. Researchers will check if higher microplastic levels are linked to lower pregnancy rates and poorer egg or sperm quality. The goal is to better…

This study tests whether co-culturing immature human eggs with lab-grown ovarian support cells (made from stem cells) helps them mature in the lab. About 100 women undergoing IVF will donate leftover immature eggs, which will be split into two groups: one with standard lab matura…

This study looks at whether a blood test can predict how well certain cancer drugs (PARP inhibitors) work in people with advanced breast, prostate, ovarian, or pancreatic cancer. Researchers will collect blood and tumor samples from 300 adults to analyze cancer cells and their DN…

This study tests whether a special education program can increase breast and cervical cancer screening among visually impaired women. About 74 women over age 40 will receive training on cancer risks and how to schedule screenings. Researchers will check if screening rates and kno…

The BALANCE study is a research project that asks Black and mixed-ancestry men with prostate cancer about their quality of life after treatment. Researchers want to learn how different treatments affect physical health, mental health, and daily life in these communities. By colle…

This study will follow 75 women aged 18-42 with early-stage triple-negative breast cancer who are receiving chemotherapy plus immunotherapy before surgery. Researchers will measure hormone levels, track menstrual patterns, and use questionnaires to see how treatment affects ovari…

This study works with patients and healthcare professionals to create educational resources about fertility and pregnancy for people with Primary Ciliary Dyskinesia (PCD). The goal is to develop a patient-friendly guide and a toolkit for doctors. The study will involve 30 partici…

This study follows 42 women with HPV-positive pelvic cancer (cervix, vagina, vulva, or anus) to understand how radiotherapy, with or without surgery, affects their sexual quality of life. Participants complete questionnaires about sexual function and emotional distress over time.…

This study looks at how satisfied young people and those with low incomes are with free HIV and STI testing and counselling in Lucerne and Zurich. Around 1,800 participants will fill out a questionnaire after their visit. The goal is to see if these free services meet people's ne…

This study looks at two ways to measure endometriosis growths in the bowel before and during surgery. About 98 women will get both a standard vaginal ultrasound before surgery and a special ultrasound during their operation. The goal is to see if the during-surgery ultrasound giv…

This study looks at whether using ultrasound during surgery helps doctors better remove deep endometriosis from the bowel while keeping the bowel wall safe. About 57 women with bowel endometriosis will have their surgery guided by ultrasound. The goal is to see if this approach r…

This study looks at why migraine and endometriosis often happen together in women. Researchers will follow 150 women over several menstrual cycles, tracking symptoms and taking blood samples. The goal is to find differences in a molecule called CGRP and hormone patterns that may …

This study surveys 480 Italian dental students to understand their attitudes, knowledge, and any discriminatory behavior toward HIV-positive patients. Participants answer anonymous questions about their comfort, knowledge of HIV, and use of safety protocols. The goal is to identi…

This study uses an anonymous online survey to ask 200 women with gynecologic cancers whether they would be interested in receiving long chemotherapy infusions at night instead of during the day. The goal is to understand patient preferences and potential barriers. No treatment is…

This study aims to find out what factors help predict a successful outcome after a type of prostate surgery called HoLEP, which treats an enlarged prostate. Researchers will follow 604 men aged 40 and older who are scheduled for HoLEP. They will measure success based on symptom r…