New drug combo aims to slow advanced cervical cancer

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Patients eligible for definitive chemoradiotherapy, including brachytherapy * Patient age ≥ 18 years. * Patients with histologically confirmed newly diagnosed advanced cervical cancer (squamous, adenosquamous, adenocarcinoma or poorly differentiated); Federation of Gynecology and Obstetrics (FIGO) 2018 clinical stages III-IVA. * Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2 * Absolute neutrophil count ≥ 1,500/mcL. * Platelets ≥ 100,000/mcL. * Hemoglobin ≥ 8 g/dL (can be transfused prior to study). * Total bilirubin ≤ 1.5 x institutional upper limit of normal (ULN); patients with known Gilbert disease with serum bilirubin ≤ 3 x ULN may be enrolled. * Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase \[SGOT\]/alanine aminotransfersase (ALT) (serum glutamate pyruvate transaminase \[SGPT\] ≤ 2.5 x ULN. * Alkaline phosphatase ≤ 2.5 x ULN. * Serum creatinine ≤ 1.5 mg/dL to receive weekly cisplatin; patients whose serum creatinine is between 1.5 and 1.9 mg/dL are eligible for cisplatin if there is no hydronephrosis and the estimated creatinine clearance (CCr) is ≥ 30 ml/min. For the purpose of estimating the CCr, formulas, including Cockcroft and Gault for females or similar, should be used. * International normalize ratio (INR) and activated partial thromboplastin time (aPTT) ≤ 1.5 x ULN (this applies only to patients who do not receive therapeutic anticoagulation; patients receiving therapeutic anticoagulation, such as low-molecular weight heparin or warfarin, should be on a stable dose). * Patient does not have uncontrolled diabetes mellitus (i.e. fasting blood glucose \>200 mg/dL). * Patient does not have a known allergy to cisplatin or compounds of similar biologic composition as CB-839. * Patient is not actively breastfeeding (or has agreed to discontinue before the initiation of protocol therapy). * Ability to understand and the willingness to sign a written informed consent document. * Patients does not have known human immunodeficiency virus syndrome (HIV testing optional). Exclusion Criteria: * Patient has another concurrent active invasive malignancy. * Patient has received prior radiation therapy to the pelvis or previous therapy of any kind for this malignancy, or pelvic radiation for any prior malignancy. * Patient is receiving another investigational agent for the treatment of cancer. * Poorly controlled diabetes, with inability to perform 18F-FDG PET scan. * Patient is pregnant or breastfeeding. * Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements. * Mean resting QTc \> 470 msec obtained by electrocardiogram (ECG). * Severe, active co-morbidity defined as follows: * Current (within 28 days of cycle 1, day 1) signs and/or symptoms of bowel obstruction * Patients who require parental hydration and/or nutrition * Patients who require drainage gastrostomy tube * Evidence of bleeding diathesis or clinically significant coagulopathy * Serious, non-healing or dehiscing wound, active ulcer or untreated bone fracture * History of hemoptysis (\>= 1/2 teaspoon of bright red blood per episode) within 1 month of study enrollment * Significant cardiovascular or cerebrovascular disease including: Uncontrolled hypertension (systolic blood pressure \[SBP\] \>= 150; diastolic blood pressure \[DBP\] \>= 90)