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Iodine trick may help surgeons remove all precancerous cervical cells

NCT ID NCT05132114

Disease control Sponsor: Ruhr University of Bochum Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether applying Lugol's iodine during LLETZ surgery helps doctors remove all precancerous cervical tissue. Iodine stains healthy tissue brown, making abnormal areas easier to see. The trial involved 230 women with cervical dysplasia and compared standard surgery to surgery with iodine staining. The goal was to see if iodine reduces the rate of incomplete removal.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Lugol's iodine solution
What this could lead to
If successful, this technique could lower the chance that precancerous cells are left behind after surgery, reducing the need for repeat procedures.
What could go wrong
This is a completed early-stage study with 230 participants. The benefit may be small or not apply to all women, and iodine allergy is a rare but possible risk.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

230 people

The number who actually took part.

Started

Jan 2022

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Written consent * Colposcopy performed preoperatively * Histologically (by previously performed colposcopy) confirmed dysplasia (CIN 1, CIN 2 or CIN 3) * Age \>18 years Exclusion Criteria: * Pregnant patients * Patients with insufficient knowledge of the German language * Treatments already performed on the cervix uteri, in particular conization * Blood coagulation disorders * Taking blood thinning substances * Iodine allergy

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Conditions

The condition(s) this trial relates to.

cervical intraepithelial neoplasia dysplasia of cervix

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cervical dysplasia

Contacts and locations

Locations

  • Marien Hospital Herne

    Herne, North Rhine-Westphalia, 44625, Germany

More trials for these conditions

Other studies related to the condition(s) this trial covers.