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Lifestyle makeover may stave off early fertility decline, new trial hopes to prove

NCT ID NCT07581444

Prevention Sponsor: Peking University Third Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a 12-week program of diet changes, supplements, exercise, and better sleep can improve fertility scores in women aged 20-40 who show early signs of fertility decline. Researchers will enroll 384 women across six medical centers in China, using the OvaRePred-Plus model to track progress. The goal is to develop a practical, low-cost strategy to prevent fertility problems before they become severe.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Comprehensive lifestyle intervention (diet, supplements, exercise, sleep)
What this could lead to
If successful, this could provide a simple, scalable way to prevent or slow early fertility decline in women, potentially reducing the need for assisted reproduction.
What could go wrong
This is a relatively small, early-stage trial with a 12-week intervention, so long-term benefits are unknown. Lifestyle changes can be hard to maintain, and results may not apply to all women.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 384 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 40 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Women aged 20-40 years * Diagnosed with infertility or planning assisted reproductive treatment * Regular menstrual cycles (21-35 days) * Willing to participate in a 12-week lifestyle intervention program * Able to provide written informed consent Exclusion Criteria: * Known chromosomal abnormalities or genetic disorders affecting fertility * History of ovarian surgery or severe ovarian damage * Diagnosed endocrine disorders affecting reproduction (e.g., uncontrolled thyroid disease, hyperprolactinemia) * Severe systemic diseases (e.g., cardiovascular, hepatic, renal diseases) * Current pregnancy or breastfeeding * Use of hormonal medications or supplements affecting ovarian function within the past 3 months * Participation in another clinical trial within the past 3 months

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Conditions

The condition(s) this trial relates to.

female infertility infertility disorder ovarian dysfunction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diminished ovarian reserve Female fertility decline Infertility prevention Reproductive health

How to take part

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  1. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  2. A doctor treating you

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Other studies related to the condition(s) this trial covers.