Blood plasma boosts IVF success for men with Low-Quality sperm
NCT ID NCT07579858
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether adding platelet-rich plasma (PRP) from a man's own blood to his sperm sample could improve embryo development during IVF. Researchers compared embryos from 66 men with severe sperm disorders, half treated with PRP and half without. The goal was to see if PRP increases the number of embryos that reach the blastocyst stage by day 5.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- platelet-rich plasma (PRP)
- What this could lead to
- If it works, this could offer a simple, low-cost way to improve embryo quality in IVF for couples facing male infertility due to poor sperm quality.
- What could go wrong
- This is a small, single-center study with only 66 participants. The results may not apply to all types of sperm disorders, and PRP's effectiveness is still uncertain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
-
66 people
The number who actually took part.
- Started
-
Jan 2023
- Finished
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Dec 2023
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
28 to 45 years
- Sex
-
Male participants only
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. sperm concentration of less than five million/mL; 2. total sperm motility \< 42%; 3. sperm normal morphology of less than four percent; 4. provided informed consent to participate in the study Exclusion Criteria: 1. leukospermia; 2. a history of HIV, hepatitis, or other reproductive tract infections; 3. a history of utilising drugs or therapies within the past three months, such as antibiotics, radiotherapy, chemotherapy, psychiatric medications, or anabolic steroids; 4. a history of fever within the past three months; 5. a history of testicular carcinoma; 6. using a second ejaculate sample for ICSI; 7. using a cryopreserved semen sample for ICSI; 8. a history of retrograde ejaculation; 9. a history of coagulopathy
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Halim Fertility Center, RSIA Stella Maris lantai 5, Jl. Samanhudi No.20, J A T I, Kec. Medan Maimun, Kota Medan, Sumatera Utara 20152
Medan, North Sumatra, 20152, Indonesia
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