Iodine trick may help surgeons remove all precancerous cervical cells

NCT ID NCT05132114

Completed Disease control Sponsor: Ruhr University of Bochum Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether applying Lugol's iodine during LLETZ surgery helps doctors remove all precancerous cervical tissue. Iodine stains healthy tissue brown, making abnormal areas easier to see. The trial involved 230 women with cervical dysplasia and compared standard surgery to surgery with iodine staining. The goal was to see if iodine reduces the rate of incomplete removal.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Lugol's iodine solution
What this could lead to: If successful, this technique could lower the chance that precancerous cells are left behind after surgery, reducing the need for repeat procedures.
What could go wrong: This is a completed early-stage study with 230 participants. The benefit may be small or not apply to all women, and iodine allergy is a rare but possible risk.

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Conditions

The condition(s) this trial relates to.

cervical intraepithelial neoplasia dysplasia of cervix

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CERVICAL DYSPLASIA

Contacts and locations

Locations

Marien Hospital Herne

Herne, North Rhine-Westphalia, 44625, Germany

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